2020-2021 Publications

Irving Aye

Aye, Irving LMH; Aiken, Catherine E; Charnock-Jones, D Stephen; Smith, Gordon CS (2020). Placental energy metabolism in health and disease—significance of development and implications for preeclampsia. American journal of obstetrics and gynecology, ISSN: 0002-9378, 1097-6868. doi:10.1016/j.ajog.2020.11.005

Thorsten Boroviak

Connor R and Boroviak T (2020). Origin and function of the yolk sac in primate embryogenesis. Nature Communications. https://doi.org/10.1038/s41467-020-17575-w

Graham Burton

Lorenzon, Aline R; Moreli, Jusciele Brogin; de Macedo Melo, Rafaela; Namba, Felipe Yukio; Staff, Anne Cathrine; Yung, Hong Wa; Burton, Graham J; Bevilacqua, Estela Stromal (2020). Cell-Derived Factor (SDF) 2 and the Endoplasmic Reticulum Stress Response of Trophoblast Cells in Gestational Diabetes Mellitus and In Vitro Hyperglycaemic Condition. Current Vascular Pharmacology 19(2): 201-209. ISSN: 15701611. doi:10.2174/1570161118666200606222123

Riley E Thompson 1, 2, Aime K Johnson 3, Pouya Dini 4, Margherita Y Turco 5, Tulio M Prado 1, Christopher Premanandan 6, Graham J Burton 5, Barry A Ball 4, Brian K Whitlock 1, and Budhan S Pukazhenthi 2 (2020). Hormone-responsive organoids from domestic mare and endangered Przewalski’s horse endometrium. Society for Reproduction and Fertility 160(6). https://doi.org/10.1530/REP-20-0266

Thomas JR, Appios A, Zhao X, Dutkiewicz R, Donde M, Lee CYC, Naidu P, Lee C, Cerveira J, Liu B, Ginhoux F, Burton G, Hamilton RS, Moffett A, Sharkey A, McGovern N (2020). Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells. Journal of Experimental Medicine 218(1): e20200891.

Sheridan, Megan A; Fernando, Ridma C; Gardner, Lucy; Hollinshead, Michael S; Burton, Graham J; Moffett, Ashley; Turco, Margherita Y (2020). Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta. Nature Protocols 15(10): 3,441-3,463. ISSN: 1754-2189, 1750-2799; doi:10.1038/s41596-020-0381-x

Sadovsky, Yoel; Mesiano, Sam; Burton, Graham J; Lampl, Michelle; Murray, Jeffrey C; Freathy, Rachel M; Mahadevan- Jansen, Anita; Moffett, Ashley; Price, Nathan D; Wise, Paul H; Wildman, Derek E; Snyderman, Ralph; Paneth, Nigel; Capra, John Anthony; Nobrega, Marcelo A; Barak, Yaacov; Muglia, Louis J (2020). Advancing human health in the decade ahead: pregnancy as a key window for discovery. American Journal of Obstetrics and Gynecology 223(3): 312-321. ISSN: 0002-9378, 1097-6868; doi:10.1016/j.ajog.2020.06.031

Jauniaux, Eric; Zosmer, Nurit; Subramanian, Devi; Shaikh, Hizbullah; Burton, Graham J (2020). Ultrasound- histopathologic features of the utero-placental interface in placenta accreta spectrum. Placenta 97: 58-64. ISSN: 0143-4004; doi:10.1016/j.placenta.2020.05.011

Abbas, Yassen; Brunel, Lucia G; Hollinshead, Michael S; Fernando, Ridma C; Gardner, Lucy; Duncan, Imogen; Moffett, Ashley; Best, Serena; Turco, Margherita Y; Burton, Graham J; Cameron, Ruth E (2020). Generation of a three- dimensional collagen scaffold-based model of the human endometrium. Interface Focus 10(2), 20190079. ISSN: 2042-8898, 2042-8901; doi:10.1098/rsfs.2019.0079

Jauniaux E, Hussein AH, Zosmer N, Elbarmelgy RM, MD, Elbarmelgy RA, Shaikh H and Burton GJ (2020). A new methodologic approach for clinico-pathologic correlations in invasive placenta previa accreta. American Journal of Obstetrics and Gynecology, 222, 379.e1-11

Jauniaux E, Moffett A and Burton GJ (2020). Placental Implantation Disorders. Obstetrics and Gynecology Clinics of North America, 7, 117-132

Lorenzon-Ojea AR, Yung HW, Burton GJ and Bevilacqua E (2020). The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866, 165386

Burton GJ, Cindrova-Davies T and Turco MY (2020). Histotrophic nutrition and the placental–endometrial dialogue during human early pregnancy. Placenta Epub ahead of print. doi:10.1016/j.placenta.2020.02.008

Tunster SJ, Watson ED, Fowden AL and Burton GJ (2020). Placental glycogen stores and fetal growth: insights from genetic mouse models. Reproduction, Epub ahead of print. PMID: 32191912

Jauniaux E, Bidhe A and Burton GJ (2020). The placenta. In: The Oxford Textbook of Obstetrics and Gynaecology (eds S Arulkurmaran, L Denny, S Doumouchtsis and W Ledger). Oxford University Press, Oxford

Burton GJ, Sibley CP and Jauniaux E (2020). Placental anatomy and physiology. In: Obstetrics: Normal and Problem Pregnancies, 8th edn (eds MB Landon, HL Galan, ERM Jauniaux, DA Driscoll, V Berghella, WA Grobman, SJ Kilpatrick and AG Cahill). Elsevier, Amsterdam

Abbas Y, Turco MY, Burton GJ, Moffett A (2020). Investigation of human trophoblast invasion in vitro. Human Reproduction Update, dmaa017, May. doi:10.1093/humupd/dmaa017

Burton GJ, Cindrova-Davies T, Yung HW and Jauniaux E (2020). Oxygen and human placental development. Reproduction, May 1:REP-20-0153.R1. Online ahead of print. doi:10.1530/REP-20-0153

Lorenzon AR, Moreli JB, de Macedo Melo R, Namba FY, Staff AC, Yung HW, Burton GJ and Bevilacqua E (2020). Stromal cell-derived Factor (SDF) 2 and the endoplasmic reticulum stress response of trophoblast cells in gestational diabetes mellitus and in vitro hyperglycaemic condition. Current Vascular Pharmacology, Jun 6. Online ahead of print. doi:10.2174/1570161118666200606222123

Plitman May R, Abbas Y, Charnock-Jones DS, Burton GJ and Marom G (2019). Three-dimensional morphological analysis of placental terminal villi. Interface Focus 9, 20190037.

Burton GJ, Redman CW, Roberts JM and Moffett A (2019). Pre-eclampsia: pathophysiology and clinical implications. British Medical Journal 366, l2381.

Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey A, Franze K, Burton GJ and Oyen ML (2019). Tissue stiffness at the human maternal–fetal interface. Human Reproduction, 4: 1,999-2,008.

Jauniaux E and Burton GJ (2019). From Etiopathology to Management of Accreta Placentation. Current Obstetrics and Gynecology Reports. Epub ahead of print.

Yung HW, Colleoni F, Dommett E, Cindrova-Davies TC, Kingdom J, Murray AJ and Burton GJ (2019). Non-canonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset pre-eclampsia. Proceedings of National Academy of Sciences USA 116: 18,109-18,118.

Abbas Y, Brunel LG, Hollinshead MS, Fernando R, Gardner L, Duncan I, Moffett A, Best S, Turco MY, Burton GJ and Cameron RE (2019). Generation of a three-dimensional collagen scaffold-based model of the human endometrium. Interface Focus 10: 20190079.

Nick Burton

Burton NO, Riccio C, Dallaire A, Price J, Jenkins B, Koulman A & Miska EA (2020). Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection. Nature Communications doi:10.1038/ s41467-020-15555-8

Steve Charnock-Jones

Lager, Susanne; Sovio, Ulla; Eddershaw, Elizabeth; Linden, Margaretha W; Yazar, Cansu; Cook, Emma; Happerfield, Lisa; Jessop, Flora A; Sebire, Neil J; Charnock-Jones, D Stephen; Smith, Gordon CS (2020). Abnormal placental CD8+ T-cell infiltration is a feature of fetal growth restriction and pre-eclampsia. The Journal of Physiology 598(23), 5,555-5,571. ISSN: 0022-3751, 1469-7793. doi:10.1113/JP279532

Gaccioli, Francesca; Lager, Susanne; de Goffau, Marcus C; Sovio, Ulla; Dopierala, Justyna; Gong, Sungsam; Cook, Emma; Sharkey, Andrew; Moffett, Ashley; Lee, Wai Kwong; Delles, Christian; Venturini, Cristina; Breuer, Judith; Parkhill, Julian; Peacock, Sharon J; Charnock-Jones, D Stephen; Smith, Gordon CS (2020). Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia. Nature Microbiology 5(7): 901-908. ISSN: 2058-5276, 2058-5276; doi:10.1038/s41564-020-0711-3

Furse, Samuel; Fernandez-Twinn, Denise S; Jenkins, Benjamin; Meek, Claire L; Williams, Huw E L; Smith, Gordon C S; Charnock-Jones, D Stephen; Ozanne, Susan E; Koulman, Albert (2020). A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Analytical and Bioanalytical Chemistry 412(12): 2,851- 2,862. ISSN: 1618-2642, 1618-2650; doi:10.1007/s00216-020-02511-0

Sovio, Ulla; Goulding, Neil; McBride, Nancy; Cook, Emma; Gaccioli, Francesca; Charnock-Jones, D Stephen; Lawlor, Debbie A; Smith, Gordon CS (2020). A maternal serum metabolite ratio predicts fetal growth restriction at term. Nature Medicine, Vol 26(3), 348-353. ISSN: 1078-8956, 1546-170X; doi:10.1038/s41591-020-0804-9

Ulla Sovio, Nancy McBride, Angela M Wood, Katya L Masconi, Emma Cook, Francesca Gaccioli, D Stephen Charnock- Jones, Debbie A Lawlor, Gordon CS Smith (2020). 4-Hydroxyglutamate is a novel predictor of pre-eclampsia.

