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Centre for Trophoblast Research


Arand J, Wossidlo M, Lepikhov K, Peat JR, Reik W, Walter J. (2015) Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo. Epigenetics Chromatin 8(1):1 2015. Doi: 10.1186/1756-8935-8-1.

Bedzhov I, Zernicka-Goetz M. (2015) Cell death and morphogenesis during early mouse development: are they interconnected? Bioessays 37(4):372-378 Apr 2015. doi: 10.1002/bies.201400147.

Bedzhov I, Bialecka M, Zielinska A, Kosalka J, Antonica F, Thompson AJ, Franze K, Zernicka-Goetz M. (2015) Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo.Cell Res. 2015 Sep 4. doi: 10.1038/cr.2015.104. [Epub ahead of print]

Berrens RV, Reik W. (2015) Prmt5: a guardian of the germline protects future generations. EMBO J 16 Feb 2015. Doi: 10.15252/embj.201591054.

Burton G.J. and Jauniaux E. (2015) What is the placenta? American Journal of Obstetrics and Gynecology, 213(4 Suppl):S6.e1-4.

Burton GJMoffett AKeverne B. (2015) Human evolution: brain, birthweight and the immune system. Philosophical Transactions B of the Royal Society of London. doi: 10.1098/rstb.2014.0061.

Burton GJ, Fowden AL.  (2015) The placenta: a multifaceted, transient organ. Philosophical Transactions B of the Royal Society of London. doi:10.1098/rstb.2014.0066.

Burton GJ, Sebire NJ, Myatt L, Tannetta D, Wang YL, Sadovsky Y, Staff AC, Redman CW. (2014) Optimising sample collection for placental research. Placenta 35(1):9-22 Jan 2014. Doi: 10.1016/j.placenta.2013.11.005.

Chandra T, Ewels PA, Schoenfelder S, Furlan-Magaril M, Wingett SW, Kirschner K, Thuret JY, Andrews S, Fraser P, Reik W. (2015) Global Reorganization of the Nuclear Landscape in Senescent Cells. Cell Rep 28 Jan 2015. Doi: 10.1016/j.celrep.2014.12.055.

Charnock-Jones DS. (2015) Placental hypoxia, endoplasmic reticulum stress and maternal endothelial sensitisation by sFLT1 in pre-eclampsia. J Reprod Immunol 18 Jul 2015 doi:10.1016/j.jri.2015.07.004.

Charnock-Jones S, Cordeaux Y, Smith G. (2015) The effect of an oxytocin receptor antagonist (retosiban, GSK221149A) on the response of human myometrial explants to prolonged mechanical stretch. Endocrine Society, 24 July 2015 doi:

Chazara O, Moffett A. (2015) Association of maternal KIR and fetal HLA-C genes with the risk of preeclampsia in the Chinese Han population, Long et alPlacenta 23 Jun 2015 doi:10.1016/j.placenta.2015.06.005.

Cheong CY, Chng K, Ng S, Chew SB, Chan L, Ferguson-Smith AC. (2015) Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation. Genome Res 25(5):611-623 May 2015 doi:10.1101/gr.183301.114.

Cindrova-Davies T, van Patot MT, Gardner L, Jauniaux E, Burton GJ, Charnock-Jones DS. (2015) Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development.   Mol Hum Reprod 21(3):296-308 Mar 2015. doi:10.1093/molehr/gau105.

Colucci F, Boulenouar S, Kieckbusch J, Moffett A. (2015) How does variability of immune system genes affect placentation? Placenta. 2011 Aug;32(8):539-45.

Colucci F, Kieckbusch J. (2015) Maternal uterine natural killer cells nurture fetal growth: In medio stat virtus. Trends in Molecular Medicine 21(2):60-67 01 Feb 2015. Doi: 10.1016/j.molmed.2014.12.009.

Colucci F. (2015) An oral commensal associates with disease: chicken, egg, or red herring?  Immunity 42(2):208-210 17 Feb 2015. Doi: 10.1016/j.immuni.2015.01.024.

