Centre for Trophoblast Research

Publications

Recent publications

Salker MS, Christian M, Steel JH, Nautiyal J, Lavery S, Trew G, Webster Z, Al-Sabbagh M, Puchchakayala G, Föller M, Landles C, Sharkey AM, Quenby S, Aplin JD, Regan L, Lang F, Brosens JJ. (2011) Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med. 17:1509-13.

F Colleoni, AJ Morash, T Ashmore, M Monk, GJ Burton, AJ Murray. Cryopreservation of placental biopsies for mitochondrial respiratory analysis. Placenta. 2012 Feb;33(2):122-3. Epub 2011 Dec 10.

Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S, Reik W. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation Nature. 2011 May 19;473(7347):398-402

Rugg-Gunn, P.J., Cox, B.J., Lanner, F., Sharma, P., Ignatchenko, V., McDonald, A.C.H., Garner, J., Gramolini, A.O., Rossant, J. and Kislinger, T. Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Developmental Cell, in press.

Rugg-Gunn, P.J. Epigenetic features of mouse trophoblast. Reproductive BioMedicine Online, in press.

Doisne JM, Tan TC, Colucci F.Guardian of the genome turns on genes that alert natural killer cells Cell Cycle.2011 Nov 15;10(22):3822. Epub 2011 Nov 15.

Colucci F, Boulenouar S, Kieckbusch J, Moffett A. How does variability of immune system genes affect placentation? Placenta. 2011 Aug;32(8):539-45. Epub 2011 Jun 12.

Kerr WG, Colucci F. Inositol phospholipid signaling and the biology of natural killer cells J Innate Immun. 2011;3(3):249-57. Epub 2011 Mar 22. Review.

Niakan K.K., Han, J., Pedersen, R.A., Simon C. and Riejo Pera R.A. Human pre-implantation embryo development. Development, in press. (Primer)
Smith GCS. First trimester determination of complications of late pregnancy. JAMA 2010;303:561-562.

Pasupathy D, Wood AM, Pell JP, Fleming M, Smith GCS. Rates of and factors associated with delivery-related perinatal death among term infants in Scotland. JAMA 2009;302:660-668.

Smith GCS, Celik E, To M, Khouri O, Nicolaides KH. Cervical length at mid-pregnancy and the risk of primary cesarean delivery. N Eng J Med 2008;358:1346-1453.

Smith GCS, Fretts R. Seminar: Stillbirth. Lancet 2007;370: 1715-25.

Smith GCS, Wood A, Pell JP, Dobbie R. Sudden infant death syndrome and complications in other pregnancies. Lancet 2005;366:2107-2111.

Fogarty NME, Mayhew TM, Ferguson-Smith AC and Burton GJ. A quantitative analysis of transcriptionally active syncytiotrophoblast nuclei across human gestation. J Anat. 2011 Aug 24. doi: 10.1111/j.1469-7580.2011.01417.x. [Epub ahead of print]

Wossidlo M, Lepikhov K, Marques CJ, Zakhartchenko V, Boiani M, Reik W, Walter J. Dynamics of 5-hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.2011Nature Communications 2:241

Graham Burton, David Barker, Ashley Moffett, Kent Thornburg (Editors).The Placenta and Human Developmental Programming. (Cambridge University Press, ISBN 987-0-521-19945-2)

Zofia Madeja, Hakim Yadi,Richard Apps, Selma Boulenouar, Stephen J. Roper, Lucy Gardner, Ashley Moffett, Francesco Colucci, and Myriam Hemberger.Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth. PNAS, 2011 March, Vol 108 No 10 4012-4017

Ionel Sandovici, Noel H. Smith, Marloes Dekker Nitert, Matthew Ackers-Johnson, Santiago Uribe-Lewis, Yoko Ito, R. Huw Jones, Victor E. Marquez, William Cairns, Mohammed Tadayyon, Laura P. O'Neill, Adele Murrell, Charlotte Ling, Miguel Constância, and Susan E. Ozanne. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. (News article).

M.H. Johnson: Robert Edwards: the path to IVF. Reproductive BioMedicine Online, in press.

M.H Johnson  and A.A. Theodosiou: PGD and the making of the 'genetic embryo' as a political tool: A historical analysis. In: (Ed. Sheila McLean) Regulating PGD: A Comparative and Theoretical Analysis. Hart Publishing, Oxford.

M.H Johnson: The Biology of Donation. In: (Eds. J. Appleby, G. Pennings and `M. Richards) Reproductive Donation: Bioethics, Policy and Practice. CUP, Cambridge.

 

Reviews

Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2011 Nov 15;13(1):7-13.

Fowden, A.L., Coan, P.M., Angiolini, E., Burton, G.J. & Constancia, M. (2011). Imprinted genes and the epigenetic regulation of placental phenotype. Prog. Biophy. Mol. Biol. 106 281-288.

 

CTR member citations

Erlebacher A with reference to the work of CTR members Francesco Colucci, Ashley Moffett and Myriam Hemberger. Strangers no more: Uterine NK cell recognition of the placenta in mice. Published online before print March 3, 2011, doi: 10.1073/pnas.1101509108 PNAS March 3, 2011

Papers

In preparation

  1. Anastasia A Theodosiou and Martin H Johnson. The politics of human embryo research and the motivation to achieve PGD (Submitted to RBMOnline).
  2. Sharkey AM, Germeyer A, , Prasadajudio M, Sherwin R, Moffett A, Bieback K, Clausmeyer S, Masters L, Popovici RM, Hess AP, Strowitzki T, von Wolff M. Uterine leucocytes regulate the function of decidualized stromal cells.
  3. Boris Novakovic, Lavinia Gordon, Nicholas C. Wong, Ashley Moffett, Ursula Manuelpillai, Jeffrey M. Craig, Andrew Sharkey, and Richard Saffery. Distinct DNA methylation profiles of primary trophoblast cell populations and derived-cell lines.
  4. Niakan KK, Eggan K. Stochastic patterning is conserved in human preimplantation development, although the timing is distinct. (Manuscript in preparation).