International Journal of Epidemiology 49(1): 301–311. https://doi.org/10.1093/ije/dyz098

Aye, Irving LMH; Aiken, Catherine E; Charnock-Jones, D Stephen; Smith, Gordon CS (2020). Placental energy metabolism in health and disease – significance of development and implications for preeclampsia. American Journal of Obstetrics and Gynecology. ISSN: 0002-9378, 1097-6868; doi:10.1016/j.ajog.2020.11.005

Sovio U, Goulding N, McBride N, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA and Smith GCS (2020). A maternal serum metabolite ratio predicts fetal growth restriction at term. Nature Medicine, 26(3), 348–353. doi:10.1038/ s41591-020-0804-9

Furse S, Fernandez-Twinn DS, Jenkins B, Meek CL, Williams HEL, Smith GCS et al (2020). A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Analytical and Bioanalytical Chemistry, 91(15), 1–12. doi:10.1007/s00216-020-02511-0

Gaccioli F, Charnock-Jones DS*, Smith GCS* et al (2020). Fetal inheritance of chromosomally integrated HHV-6 predisposes to preeclampsia in the mother. Nature Microbiology. [* Joint senior author]

Albrecht C, Chamley L, Charnock-Jones DS, Collins S, Fujiwara H, Golos T et al (2019). IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery. Placenta, 1-0. doi:10.1016/j.placenta.2019.02.006

Cater JH, Kumitac JR, Abdallah RZ, Zhao G, Bernardo-Gancedo A, Henry A, Winata W, Chi M, Grenyer BSF, Townsend ML, Ranson M, Buhimschi CS, Charnock-Jones DS, Dobson CM, Wilson MR, Buhimschi IA and Wyatt AR (2019). Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide. Proceedings of the National Academy of Sciences of the United States of America, 116(13), 201817298– 6110. doi:10.1073/pnas.1817298116

Mayo RP, Abbas Y, Charnock-Jones DS, Burton GJ and Marom G (2019). Three-dimensional morphological analysis of placental terminal villi. Interface Focus, 9, 20190037–9. doi:10.1098/rsfs.2019.0037

Jayasuriya NA, Hughes AE, Sovio U, Cook E, Charnock-Jones DS & Smith GCS (2019). A lower maternal cortisol to cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks. The Journal of Clinical Endocrinology and Metabolism. doi:10.1210/jc.2018-02312

Sovio U, McBride N, Wood AM, Masconi KL, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA and Smith GCS (2019). 4-Hydroxyglutamate is a novel predictor of pre-eclampsia. International Journal of Epidemiology, 388, 1775. doi:10.1093/ije/dyz098

Hughes AE, Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Smith GCS (2019). The association between first trimester AFP to PAPP-A ratio and placentally-related adverse pregnancy outcome. Placenta. 81:25–31. doi:10.1016/j.placenta.2019.04.005

Lawera A, Tong Z, Thorikay M, Redgrave RE, Cai J, van Dinther M, Morrell NW, Afink GB, Charnock-Jones DS, Arthur HM, ten Dijke P and Li W (2019). Role of soluble endoglin in BMP9 signaling. P Natl Acad Sci USA. Sep 3;116(36):17800–8. doi:10.1073/pnas.1816661116

de Goffau MC, Lager S, Sovio U, Gaccioli F, Cook E, Peacock SJ, Parkhill J, Charnock-Jones DS* and Smith GCS* (2019). Human Placenta Has No Microbiome but Can Contain Potential Pathogens. Nature 572, no. 7769: 329–34. doi:10.1038/s41586-019-1451-5

William Colledge

Schacker, M, Cheng, Y-H, Eckersley-Maslin, M, Snaith, RM, Colledge, WH (2020). Hypermethylation and reduced expression of Gtl2, Rian and Mirg at the Dlk1-Dio3 imprinted locus as a marker for poor developmental potential of mouse embryonic stem cells. Stem Cell Research, 48, art no 101931,

Lass, G, Li, XF, de Burgh, RA, He, W, Kang, Y, Hwa-Yeo, S, Sinnett-Smith, LC, Manchishi, SM, Colledge, WH, Lightman, SL, O’Byrne, KT (2020). Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases luteinising hormone pulse frequency in female mice. Journal of Neuroendocrinology, 32 (2), art. no. e12823,

Alfaia, C, Robert, V, Poissenot, K, Levern, Y, Guillaume, D, Yeo, S-H, Colledge, WH, Franceschini, I (2020). Sexually dimorphic gene expression and neurite sensitivity to estradiol in fetal arcuate Kiss1 cells. Journal of Endocrinology, 244(2): 273-283.

Yeo, SH, Kyle, V, Blouet, C, Jones, S, and Colledge, WH (2019). Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PLoS One 14: e0213927.

Francesco Colucci

Colucci F (2020). Sharing Knowledge With Young and Established Students of Immunology by the Neapolitan Gulf at the Ruggero Ceppellini Advanced School. Front Immunol. 11: 43. doi:10.3389/fimmu.2020.00043

Huhn O, Ivarsson MA, Gardner L, Hollinshead M, Stinchcombe JC, Chen P, Shreeve N, Chazara O, Farrell LE, Theorell J, Ghadially H, Parham P, Griffiths G, Horowitz A, Moffett A, Sharkey AM, Colucci F (2020). Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy. Nat Commun. Jan 20;11(1):381. doi:10.1038/s41467-019-14123-z

Colucci F, Carbone E (2019). Microbes, immunity and cancer in Capri: Another successful course of the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology founded by Serafino Zappacosta. Eur J Immunol. 49(12): 2,123-2,126. doi:10.1002/eji.201970125

Colucci F (2019). The immunological code of pregnancy. Science. 365(6456): 862-863. doi:10.1126/science.aaw1300

Colucci F (2019). Placentation and antitumor immunity regulated by a scaffolding protein in NK cells. Review. Sci Immunol. 4(38). doi:10.1126/sciimmunol.aax9589

Miguel Constancia

Hammerle, Constanze M; Sandovici, Ionel; Brierley, Gemma V; Smith, Nicola M; Zimmer, Warren E; Zvetkova, Ilona; Prosser, Haydn M; Sekita, Yoichi; Lam, Brian Y H; Ma, Marcella; Cooper, Wendy N; Vidal-Puig, Antonio; Ozanne, Susan E; Medina-Gómez, Gema; Constância, Miguel; Hill, David J (2020). Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLOS Genetics, Vol 16(10), e1009069. ISSN: 1553-7390, 1553-7404; doi:10.1371/journal.pgen.1009069

Agnes Wieczorek, Clara V Perani, Mark Nixon, Miguel Constancia, Ionel Sandovici, Dimitra E. Zazara, Gustavo Leone,Ming- Zhi Zhang, Petra C Arck, María Emilia Solano (2019). Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. American Journal of Physiology, Volume 317, Issue 1, 2 Jul, https://doi.org/10.1152/ ajpendo.00551.2018

Jorge López-Tello, Vicente Pérez-García, Jaspreet Khaira, Laura C Kusinski, Wendy N Cooper, Adam Andreani, Imogen Grant, Edurne Fernández de Liger, Brian YH Lam, Myriam Hemberger, Ionel Sandovici, Miguel Constancia, Amanda N Sferruzzi-Perri (2019). Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice. eLife, 8, e45282.

Ziegler, Amber N; Feng, Qiang; Chidambaram, Shravanthi; Testai, Jaimie M; Kumari, Ekta; Rothbard, Deborah E; Constancia, Miguel; Sandovici, Ionel; Cominski, Tara; Pang, Kevin; Gao, Nan; Wood, Teresa L; Levison, Steven W (2019). Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. Stem Cell Reports, 12(4), 816-830. ISSN: 2213-6711; doi:10.1016/j.stemcr.2019.02.011

Anne Ferguson-Smith

Westoby J#, Artemov P, Hemberg M*, Ferguson-Smith AC* (2020). Obstacles to studying alternative splicing using sc- RNAseq. (*Co-senior authors; #corresponding author.) Genome Biology 21(1): 74. doi:10.1186/s13059-020-01981-w

Liang ZS*, Cimino I, Yalcin B, Raghupathy N, Vancollie V, Soria X, Rimmington D, Firth HV, Farooqi S, Lelliot C, Munger S, O’Rahilly S, Ferguson-Smith AC, Coll AP*, Logan D* (2020). Trappc9 imprinting regulates brain development and body weight in mice. PLOS Genetics 16(9): e1008916.

