Research
Current Research Interests
- Single cell Transcriptomics
- Placental architecture and perturbations
Research Summary
My project is a collaboration between the Centre for Trophoblast Research; Physiology, Development, & Neuroscience; & Chemistry Departments in the development of novel single cell sequencing techniques aimed at analyzing the placenta as our model system. By better characterizing tissues – placenta or otherwise – at a single cell level, we can move beyond understanding cell populations as an average (i.e. Britons drink tea) and instead as individual and often unique cells contributing to an overall system (i.e. some Britons drink more tea than others; some like coffee instead; some like both tea and coffee, and some like neither. Fascinating, eh?). Single cell analysis will allow us to discover new cell types among seemingly ‘homogeneous’ samples and tissues, allowing us to better understand the complex interplay between cells as well as identify subtle changes in those cell types that may be involved in disease pathologies such as pre-eclampsia.
Publications
Sivaraj D, Bacon W, Long GD, Rizzieri DA, Horwitz ME, Sullivan KM, Kang Y, Li Z, Chao NJ, Gasparetto C. High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma. Bone Marrow Transplant. 2018 Jan
Huang LW, Bacon W, Cirrincione C, Peterson B, Long G, Rizzieri D, Sullivan KM, Corbet K, Horwitz M, Chao N, Gasparetto C, Tuchman SA. Efficacy and safety of high-dose chemotherapy with autologous stem cell transplantation in senior versus younger adults with newly diagnosed multiple myeloma. Hematol Oncol. 2017 Dec
Barrett NA, Malouf C, Kapeni C, Bacon WA, Giotopoulos G, Jacobsen SEW, Huntly BJ, Ottersbach K. Mll-AF4 confers enhanced self-renewal and lymphoid potential during a restricted window in development. Cell Reports. 2016 Jul 26
Mascarenhas MI, Bacon WA, Kapeni C, Fitch SR, Kimber G, Cheng SW, Li J, Green AR, Ottersbach K. Analysis of cytokine signalling reveals resistance of embryonic hematopoietic stem cells to myeloproliferative disease mutation. Blood. 2016 Feb 10.
Tuchman SA, Bacon WA, Huang LW, Long G, Rizzierie D, Horwitz M, Chute JP, Sullivan K, Morris Engemann A, Yopp A, Li Z, Corbet K, Chao N, Gasparetto C. Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma. J Clin Apher. 2014 Oct 8.
Olson IA, Bacon WA, Baez Sosa YY, Delaney KM, Forte SA, Guglielmo MA, Hill AN, Kiesow KH, Langenbacher RE, Xun Y, Young RO, Bowyer WJ. Measurement of heterogeneous reaction rates: three strategies for controlling mass transport and their application to indium-mediated allylations. J Phys Chem A. 2011 Oct 13