2011

  1. Watson ED, Hughes M, Natale DRC, Simmons DG, Natale DRC, Sutherland AE and Cross JC. Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development. 2011 Development Dynamics (In press).
  2. Sferruzzi-Perri, A.N., Vaughan, O.R., Coan, P.M., Suciu, M.C., Darbyshire, R., Constancia, M., Burton, G.J. & Fowden, A.L. (2011). Placental specific Igf2 deficiency alters developmental adaptations to undernutrition in mice. Endocrinol. 152 3202-3212.
  3. Coan, P.M., Vaughan, O.R., McCarthy, J., Mactier, C., Burton, G.J., Constancia, M. & Fowden, A.L. (2011). Dietary composition programs placental phenotype in mice. J. Physiol. 589 3659-3670.
  4. Graham J. Burton, Hong-Wa Yung. Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 1(2011)72-78.
  5. Burton, G.J. (2011) Deportation of syncytial sprouts from the term human placenta. Placenta, 32, 96-98.
  6. Cindrova-Davies, T., Sanders, D.A., Burton, G.J. and Charnock-Jones, D.S. (2011) Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonising VEGF receptor-mediated signalling. Cardiovascular Research, 89, 671-679.
  7. Burton, G.J and Jauniaux, E. (2011) Oxidative stress. Best Practice & Research Clinical Obstetrics & Gynaecology Epub ahead of print.
  8. Angiolini, E., Coan, P.M., Sandovici, I., Unuigbe, O.H., Peck, G., Burton, G.J., Sibley, C.P., Reik, W., Fowden, A.L. and Constância, M. (2011) Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth. FASEB J.
  9. Cetin, I., Huppertz, B., Burton, G., Cuckle, H. Gonen, R., Lapaire, O., Mandia, L., Nicolaides, K., Redman, C., Soothill, P., Spencer, K., Thilaganathan, B., Williams, D. and Meiri, H. (2011) Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies? Placenta, Suppl., S4-S16.
  10. Burton, G.J. and Yung, H-W. (2011) Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia. Pregnancy Hypertension 1, 72-78.
  11. Evans, P., Cindrova-Davies, T., Muttukrishna, S., Burton, G.J., Porter, J. and Jauniaux, E. (2011) Hepcidin and iron species distribution inside the first trimester human gestational sac. Molecular Human Reproduction, 17, 227-232.
  12. Nelson, D.M. and Burton, G.J. (2011) A technical note to improve the reporting of studies of the human placenta. Placenta, 32, 195-196.
  13. Yung, H.W., Charnock-Jones, D.S. and Burton, G.J. (2011) Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner. PLoS One. 6, e17894.
  14. Burton, G.J., Scioscia, M. and Rademacher, T.W. (2011) Endometrial secretions; creating a stimulatory microenvironment within the early human placenta. Implications for the etiopathogenesis of pre-eclampsia. Journal of Reproductive Immunology, in press.
  15. Angioloni, E., Smith, R.J., Sandovici, I., Yung, H-W., Komfortova, G., Burton, G.J., Constancia, M. and Kelsey, G. The imprinted amino acid transporter SNAT4 controls fetal growth by regulating uptake of amino acids required for placental growth. Developmental Cell, Submitted.
  16. A.A. Theodosiou and M.H Johnson: The politics of human embryo research and the motivation to achieve PGD. Reproductive BioMedicine 22, 457-471.
  17. R.L. Gardner and M.H. Johnson: Bob Edwards and the first decade of Reproductive BioMedicine Online. Reproductive BioMedicine Online 22, 103- 121.
  18. M.H. Johnson: Bob Edwards: The trail that led to the Nobel Prize. The Galton Institute Newsletter 75, 1-3.
  19. Vaughan, O.R. Forhead, A.J. & Fowden, A.L. (2011). Glucocorticoids and placental programming. In The Placenta and Human Developmental Programming Eds. Burton, G.J., Barker, D.J.P., Moffett, A., & Thornburg, K.L. pp 175-186. Cambridge University Press, Cambridge.
  20. Angiolini, E., Coan, P.M., Sandovici, I., Unuighe, O.H., Peck, G., Burton, G.J., Reik, W., Fowden, A.L. & Constancia, C. (2011). Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth. FASEB J. 25 1737-1745.
  21. Ferguson-Smith, A (2011). Genomic imprinting: the emergence of an epigenetic paradigm. Genetics Vol. 12 pp565-575.
  22. Smallwood, S.A., Tomizawa, S., Krueger, F., Ruf, N, Carli, N., Sato, S., Hata, K., Andrews, S. and Kelsey, G. (2011) Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nature Genetics Vol 43, pp811–814.
  23. Tomizawa, S., Kobayashi, H., Watanabe, T., Hata, K., Kelsey, G. and Sasaki, H. (2011) Dynamic stage-specific changes of imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes. Development Vol 138, pp811-820.

  24. Ajduk A, Ilozue T, Windsor S,  Yu Y, Seres KB, Bomphrey RJ, Tom BD, Swann K,  Thomas A, Graham C and Zernicka-Goetz M (2011). Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability Nature Communications 2, Article number: 417 doi:10.1038/ncomms1424.

  25. Zernicka-Goetz M. (2011) Proclaiming fate in the early mouse embryo. Nat Cell Biol. 13(2):112-4.

2010

  1. Sferruzzi-Perri AN, Owens JA, Pringle KG, Roberts CT. The neglected role of insulin-like growth factors in the maternal circulation egulating fetal growth. Journal of Physiology (Pubmed ID 20921199) in Press.
  2. Recognition of paternal trophoblast HLA-C by maternal uterine NK cell KIR determines the outcome of pregnancy. SE Hiby, R Apps, AM Sharkey, L Gardner, LE Farrell, M Carrington, A Moffett. J Clin Invest. 2010 Nov 1;120(11):4102-10.
  3. Immature NK cells, capable of producing IL-22, are present in human uterine mucosa. Male V, Hughes T, McClory S, Colucci F, Caligiuri MA, Moffett A. J Immunol 2010 Oct 1;185(7):3913-8. Epub 2010 Aug 27.
  4. Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2. Hiby SE, Apps R, Sharkey AM, Farrell LE, Gardner L, Mulder A, Claas FH, Walker JJ, Redman CC, Morgan L, Tower C, Regan L, Moore GE, Carrington M, Moffett A. J Clin Invest. 2010 Oct 25. pii: 43998. doi: 10.1172/JCI43998.
  5. Genome-wide expression profile of first trimester villous and extravillous human trophoblast cells. Richard Apps, Andrew Sharkey, Lucy Gardner, Victoria Male, Matthew Trotter, Nigel Miller, Robyn North, Sandra Founds and Ashley Moffett. Placenta In press.
  6. Hiby SE, Apps R, Sharkey AM, Farrell LE, Gardner L, Mulder A, Claas FH, Walker JJ, Redman CC, Morgan L, Tower C, Regan L, Moore GE, Carrington M, Moffett A. Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2. J Clin Invest. 2010 Oct 25. Epub ahead of print.
  7. Regulation of early trophoblast differentiation - Lessons from the mouse. Senner CE, Hemberger M. Placenta. 2010 Aug 24. [Epub ahead of print] PMID: 20797785 [PubMed - as supplied by publisher]