Bertozzi T, Elmer JL. MacFarlan T, Ferguson-Smith AC (2020). KRAB zinc finger protein diversification drives interindividual methylation variability. Proc Natl Acad Sci (USA), Nov, doi:10.1073/pnas.2017053117

Takahashi N*, Collucio A*, Thorball CW, Planet E, Shi H, Offner S, Turelli P, Imbeault M, Ferguson-Smith AC#, Trono D# (2019). The highly conserved KRAB zinc-finger protein ZNF445 is a primary regulator of imprinting. (# Joint senior authors.) Genes and Development 33(1-2):49-54. doi:10.1101/gad.320069.118

Juan AM and Bartolomei MS (2019). Evolving imprinting control regions: KRAB zinc fingers hold the key. Genes Dev 33(1-2):1-3. doi:10.1101/gad.322990

Lorgen-Ritchie M, Murray AD, Staff RT, Ferguson-Smith AC, Richards M, Horgan GW, Phillips L, Hoad G, Gall I, Whalley L, Harrison K, McNeill G, Ito M, Haggarty P (2019). Imprinting methylation of SNRPN and MEST1 in adult blood predicts cognitive ability. PLoS One 14(4): e0215422

Montalban-Loro R, Lorano-Urena A, Ito M, Ferragud E, Strogantsev R, Krueger C, Reik W, Ferguson-Smith AC, Ferron SR (2019). Non-catalytic action of TET3 at Snrpn regulates terminal differentiation of adult NSCs. Nature Communications 10(1) 1,726.

Shi H*, Strogantsev R*, Takahashi N, Kazachenka A, Lorincz MC, Hemberger M, Ferguson-Smith AC (2019). ZFP57 regulation of transposable elements and gene expression within and beyond imprinted genes. (* Joint first authors.) Epigenetics and Chromatin 12(1) 49. PMID 31399135

Loo TH, Ye XQ, Chai JF, Ito M, Bonne G, Ferguson-Smith AC, Stewart CL (2019). The LINC complex member SUN1 regulates muscle regeneration by modulating DROSHA activity. eLife 8: e49485 doi:10.7554

Alison Forhead

Valenzuela OA, Jellyman JK, Allen V, Niu Y, Forhead AJ, Giussani DA, Fowden AL & Herrera EA (2020). Neonatal glucocorticoid overexposure alters cardiovascular function in young adult horses in a sex-linked manner. Journal of Developmental Origins of Health and Disease

Davies KL, Camm JE, Atkinson EV, Lopez T, Forhead AJ, Murray AJ & Fowden AL (2020, In Press). Development and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth. Journal of Physiology

Harris SE, De Blasio MJ, Zhao X, Ma M, Davies KL, Wooding FBP, Hamilton RS, Blache D, Meredith D, Murray AJ, Fowden AL & Forhead AJ (2020). Thyroid deficiency before birth modifies the adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity. Thyroid

Fowden AL, Giussani DA & Forhead AJ (2020). Developmental physiology of the equine fetus during late gestation.

Equine Veterinary Journal 52: 165-173.

Forhead AJ (2019). Breathing for two: maternal asthma and lung development in the fetus. Journal of Physiology 597: 4125-4126.

Abby Fowden

Hardwick LJA, Phythain CJ, Fowden AL & Hughes K (2020). Size of supernumerary teats in sheep correlated with complexity of the anatomy and microenvironment. J Anat. doi:10.1111/joa.13149

Harris S, De Blasio M, Zhao X, Ma M, Davies KL, Wooding FBP, Hamilton R, Blache D, Meredith D, Murray AJ, Fowden AL & Forhead AJ (2020). Thyroid deficiency before birth modifies adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity. Thyroid. doi:10.1089/thy2019.0749

Davies KL, Camm EJ, Atkinson EV, Lopez T, Forhead AJ, Murray AJ & Fowden AL (2020). Developmental and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth. J Physiol. doi:10.1113/JP279194

Fowden AL, Giussani DA & Forhead AJ (2020). Physiological development of the equine fetus during late gestation.Equine Vet J. 52: 165-173.

Tunster SJ, Watson ED, Fowden AL & Burton GJ (2020). Placental glycogen function and fetal growth: insights from genetic mouse models. Reproduction 159: R213-R235.

Fowden AL, Giussani DA & Forhead AJ (2020). Physiological development of the equine fetus during late gestation.Equine Vet J. 52: 165-173.

Sferruzzi-Perri AN, Higgins JS, Vaughan OR, Murray AJ & Fowden AL (2019). Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth. PNAS 116 1621-1626

Musial B, Fernandez-Twinn DS, Duque-Guimaraes D, Carr SK, Fowden AL, Ozanne SE & Sferruzzi-Perri AN (2019). Exercise alters the molecular pathways of insulin signalling and lipid handling in tissues of obese pregnant mice. Physiol. Reports 7 e14202

Kristian Franze

Jakobs M, Franze K, Zemel A (2020, accepted). Mechanical regulation of neurite polarization and growth—A computational study. Biophys J

Kulenkampff K, Lippert AH, McColl J, Santos AM, Ponjavic A, Jenkins E, Humphrey J, Winkel A, Franze K, Lee SF, Davis SJ, Klenerman D (2020). The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale. Biophys J. doi:10.1016/j.bpj.2020.01.019

Kjell J, Fischer-Sternjak J, Thompson AJ, Friess C, Sticco MJ, Salinas F, Cox J, Martinelli DC, Ninkovic J, Franze K*, Schiller HB*, Götz M* (2020). Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis. Cell Stem Cell. 26(2):277-293

Rheinlaender J, Dimitracopoulos A, Wallmeyer B, Kronenberg NM, Chalut KJ, Gather MC, Betz T, Charras G & Franze K (2020). Cortical cell stiffness is independent of substrate mechanics. Nature Materials. doi:10.1038/s41563-020- 0684-x

Jakobs MAH, Dimitracopoulos A, Franze K (2019). KymoButler, a deep learning software for automated kymograph analysis. eLife 8:e42288

Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez G, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KF (2019). Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature 573:130–134

Caglar M, Pandya R, Xiao J, Foster SK, Divitini G, Chen RYS, Greenham NC, Franze K, Rao A, Keyser UF (2019). All- optical detection of neuronal membrane depolarization in live cells using colloidal quantum dots. Nano Letters 19(12):8539-8549

Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey A, Franze K, Burton GJ, Oyen ML (2019). Tissue stiffness at the human maternal-fetal interface. Human Reproduction 34(10):1999-2008

Pocaterra A, Santinon G, Romani P, Brian I, Dimitracopoulos A, Ghisleni A, Carnicer-Lombarte A, Forcato M, Braghetta P, Montagner M, Galuppini F, Aragona M, Pennelli G, Bicciato S, Gauthier N, Franze K, Dupont S (2019). F-actin dynamics regulates mammalian organ growth and cell fate maintenance. J Hepatol S0168-8278(19)30144-8

Dino Giussani

Frasch MG, Herry CL, Niu Y & Giussani DA (2020). First evidence that intrinsic fetal heart rate variability exists and is affected by hypoxic pregnancy. J Physiol 598(2): 249-263.

Cetin I, Taricco E, Mandò C, Radaelli T, Boito S, Nuzzo AM & Giussani DA (2020). Fetal oxygen and glucose consumption in human pregnancy complicated by fetal growth restriction. Hypertension 75(3): 748-754

Valenzuela OA, Jellyman JK, Allen VL, Niu Y, Holdstock NB, Forhead AJ, Giussani DA, Fowden AL & Herrera EA (2020). Neonatal glucocorticoid overexposure alters cardiovascular function in young adult horses in a sex-linked manner. J Dev Orig Health Dis: 1-10. doi:10.1017/S2040174420000446

Fowden AL, Giussani DA & Forhead AJ (2020). Physiological development of the equine fetus during late gestation. Equine Vet J 52(2): 165-173.

Jellyman JK, Fletcher AJW, Fowden AL & Giussani DA (2020). Glucocorticoid Maturation of Fetal Cardiovascular Function. Trends Mol Med. 26(2), 170-184.

Kane AD, Kothmann E & Giussani DA (2020). Detection and response to acute systemic hypoxia. BJA Education 20(2), 58-64.

Frasch MG & Giussani DA (2020). Impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development. Cells 9(3), pii: E733.