Colucci F, (2015) NK cells and other innate lymphoid cells at the maternal-fetal interface. Journal of Reproductive Immunology. 111: 4-5. Sep 2015 doi:10.1016/j.jri.2015.06.056.

De Blasio MJ, Boije M, Vaughan OR, Bernstein BS, Davies KL, Plein A, Kempster SL, Smith GC, Charnock-Jones DS, et al. Developmental Expression and Glucocorticoid Control of the Leptin Receptor in Fetal Ovine Lung. PLoS One. 2015 Aug 19;10(8):e0136115. doi: 10.1371/journal.pone.0136115. eCollection 2015.

Doisne JM, Balmas E, Boulenouar S, Gaynor LM, Kieckbusch J, Gardner L, Hawkes DA, Barbara CF, Sharkey AM, et al. (2015) Composition, Development, and Function of Uterine Innate Lymphoid Cells. J Immunol. 2015 Oct 15;195(8):3937-45. doi: 10.4049/jimmunol.1500689. Epub 2015 Sep 14.

Dunphy SE, , Guinan KJ, , Chorcora CN, Jayaraman J, Traherne JA, Traherne JA, Trowsdale J, Pende D, Middleton D, Gardiner CM. (2015) 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells. Genes and Immunity 16(5):301-310 01 Jan 2015 doi:10.1038/gene.2015.15.

Fernandez-Twinna DS, Constância M, Ozanne SE. (2015) Intergenerational epigenetic inheritance in models of developmental programming of adult disease. Semin Cell Dev Biol 30 Jun 2015 doi:10.1016/j.semcdb.2015.06.006.

Fogarty NM, Burton GJ, Ferguson-Smith AC. (2015) Different epigenetic states define syncytiotrophoblast and cytotrophoblast nuclei in the trophoblast of the human placenta. Placenta 36(8):796-802 Aug 2015 doi:10.1016/j.placenta.2015.05.006. 

Forhead AJ, Jellyman JK, De Blasio MJ, Johnson E, Giussani DA, Broughton Pipkin F, Fowden AL. (2015) Maternal Dexamethasone Treatment Alters Tissue and Circulating Components of the Renin-Angiotensin System in the Pregnant Ewe and Fetus. Endocrinology 156(8):3038-3046 Aug 2015 doi:

Fowden AL, Forhead AJ. (2015) Glucocorticoids as regulatory signals during intrauterine development. Exp Physiol 04 Jun 2015 doi:10.1113/EP085212.

Fowden, A.L., Forhead, A.J., Sferruzzi-Perri, A.N., Burton, G.J. & Vaughan, O.R. (2015). Endocrine regulation of placental phenotype. Placenta 36 Supplement 1, Trophoblast Research 29 S50-S59.

Gautier HO, Thompson AJ, Achouri S, Koser DE, Holtzmann K, Moeendarbary E, Franze K. (2015) Atomic force microscopy-based force measurements on animal cells and tissues. Methods Cell Biol 125:211-235 2015 doi:10.1016/bs.mcb.2014.10.005.

Hartley JD, Ferguson BJ, Moffett A. (2015) The role of shed placental DNA in the systemic inflammatory syndrome of preeclampsia. Am J Obstet Gynecol 17 Mar 2015 doi:10.1016/j.ajog.2015.03.026.

Herreboudt AM, Kyle VR, Lawrence J, Doran J, and Colledge WH (2015). Kiss1 mutant placentas show normal structure and function in the mouse. Placenta 36:52-58.

Herrera EA, Rojas RT, Krause BJ, Ebensperger G, Reyes RV, Giussani DA, Parer JT, Llanos AJ. (2015) Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano. J Physiol. 2015 Sep 4. doi: 10.1113/JP271110. [Epub ahead of print].

Higgins JS, Vaughan OR, de Liger EF, Fowden AL, Sferruzzi-Perri AN. (2015) Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy. J Physiol. 2015 Sep 17. doi: 10.1113/JP271057. [Epub ahead of print].

