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Making sense of complexity: how do tissue lymphocytes work in the uterus?

Making sense of complexity: how do tissue lymphocytes work in the uterus?

 

Supervisor: Francesco Colucci

We aim to decipher how Group 1 Innate Lymphoid Cell (ILC) subsets affect physiology and pathology of pregnancy (1). The aim of this project is to understand how NK cells and other Group 1 ILC subsets respond to cytomegalovirus and if and how they retain memory of pregnancy. You will work with a dynamic team of talented PhD students, a dedicated research assistant and a laboratory manager within a close collaboration with a bioinformatician. You will have access to transgenic mice lacking specific subsets of Group 1 ILCs, infection models, flow and mass cytometry (including imaging mass cytometry), RNA-sequencing, 3D-micro-CT imaging to study fetal organ development, and other, conventional methods.  We are based at the Clinical School in the Department of Obstetrics and Gynaecology. The Cambridge Biomedical Campus is the largest in Europe.

Reference:

(1) Filipovic et al, Molecular definition of group 1 innate lymphoid cells in the mouse uterus. BioRxiv; doi: https://doi.org/10.1101/330068