  8. M.H. Johnson, S.B. Franklin, M. Cottingham and N. Hopwood: Why the Medical Research Council refused Robert Edwards and Patrick Steptoe support for research on human conception in 1971. Human Reproduction 25, 2157-74. Epub 2010 Jul 24
  9. M.H. Johnson, S.B. Franklin, M. and N. Hopwood: Why the MRC did not fund the first test-tube baby. BioNews
  10. The endometrial response to chorionic gonadotropin is blunted in a baboon model of endometriosis. Sherwin JR, Hastings JM, Jackson KS, Mavrogianis PA, Sharkey AM, Fazleabas AT. Endocrinology. 2010 Oct;151(10):4982-93. Epub 2010 Jul 28.
  11. Parfitt DM and Zernicka-Goetz M (2010). Epigenetic Modification Affecting Expression of Cell Polarity and Cell Fate Genes to Regulate Lineage Specification in the Early Mouse Embryo. Mol Biol Cell. 21(15):2649-60.
  12. Bruce AW and Zernicka-Goetz M (2010). Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate. Curr Opin Genet Dev. 2010
  13. Jedrusik A, Bruce, AW Hahn-Windgassen A, Leong, Skamagki M, Yao M, and Zernicka-Goetz M. (2010). Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo. Dev Biol. 344(1):66-78
  14. Morris SA, Teo RT, Li H, Robson P, Glover DM, and Zernicka-Goetz M (2010). Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc Natl Acad Sci U S A. 6;107(14):6364-9.
  15. Male V, Hughes T, McClory S, Colucci F, Caligiuri MA, Moffett A (2010) Immature NK cells, capable of producing IL-22, are present in human uterine mucosa J Immunol 185:3913-3918
  16. Burke S, Laksmikanth T, Colucci F, Carbone E (2010) New views on natural killer cell-based immunotherapy for melanoma treatment Trends Immunol, 31:339-345.
  17. Ali, K.Z., Burton, G.J., Khalid, M.E., Moosa, R. and Abd-Alla, S. (2010) Concentrations of free vascular endothelial growth factor in the maternal and fetal circulations during pregnancy; a cross-sectional study. Journal of Maternal-Fetal & Neonatal Medicine.
  18. Apps R, Sharkey A, Gardner L, Male V, Kennedy P, Masters L, Farrell L, Jones D, Kulkarni S and Moffett A. Stimulation of decidual NK cells by the different conformations of HLA-G expressed on fetal extravillous trophoblast cells (submitted).
  19. Apps R, Sharkey A, Gardner L, Male V, and Moffett A. Microarray-based expression analysis of first trimester human trophoblast cells. In press at Placenta.
  20. Burton, G.J., Jauniaux, E. and Charnock-Jones, D.S. (2010). The influence of the intrauterine environment on human placental development. International Journal of Developmental Biology ;54:303-312.
  21. Christian Popp, Wendy Dean, Suhua Feng, Shawn J. Cokus, Simon Andrews, Matteo Pellegrini, Steven E. Jacobsen & Wolf Reik. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 463, 1101-1105 (25 February 2010). (PDF)
  22. Coan, P.M., Vaughan, O.R., Sekita, Y., Finn, S.L., Burton, G.J., Constancia, M. & Fowden, A.L. (2010). Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice. J. Physiol 588 527-538.
  23. Francesco Colucci, Corrado M. Cilio. Taming killer cells may halt diabetes progression. Nat Immunol. 2010 Feb;11(2):111-2.
  24. Dilworth M, Kusinski, L, Cowley E, Ward S, Husain S, Constancia M, Sibley C and Glazier J (2010) Placental-specific Igf2 knockout mice exhibit hypocalcaemia and adaptive changes in placental calcium transport Proc Natl Acad Sci USA 107:3894-3899.
  25. Hemberger M., Udayashankar R. Tesar P., Moore H. and Burton G.J. (2010). ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta. Hum. Mol. Gen., 19: 2456-2467.
  26. Hemberger M. (2010). Genetic-epigenetic intersection in trophoblast differentiation: Implications for extraembryonic tissue function. Epigenetics, 5: 1-6.
  27. Hiby, S.E., M. Ashrafian-Bonab, L. Farrell, R.M. Single, F. Balloux, M. Carrington, and A. Moffett. Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations. Immunogenetics. 2010 62:65-73.
  28. M.H. Johnson, S.B. Franklin, M. Cottingham and N. Hopwood: Why the Medical Research Council refused Robert Edwards and Patrick Steptoe support for research on human conception in 1971. Human Reproduction, in press.
  29. Madeja Z, Yadi H, Apps R, Roper S, Moffett A, Colucci F, Hemberger M 'Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth' (Submitted).
  30. Madigan J, Freeman DJ, Menzies F, Forrow S, Nelson SM, Young A, Sharkey A, Moffett A, Graham GJ, Greer IA, Rot A, Nibbs RJ. Chemokine scavenger D6 is expressed by trophoblasts and AIDS the survival of mouse embryos transferred into allogeneic recipients. J Immunol. 2010 Mar 15;184(6):3202-12. PMID: 20147628
  31. Male V, Trundley A, Gardner L, Northfield J, Chang C, Apps R, Moffett A. Natural killer cells in human pregnancy. Methods Mol Biol. 2010;612:447-63 PMID: 20033659.
  32. Moberg, C., Catalano, R. D., Charnock-Jones, D. S. and Olovsson, M. (2010) VEGF-A and Serum Withdrawal Induced Changes in the Transcript Profile in Human Endometrial Endothelial Cells. Reprod Sci.2010:17(6):590-611.
  33. Mokhtar, N. M., Cheng, C. W., Cook, E., Bielby, H., Smith, S. K. and Charnock-Jones, D. S. (2010) Progestin regulates chemokine (C-X-C motif) ligand 14 transcript level in human endometrium. Mol Hum Reprod, 16, 170-177.
  34. Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal Genes Dev. 2010 Feb 1;24(3):312-26.
  35. Li P, Burke S, Chen SX, Ortiz M, Lee S-C, Dong Lu D, Dougan G, Huntly B, Gottgens B, Jenkins N, Copeland N, Colucci F, and Liu P (2010) Bcl11b Deficient T Cells Lose T Cell Identity and Differentiate into Potent Killer Cells Science, 329:85-9. (Comment in Science, 329:44-45)
  36. Petry CJ, Evans ML, Wingate DL, Ong KK, Reik, W, Constancia M & Dunger BD (2010). Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19 delta 13. Diabetes 59:282-286.
  37. Smith GCS, Wood AM, White IR, Pell JP, Hattie J. Birth weight and the risk of cardiovascular disease in the maternal grandparents. American Journal of Epidemiology 2010; 171:736-744.
  38. MC Tissot van Patot, AJ Murray, V Becky, T Cindrova-Davies, J Johns, E Jauniaux, GJ Burton and NJ Serkova. Human placental metabolic adaptation to chronic hypoxia, high altitude: Hypoxic pre-conditioning. Am J Physiol Regul Integr Comp Physiol, 298:R166-72 2010.
  39. Watson ED, Jia WD, Wu X, Fung E, Zhao X, Bieda MC, Snyder FF, Gravel RA and Cross JC. 2010. Maternal grandparental mutation in folate metabolism causes congenital malformations. (Submitted)
  40. M.H. Johnson, S.B. Franklin, M. Cottingham and N. Hopwood: Why the Medical Research Council refused Robert Edwards and Patrick Steptoe support for research on human conception in 1971. Human Reproduction 25, 2157-2174.

