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Centre for Trophoblast Research



Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, Del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, Heckerman D, Stein JL, Soderberg KA, Moody MA, Denny TN, Zeng X, Fang J, Moffett A, Lifson JD, Goedert JJ, Buchbinder S, Kirk GD, Fellay J, McLaren P, Deeks SG, Pereyra F, Walker B, Michael NL, Weintrob A, Wolinsky S, Liao W, Carrington M. (2013) Influence of HLA-C expression level on HIV control. Science.  Apr 5;340(6128):87-91. doi: 10.1126 PMID: 23559252.

Arnaiz I, Johnson MH, Cook DI, Day ML. (2013) Changing expression of chloride channels during preimplantation mouse development. Reproduction 145(1):73-84 Jan 2013. doi: 10.1530/REP-12-0055.

Booth MJ, Ost TW, Beraldi D, Bell NM, Branco MR, Reik W, Balasubramanian S. (2013) Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine.Nat Protoc 8(10):1841-1851 Oct 2013. doi: 10.1038/nprot.2013.115.

Burke KA, Jauniaux E, Burton GJ, Cindrova-Davies T. (2013) Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation. Placenta, 34, 1105-1109.

Cindrova-Davies T, Herrera E.A, Niu Y, Kingdom J, Giussani DA, Burton GJ. (2013) Reduced cystathionine g-lyase and increased miR-21 are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator. Am J Pathol, 182, 1448-1458.

Colleoni F, Padmanabhan N, Yung H-W, Watson ED, Cetin I, Tissot van Patot MC, Burton GJ, Murray AJ. (2013) Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miR-210 and protein synthesis inhibition. PLoS One, 8, e55194.

Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S, Levasseur DN, Li Z, Xu M, Reik W, Silva JC, Wang J. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013 Mar 21;495(7441):370-4. doi: 10.1038/nature11925. Epub 2013 Feb 10.

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D, Paul YL, Walter J, Cook SJ, Andrews S, Branco MR, Reik W. FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency. Cell Stem Cell. 2013 Jul 10. doi:pii: S1934-5909(13)00262-2. 10.1016/j.stem.2013.06.004. [Epub ahead of print]

Grossniklaus U, Kelly WG, Ferguson-Smith AC, Pembrey M, Lindquist S (2013) Transgenerational epigenetic inheritance: how important is it? Nat Rev Genet 14(3):228-235 Mar 2013. Doi: 10.1038/nrg3435.

Fogarty NM, Ferguson-Smith AC, Burton GJ. Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage. Am J Pathol. 2013 Jul;183(1):144-52.

Hemberger M. and Dean W. (2013). First cell fate decisions in early development – towards establishment of the trophoblast lineage. In The Guide of Investigations of Mouse Pregnancy, Elsevier Press 2013. 

Hemberger M. (2013). Immune balance at the feto-maternal interface as the fulcrum of reproductive successJ. Reprod. Immunol., 97: 36-42.

Iurlaro M, Ficz G, Oxley D, Raiber EA, Bachman M, Booth MJ, Andrews S, Balasubramanian S, Reik W. (2013) A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol 14(10):R119 2013. Doi: 10.1186/gb-2013-14-10-r119.

Latos PA, Hemberger M. Review: The transcriptional and signalling networks of mouse trophoblast stem cells. Placenta. 2013 Nov 1. pii: S0143-4004(13)00786-8. doi: 10.1016/j.placenta.2013.10.013. [Epub ahead of print].

Lu L, Burton GJ, Cindrova-Davies T. (2013) P26 Placental stem villus arteries undergo dedifferentiation via reduced hydrogen sulfide production by cystathionine-γ-lyase upon exposure to oxidative stress. United States. Nitric Oxide. 31 Suppl 2: S46. 01 Sep 2013. Doi: 10.1016/j.niox.2013.06.088.

Mikaelsson MA, Constância M, Dent CL, Wilkinson LS, Humby T (2013) Placental programming of anxiety in adulthood revealed byIgf2-null models. Nature CommunicationsDOI: 10.1038/ncomms3311.

Mohun TJ, Adams DJ, Baldock R, Bhattacharya S, Copp AJ, Hemberger M, Houart C, Hurles ME, Robertson E, Smith JC, Weaver T, Weninger W. (2013). Deciphering the Mechanisms of Developmental Disorders (DMDD): A new programme for phenotyping embryonic lethal mice. Disease Models & Mechanisms, 6: 562-566.

Morgani SM, Canham MA, Nichols J, Sharov AA, Migueles RP, Ko MS, Brickman JM (2013) Totipotent embryonic stem cells arise in ground-state culture conditions. Cell Rep 3(6):1945-1957 27 Jun 2013. Doi: 10.1016/j.celrep.2013.04.034.

Naicker T, Dorsamy E, Ramsuran D, Burton GJ, Moodley J. (2013) The role of apoptosis on trophoblast cell invasion in the placental bed of normotensive and hypertensive pregnancies. Hypertension in Pregnancy, 32, 245-256.

Nakimuli A, Chazara O, Byamugisha J, Elliott AM, Kaleebu P, Mirembe F, Moffett A. (2013) Pre-eclampsia, Pregnancy and Parturition in Women of African Ancestry.American Journal of Obstetrics and Gynecology doi: 10.1016/j.ajog. 2013.10.879

Nakimuli A, Chazara O, Farrell L, Hiby SE, Tukwasibwe S, Knee O, Jayaraman J, Traherne JA, Elliott AM, Kaleebu P, Mirembe F, Moffett A. (2013) Killer cell immunoglobulin-like receptor (KIR) genes and their HLA-C ligands in a Ugandan population. Immunogenetics. Aug 24. PMID: 23974321. doi:10.1007.

