skip to primary navigationskip to content
 

Graham J Burton F-MedSci

Graham J Burton, F-MedSci

Mary Marshall and Arthur Walton Professor of the Physiology of Reproduction

Director of Centre for Trophoblast Research

Graham Burton is accepting applications for PhD students.


Office Phone: +44 (0)1223 333856

Research Interests

Research summary
Our focus is on human placental development, and the involvement of the placenta in complications of pregnancy such as miscarriage, intrauterine growth restriction and pre-eclampsia. In particular, we are interested in the effects of oxygen, hypoxia and oxidative stress on trophoblast differentiation and function. This interest stems from our finding, in collaboration with Eric Jauniaux, that there is a threefold increase in the oxygen concentration at the end of the first trimester as a result of the onset of the maternal arterial circulation to the placenta. We have demonstrated that prior to this time the embryo is supported by secretions from the endometrial glands.

Our research has shown that fluctuations in oxygenation are particularly damaging to the trophoblast. Recent work has elucidated signalling pathways activated by that stress, leading to changes in gene transcript profiles and cytokine secretion that may stimulate the development of pre-eclampsia. We have also provided the first evidence that the syncytiotrophoblast is vulnerable to endoplasmic reticulum stress, and that this plays a major role in the pathophysiology of the reduced placental growth and endocrine activity seen in cases of intrauterine growth restriction. We are currently investigating how this impaired placental function may affect developmental programming of the fetus.

We have a number of highly productive collaborations both within and outside the Centre.

Funding: Wellcome Trust Programme grant, Anatomical Society, Action Medical Research, MRC, Evelyn Trust

Key Publications

Cindrova-Davies T, Jauniaux E, Elliot MG, Gong S, Burton GJ, Charnock-Jones DS. RNA-seq reveals conservation of function among the yolk sacs of human, mouse, and chicken. Proc Natl Acad Sci U S A. 2017;114(24):E4753-E61.

Turco MY, Gardner L, Hughes J, Cindrova-Davies T, Gomez MJ, Farrell L, et al. Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium. Nat Cell Biol. 2017;19(5):568-77.

Burton GJ, Fowden AL, Thornburg KL. Placental Origins of Chronic Disease. Physiol Rev. 2016;96(4):1509-65.

Burton GJ, Jauniaux E. What is the placenta? Am J Obstet Gynecol. 2015;213(4 Suppl):S6 e1, S6-8.

Benirschke K, Burton GJ, Baergen RN. Pathology of the Human Placenta. 6th ed. Heidelberg: Springer; 2012. 941 p.

For a full list of publications see: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48013370/?sort=date&direction=descending