  41. Fowden, A.L., Ward, J.W., Wooding, F.B.P. & Forhead, A.J. (2010). Developmental programming of the ruminant placenta. In Reproduction in Domestic Ruminants Editors: Lucy, M.C., Pate, J.L., Smith, M.F. & Spencer, T.E. pp 41-57. Nottingham University Press.
  42. Coan, P.M., Vaughan, O.R., Sekita, Y., Finn, S.L., Burton, G.B., Constancia, M. & Fowden, A.L. (2010). Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice. J. Physiol 588 527-538.

  43. Zernicka-Goetz M and Huang S (2010). Stochasticity vs. determinism in development: a false dichotomy?Nature Reviews Genetics 11:743-4.

  44. Sharif B, Na J, Lykke-Hartmann K, McLaughlin SM, Laue E, Glover DM, and Zernicka-Goetz M. (2010). The Chromosome Passenger Complex is required for Fidelity of Chromosome Transmission and Cytokinesis in Meiosis of mouse Oocytes. J Cell Sci 15;123(Pt 24):4292-30.

2009

  1. Apps R, Murphy SP, Fernando R, Gardner L, Ahad T, Moffett A. Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies. Immunology 2009;127:26-39.
  2. Araki, H., Tamada, Y., Imoto, S., Dunmore, B., Sanders, D., Humphrey, S., Nagasaki, M., Doi, A., Nakanishi, Y., Yasuda, K. et al. (2009) Analysis of PPARalpha-dependent and PPARalpha-independent transcript regulation following fenofibrate treatment of human endothelial cells. Angiogenesis, 12, 221-229.
  3. Bao, S, Tang, F, Li, X, Haayashi, K, Gillich, A, Lao, K, Surani, MA. (2009) Epigenetic reversion of postimplantation epiblast to pluripotent embryonic stem cells. Nature 461, 1292-1295.
  4. Burton GJ. Oxygen, the Janus gas; its effects on human placental development and function. J Anat 2009;215:27-35.
  5. Burton GJ, Charnock-Jones DS, Jauniaux E. Regulation of vascular growth and function in human placenta. Reproduction 2009, 138, 896-902.
  6. Burton GJ, Jauniaux E, Charnock-Jones DS. The influence of the intrauterine environment on human placental development. Int J Dev Biol 2009; 54:303-312.
  7. Burton GJ, Jones CJ. Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta. Taiwan J Obstet Gynecol 2009;48:28-37.
  8. Burton GJ, Woods AW, Jauniaux E, Kingdom JC. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 2009;30:473-82.
  9. Burton GJ, Yung HW, Cindrova-Davies T, Charnock-Jones DS. Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia. Placenta 2009;30 Suppl A:S43-8.
  10. Chotalia M, Smallwood SA, Ruf N, Dawson C, Lucifero D, Frontera M, James K, Dean W, Kelsey G. Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev 2009;23:105-17.
  11. Chua WK, Oyen ML. Viscoelastic properties of membranes measured by sperical indentation. Cellular and Molecular Bioengineering 2009;in press:
  12. Chua WK, Oyen ML. Do we know the strength of the chorioamnion? A critical review and analysis. Eur J Obstet Gynecol Reprod Biol 2009;144 Suppl 1:S128-33.
  13. Cordeaux, Y., Pasupathy, D., Bacon, J., Charnock-Jones, D. S. and Smith, G. C. (2009) Characterization of serotonin receptors in pregnant human myometrium. J Pharmacol Exp Ther, 328, 682-691.
  14. Dolatshad H, Davis FC, Johnson MH. Circadian clock genes in reproductive tissues and the developing conceptus. Reprod Fertil Dev 2009;21:1-9.
  15. Eguizabel C, Shovlin TC, Durcova-Hills G, Surani A, McLaren A. (2009) Generation of primordial germ cells from pluripotent stem cells . Differentiation 78, 116-123
  16. Ellery PM, Cindrova-Davies T, Jauniaux E, Ferguson-Smith AC, Burton GJ. Evidence for transcriptional activity in the syncytiotrophoblast of the human placenta. Placenta 2009;30:329-34.
  17. Fedeli M, Napolitano A, Wong MP, Marcais A, de Lalla C, Colucci F, Merkenschlager M, Dellabona P, Casorati G. Dicer-dependent microRNA pathway controls invariant NKT cell development. J Immunol. 2009 Aug 15;183(4):2506-12. Epub 2009 Jul 22.
  18. Fowden AL, Sferruzzi-Perri AN, Coan PM, Constancia M, Burton GJ. Placental efficiency and adaptation: endocrine regulation. J Physiol 2009;587:3459-72.
  19. Fowden, A.L. & Forhead, A.J. Endocrine regulation of feto-placental growth. Hormone Research, 2009, in press.
  20. Fowden, A.L. & Sibley, C.P. Placental phenotype and fetal growth. J. Physiol 2009;587 3429.
  21. Frøen JF, Pinar H, Flenady V, Bahrin S, Charles A, Chauke L, Day K, Duke CW, Facchinetti F, Fretts RC, Gardener G, Gilshenan K, Gordijn SJ, Gordon A, Guyon G, Harrison C, Koshy R, Pattinson RC, Petersson K, Russell L, Saastad E, Smith GCS, Torabi R. Causes of death and associated conditions (Codac): a utilitarian approach to the classification of perinatal deaths. BMC Pregnancy Childbirth 2009;9:22.
  22. Gabory A, Ripoche MA, Le Digarcher A, Watrin F, Ziyyat A, Forné T, Jammes H, Ainscough JF, Surani MA, Journot L, Dandolo L. (2009) H19 acts as a trans regulator of the imprinted gene network controlling growth in mice . Development 136, 3413-3421
  23. Germeyer, A., A.M. Sharkey, M. Prasadajudio, R. Sherwin, A. Moffett, K. Bieback, S. Clausmeyer, L. Masters, R.M. Popovici, A.P. Hess, T. Strowitzki, and M. von Wolff. 2009. Paracrine effects of uterine leucocytes on gene expression of human uterine stromal fibroblasts. Mol Hum Reprod. 15:39-48.
  24. Ghosh, D., Sharkey, A. M., Charnock-Jones, D. S., Smith, S. K. and Sengupta, J. (2009) Effect of low-dose mifepristone administration on day 2 after ovulation on transcript profiles in implantation-stage endometrium of rhesus monkeys. Reproduction, 138, 357-370.
  25. Hayashi, K. and Surani, MA. (2009) Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro Development 136, 3549-3556.
  26. Hayashi K., Surani M.A. (2009) Resetting the epigenome beyond pluripotency in the germline. Cell Stem Cell 4, 493-498.
  27. Hemberger M, Dean W & Reik W. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nature Reviews Molecular Cell Biology, 10:526-537.
  28. Johnson, MH. From Mouse Egg to Mouse Embryo: Polarities, Axes, and Tissues. Annual Review of Cell and Developmental Biology (2009. 25:483-512. First published on line as a Review in Advance on July 20, 2009). Annual Reviews in Cell and Developmental Biology 25, 483-512
  29. M.H. Johnson, S Franklin and N Hopwood: Mammalian embryology and assisted conception in postwar Britain. Wellcome History 32, 12.
  30. Kaneda M., Tang F., O'Carroll D., Lao K., Surani A. (2009) Essential role for Argonaute2 protein in mouse oogenesis. Epigenetics & Chromatin 2, 9.
  31. Katsanou V., Milatos S., Yiakouvaki A., Kotsoni A., Alexiou M., Harokopos V., Aidinis V., Hemberger M. and Kontoyannis D.L. (2009). The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol. Cell. Biol., 29: 2762-2776.