Reyes R, Herrera EA, Ebensperger G, Sanhueza E, Giussani DA & Llanos AJ (2020). Perinatal cardiopulmonary adaptation to the thin air of the Alto Andino by a native Altiplano dweller, the llama. Journal of Applied Physiology (1985) 129(1): 152-161. doi:10.1152/japplphysiol.00800.2019

Teulings NEWD, Garrud TAC, Niu Y, Skeffington KL, Beck C, Itani N, Conlon F, Botting KJ, Nicholas LM, Ashmore TJ, Blackmore HL, Tong W, Camm EJ, Derks JB, Logan A, Murphy MP, Ozanne SE & Giussani DA (2020). Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system. FASEB J. doi:10.1096/ fj.202000697R

Skeffington KL, Beck C, Itani N, Niu Y, Shaw CJ & Giussani DA (2020). Hypertension programmed in adult hens by isolated effects of developmental hypoxia in ovo. Hypertension.

Botting KJ, Skeffington KL, Niu Y, Allison BJ, Brain KL, Itani N, Beck C, Logan A, Murray AJ, Murphy MP & Giussani DA (2020). Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction. Science Advances.

Shaw CJ, Botting KJ, Niu Y, Lees CC & Giussani DA (2020). Maternal and fetal cardiovascular and metabolic effects of intra-operative uterine handling under general anesthesia during pregnancy in sheep. Scientific Reports.

Itani N, Skeffington KL, Beck C, Niu Y, Katzilieris-Petras G, Smith N & Giussani DA (2020). Protective effects of pravastatin on the embryonic cardiovascular system suring hypoxic development. Hypertension.

Allison BJ, Brain KL, Niu Y, Kane AD, Herrera EA, Thakor AS, Botting KJ, Cross CM, Itani N, Shaw CJ, Skeffington KL, Beck C & Giussani DA (2020). Altered Cardiovascular Defense to Hypotensive Stress in the Chronically Hypoxic Fetus. Hypertension.

Hess RM, Niu Y, Garrud TA, Botting KJ, Ford SG & Giussani DA (2020). Embryonic cardioprotection by hydrogen sulphide: studies of isolated cardiac function and ischaemia-reperfusion injury in the chicken embryo. The Journal of Physiology.

Tay J, Masini G, McEniery C, Giussani DA, Shaw CJ, Wilkinson IB, Bennett PR & Lees CC (2019). Maternal Cardiac Output and Vascular Resistance are associated with maternal uterine and fetal umbilical artery but not cerebral Doppler changes. American Journal of Obstetrics & Gynecology. 220(1), 96.e1-96.e8

Brain KL, Allison BJ, Niu Y, Cross CM, Itani N, Kane AD, Herrera EA, Skeffington KL, Botting KJ & Giussani DA (2019). Intervention against hypertension in the next generation programmed by developmental hypoxia. PLoS Biology 17(1): e2006552

Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA & Ozanne SE (2019). Chronic fetal hypoxia disrupts the peri-conceptual environment in adult female rats. The Journal of Physiology 597(9): 2,391-2,401.

Manuscript chosen for an Editorial Focus by Nathanielsz PW (2019). Maternal programming by hypoxia alters the molecular composition of the oviduct of her offspring, the first pathway her grandchildren will transit: a potential novel pathway for intergenerational programming? J Physiol 597(9): 2,325-2,326.

Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore T, Giussani DA & Ozanne SE (2019). Chronic gestational hypoxia induces low ovarian reserve in adult female rats. FASEB J 33(6): 7,758-7,766.

Snelling EP, Seymour RS, Giussani DA, Fuller A, Maloney SK, Farrell AP, Mitchell D, George K, Kamerman PR, Mitchell G, Dzialowski EM, Jonker SS, Wube T (2019). Scaling of heart mass is interrupted by birth in the developing sheep Ovis aries. The Journal of Anatomy 235(1): 96-105.

Shaw CJ, Rivens I, Civale J, Botting KJ, Allison BJ, Brain KL, Niu Y, Ter Haar G, Giussani DA & Lees CC (2019). Maternal and fetal cardiometabolic recovery following ultrasound-guided high-intensity focused ultrasound placental vascular occlusion. J R Soc Interface 16(154): 20190013.

Fratelli N, Prefumo F, Wolf H, Hecher K, Visser GHA, Giussani DA, Derks JB, Shaw CJ, Frusca T, Ghi T, Ferrazzi E, Lees CC; TRUFFLE Group; TRUFFLE Group authors; TRUFFLE Group collaborating authors (2019). Effects of Antenatal Betamethasone on Fetal Doppler Indices and Short Term Fetal Heart Rate Variation in Early Growth Restricted Fetuses. Ultraschall Med. doi:10.1055/a-0972-1098

Garrud TAC & Giussani DA (2019). Combined glucocorticoid and antioxidant therapy for the safer treatment of preterm birth. Trends in Endocrinology & Metabolism 30(4), 258-269.

Tong W & Giussani DA (2019). Preeclampsia link to gestational hypoxia. The Journal of Developmental Origins of Helath and Disease 10(3), 322-333.

Giussani DA (2019). Fatty vessels shed tonnes on programmed cardiovascular risk. The Journal of Physiology 597.22, 5,317-5,318.

Russell Hamilton

Harris, Shelley E; De Blasio, Miles J; Zhao, Xiaohui; Ma, Marcella; Davies, Katie; Wooding, FB Peter; Hamilton, Russell S; Blache, Dominique; Meredith, David; Murray, Andrew J; Fowden, Abigail L; Forhead, Alison J (2020). Thyroid Deficiency Before Birth Alters the Adipose Transcriptome to Promote Overgrowth of White Adipose Tissue and Impair Thermogenic Capacity. Thyroid 30(6): 794–805. ISSN: 1050-7256, 1557-9077. doi:10.1089/thy.2019.0749

Menelaou, Katerina; Prater, Malwina; Tunster, Simon J; Blake, Georgina E T; Geary Joo, Colleen; Cross, James C; Hamilton, Russell S; Watson, Erica D (2020). Blastocyst transfer in mice alters the placental transcriptome and growth. Reproduction: The Official Journal of the Society for the Study of Fertility 159(2): 115–132. ISSN: 1470-1626, 1741-7899. doi:10.1530/REP-19-0293

Kyprianou, Christos; Christodoulou, Neophytos; Hamilton, Russell S; Nahaboo, Wallis; Boomgaard, Diana Suarez; Amadei, Gianluca; Migeotte, Isabelle; Zernicka-Goetz, Magdalena (2020). Basement membrane remodelling regulates mouse embryogenesis. Nature, 582(7811), 253–258. ISSN: 0028-0836, 1476-4687; doi:10.1038/s41586-020-2264-2

Napso T, Zhao X, Ibañez Lligoña M, Sandovici I, Kay RG, Gribble FM, Reimann F, Meek CL, Hamilton RS, Sferruzzi-Perri AN (2020). Unbiased placental secretome characterization identifies candidates for pregnancy complications. https://biorxiv.org/cgi/content/short/2020.07.12.198366v1

Blake GET, Zhao X, Yung HW, Burton GJ, Ferguson-Smith AC, Hamilton RS, Watson ED (2020). Disruption of folate metabolism causes germline epigenetic instability and distinguishes HIRA as a biomarker of maternal transgenerational epigenetic inheritance. bioRxiv. doi:10.1101/2020.05.21.109256

Pisapia, Laura; Hamilton, Russell S; Farina, Federica; D’Agostino, Vito; Barba, Pasquale; Strazzullo, Maria; Provenzani, Alessandro; Gianfrani, Carmen; Del Pozzo, Giovanna (2019). Tristetraprolin/ZFP36 Regulates the Turnover of Autoimmune-Associated HLA-DQ mRNAs. Cells, 8(12): 1,570. ISSN: 2073-4409, 2073-4409; doi:10.3390/ cells8121570

Courtney Hanna

Hanna CW (2020). Placental imprinting: Emerging mechanisms and functions. PLoS Genetics. 16(4): e1008709

Hemberger M, Hanna CW, Dean W (2020). Mechanisms of early placental development in mouse and humans. Nature Reviews Genetics. 21(1):27-43

Argelaguet R, Clark SJ, Mohammed H, Stapel LC, Krueger C, Kapourani CA, Imaz-Rosshandler I, Lohoff T, Xiang Y, Hanna CW, Smallwood S, Ibarra-Soria X, Buettner F, Sanguinetti G, Xie W, Krueger F, Göttgens B, Rugg-Gunn PJ, Kelsey G, Dean W, Nichols J, Stegle O, Marioni JC, Reik W (2019). Multi-omics profiling of mouse gastrulation at single cell resolution. Nature. 576(7787):487-491

Hanna CW*, Pérez-Palacios R, Gahurova L, Schubert M, Krueger F, Biggins L, Andrews S, Colomé-Tatché M, Bourc’his D, Dean W, Kelsey G* (2019). Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues. Genome Biology. 20(1):225 [*Co-corresponding authors]

Martin Johnson

Williams K, Johnson MH (2020). Adapting the 14-day rule for embryo research to encompass evolving technologies.RBMS 10: 1-9.

Johnson MH (2019). IVF: The women who helped make it happen. Reprod Biomed Soc. 8: 1-6.

Johnson MH (2019). The Significance of Cell Polarity in Early Mammalian Development. Reference Module in Biomedical Sciences, Elsevier. doi:10.1016/B978-0-12-801238-3.99504-7

Braude PR, Johnson MH (2019). Reflections on 40 years of IVF. BJOG 126: 135-137.

