Research
Research summary
The aim of my project is to characterize the role of placental infection in the aetiology of pregnancy complications. In this study we will utilize samples from a large, prospective cohort study consisting of approximately 4500 primiparous women. Using well-phenotyped cases and matched controls, we will explore the potential presence of infectious agents in the placenta, as well as investigating markers of inflammation in maternal blood serially-collected throughout pregnancy. Potentially, this project will further our understanding of the biological basis of foetal growth restriction and pre-eclampsia, while identifying biomarkers for clinical applications.
Publications
1) Lager S, Gaccioli F, Ramirez VI, Jones HN, Jansson T, Powell TL. “Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4.” J Lipid Res. 2013 Mar;54(3):725-33
2) Lager S, Jansson N, Olsson AL, Wennergren M, Jansson T, Powell TL. “Effect of IL-6 and TNF-α on fatty acid uptake in cultured human primary trophoblast cells.” Placenta. 2011 Feb;32(2):121-7
3) Magnusson-Olsson AL, Lager S, Jacobsson B, Jansson T, Powell TL. “Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency.” Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E24-30.