  32. Krueger F., Madeja Z., Hemberger M., McMahon M., Cook S.J. and Gaunt S.J. (2009). Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK1/2 pathway. Cell. Signalling, 21: 1846-1856.
  33. Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Hoglund P, Kato M, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Karre K, Shibuya A, Carbone E, Colucci F. NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. J Clin Invest 2009;119:1251-63.
  34. Moffett, A., and S. Hiby. 2009. Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages. Hum Reprod. 24:2048-9.
  35. AJ Murray, NS Knight, LE Cochlin, S McAleese, RM Deacon, JN Rawlins and K Clarke. Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding. FASEB J 23:4353-60, 2009.
  36. AJ Murray. Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could solve the controversies. Genome Medicine, 1:117 2009.
  37. Natale D.R.C., Hemberger M., Hughes M. and Cross J.C. (2009). Activin promotes differentiation of mouse trophoblast stem cells towards a labyrinth cell fate. Dev. Biol., 335: 120-131.
  38. Nelson SM, Coan PM, Burton GJ, Lindsay RS. Placental structure in type 1 diabetes: relation to fetal insulin, leptin and IGF-I. Diabetes 2009.
  39. Ng R.K., Dean W., Dawson C., Lucifero D., Madeja Z., Reik W. and Hemberger, M. (2008). Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5. Nature Cell Biology, 10: 1280-1290. This paper has been highlighted in Faculty of 1000 Biology with a 9.0 ("Exceptional") rating and has attracted a research highlight article in Nature Reports Stem Cells.
  40. Pasupathy D, Wood AM, Pell JP, Fleming M, Smith GCS. Advanced maternal age and the risk of perinatal death due to intrapartum anoxia at term. Journal of Epidemiology and Community Health 2009. In press.
  41. Pasupathy D, Wood AM, Pell JP, Fleming M, Smith GCS. Rates of and factors associated with delivery-related perinatal death among term infants in Scotland. JAMA 2009;302:660-668.
  42. Pasupathy DP, Wood AM, Pell JP, Fleming M, Smith GCS. Time trend in the risk of delivery-related perinatal and neonatal death associated with breech presentation at term. International Journal of Epidemiology 2009;38:490-8.
  43. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell 2009;136:629-41.
  44. Pringle, KG, Kind KL, Sferruzzi-Perri AN, Thompson J, Roberts CT (2009) Beyond Oxygen: Complex Regulation and Activity of HIFs in Pregnancy. Human Reproduction Update, Accepted with revisions HRU-09-0006.
  45. Proctor LK, Toal M, Keating S, Chitayat D, Okun N, Windrim RC, Smith GCS, Kingdom JCP. Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol 2009;34:274-82.
  46. Redrup L, Branco MR, Perdeaux ER, Krueger C, Lewis A, Santos F, Nagano T, Cobb BS, Fraser P, Reik W. The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development 2009;136:525-30.
  47. Richter HG, Hansell JA, Raut S, Giussani DA. Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy. J Pineal Res 2009;in press:
  48. Roper S. and Hemberger M. (2009). Defining pathways that enforce cell lineage specification in early development and stem cells. Cell Cycle, 15: 1515-1525.
  49. Saudemont A, Colucci F. PI3K signaling in lymphocyte migration. Cell Cycle. 2009 Oct 15;8(20):3307-10.
  50. Saudemont A, Garcon F, Yadi H, Roche-Molina M, Kim N, Segonds-Pichon A, Martin-Fontecha A, Okkenhaug K, Colucci F. p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease. Proc Natl Acad Sci U S A 2009;106:5795-800.
  51. Smith GCS. Age at menarche and the risk of operative first delivery. BJOG 2009;116:1613-21.
  52. Screen M., Dean W., Cross J.C. and Hemberger M. (2008). Cathepsin proteases have distinct roles in trophoblast proliferation and vascular remodelling. Development, 135: 3311-3320.
  53. Tamada, Y., Araki, H., Imoto, S., Nagasaki, M., Doi, A., Nakanishi, Y., Tomiyasu, Y., Yasuda, K., Dunmore, B., Sanders, D. et al. (2009) Unraveling dynamic activities of autocrine pathways that control drug-response transcriptome networks. Pac Symp Biocomput, 251-263.
  54. Thomas, R., R. Apps, Y. Qi, X. Gao, V. Male, C. O'HUigin, G. O'Connor, D. Ge, J. Fellay, J.N. Martin, J. Margolick, J.J. Goedert, S. Buchbinder, G.D. Kirk, M.P. Martin, A. Telenti, S.G. Deeks, B.D. Walker, D. Goldstein, D.W. McVicar, A. Moffett, and M. Carrington. 2009. HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat Genet. 41:1290-4.
  55. Thomas R, Apps R, Qi Y, O'Connor G, Ge D, Fellay J, Phair J, Goedert JJ, Buchbinder S, Kirk GD, Telenti A, Deeks SG, Walker BD, Goldstein D, McVicar DW, Moffett A and Carrington M. Dual influence of an HLA-C associated variant on distinct aspects of HIV pathogenesis. Nature Genetics (2009) 41:1290-4.
  56. Trogstad L, Magnus P, Moffett A, Stoltenberg C. The effect of recurrent miscarriage and infertility on the risk of pre-eclampsia. Bjog 2009;116:108-13.
  57. Turner RM, Spiegelhalter DJ, Smith GCS, Thompson SG. Bias modelling in evidence synthesis. Journal of the Royal Statistical Society (Series A) 2009;172:21-47.
  58. van Patot MC, Valdez M, Becky V, Cindrova-Davies T, Johns J, Zwerdling L, Jauniaux E, Burton GJ. Impact of pregnancy at high altitude on placental morphology in non-native women with and without preeclampsia. Placenta 2009;30:523-8.
  59. Watson ED, Mattar P, Schuurmans C and Cross JC. 2009. Neural stem cell self-renewal requires the Mrj co-chaperone. Developmental Dynamics 238(10): 2564-2574.
  60. West J.A., Viswanathan S.R., Yabuuchi A., Cunniff K., Takeuchi A., Park I.H., Sero J.E., Zhu H., Perez-Atayde A., Frazier A.L., Surani M.A. Daley G.Q. (2009) A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460, 909-913.
  61. Yadi H., Burke S., Madeja Z., Hemberger M., Moffett A. and Colucci F. (2008). Unique receptor repertoire in mouse uterine NK cells. J. Immunol., 181: 6140-6147. This paper was highlighted in the BBSRC business magazine- January 2009.
  62. Yeap, LS, Hayashi, K, Surani, MA. (2009) SUMOylated ESET-Oct4 interaction regulates pluripotency and repression of the trophectoderm lineage. Epigenetics and Chromatin 2, 12
  63. Zernicka-Goetz M, Morris S, Bruce A. (2009): Making a firm decision: layers of regulation in early mouse embryo. Nature Rev Genet.10(7):467-77.
  64. Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford, CF, Glover DM, and Zernicka-Goetz M. (2009). CARM1 is required in ES cells to maintain pluripotency and resist differentiation. Stem Cells 27(11):2637-45.
  65. Meilhac SM, Adams RJ, Morris SA, Danckaert A, Le Garrec JF, and Zernicka-Goetz M. (2009). Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst. Dev Biol. 332, 210-221