Fauser B, Alikani M, Anderson R, Franklin S, Johnson MH, Garcia Velasco J (2019). Another new year. RBMO 38: 5-6. Johnson MH (2019). A short history of in vitro fertilization (IVF). Int. J. Dev. Biol. 63: 83-92.

Johnson MH (2019). Human in vitro fertilisation and developmental biology: a mutually influential history. Development 146. doi:10.1242/dev.183145

Aiken C, Johnson MH (2019). A mouse model for the effects of IVF procedures on the development of embryos. RBMO 39: 355-356.

Gavin Kelsey

Olsen KW, Castillo-Fernandez J, Zedeler A, Freiesleben NC, Bungum M, Chan AC, Cardona A, Perry JRB, Skouby SO, Borup R, Hoffmann ER, Kelsey G and Grøndahl ML (2020). A distinctive epigenetic ageing profile in granulosa cells. Human Reproduction.

Wołodko K, Walewska E, Adamowski M, Castillo-Fernandez J, Kelsey G and Galvão A (2020). Leptin resistance in the ovary of obese mice is associated with profound changes in the transcriptome of cumulus cells. Cellular Physiology and Biochemistry 54: 417-437.

Ivanova E, Canovas S, Garcia-Martinez S, Romar R, Lopes JS, Rizos D, Sanchez-Calabuig MJ, Krueger F, Andrews S, Perez-Sanz F, Kelsey G and Coy P (2020). DNA methylation changes during preimplantation development reveal interspecies differences and reprogramming events at imprinted genes. Clinical Epigenetics 12: 64.

Demond H and Kelsey G (2020). The enigma of DNA methylation in oocytes. F1000 Research 9: 146.

Saenz-de-Juano MD, Ivanova E, Romero S, Lolicato F, Sanchez F, Van Ranst H, Krueger F, Segonds-Pichon A, De Vos M, Andrews S, Smitz J, Kelsey G and Anckaert E (2019). DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved IVM method for oocytes from small antral follicles in PCOS patients. Human Reproduction 34: 1,640-1,649.

Hanna CW, Pérez-Palacios R, Gahurova L, Schubert M, Krueger F, Biggins L, Andrews S, Colomé-Tatché M, Bourc’his D, Dean W and Kelsey G (2019). Non-canonical imprinting in extra-embryonic tissues is driven by endogenous retroviral insertions. Genome Biology 20: 225.

Argelaguet R, Mohammed H, Clark SJ, Stapel LC, Krueger C, Kapourani C-A, Xiang Y, Hanna C, Smallwood S, Ibarra- Soria X, Buettner F, Sanguinetti G, Krueger F, Xie W, Rugg-Gunn P, Kelsey G, Dean W, Nichols J, Stegle O, Marioni JC, Reik W (2019). Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification. Nature 576: 487-491.

Demond H, Anvar Z, Jahromi BN, Sparago A, Verma A, Davari M, Calzari L, Russo S, Jahromi MA, Monk D, Andrews S, Riccio A and Kelsey G (2019). A KHDC3L mutation resulting in recurrent hydatidiform mole causes genome-wide DNA methylation loss in oocytes and persistent imprinting defects post-fertilisation. Genome Medicine 11: 84.

Saenz-de-Juano MD, Ivanova E, Billooye K, Herta AC, Smitz J, Kelsey G and Anckaert A (2019). Genome-wide DNA methylation assessment in mouse oocytes reveals effects associated with in vitro growth, superovulation, and sexual immaturity. Clinical Epigenetics 11: 197.

Sendžikaitė G and Kelsey G (2019). The role and mechanisms of DNA methylation in the oocyte. Essays in Biochemistry EBC20190043. doi:10.1042/EBC20190043

Naomi McGovern

Thomas, JR, Appios, A, Zhao, X, Dutkiewicz, R, Donde, M, Lee, CYC, Naidu, P, Lee, C, Cerveira, J, Liu, B, Ginhoux, F, Burton, G, Hamilton, RS, Moffett, A, Sharkey, A, McGovern, N (2020). Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells. Journal of Experimental Medicine 218(1): e20200891. doi:10.1084/JEM.20200891

Tieppo, P, Papadopoulou, M, Gatti, D, McGovern, N, Chan, JKY, Gosselin, F, Goetgeluk, G, Weening, K, Ma, L, Dauby, N, Cogan, A, Donner, C, Ginhoux, F, Vandekerckhove, B, Vermijlen, D (2020). The human fetal thymus generates invariant effector γδ T cells. Journal of Experimental Medicine 217(3): e20190580.

Karen Phaik Har Lim, Paul Milne, Michael Poidinger, Kaibo Duan, Howard Lin,1 Naomi McGovern, Harshal Abhyankar, Daniel Zinn, Thomas M. Burke, Olive S. Eckstein, Rikhia Chakraborty, Amel Sengal, Brooks Scull, Evan Newell, Miriam Merad, Kenneth L. McClain, Tsz-Kwong Man, Florent Ginhoux, Matthew Collin, and Carl E Allen (2020). Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells. Blood Adv, 4(1): 87–99. Published online 3 Jan 2020. doi:10.1182/bloodadvances.2019000488

Papadopoulou, Maria; Tieppo, Paola; McGovern, Naomi; Gosselin, Françoise; Chan, Jerry K Y; Goetgeluk, Glenn; Dauby, Nicolas; Cogan, Alexandra; Donner, Catherine; Ginhoux, Florent; Vandekerckhove, Bart; Vermijlen, David (2019). TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells. The Journal of Immunology, 203(6): 1,468-1,479. ISSN: 0022-1767, 1550-6606; doi:10.4049/jimmunol.1900592

Lum, Fok-Moon; Narang, Vipin; Hue, Susan; Chen, Jie; McGovern, Naomi; Rajarethinam, Ravisankar; Tan, Jeslin JL; Amrun, Siti Naqiah; Chan, Yi-Hao; Lee, Cheryl YP; Chua, Tze-Kwang; Yee, Wearn-Xin; Yeo, Nicholas KW; Tan, Thiam- Chye; Liu, Xuan; Haldenby, Sam; Leo, Yee-sin; Ginhoux, Florent; Chan, Jerry KY; Hiscox, Julian (2019). Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women. Clinical & Translational Immunology 8(11). ISSN: 2050-0068, 2050-0068; doi: 10.1002/cti2.1082

Ashley Moffett

Abbas Y, Turco MY, Burton GJ, Moffett A (2020). Investigation of human trophoblast invasion in vitro. Hum Reprod Update. doi:10.1093/humupd/dmaa017

Gaccioli F, Lager S, de Goffau MC, Sovio U, Dopierala J, Gong S, Cook E, Sharkey A, Moffett A, Lee WK, Delles C, Venturini C, Breuer J, Parkhill J, Peacock SJ, Charnock-Jones DS, Smith GCS (2020). Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia. Nat Microbiol. doi:10.1038/s41564-020-0711-3

Nakimuli A, Starling JE, Nakubulwa S, Namagembe I, Sekikubo M, Nakabembe E, Scott JG, Moffett A, Aiken CE (2020). Relative impact of pre-eclampsia on birth weight in a low resource setting: A prospective cohort study. Pregnancy Hypertens 21: 1-6. doi:10.1016/j.preghy.2020.04.002

Abbas Y, Brunel LG, Hollinshead MS, Fernando RC, Gardner L, Duncan I, Moffett A, Best S, Turco MY, Burton GJ, Cameron RE (2020). Generation of a three-dimensional collagen scaffold-based model of the human endometrium. Interface Focus 10(2): 20190079. doi:10.1098/rsfs.2019.0079

Jauniaux E, Moffett A, Burton GJ (2020). Placental Implantation Disorders. Obstet Gynecol Clin North Am. 47(1): 117- 132. doi:10.1016/j.ogc.2019.10.002

Huhn O, Ivarsson MA, Gardner L, Hollinshead M, Stinchcombe JC, Chen P, Shreeve N, Chazara O, Farrell LE, Theorell J, Ghadially H, Parham P, Griffiths G, Horowitz A, Moffett A, Sharkey AM, Colucci (2020). Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy. F. Nat Commun. 11(1): 381. doi:10.1038/s41467-019-14123-z

Lensen S, Shreeve N, Barnhart KT, Gibreel A, Ng EHY, Moffett A (2019). In vitro fertilization add-ons for the endometrium: it doesn’t add-up. Fertil Steril 112(6): 987-993. doi:10.1016/j.fertnstert.2019.10.011

Turco MY, Moffett A (2019). Development of the human placenta. Development 146(22): dev163428. doi:10.1242/ dev.163428

Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey AM, Franze K, Burton GJ, Oyen ML (2019). Tissue stiffness at the human maternal-fetal interface. Hum Reprod 34(10):1,999-2,008. doi:10.1093/humrep/ dez139

Burton GJ, Redman CW, Roberts JM, Moffett A (2019). Pre-eclampsia: pathophysiology and clinical implications. BMJ