Hiramuki Y, Sato T, Furuta Y, Surani MA, Sehara-Fujisawa A. (2015) Mest but Not MiR-335 Affects Skeletal Muscle Growth and RegenerationPLoS One 10(6):e0130436 2015 doi:10.1371/journal.pone.0130436.

Hüber CM, Doisne JM, Colucci F. (2015) IL-12/15/18-preactivated NK cells suppress GvHD in a mouse model of mismatched hematopoietic cell transplantation. Eur J Immunol, 2015 Jun;45(6):1727-35. doi: 10.1002/eji.201445200. Epub 2015 Apr 17.

Irie N, Tang WW, Azim Surani M. (2015) Germ cell specification and pluripotency in mammals: a perspective from early embryogenesis. Reprod Med Biol 13(4):203-215 2014 doi: 10.1007/s12522-014-0184-2.

Irie N, Weinberger L, Tang WWC, Kobayashi T, et al. (2015) SOX17 is a critical specifier of human primordial germ cell fate. Cell 160(1-2):253-268 15 Jan 2015 doi:10.1016/j.cell.2014.12.013.

Ito M, Sferruzzi-Perri AN, Edwards CA, Adalsteinsson BT, Allen SE, Loo TH, Kitazawa M, Kaneko-Ishino T, Ishino F, et al. (2015) A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development. Development 142(14):2425-2430 15 Jul 2015 doi:10.1242/dev.121996.    

Iyer D, Gambardella L, Bernard WG, Serrano F, Mascetti VL, Pedersen RA, Talasila A, Sinha S. (2015) Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development 142(8):1528-1541 15 Apr 2015 doi: 10.1242/dev.119271.

Jedrusik A, Cox, Wicher K, Glover DM, Zernicka-Goetz M. (2015) Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition.Developmental Biology 398(2):147-152 01 Jan 2015 doi:10.1016/j.ydbio.2014.12.004.

Kang J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, et al. (2015) Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A 112(31):E4236-E4245 04 Aug 2015 doi: 10.1073/pnas.1510510112.

Kieckbusch J, Balmas E, Hawkes DA, Colucci F. (2015) Disrupted PI3K p110δ Signaling Dysregulates Maternal Immune Cells and Increases Fetal Mortality In Mice. Cell Reports. 2015.

Kieckbusch J, Gaynor LM, Colucci F. (2015) Assessment of maternal vascular remodeling during pregnancy in the mouse uterus. JoVE (Journal of Visualized Experiments), e53534-e53534. 2015

Kieckbusch J, Gaynor LM, Moffett A, Colucci F. (2015) MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling. Nature Communications. 2014 5:3359. DOI 10.1038/ncomms4359.

Knee O, Gupta A, Curley A, Charnock-Jones DS, Smith GC, Belteki G. (2015) The acute-phase protein SAA3 is present in the preterm human colostrum and breast milk.Arch Dis Child Fetal Neonatal Ed 100(4):F369-F371 Jul 2015 doi:10.1136/archdischild-2014-307795.

Latos PA, Goncalves A, Oxley D, Mohammed H, Turro E, Hemberger M. (2015) Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.  Nat Commun 6:7776 2015 doi:10.1038/ncomms8776.

Lopes Novo C, Rugg-Gunn PJ. (2015) Chromatin organization in pluripotent cells: emerging approaches to study and disrupt function. Brief Funct Genomics. 2015 Jul 23. pii: elv029. [Epub ahead of print]

Macaulay IC, Haerty W, Kumar P, Li YI, Hu TX, Teng MJ, Goolam M, Saurat N, Coupland P, et al. (2015) G&T-seq: parallel sequencing of single-cell genomes and transcriptomes. Nat Methods 12(6):519-522 Jun 2015 doi:10.1038/nmeth.3370.