2008

  1. Aiken CE, Cindrova-Davies T, Johnson MH. Variations in mouse mitochondrial DNA copy number from fertilization to birth are associated with oxidative stress. Reprod Biomed Online 2008;17:806-13.
  2. Apps R, Gardner L, Hiby SE, Sharkey AM, Moffett A. Conformation of human leucocyte antigen-C molecules at the surface of human trophoblast cells. Immunology 2008;124:322-8.
  3. Apps R, Gardner L, Moffett A. A critical look at HLA-G. Trends Immunol 2008;29:313-21.
  4. Apps R, Gardner L, Traherne J, Male V, Moffett A. Natural-killer cell ligands at the maternal-fetal interface: UL-16 binding proteins, MHC class-I chain related molecules, HLA-F and CD48. Hum Reprod 2008;23:2535-48.
  5. Breeze ACG, Gallagher FA, Lomas DJ, Smith GCS, Lees CC. Postmortem fetal organ volumetry using magnetic resonance imaging and comparison to organ weights at conventional autopsy. Ultrasound in Obstetrics & Gynecology 2008;31:187-193.
  6. Bukowski R, Uchida T, Smith GCS, Malone FD, Ball RH, Nyberg DA, Comstock CH, Hankins GD, Berkowitz RL, Gross SJ, Dugoff L, Craigo SD, Timor IE, Carr SR, Wolfe HM, D'Alton ME. Individualized Norms of Optimal Fetal Growth: Fetal Growth Potential. Obstetrics & Gynecology 2008;111:1065-1076.
  7. Burton G, Sibley C, Jauniaux E. Placental Anatomy and Physiology (Chapter 1) In:  Obstetrics: Normal and Problem Pregnancies (Steven G. Gabbe, Jennifer R. Niebyl, Joe Leigh Simpson) (ISBN 978-0-443-06930-7, Churchill Livingstone Elsevier, November 2008)
  8. Celik E, To M, Gajewska K, Smith GCS, Nicolaides KH. Cervical length and obstetric history predict spontaneous preterm birth: development and validation of a model to provide individualized risk assessment. Ultrasound in Obstetrics & Gynecology 2008;31:549-54.
  9. Cheng, C. W., Smith, S. K. and Charnock-Jones, D. S. (2008) Transcript profile and localization of Wnt signaling-related molecules in human endometrium. Fertil Steril, 90, 201-204.
  10. Cheng, C. W., Yeh, J. C., Fan, T. P., Smith, S. K. and Charnock-Jones, D. S. (2008) Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun, 365, 285-290.
  11. Chuva de Sousa Lopes S.M., Hayashi K., Shovlin T.C., Mifsud W., Surani M.A., McLaren A. (2008) X Chromosome Activity in Mouse XX Primordial Germ Cells PloS genetics 4, e30.
  12. Coan PM, Angiolini E, Sandovici I, Burton GJ, Constancia M, Fowden AL. Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice. J Physiol 2008;586:4567-76.
  13. Coan PM, Fowden AL, Constancia M, Ferguson-Smith AC, Burton GJ, Sibley CP. Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse. J Physiol 2008;586:5023-32.
  14. Cordeaux, Y., Missfelder-Lobos, H., Charnock-Jones, D. S. and Smith, G. C. (2008) Stimulation of Contractions in Human Myometrium by Serotonin is Unmasked by Smooth Muscle Relaxants. Reprod Sci, 15, 727-734.
  15. Durcova-Hills G., Tang F., Doody G., Tooze R., Surani M.A. (2008) Reprogramming primordial germ cells into pluripotent stem cells. Plos One 3, e3531.
  16. Farthing CR, Ficz G, Ng RK, Chan CF, Andrews S, Dean W, Hemberger M, Reik W. Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet 2008;4:e1000116.
  17. Fowden AL, Forhead AJ, Coan PM, Burton GJ. The placenta and intrauterine programming. J Neuroendocrinol 2008;20:439-50.
  18. Hemberger M., Yang W., Natale D., Brown T.L., Dunk C., Gargett C.E. and Tanaka S. (2008). Stem cells from fetal membranes – A Workshop Report. Placenta, 29S: 17-19.
  19. Hemberger M. (2008). IFPA award in placentology lecture – Characteristics and significance of trophoblast giant cells. Placenta, 29S: 4-9.
  20. Hajkova P., Ancelin K., Waldmann T., Lacoste N., Lange U.C., Cesari F., Lee C., Almouzni G., Schneider R., Surani M.A. (2008) Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature 452, 877-881
  21. Hayashi K., Chuva de Sousa Lopes S.M., Tang F., Surani M.A. (2008) Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states . Cell Stem Cell 3, 391-401
  22. Hayashi K., Chuva de Sousa Lopes S.M., Kaneda M., Tang F., Hajkova P., Lao K., O'Carroll D., Das P.P., Tarakhovsky A., Miska E.A., Surani M.A. (2008) MicroRNA Biogenesis is required for mouse primordial germ cell development and Spermatogenesis Plos One 3, e1738
  23. Hiby SE, Regan L, Lo W, Farrell L, Carrington M, Moffett A. Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage. Hum Reprod 2008;23:972-6.
  24. Hirose, O., Yoshida, R., Imoto, S., Yamaguchi, R., Higuchi, T., Charnock-Jones, D. S., Print, C. and Miyano, S. (2008) Statistical inference of transcriptional module-based gene networks from time course gene expression profiles by using state space models. Bioinformatics, 24, 932-942.
  25. Holmes, K., Charnock Jones, S. D., Forhead, A. J., Giussani, D. A., Fowden, A. L., Licence, D., Kempster, S. and Smith, G. C. (2008) Localization and Control of Expression of VEGF-A and the VEGFR-2 Receptor in Fetal Sheep Intestines. Pediatr Res, 63, 143-148.
  26. Hull, M. L., Escareno, C. R., Godsland, J. M., Doig, J. R., Johnson, C. M., Phillips, S. C., Smith, S. K., Tavare, S., Print, C. G. and Charnock-Jones, D. S. (2008) Endometrial-peritoneal interactions during endometriotic lesion establishment. Am J Pathol, 173, 700-715.
  27. Jauniaux E, Burton GJ. Placental circulations. In: Yagel S, Gembruch U,Silverman NH editor. Fetal Cardiology:Embryology, Genetics, Physiology, Echocardiographic Evaluation, Diagnosis and Perinatal Management of Cardiac Diseases. London: Informa Healthcare; 2008, pp. 41-56.
  28. A. Jedrusik, D.-E. Parfitt, G. Guo, M. Skagami, J.B. Grabarek, M.H. Johnson, P. Robson and M. Zerncika-Goetz: Role of Cdx2 and cell polarity in cell allocation and specification of trophectorderm and inner cell mass in the mouse embryo. Genes and Development 22, 2692-2706.
  29. M.H. Johnson and K. Petersen: Public Interest or Public Meddling? Towards an objective framework for the regulation of Assisted Reproductive Technologies. Human Reproduction (2008) 23, 716-728.
  30. M.H. Johnson: Human ES cells and a blastocyst from one Embryo: exciting science but conflicting ethics? (2008) Cell Stem Cell 2, 103-104
  31. AJ Murray, MA Cole, CA Lygate, CA Carr, DJ Stuckey, SE Little, S Neubauer, K Clarke. Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart. J Mol Cell Cardiol 44:694-700, 2008.
  32. Ng RK, Dean W, Dawson C, Lucifero D, Madeja Z, Reik W, Hemberger M. Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5. Nat Cell Biol 2008;10:1280-90.
  33. Pasupathy, D., Dacey, A., Cook, E., Charnock-Jones, D. S., White, I. R. and Smith, G. C. (2008) Study protocol. A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction study. BMC Pregnancy Childbirth, 8, 51.
  34. Screen M, Dean W, Cross JC, Hemberger M. Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling. Development 2008;135:3311-20.
  35. Sharkey AM, Gardner L, Hiby S, Farrell L, Apps R, Masters L, Goodridge J, Lathbury L, Stewart CA, Verma S, Moffett A. Killer Ig-like receptor expression in uterine NK cells is biased toward recognition of HLA-C and alters with gestational age. J Immunol 2008;181:39-46.
  36. Sharkey AM, Gardner L, Hiby S, Farrell L, Apps R, Masters L, Goodridge J, Lathbury L, Stewart CA, Verma S, Moffett A. KIR expression in uterine NK cells is biased towards recognition of HLA-C and alters with gestational age. J Immunol. 2008 181:39-46.
  37. Smith, G. C., Cordeaux, Y., White, I. R., Pasupathy, D., Missfelder-Lobos, H., Pell, J. P., Charnock-Jones, D. S. and Fleming, M. (2008) The Effect of Delaying Childbirth on Primary Cesarean Section Rates. PLoS Med, 5, e144.
  38. Smith GCS, Celik E, To M, Khouri O, Nicolaides KH. Cervical length at mid-pregnancy and the risk of primary cesarean delivery during labor at term. New England Journal of Medicine 2008;358:1346-1353.
  39. Sowpati D.T., Thiagarajan D., Sharma S., Sultana H., John R., Surani A., Mishra R.K., Khosla S. (2008) An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila . Mech Dev 125, 963-973
  40. Surani M.A., Durcova-Hills G., Hajkova P., Hayashi K., Tee W.W. (2008) Germ Line, Stem Cells and Epigenetic Reprogramming . In 73rd Cold Spring Harbor Symposium on Stem Cells Quant Biol 73, 9-15
  41. Tian G., Singh U., Yu Y., Ellsworth B.S., Hemberger M., Geyer R., Stewart M.D., Behringer R.R. and Fundele R. (2008). Expression and function of the LIM-homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Dev. Dyn., 237: 1517-1525.
  42. Trowsdale J, Moffett A. NK receptor interactions with MHC class I molecules in pregnancy. Semin Immunol 2008;20:317-20.
  43. Watanabe T., Totoki Y., Toyoda A., Kaneda M., Kuramochi-Miyagawa S., Obata Y., Chiba H., Kohara Y., Kono T., Nakano T., Surani M.A., Sakaki Y., Sasaki H. (2008) Endogenous SiRNAs from naturally formed dsRNAs regulate transcripts in mouse Oocytes Nature 453, 539-543.
  44. Yadi H, Burke S, Madeja Z, Hemberger M, Moffett A, Colucci F. Unique receptor repertoire in mouse uterine NK cells. J Immunol 2008;181:6140-7.
  45. Yung HW, Calabrese S, Hynx D, Hemmings BA, Cetin I, Charnock-Jones DS, Burton GJ. Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction. Am J Pathol 2008;173:451-62.
  46. Jedrusik A, Parfitt DE, Guo G, Skamagki M, Grabarek JB, Johnson MH, Robson P and Zernicka-Goetz M. (2008). Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 22(19):2692-706.
  47. Bischoff M, Parfitt DE, Zernicka-Goetz M (2008). Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions. Development 135(5) 953-62.
  48. Adjaye JA, Byskov AG, Cibelli JB, De Maria R, Minger S, Sampaolesi M, Testa G, Verfaillie C and Zernicka-Goetz M, Schöler H, Boiani M, Crosetto N, Redi CA (2008). Pluripotency and differentiation in embryos and stem cells. Int J Dev Biol. 52(7):801-9.

