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Hannah Yong

Research Interests

Inappropriate materno-fetal resource allocation causes pregnancy complications and abnormal fetal growth with lifelong consequences for both mother and child. The placenta, the site of maternal-fetal exchange, secretes hormones that modify maternal metabolism and thereby impacts the nutrient availability for fetal growth. However, the precise role of placental endocrine function in supporting fetal growth and influencing future health outcomes of the offspring is unknown. To investigate this, I will exclusively delete or over-express Igf2, a driver of placental endocrine cell formation, in placental endocrine cells as a tool to modify placental endocrine function in mice. By examining the effect of altered placental endocrine function on fetal growth, birth outcomes and postnatal offspring metabolism, and identifying the molecular mechanisms involved in programming the postnatal phenotype, we will advance knowledge of the endocrine placenta and its long-term impact on future health.

 

 

Key Publications

1. *Panagodage S, Yong HEJ, Da Silva Costa F, Borg AJ, Kalionis B, Brennecke SP and Murthi P. Low-Dose Acetylsalicylic Acid Treatment Modulates the Production of Cytokines and Improves Trophoblast Function in an in Vitro Model of Early-Onset Preeclampsia. American Journal of Pathology 2016;186(12):3217-24 (*Joint first-author)

2. Yong HEJ, Melton PE, Johnson MP, Freed KA, Kalionis B, Murthi P, Brennecke SP, Keogh RJ and Moses EK. Genome-wide transcriptome directed pathway analysis of maternal preeclampsia susceptibility genes. PLoS One 2015; 10(5): e0128230

3. Yong HEJ, Murthi P, Borg A, Kalionis B, Moses EK, Brennecke SP and Keogh RJ. Increased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity. Placenta 2014; 35(2):117-24