366: l2381. doi:10.1136/bmj.l2381

Lee CQE, Bailey A, Lopez-Tello J, Sferruzzi-Perri AN, Okkenhaug K, Moffett A, Rossant J, Hemberger (2019). Inhibition of Phosphoinositide-3-Kinase Signaling Promotes the Stem Cell State of Trophoblast. M. Stem Cells 37(10): 1,307- 1,318. doi:10.1002/stem.3052

Andrew Murray

Thisted, L, Østergaard, MV, Pedersen, AA, Pedersen, PJ, Lindsay, RT, Murray, AJ, Fink, LN, Pedersen, TX, Secher, T, Johansen, TT, Thrane, ST, Skarsfeldt, T, Jelsing, J, Thomsen, MB, Zois, NE (2020). Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy. Scientific Reports 10(1). doi:10.1038/s41598-020-73046-8

Griffin, JL, Liu, K-D, Acharjee, A, Hinz, C, Liggi, S, Murgia, A, Denes, J, Gulston, MK, Wang, X, Chu, Y, West, JA, Glen, RC, Roberts, LD, Murray, AJ (2020). Consequences of lipid remodeling of adipocyte membranes being functionally distinct from lipid storage in obesity. Journal of Proteome Research 19(10). doi:10.1021/acs.jproteome.9b00894

McKenna, HT, Murray, AJ, Martin, DS (2020). Human adaptation to hypoxia in critical illness. Journal of Applied Physiology 129(4). doi:10.1152/japplphysiol.00818.2019

Botting, KJ, Skeffington, KL, Niu, Y, Allison, BJ, Brain, KL, Itani, N, Beck, C, Logan, A, Murray, AJ, Murphy, MP, Giussani, DA (2020). Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction. Science Advances 6(34). doi:10.1126/sciadv.abb1929

Davies, KL, Camm, EJ, Atkinson, EV, Lopez, T, Forhead, AJ, Murray, AJ, Fowden, AL (2020). Development and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth. Journal of Physiology, 598(12). doi:10.1113/JP279194

Sowton, AP, Padmanabhan, N, Tunster, SJ, McNally, BD, Murgia, A, Yusuf, A, Griffin, JL, Murray, AJ, Watson, ED (2020). Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Molecular Genetics and Metabolism Reports, 23. doi:10.1016/j.ymgmr.2020.100580

Harris, SE, De Blasio, MJ, Zhao, X, Ma, M, Davies, K, Wooding, FBP, Hamilton, RS, Blache, D, Meredith, D, Murray, AJ, Fowden, AL, Forhead, AJ (2020). Thyroid Deficiency before Birth Alters the Adipose Transcriptome to Promote Overgrowth of White Adipose Tissue and Impair Thermogenic Capacity. Thyroid 30 (6). doi:10.1089/thy.2019.0749

McKenna, HT, Murray, AJ (2020). Reconsidering critical illness as an uncharacterised acquired mitochondrial disorder. Journal of the Intensive Care Society 21(2). doi:10.1177/1751143719892788

McNally, BD, Moran, A, Watt, NT, Ashmore, T, Whitehead, A, Murfitt, SA, Kearney, MT, Cubbon, RM, Murray, AJ, Griffin, JL, Roberts, LD (2020). Inorganic nitrate promotes glucose uptake and oxidative catabolism in white adipose tissue through the XOR-catalyzed nitric oxide pathway. Diabetes 69(5). doi:10.2337/db19-0892

O’Brien, KA, Simonson, TS, Murray, AJ (2020). Metabolic adaptation to high altitude. Current Opinion in Endocrine and Metabolic Research 11. doi:10.1016/j.coemr.2019.12.002

Makrecka-Kuka, M, Liepinsh, E, Murray, AJ, Lemieux, H, Dambrova, M, Tepp, K, Puurand, M, Käämbre, T, Han, WH, de Goede, P, O’Brien, KA, Turan, B, Tuncay, E, Olgar, Y, Rolo, AP, Palmeira, CM, Boardman, NT, Wüst, RCI, Larsen, TS (2020). Altered mitochondrial metabolism in the insulin-resistant heart. Acta Physiologica 228(3). doi:10.1111/apha.13430

Perrotta, S, Roberti, D, Bencivenga, D, Corsetto, P, O’Brien, KA, Caiazza, M, Stampone, E, Allison, L, Fleck, RA, Scianguetta, S, Tartaglione, I, Robbins, PA, Casale, M, West, JA, Franzini-Armstrong, C, Griffin, JL, Rizzo, AM, Sinisi, AA, Murray, AJ, Borriello, A, Formenti, F, Ragione, FD (2020). Effects of germline VHL deficiency on growth, metabolism, and mitochondria. New England Journal of Medicine 382(9). doi:10.1056/NEJMoa1907362

Verma, N, Liu, M, Ly, H, Loria, A, Campbell, KS, Bush, H, Kern, PA, Jose, PA, Taegtmeyer, H, Bers, DM, Despa, S, Goldstein, LB, Murray, AJ, Despa, F (2020). Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries. Kidney International 97(1). doi:10.1016/j.kint.2019.07.028

Lindsay, RT, Demetriou, D, Manetta-Jones, D, West, JA, Murray, AJ, Griffin, JL (2019). A model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolites. Metabolomics 15(12). doi:10.1007/s11306- 019-1618-y

O’Brien, KA, Atkinson, RA, Richardson, L, Koulman, A, Murray, AJ, Harridge, SDR, Martin, DS, Levett, DZH, Mitchell, K, Mythen, MG, Montgomery, HE, Grocott, MPW, Griffin, JL, Edwards, LM (2019). Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp. Scientific Reports 9(1). doi:10.1038/s41598- 019-38832-z

Yung, HW, Colleoni, F, Dommett, E, Cindrova-Davies, T, Kingdom, J, Murray, AJ, Burton, GJ (2019). Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia. Proceedings of the National Academy of Sciences of the United States of America, 116(36). doi:10.1073/ pnas.1907548116

Horscroft, JA, O’Brien, KA, Clark, AD, Lindsay, RT, Steel, AS, Procter, NEK, Devaux, J, Frenneaux, M, Harridge, SDR, Murray, AJ (2019). Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration—probing the role of PPARα. FASEB Journal, 33(6). doi:10.1096/fj.201900067R

O’Brien, KA, Horscroft, JA, Devaux, J, Lindsay, RT, Steel, AS, Clark, AD, Philp, A, Harridge, SDR, Murray, AJ (2019). PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia. Biochimica et Biophysica Acta – Molecular Basis of Disease, 1865(4). doi:10.1016/j.bbadis.2018.07.027

Sferruzzi-Perri, AN, Higgins, JS, Vaughan, OR, Murray, AJ, Fowden, AL (2019). Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth. Proceedings of the National Academy of Sciences of the United States of America, 116(5). doi:10.1073/pnas.1816056116

Sowton, AP, Griffin, JL, Murray, AJ (2019). Metabolic profiling of the diabetic heart: Toward a richer picture. Frontiers in Physiology 10. doi:10.3389/fphys.2019.00639

Kathy Niakan

Gerri C, McCarthy A, Alanis-Lobato G, Demtschenko A, Bruneau A, Loubersac S, Fogarty NME, Hampshire D, Elder K, Snell P, Christie L, David L, Van de Velde H, Fouladi-Nashta AA and Niakan KK (2020) A conserved molecular cascade initiates trophectoderm differentiation in human, bovine and mouse embryos prior to blastocyst formation. Nature 587: 443-447.

Ruis P, Van Ly D, Borel V, Kafer G, McCarthy A, Howell S, Blassberg R, Snijders A, Briscoe J, Niakan KK, Marzec P, Cesare A and Boulton S (2020). TRF2-independent chromosome end protection in pluripotent cells and early development. Nature 589: 103-109

Alanis-Lobato G, Zohrxen J, McCarthy A, Fogarty NME, Kubikova N, Hardman E, Greco M, Wells D, Turner JMA and Niakan KK (2020). Frequent loss-of-heterozygosity in CRISRP-Cas9-edited early human embryos. BioRxiv. PNAS, manuscript accepted.

Gerri, C, Menchero, S, Mahadevaiah, SK, Turner, JMA, Niakan, KK (2020). Human Embryogenesis: A Comparative Perspective. Annual Review of Cell and Developmental Biology 36: 411-440. doi:10.1146/annurev-cellbio-022020-024900

Wamaitha, SE, Grybel, KJ, Alanis-Lobato, G, Gerri, C, Ogushi, S, McCarthy, A, Mahadevaiah, SK, Healy, L, Lea, RA, Molina-Arcas, M, Devito, LG, Elder, K, Snell, P, Christie, L, Downward, J, Turner, JMA, Niakan, KK (2020). IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche. Nature Communications 11(1): 764.