  49. Lykke-Andersen K, Gilchrist MJ, Grabarek JB, Das P, Miska E, Zernicka-Goetz M. (2008). Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition. Mol Biol Cell. 19(10):4383-92.

  50. Soares ML, Torres-Padilla ME, Zernicka-Goetz M. (2008). Bone morphogenetic protein 4 signalling regulates development of the anterior visceral endoderm in the mouse embryo. Dev Growth Differ. 50(7):615-21.

  51. Bischoff M, Parfitt DE, Zernicka-Goetz M (2008). Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions.  Development 135(5) 953-62

2007

  1. Affara, M., Dunmore, B., Savoie, C., Imoto, S., Tamada, Y., Araki, H., Charnock-Jones, D. S., Miyano, S. and Print, C. (2007) Understanding Endothelial Cell Apoptosis: What can the transcriptome, glycome and proteome reveal? Philos Trans R Soc Lond B Biol Sci, 362, 1469-1487.
  2. Burdon, C., Mann, C., Cindrova-Davies, T., Ferguson-Smith A.C. and Burton, G.J. (2007) Oxidative stress and the induction of cyclooxygenase enzymes and apoptosis in the murine placenta. Placenta, 28, 724-733.
  3. Schlabritz-Loutsevitch, N., Ballesteros, B., Dudley, C., Jenkins, S., Hubbard, G., Burton, G.J. and Nathanielsz, P. (2007) Moderate maternal nutrient restriction, but not glucocorticoid administration, leads to placental morphological changes in the baboon (Papio sp.). Placenta 28, 783-793.
  4. Jauniaux, E., Johns, J., Gulbis, B., Spasic-Boskovic, O. and Burton, G.J. (2007) Transfer of folic acid inside the first trimester gestational sac and the effect of maternal smoking. American Journal of Obstetrics and Gynecology, 197, 58.e1-6.
  5. Jauniaux, E. and Burton, G.J. (2007) Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit. Early Human Development, 83, 699-706.
  6. Jones, C.J., Aplin, J. D. and Burton, G.J. (2010) First trimester histiotrophe shows altered sialylation compared with secretory phase glycoconjugates in human endometrium. Placenta, 31, 576-580.
  7. Derks, J.B., Torrance, H.L., Oudijk, M.A., Thakor, A.S., Rademaker C.M.A., Benders, M.J., Rosen, K.G., Cindrova-Davies, T., Visser, G.H.A., Burton, G.J., van Bel, F. and Giussani, D.A. (2010) Allopurinol reduces oxidative stress in the ovine fetal cardiovascular system following repeated episodes of ischemia-reperfusion. Pediatric Research, 68, 374-380.
  8. Jauniaux, E., van Oppenraaij, R.H.F. and Burton, G.J. (2010) Obstetric outcome after early placental complications. Current Opinion in Obstetrics and Gynecology, 22, 452-457.
  9. Andrews S.C., Wood M.D., Tunster S.J., Barton S.C., Surani M.A., John R.M. (2007) Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. BMC Dev Biol 7, 53.
  10. Apps R, Gardner L, Sharkey AM, Holmes N, Moffett A. A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1. Eur J Immunol. 2007 37:1924-37.
  11. Bukowski R, Smith GCS, Malone F, et al for the FASTER Consortium. Human sexual size dimorphism in early pregnancy. American Journal of Epidemiology 2007;165:1216-1218.
  12. Bukowski R, Smith GCS, Malone F, et al for the FASTER Consortium. Early pregnancy fetal growth and the risk of delivering a low birth weight infant. BMJ 2007;334:836.
  13. Burton, G. J., Jauniaux, E. and Charnock-Jones, D. S. (2007) Human early placental development: potential roles of the endometrial glands. Placenta, 28 Suppl A, S64-69.
  14. Catalano, R. D., Critchley, H. O., Heikinheimo, O., Baird, D. T., Hapangama, D., Sherwin, J. R., Charnock-Jones, D. S., Smith, S. K. and Sharkey, A. M. (2007) Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod, 13, 641-654.
  15. Cheng, C. W., Bielby, H., Licence, D., Smith, S. K., Print, C. G. and Charnock-Jones, D. S. (2007) Quantitative cellular and molecular analysis of the effect of progesterone withdrawal in a murine model of decidualization. Biol Reprod, 76, 871-883.
  16. Cindrova-Davies, T., Spasic-Boskovic, O., Jauniaux, E., Charnock-Jones, D. S. and Burton, G. J. (2007) Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitamins. Am J Pathol, 170, 1511-1520.
  17. Cindrova-Davies, T., Yung, H. W., Johns, J., Spasic-Boskovic, O., Korolchuk, S., Jauniaux, E., Burton, G. J. and Charnock-Jones, D. S. (2007) Oxidative Stress, Gene Expression, and Protein Changes Induced in the Human Placenta during Labor. Am J Pathol, 171, 1168-1178.
  18. Duval, H., Johnson, N., Li, J., Evans, A., Chen, S., Licence, D., Skepper, J., Charnock-Jones, D. S., Smith, S. and Print, C. (2007) Vascular development is disrupted by endothelial cell-specific expression of the anti-apoptotic protein Bcl-2. Angiogenesis, 10, 55-68.
  19. Evans, A. L., Bryant, J., Skepper, J., Smith, S. K., Print, C. G. and Charnock-Jones, D. S. (2007) Vascular development in embryoid bodies: quantification of transgenic intervention and antiangiogenic treatment. Angiogenesis.
  20. Hayashi K., De Sousa Lopes S.M., Surani M.A. (2007) Germ cell specification in mice Science 316, 394-396
  21. Hemberger M. (2007). Epigenetic landscape required for placental development. Cell. and Mol. Life Sciences, 64: 2422-2436.
  22. Hemberger M. and Dean W. (2007). Epigenetic arbitration of cell fate decisions: Tipping the bias. Dev. Cell, 12: 176-178.
  23. OJ How, TS Larsen, AD Hafstad, A Khalid, ES Myhre, AJ Murray, NT Boardman, M Cole, K Clarke, DL Severson, E Aasum. Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice.Arch Physiol Biochem 113:211-20, 2007.
  24. Moffett A, Hiby SE. (2007) How Does the Maternal Immune System Contribute to the Development of Pre-eclampsia? Placenta 28 Supplement A S51-S56
  25. AJ Murray, LM Edwards, K Clarke. Mitochondria in heart failure. Curr Opin Clin Nutr Metab Care 10: 704-711, 2007.
  26. K Petersen and M.H. Johnson: SmARTest regulation? Comparing the regulatory structures for ARTs in the UK and Australia. (2007)Reproductive BioMedicine 15, 236-244.
  27. Roberts CT, Owens JA, Sferruzzi-Perri AN (2007) Distinct actions of insulin-like growth factors (IGFs) on placental development and fetal growth. Placenta 29 Suppl A:S42-7.
  28. Sengupta, J., Lalitkumar, P. G., Najwa, A. R., Charnock-Jones, D. S., Evans, A. L., Sharkey, A. M., Smith, S. K. and Ghosh, D. (2007) Immunoneutralization of vascular endothelial growth factor inhibits pregnancy establishment in the rhesus monkey (Macaca mulatta). Reproduction, 133, 1199-1211.
  29. Smith GCS, Crossley JA, Aitken DA, Jenkins N, Lyall F, Cameron AD, Connor JM, Dobbie R Circulating angiogenic factors in early pregnancy and the risk of pre-eclampsia, intra-uterine growth restriction, spontaneous preterm birth and stillbirth. Obstetrics & Gynecology 2007;109:1316-24.
  30. Smith GCS, Shah I, White I, Pell JP, Crossley JA, Dobbie R. Maternal and biochemical predictors of antepartum stillbirth among nulliparous women in relation to gestational age of fetal death. BJOG 2007;114:705-714.
  31. Smith GCS, Fleming K, White IR. Birth order of twins and the risk of delivery-related perinatal death in England, Northern Ireland and Wales, 1994-2003. BMJ 2007;334:576
  32. Smith GCS, Shah I, White IR, Pell JP, Dobbie R. Previous pre-eclampsia, preterm delivery and delivery of a small for gestational age infant and the risk of unexplained stillbirth in the second pregnancy: a retrospective cohort study. American Journal of Epidemiology 2007;165:194-202.
  33. Smith GCS, Shah I, Pell JP, Crossley JA, Dobbie R. Maternal obesity and the risk of spontaneous and elective preterm birth: a retrospective cohort study. American Journal of Public Health 2007;97:157-162.
  34. Smith GCS, Yu CKH, Papageorghiou AT, Cacho AM, Nicolaides KM, for the Fetal Medicine Foundation Second Trimester Screening Group Maternal uterine artery Doppler flow velocimetry and the risk of stillbirth. Obstetrics & Gynecology 2007;109:144-151.
  35. Surani M.A., Hayashi K., Hajkova P. (2007) Genetic and Epigenetic Regulators of Pluripotency. Cell 128, 747-762
  36. Surani, M. A. (2007). Germ cells: The eternal link between generations. The Pontifical Academy of Sciences, Vatican City
  37. Tang F., Kaneda M., O'Carroll D., Hajkova P., Barton S.C., Sun Y.A., Lee C., Tarakhovsky A., Lao K., Surani M.A. (2007) Maternal microRNAs are essential for mouse Zygotic development. Genes Dev. 21, 644-648
  38. Yung, H. W., Korolchuk, S., Tolkovsky, A. M., Charnock-Jones, D. S. and Burton, G. J. (2007) Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells. Faseb J, 21, 872-884.
  39. Torres-Padilla ME, Parfitt DE, Kouzarides T and Zernicka-Goetz M (2007). Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 445, 214-218
  40. Frankenberg S, Smith L, Greenfield A, and Zernicka-Goetz M (2007). Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. BMC Dev Biol 15;7(1):8
  41. Perea-Gomez A, Meilhac SM, Piotrowska-Nitsche K, Gray D, Collignon J, Zernicka-Goetz M (2007.) Regionalisation of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder. BMC Dev Biol. 16, 7(1), 96
  42. Torres-Padilla ME, Richardson L, Kolasinska P, Meilhac SM, Luetke-Eversloh MV, Zernicka-Goetz M (2007). The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation. Dev Biol 309, 97-11