Mackay DF, Wood R, King A, Clark DN, Cooper SA, Smith GC, Pell JP. (2015) Educational outcomes following breech delivery: a record-linkage study of 456947 children.Int J Epidemiol 44(1):209-217 Feb 2015, doi: 10.1093/ije/dyu270.

Matheson H, Veerbeek JH, Charnock-Jones DS, Burton GJ, Yung HW (2015) Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy.  J Physiol. 2015 Aug 17. doi: 10.1113/JP271073. [Epub ahead of print].

Mauri A, Ehret AE, Perrini M, Perrini M, Maake C, Ochsenbein-Kölble N, Ehrbar M, Oyen ML, Mazza E. (2015) Deformation mechanisms of human amnion: Quantitative studies based on second harmonic generation microscopy. Journal of Biomechanics 48(9):1606-1613 01 Jan 2015 doi:10.1016/j.jbiomech.2015.01.045.

McInroy GR, Bell NM, Ficz G, Balasubramanian S, Reik W, Raiber E-A. (2015) The biology and genomic localization of cytosine modifications. Epigenetics and Human Health 4:167-191 2015. Doi: 10.1007/978-3-642-31974-7_8.

Moffett A, Colucci F. (2015) Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction. Immunol Rev. 2015 Sep;267(1):283-97. doi: 10.1111/imr.12323.

Moffett A, Hiby SE, Sharkey AM. (2015) The role of the maternal immune system in the regulation of human birthweight. Philos Trans R Soc Lond B Biol Sci 370(1663) 05 Mar 2015.

Moffett A, Shreeve N. (2015) First do no harm: uterine natural killer (NK) cells in assisted reproduction. Hum Reprod 30(7):1519-1525 Jul 2015 doi: 10.1093/humrep/dev098.

Nakimuli A, Chazara O, Hiby SE, Farrell L, Tukwasibwe S, Jayaraman J, Traherne JA, Trowsdale J, Colucci F, et al. (2015) A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia. Proc Natl Acad Sci U S A 112(3):845-850 20 Jan 2015. Doi: 10.1073/pnas.1413453112.

Oliver-Williams C, Fleming M, Wood A, Smith G. (2015) Previous miscarriage and the subsequent risk of preterm birth in Scotland, 1980–2008: a historical cohort study.BJOG 28 Jan 2015 doi: 10.1111/1471-0528.13276.

Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, et al. (2015) Redundant mechanisms to form silent chromatin at pericentromeric regions rely on BEND3 and DNA methylation. Mol Cell 56(4):580-594 20 Nov 2014 doi:10.1016/j.molcel.2014.10.001.

Sharkey AM, Xiong S, Kennedy PR, Gardner L, Farrell LE, Chazara O, Ivarsson MA, Hiby SE, Colucci F, Moffett A. (2015) Tissue-Specific Education of Decidual NK Cells. J Immunol. 2015 Oct 1;195(7):3026-32. doi: 10.4049/jimmunol.1501229. Epub 2015 Aug 28.

Shen H, Cavallero S, Estrada KD, Sandovici I, Kumar SR, Makita T, Lien CL, Constancia M, Sucov HM. (2015) Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res 105(3):271-278 01 Mar 2015 doi:

Skeffington KL, Higgins JS, Mahmoud AD, Evans AM, Sferruzzi-Perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG. (2015) Hypoxia, AMPK activation and uterine artery vasoreactivity. J Physiol 25 Jun 2015 doi:10.1113/JP270995.

Sovio U, White IR, Dacey A, Pasupathy D, Smith GC (2015).Screening for fetal growth restriction with universal third trimester ultrasonography in nulliparous women in the Pregnancy Outcome Prediction (POP) study: a prospective cohort study. Lancet. 2015 Sep 7. pii: S0140-6736(15)00131-2. doi: 10.1016/S0140-6736(15)00131-2. [Epub ahead of print].

Strogantsev R, Krueger F, Yamazawa K, Shi H, Gould P, Goldman-Roberts M, McEwen K, Sun B, Pedersen R, Ferguson-Smith AC. (2015) Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression. Genome Biol 16(1):112 2015 doi:10.1186/s13059-015-0672-7.