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ElInati, E, Zielinska, AP, McCarthy, A, Kubikova, N, Maciulyte, V, Mahadevaiah, S, Sangrithi, MN, Ojarikre, O, Wells,

D, Niakan, KK, Schuh, M, Turner, JMA (2020). The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes. Nature Communications 11(1): 2,598. doi:10.1038/s41467-020-16441-z

Lea, RA, Niakan, KK (2019). Human germline genome editing. Invited review. Nature Cell Biology 21(12): 1,479-1,489. doi:10.1038/s41556-019-0424-0

Noli L, Khorsandi SE, Pyle A, Giritharan G, Fogarty N, Capalbo A, Devito L, Jovanovic VM, Khurana P, Rosa H, Kolundzic N, Cvoro A, Niakan KK, Malik A, Foulk R, Heaton N, Ardawi MS, Chinnery PF, Ogilvie C, Khalaf Y, Ilic D (2019). Effects of Thyroid Hormone on Mitochondria and Metabolism of Human Preimplantation Embryos. Stem Cells 38(3): 369-381.

Jennifer Nichols

Argelaguet, R, Clark, SJ, Mohammed, H, Stapel, LC, Krueger, C, Kapourani, C-A, Imaz-Rosshandler, I, Lohoff, T, Xiang, Y, Hanna, CW, Smallwood, S, Ibarra-Soria, X, Buettner, F, Sanguinetti, G, Xie, W, Krueger, F, Göttgens, B, Rugg-Gunn, PJ, Kelsey, G, Dean, W, Nichols, J, Stegle, O, Marioni, JC, Reik, W (2019). Multi-omics profiling of mouse gastrulation at single-cell resolution. Nature 576(7787). doi:10.1038/s41586-019-1825-8

Stuart, HT, Stirparo, GG, Lohoff, T, Bates, LE, Kinoshita, M, Lim, CY, Sousa, EJ, Maskalenka, K, Radzisheuskaya, A, Malcolm, AA, Alves, MRP, Lloyd, RL, Nestorowa, S, Humphreys, P, Mansfield, W, Reik, W, Bertone, P, Nichols, J, Göttgens, B, Silva, JCR (2019). Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell 25(3). doi:10.1016/j.stem.2019.07.009

Bredenkamp, N, Stirparo, GG, Nichols, J, Smith, A, Guo, G (2019). The Cell-Surface Marker Sushi Containing Domain 2 Facilitates Establishment of Human Naive Pluripotent Stem Cells. Stem Cell Reports 12(6). doi:10.1016/j. stemcr.2019.03.014

Filipponi, D, Emelyanov, A, Muller, J, Molina, C, Nichols, J, Bulavin, DV (2019). DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse. Molecular Cell 74(4). doi:10.1016/j.molcel.2019.03.002

Kalkan, T, Bornelöv, S, Mulas, C, Diamanti, E, Lohoff, T, Ralser, M, Middelkamp, S, Lombard, P, Nichols, J, Smith, A (2019). Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency. Cell Stem Cell 24(5). doi:10.1016/j.stem.2019.03.017

Mulas, C, Kalkan, T, von Meyenn, F, Leitch, HG, Nichols, J, Smith, A (2019). Correction: Defined conditions for propagation and manipulation of mouse embryonic stem cells. Development (Cambridge) 146(7). doi:10.1242/ dev.173146

Sainz de Aja, J, Menchero, S, Rollan, I, Barral, A, Tiana, M, Jawaid, W, Cossio, I, Alvarez, A, Carreño-Tarragona, G, Badia- Careaga, C, Nichols, J, Göttgens, B, Isern, J, Manzanares, M (2019). The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1. EMBO Journal 38(7). doi:10.15252/embj.201899122

Mulas, C, Kalkan, T, von Meyenn, F, Leitch, HG, Nichols, J, Smith, A (2019). Defined conditions for propagation and manipulation of mouse embryonic stem cells. Development (Cambridge) 146(6). doi:10.1242/dev.173146

Pijuan-Sala, B, Griffiths, JA, Guibentif, C, Hiscock, TW, Jawaid, W, Calero-Nieto, FJ, Mulas, C, Ibarra-Soria, X, Tyser, RCV, Ho, DLL, Reik, W, Srinivas, S, Simons, BD, Nichols, J, Marioni, JC, Göttgens, B (2019). A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745). doi:10.1038/s41586-019-0933-9

Zhang, W, Chronis, C, Chen, X, Zhang, H, Spalinskas, R, Pardo, M, Chen, L, Wu, G, Zhu, Z, Yu, Y, Yu, L, Choudhary, J, Nichols, J, Parast, MM, Greber, B, Sahlén, P, Plath, K (2019). The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Cell Stem Cell, 24(1). doi:10.1016/j. stem.2018.12.001

Sue Ozanne

Dearden, L, Buller, S, Furigo, IC, Fernandez-Twinn, DS, Ozanne, SE (2020). Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways. Molecular Metabolism 42. doi:10.1016/j.molmet.2020.101079

Teulings, NEWD, Wood, AM, Sovio, U, Ozanne, SE, Smith, GCS, Aiken, CE (2020). Independent influences of maternal obesity and fetal sex on maternal cardiovascular adaptation to pregnancy: a prospective cohort study. International Journal of Obesity 44(11). doi:10.1038/s41366-020-0627-2

Hammerle, CM, Sandovici, I, Brierley, GV, Smith, NM, Zimmer, WE, Zvetkova, I, Prosser, HM, Sekita, Y, Lam, BYH, Ma, M, Cooper, WN, Vidal-Puig, A, Ozanne, SE, Medina-Gómez, G, Constância, M (2020). Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genetics 16. doi:10.1371/journal.pgen.1009069

Gil, A, Rueda, R, Ozanne, SE, van der Beek, EM, van Loo-Bouwman, C, Schoemaker, M, Marinello, V, Venema, K, Stanton, C, Schelkle, B, Flourakis, M, Edwards, CA (2020). Is there evidence for bacterial transfer via the placenta and any role in the colonization of the infant gut?–a systematic review. Critical Reviews in Microbiology 46(5). doi:10.1080/104084 1X.2020.1800587

Wargent, ET, Martin-Gronert, MS, Cripps, RL, Heisler, LK, Yeo, GSH, Ozanne, SE, Arch, JRS, Stocker, CJ (2020). Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity. International Journal of Obesity 44(9). doi:10.1038/s41366-020-0643-2

Kanakis, I, Alameddine, M, Scalabrin, M, van ‘t Hof, RJ, Liloglou, T, Ozanne, SE, Goljanek-Whysall, K, Vasilaki, A (2020). Low protein intake during reproduction compromises the recovery of lactation-induced bone loss in female mouse dams without affecting skeletal muscles. FASEB Journal 34(9). doi:10.1096/fj.202001131R

Reynolds, RM, Ozanne, SE (2020). Early-life development and future health: Mechanisms and opportunities for intervention. Current Opinion in Endocrine and Metabolic Research 13. doi:10.1016/j.coemr.2020.11.003

Teulings, NEWD, Garrud, TAC, Niu, Y, Skeffington, KL, Beck, C, Itani, N, Conlon, FG, Botting, KJ, Nicholas, LM, Ashmore, TJ, Blackmore, HL, Tong, W, Camm, EJ, Derks, JB, Logan, A, Murphy, MP, Ozanne, SE, Giussani, DA (2020). Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system. FASEB Journal 34(7). doi:10.1096/ fj.202000697R

Tarry-Adkins, JL, Aiken, CE, Ozanne, SE (2020). Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry independent of maternal glycaemic control: A systematic review and meta- analysis. PLoS Medicine 17(5). doi:10.1371/journal.pmed.1003126

Parkinson, JRC, Emsley, R, Adkins, JLT, Longford, N, Ozanne, SE, Holmes, E, Modi, N (2020). Clinical and molecular evidence of accelerated ageing following very preterm birth. Pediatric Research 87(6). doi:10.1038/s41390-019-0709- 9

Furse, S, Fernandez-Twinn, DS, Jenkins, B, Meek, CL, Williams, HEL, Smith, GCS, Charnock-Jones, DS, Ozanne, SE, Koulman, A (2020). A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Analytical and Bioanalytical Chemistry 412(12). doi:10.1007/s00216-020-02511-0

de Barros Mucci, D, Kusinski, LC, Wilsmore, P, Loche, E, Pantaleão, LC, Ashmore, TJ, Blackmore, HL, Fernandez-Twinn, DS, Carmo, MGT, Ozanne, SE (2020). Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. International Journal of Obesity 44(5). doi:10.1038/s41366-020-0561-3

Nicholas, LM, Nagao, M, Kusinski, LC, Fernandez-Twinn, DS, Eliasson, L, Ozanne, SE (2020). Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice. Diabetologia 63(2). doi:10.1007/ s00125-019-05037-y

Grunnet, LG, Pilgaard, K, Alibegovic, A, Jensen, CB, Hjort, L, Ozanne, SE, Bennett, M, Vaag, A, Brøns, C (2019). Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight. Scientific Reports 9(1). doi:10.1038/s41598-019-43387-0

Teulings, NEWD, Masconi, KL, Ozanne, SE, Aiken, CE, Wood, AM (2019). Effect of interpregnancy weight change on perinatal outcomes: Systematic review and meta-analysis. BMC Pregnancy and Childbirth 19(1). doi:10.1186/s12884- 019-2566-2

Fernandez-Twinn, DS, Hjort, L, Novakovic, B, Ozanne, SE, Saffery, R (2019). Intrauterine programming of obesity and type 2 diabetes. Diabetologia 62(10). doi:10.1007/s00125-019-4951-9