2006

  1. H. Dolatshad, E.A. Campbell, L. O'Hara, E.S. Maywood, M.H. Hastings and M.H. Johnson: Developmental and reproductive performance in circadian mutant mice. Human Reproduction 21, 68-79.
  2. Jauniaux, E. and Burton, G.J. (2006) Villous histomorphometry and placental bed biopsy investigation in Type I diabetic pregnancies. Placenta, 27, 468-474.
  3. Raijmakers, M.T.M., Burton, G.J., Jauniaux, E., Seed, P.T., Peters, W.H.M., Steegers, E.A.P. and Poston, L. (2006) Placental NAD(P)H oxidase mediated superoxide generation in early pregnancy. Placenta, 27, 158-163.
  4. Angiolini, E., Fowden, A., Coan, P., Sandovici, I., Ferguson-Smith, A., Smith, P., Dean, W., Burton, G., Tycko, B., Reik, W., Sibley, C.  and M Constância, M. (2006) Regulation of placental efficiency for nutrient transport by imprinted genes. Placenta, 27 Suppl A, S98-S102.
  5. Varanou, A., Withington, S.L., Lakasing, L., Williamson, C., Burton, G.J. and Hemberger, M. (2006) The importance of cysteine cathepsin proteases for placental development. Journal of Molecular Medicine, 84, 305-317. (Featured by Editorial)
  6. Huppertz, B. Burton G., Cross, J.C. and Kingdom, J.C.P. (2006) Placental morphology: From molecule to mother – A dedication to Peter Kaufmann. Placenta, 27 Suppl A, S3-S8.
  7. Jauniaux, E., Poston, L and Burton G.J. (2006) Placental-related diseases of pregnancy, human evolution and oxygen. Human Reproduction Update, 12, 747-755.
  8. Tjoa, M.L., Cindrova-Davies, T., Spasic-Boskovic, O., Bianchi, D.W. and Burton, G.J. (2006) Trophoblastic oxidative stress and the release of cell-free feto-placental DNA. American Journal of Pathology, 169, 400-404.
  9. Johns, J. Jauniaux, E. and Burton, G.J. (2006) Factors affecting the early embryonic environment. Reviews in Gynaecological and Perinatal Practice, 6, 199-210.
  10. Bell, S.E., Sanchez, M.J.,  Spasic-Boskovic, O., Santalucia, T., Burton, G.J., Murphy, J.J., Norton, J.D., Clark, A.R.  and Turner, M. (2006) The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Developmental Dynamics, 235, 3144-3155.
  11. Coan, P.M., Conroy, N., Burton, G.J. and Ferguson-Smith, A.C. (2006) Origin and characteristics of glycogen cells in the developing murine placenta. Developmental Dynamics, 235, 3280-3294.
  12. Hung, T-H. and Burton, G.J. (2006) Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwanese Journal of Obstetrics and Gynecology, 45, 189-200.
  13. Zusterzeel, P.L.M., Peters, W.H.M., Burton, G.J., Visser, W., Roelofs, H.M.J. and Steegers, E.A.P. (2006) Multiple genetic polymorphisms in maternal biotransformation enzymes and susceptibility to preeclampsia. Gynecologic and Obstetric Investigation, 63, 209-213.
  14. L. Selwood and M.H. Johnson: Trophoblast and hypoblast in the monotreme, marsupial and eutherian mammal: evolution and origins. BioEssays 28, 128-145.
  15. M.H. Johnson: Regulating the Science and Therapeutic Application of Human Embryo Research: Managing the Tension Between Biomedical Creativity and Public Concern. Chap. 10 in: Freedom and Responsibility in Reproductive Choice. Editors A.L. Pedain and J.R. Spencer. Hart Publishing, Oxford and Portland, pp.91-106.
  16. E.A. Campbell, L. O'Hara, R.D. Catalano, A.M. Sharkey, T.C. Freeman and M.H. Johnson: Temporal expression profiling of the uterine luminal epithelium of the pseudo-pregnant mouse suggests receptivity to the fertilised egg is associated with complex transcriptional changes. Human Reproduction 21, 2495-2513.
  17. M.H. Johnson: Escaping the tyranny of the embryo? A new approach to ART regulation based on UK and Australian experiences. Human Reproduction 21, 2756-2765.
  18. M.H. Johnson: Defining the human embryo: A way with words? BioNews (July, 2006) 366

Book Chapters

  1. G. Burton, E. Jauniaux, 2009 Early placental development and pregnancy outcome In: Textbook of Periconceptional Medicine (eds. N.S. Macklon, I.A. Greer & E.A.P. Steegers) (ISBN 978-0-203-09220-0).
  2. Graham Burton, Colin Sibley and Eric Jauniaux. Placental Anatomy and Physiology (Chapter 1) In: Obstetrics: Normal and Problem Pregnancies (Steven G. Gabbe, Jennifer R. Niebyl, Joe Leigh Simpson) (ISBN 978-0-443-06930-7, Churchill Livingstone Elsevier, Nov 08).
  3. Burton, G.J., Sibley, C.P. and Jauniaux, E. (2007) Placental anatomy and physiology In; Obstetrics: Normal and Problem Pregnancies (eds S.G. Gabbe, J.R. Niebyl and J.L. Simpson). 5th Edition, 3-25. Churchill Livingstone, Philadelphia.
  4. Burton, G.J., Sibley, C.P. and Jauniaux, E. (in press) Placental anatomy and physiology In; Obstetrics: Normal and Problem Pregnancies (eds S.G. Gabbe, J.R. Niebyl and J.L. Simpson). 6th Edition. Churchill Livingstone, Philadelphia.
  5. Anne Croy, Jianhong Zhang, Chandrakant Tayade, Francesco Colucci, Hakim Yadi, and Aureo T. Yamada 2009. Analysis of Uterine Natural Killer Cells in Mice In: Natural Killer Cell Protocols: Cellular and Molecular Methods. Methods in Molecular Biology Series, Humana Press. Kerry Campbell and Marco Colonna, Editors.
  6. Jauniaux E, Burton GJ. In: Pijnenborg R, Brosens I, Romero R editor. Oxygen delivery at the deciduo-placental interfacePlacental Bed Vascular Failure: Basic Science & Clinical Management. Cambridge: Cambridge University Press; 2009, pp. in press.
  7. M.H. Johnson and K, Petersen. Instruments for ART regulation: what are the most appropriate mechanisms for achieving smart regulation? In: Regulating Autonomy: Sex, Reproduction and Fertility. Edited by F Ebtehaj, E Jackson, M Richards & S Day Sclater, Hart Publishing, Oxford and Portland, in press.
  8. M. Richards and M.H. Johnson. Introduction: Death writes In: Death Rites and Rights. Editors B. Brooks-Gordon, F. Ebtehaj, J Herring, M.H. Johnson and M Richards. Hart Publishing, Oxford and Portland, pp.1-10.
  9. Saudemont A, Burke S, Colucci F. A simple method to measure NK cell cytotoxicity in vivo In: Methods Mol Biol. 2010;612:325-34.
  10. Burton, G.J., Charnock-Jones, D.S and Jauniaux, E. (2006) Working with oxygen and oxidative stress in vitro. In: Placenta and Trophoblast: Methods and Protocols, Vol. II (eds. M.J. Soares and J.S. Hunt), pp 413-425. Methods in Molecular Medicine Series, Vol. 122. Humana Press Inc., Totowa, NJ.
  11. Burton, G.J., Kaufmann, P. and Huppertz, B. (2006) Anatomy and Genesis of the Placenta. In: Knobil and Neill’s Physiology of Reproduction (ed. J.D. Neill). 3rd Edition, 189-243. Academic Press, Amsterdam.
  12. Burton, G.J. and Jauniaux, E. (2006) Trophoblast and the first trimester environment. In: Biology and Pathology of the Trophoblast (eds. A. Moffett, C. Loke and A. McClaren), pp 111-131. Cambridge University Press, Cambridge.
  13. Burton, G.J., Hung, T-H. and Jauniaux, E. (2007) Placental hypoxia, hyperoxia and ischaemia-reperfusion injury in pre-eclampsia In: Pre-eclampsia – Etiology and Clinical Practice (eds. F. Lyall and M. Belfort), 138-151. Cambridge University Press, Cambridge.
  14. Jauniaux, E. and Burton, G.J. (2008) Placental circulations In: Fetal Cardiology: Embryology, Genetics, Physiology, Echocardiographic Evaluation, Diagnosis and Perinatal Management of Cardiac Diseases (eds. S Yagel, U. Gembruch and N.H. Silverman), 41-56. Informa Healthcare, London.
  15. Jauniaux, E. and Burton, G.J. (2010) Maternofetal transport pathways during embryogenesis and organogenesis In: The Placenta and Human Developmental Programming (eds. G.J. Burton, D.J.P. Barker, A. Moffett and K. Thornburg), 47-54. Cambridge University Press.
  16. Burton, G.J. and Jauniaux, E. (2010) The maternal circulation and placental shape: villus remodelling induced through haemodynamics and oxidative and endoplasmic reticulum stress In: The Placenta and Human Developmental Programming (eds. G.J. Burton, D.J.P. Barker, A. Moffett and K. Thornburg), 161-171. Cambridge University Press.

Books

  1. The Placenta and Human Developmental Programming (Cambridge University Press, ISBN 987-0-521-19945-2) Graham Burton, David Barker, Ashley Moffett, Kent Thornburg (Editors)
  2. Comparative Placentation (Springer-Verlag Berlin Heidelberg, ISBN 978-3-540-78796-9)
    Peter Wooding, Graham Burton, Aug-08