Surani MA. (2015) Human Germline: A New Research Frontier. Stem Cell Reports 4(6):955-960 09 Jun 2015 doi:10.1016/j.stemcr.2015.04.014.

Tallerico R, Cristiani CM,  Capone M,  Madonna G, Mallardo D, Simeone E, Dominijanni A, Grimaldi AM, Colucci F, Ascierto PA, Carbone E. (2015) Analysis of T and NK cells immune response in Ipilimumab treated Melanoma patients.  J Transl Med. 2015; 13(Suppl 1): O8. Published online 2015 Jan 15.  doi:  10.1186/1479-5876-13-S1-O8.

Tang WW, Dietmann S, Irie N, Leitch HG, Floros VI, Bradshaw CR, Hackett JA, Chinnery PF, Surani MA. (2015) A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development. Cell 161(6):1453-1467 04 Jun 2015 doi:10.1016/j.cell.2015.04.053. 

Thakor AS, Allison BJ, Niu Y, Botting KJ, Serõn-Ferré M, Herrera EA, Giussani DA. (2015) Melatonin modulates the fetal cardiovascular defense response to acute hypoxia.Journal of Pineal Research 59(1):80-90 01 Aug 2015 doi:10.1111/jpi.12242.

Tilburgs T, Crespo ÂC, van der Zwan A, Rybalov B, Raj T, Stranger B, Gardner L, Moffett A, Strominger JL. (2015) Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes. Proc Natl Acad Sci U S A 112(23):7219-7224 09 Jun 2015 doi:10.1073/pnas.1507977112/-/DCSupplemental.

Vaughan OR, Phillips HM, Everden AJ, Sferruzzi-Perri AN, Fowden, AL. (2015). Dexamethasone treatment of pregnant F0 mice leads to parent of origin-specific changes in placental function of the F2 generationReprod. Fert. Develop. 27 704-711.

Vaughan OR, Fisher HM, Dionelis KN, Jefferies EC, Higgins JS, Musial B, Sferruzzi-Perri AN, Fowden AL. (2015) Corticosterone alters materno-fetal glucose partitioning and insulin signalling in pregnant mice. J Physiol 27 Jan 2015. DOI: 10.1113/jphysiol.2014.287177.

Veerbeek JH, Post Uiterweer ED, Nikkels PG, Koenen SV, van der Zalm M, Koster MP, Burton GJ, van Rijn BB, Franx A (2015) Biopsy techniques to study the human placental bed. Placenta 05 Jun 2015 doi:10.1016/j.placenta.2015.05.008.

Veerbeek JH, Tissot Van Patot MC, Burton GJ, Yung HW. (2015) Endoplasmic reticulum stress is induced in the human placenta during labour. Doi: 10.1016/j.placenta.2014.11.005.

Veselovska L, Smallwood SA, Saadeh H, Stewart KR, Krueger F, Maupetit-Méhouas S, Arnaud P, Tomizawa S, Andrews S, Kelsey G. (2015) Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscapeGenome Biol. 2015 Sep 25;16(1):209. doi: 10.1186/s13059-015-0769-z. PMID: 26408185.

von Meyenn F, Reik W, (2015) Forget the Parents: Epigenetic Reprogramming in Human Germ Cells. Cell 2015 Jun 4;161(6):1248-51. doi: 10.1016/j.cell.2015.05.039.

Wang X, West JA, Murray AJ, Griffin JL (2015) Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse HeartJ Proteome Res 14(7):2849-2862 02 Jul 2015 doi:10.1021/acs.jproteome.5b00128.

Zhong C, Yin Q, Xie Z, Bai M, Dong R, Tang W, Xing YH, Zhang H, Yang S, et al. (2015) CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library. Cell Stem Cell. 2015 Aug 6;17(2):221-32. doi: 10.1016/j.stem.2015.06.005. Epub 2015 Jul 9.