Nakimuli A, Elliott AM, Kaleebu P, Moffett A, Mirembe F. Hypertension persisting after pre-eclampsia: a prospective cohort study at Mulago Hospital, Uganda. PLoS One. 2013 Dec 31;8(12)

Niakan KK, Eggan K. (2013) Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse. Developmental Biology375(1):54-64.

Oda M, Oxley D, Dean W, Reik W. Regulation of lineage specific DNA hypomethylation in mouse trophectoderm. PLoS One. 2013 Jun 25;8(6):e68846. doi: 10.1371/journal.pone.0068846. Print 2013.

Padmanabhan N, Jia D, Geary-Joo C, Wu X, Ferguson-Smith AC, Fung E, Bieda MC, Snyder FF, Gravel RA, Cross JC and Watson ED. (2013). Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development. Cell 155(1): 81-93.

Padmanabhan N, Watson ED. (2013) Lessons from the one-carbon metabolism: passing it along to the next generation. Reprod Biomed Online 27(6):637-643 Dec 2013. Doi: 10.1016/j.rbmo.2013.09.008.

Parham P, Moffett A.  (2013) Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution. Nat Rev Immunol 13:133.

Raddatz G, Guzzardo PM, Olova N, Fantappié MR, Rampp M, Schaefer M, Reik W, Hannon GJ, Lyko F. Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8627-31. doi: 10.1073/pnas.1306723110. Epub 2013 May 2.

Sandovici I, Hammerle CM, Ozanne SE, Constância M. (2013) Developmental and environmental epigenetic programming of the endocrine pancreas: Consequences for type 2 diabetes. Cellular and Molecular Life Sciences 70(9):1575-1595 May 2013. Doi: 10.1007/s00018-013-1297-1.

Santos F, Peat J, Burgess H, Rada C, Reik W, Dean W. (2013) Active demethylation in mouse zygotes involves cytosine deamination and base excision repair. Epigenetics Chromatin 6(1):39 2013. Doi: 10.1186/1756-8935-6-39.

Seisenberger S, Peat JR, Reik W. (2013) Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells. Curr Opin Cell Biol.2013 Jun;25(3):281-8. doi: 10.1016/ Epub 2013 Mar 17.

Seisenberger S, Peat JR, Hore TA, Santos F, Dean W, Reik W. Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers.Philos Trans R Soc Lond B Biol Sci. 2013 Jan 5;368(1609):20110330. doi: 10.1098/rstb.2011.0330. Review.

Sferruzzi-Perri AN, Vaughan OR, Haro M, Cooper WN, Musia B, Charalambous M, Pestana D, Ayyar S, Ferguson-Smith AC, Burton GJ, Constancia M, Fowden AL (2013) An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectoryThe FASEB Journal, article fj.13-234823. Published online July 15, 2013.

Sferruzzi-Perri AN, Vaughan OR, Forhead AJ, Fowden AL. (2013) Hormonal and nutritional drivers of intrauterine growth. Current Opinion in Clinical Nutrition and Metabolic Care 16(3):298-309 May 2013. Doi: 10.1097/MCO.0b013e32835e3643.

Sharkey AM, Macklon NS. (2013) The science of implantation emerges blinking into the light. Reproductive BioMedicine Online 27(5):453-460 Nov 2013. Doi: 10.1016/j.rbmo.2013.08.005.

Staff AC, Benton SJ, von Dadelszen P, Roberts JM, Taylor RN, Powers RW, Charnock-Jones DS, Redman CW. (2013) Redefining preeclampsia using placenta-derived biomarkers. Hypertension 61(5):932-942 May 2013. Doi: 10.1161/HYPERTENSIONAHA.111.00250.

Van Uitert, E.M., Exalto, N., Burton, G.J., Willemsen, S.P., Koning, A.H.J., Eilers, P.H.C., Laven, J.S.E., Steegers, E.A.P. and Steegers-Theunissen, R.P.M. (2013) Human embryonic growth trajectories and associations with fetal growth and birthweight. Human Reproduction, 28, 1753-1761.

Vaughan OR, Sferruzzi-Perri AN, Coan PM, Fowden AL. (2013) Adaptations in Placental Phenotype Depend on Route and Timing of Maternal Dexamethasone Administration in Mice, Biology of reproduction, biolreprod.113.109678.

Walters SB, Kieckbusch J, Nagalingam G, Swain A, Latham SL, Grau GE, Britton WJ, Combes V, Saunders BM. (2013) Microparticles from mycobacteria-infected macrophages promote inflammation and cellular migration. The Journal of Immunology. 2013 190 (2), 669-677.

Wilkens J, Male V, Ghazal P, Forster T, Gibson DA, Williams AR, Brito-Mutunayagam SL, Craigon M, Lourenco P, Cameron IT, Chwalisz K, Moffett A*, Critchley HO*. (2013)Uterine NK cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil.   *Joint senior authors. J Immunol. Sep 1;191(5):2226-35. doi: 10.4049 PMID: 23913972.

Xiong S, Sharkey AM, Kennedy PR, Gardner L, Farrell LE, Chazara O, Bauer J, Hiby SE, Colucci F, Moffett A (2013) Maternal uterine NK cell–activating receptor KIR2DS1 enhances placentation Journal of Clinical Investigation.  doi:10.1172/JCI68991.


For publications pre-2013 please visit the publication archive