Aiken, CE, Tarry-Adkins, JL, Spiroski, A-M, Nuzzo, AM, Ashmore, TJ, Rolfo, A, Sutherland, MJ, Camm, EJ, Giussani, DA, Ozanne, SE (2019). Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next- generation adult rats. FASEB Journal 33(6). doi:10.1096/fj.201802772R

Aiken, CE, Tarry-Adkins, JL, Ashmore, TJ, Ozanne, SE (2019). Early life environment influences the trajectory of post- partum weight loss in adult female rats. Reproductive BioMedicine Online 38(5). doi:10.1016/j.rbmo.2018.12.002

Aiken, CE, Tarry-Adkins, JL, Spiroski, A-M, Nuzzo, AM, Ashmore, TJ, Rolfo, A, Sutherland, MJ, Camm, EJ, Giussani, DA, Ozanne, SE (2019). Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats. Journal of Physiology 597(9). doi:10.1113/JP277431

Menting, MD, Mintjens, S, van de Beek, C, Frick, CJ, Ozanne, SE, Limpens, J, Roseboom, TJ, Hooijmans, CR, van Deutekom, AW, Painter, RC (2019). Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies. Obesity Reviews 20(5). doi:10.1111/obr.12817

Nicholas, LM, Ozanne, SE (2019). Early life programming in mice by maternal overnutrition: Mechanistic insights and interventional approaches. Philosophical Transactions of the Royal Society B: Biological Sciences 374(1770). doi:10.1098/rstb.2018.0116

Kuijper, B, Hanson, MA, Vitikainen, EIK, Marshall, HH, Ozanne, SE, Cant, MA (2019). Developing differences: Early-life effects and evolutionary medicine. Philosophical Transactions of the Royal Society B: Biological Sciences 374(1770). doi:10.1098/rstb.2019.0039

Menting, MD, van de Beek, C, Mintjens, S, Wever, KE, Korosi, A, Ozanne, SE, Limpens, J, Roseboom, TJ, Hooijmans, C, Painter, RC (2019). The link between maternal obesity and offspring neurobehavior: A systematic review of animal experiments. Neuroscience and Biobehavioral Reviews 98. doi:10.1016/j.neubiorev.2018.12.023

Tarry-Adkins, JL, Ozanne, SE (2019). Poor early growth and age-associated disease. Subcellular Biochemistry 91. doi:10.1007/978-981-13-3681-2_1

Tarry-Adkins, JL, Aiken, CE, Ozanne, SE (2019). Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. PLoS Medicine 16(8). doi:10.1371/ journal.pmed.1002848

Aiken, CE, Tarry-Adkins, JL, Ozanne, SE (2019). Assaying Reproductive Capacity in Female Rodents. Methods in Molecular Biology 1916. doi:10.1007/978-1-4939-8994-2_15

Tarry-Adkins, JL, Aiken, CE, Ashmore, TJ, Fernandez-Twinn, DS, Chen, J-H, Ozanne, SE (2019). A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats.

FASEB Journal 33(1). doi:10.1096/fj.201701350RR

Musial, B, Fernandez-Twinn, DS, Duque-Guimaraes, D, Carr, SK, Fowden, AL, Ozanne, SE, Sferruzzi-Perri, AN (2019). Exercise alters the molecular pathways of insulin signaling and lipid handling in maternal tissues of obese pregnant mice. Physiological Reports 7(16). doi:10.14814/phy2.14202

Furse, S, White, SL, Meek, CL, Jenkins, B, Petry, CJ, Vieira, MC, Ozanne, SE, Dunger, DB, Poston, L, Koulman, A (2019). Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy. Molecular Omics 15(6). doi:10.1039/c9mo00117d

Vicente Perez Garcia

Woods L, Morgan N, Zhao X, Dean W, Perez-Garcia V, Hemberger M (2020). Epigenetic changes occur at decidualisation genes as a function of reproductive ageing in mice. Development 147(6).

Perez-Garcia, V, Lopez-Jimenez P, GJ Burton, A Moffett, Turco, M Hemberger (2020). BAP1/ASXL complex modulation regulates Epithelial–Mesenchymal Transition during trophoblast differentiation and invasion. bioRxiv. doi. org/10.1101/2020.12.01.40590

Perez-Garcia V, Turco MY (2020). Keep Calm and the Placenta will Carry On. Dev Cell. 10;54(3): 295-296.

López-Tello J, Pérez-García V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernández de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN (2019). Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice. eLife 8.

Wolf Reik

Thompson O, von Meyenn F, Hewitt Z, Alexander J, Wood A, Weightman R, Gregory S, Krueger F, Andrews S, Barbaric I, Gokhale PJ, Moore HD, Reik W, Milo M, Nik-Zainal S, Yusa K, Andrews PW (2020). Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions. Nat Commun. 11(1): 1,528. doi:10.1038/ s41467-020-15271-3

Rajewsky, N, Almouzni, G, Gorski, SA, Aerts, S, […], Reik, W, […] (2020). LifeTime and improving European healthcare through cell-based interceptive medicine. Nature 587(7834). doi:101038/s41586-020-2715-9

Antunes C, Da Silva JD, Guerra-Gomes S, Alves ND, Ferreira F, Loureiro-Campos E, Branco MR, Sousa N, Reik W, Pinto L, Marques CJ (2020). Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice. Mol Psychiatry. doi:10.1038/s41380-020-0695-7

Evano, B, Gill, D, Hernando-Herraez, I, Comai, G, Stubbs, TM, Commere, P-H, Reik, W, Tajbakhsh, S (2020). Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation. PLoS Genetics 16(10). doi:101371/journalpgen1009022

Eckersley-Maslin, MA, Parry, A, Blotenburg, M, Krueger, C, Ito, Y, Franklin, VNR, Narita, M, D’Santos, CS, Reik, W (2020). Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Nature Structural and Molecular Biology, 27(8). doi:101038/s41594-020-0443-3

D’Anna, F, Van Dyck, L, Xiong, J, Zhao, H, Berrens, RV, Qian, J, Bieniasz-Krzywiec, P, Chandra, V, Schoonjans, L, Matthews, J, De Smedt, J, Minnoye, L, Amorim, R, Khorasanizadeh, S, Yu, Q, Zhao, L, De Borre, M, Savvides, SN, Simon, MC, Carmeliet, P, Reik, W, Rastinejad, F, Mazzone, M, Thienpont, B, Lambrechts, D (2020). DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance. Genome Biology 21(1). doi:101186/s13059-020-02087-z

Alda-Catalinas, C, Bredikhin, D, Hernando-Herraez, I, Santos, F, Kubinyecz, O, Eckersley-Maslin, MA, Stegle, O, Reik, W (2020). A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program. Cell Systems 11(1). doi:101016/jcels202006004

Santiago, M, Antunes, C, Guedes, M, Iacovino, M, Kyba, M, Reik, W, Sousa, N, Pinto, L, Branco, MR, Marques, CJ (2020). Correction to: Tet3 regulates cellular identity and DNA methylation in neural progenitor cells. Cellular and Molecular Life Sciences 77(14). doi: 101007/s00018-019-03335-7

Montalbán-Loro, R, Lozano-Ureña, A, Ito, M, Krueger, C, Reik, W, Ferguson-Smith, AC, Ferrón, SR (2019). TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn. Nature Communications, 10(1). doi:101038/ s41467-019-09665-1

Gdula, MR, Nesterova, TB, Pintacuda, G, Godwin, J, Zhan, Y, Ozadam, H, McClellan, M, Moralli, D, Krueger, F, Green,

CM, Reik, W, Kriaucionis, S, Heard, E, Dekker, J, Brockdorff, N (2019). The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome. Nature Communications 10(1). doi:101038/s41467-018-07907-2

Martin-Herranz, DE, Aref-Eshghi, E, Bonder, MJ, Stubbs, TM, Choufani, S, Weksberg, R, Stegle, O, Sadikovic, B, Reik, W, Thornton, JM (2019). Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1. Genome Biology 20(1). doi:101186/s13059-019-1753-9

Gao, X, Nowak-Imialek, M, Chen, X, Chen, D, Herrmann, D, Ruan, D, Chen, ACH, Eckersley-Maslin, MA, Ahmad, S, Lee, YL, Kobayashi, T, Ryan, D, Zhong, J, Zhu, J, Wu, J, Lan, G, Petkov, S, Yang, J, Antunes, L, Campos, LS, Fu, B, Wang, S, Yong, Y, Wang, X, Xue, S-G, Ge, L, Liu, Z, Huang, Y, Nie, T, Li, P, Wu, D, Pei, D, Zhang, Y, Lu, L, Yang, F, Kimber, SJ,

Reik, W, Zou, X, Shang, Z, Lai, L, Surani, A, Tam, PPL, Ahmed, A, Yeung, WSB, Teichmann, SA, Niemann, H, Liu, P (2019). Establishment of porcine and human expanded potential stem cells. Nature Cell Biology 21(6). doi:101038/s41556- 019-0333-2

Olova, N, Krueger, F, Andrews, S, Oxley, D, Berrens, RV, Branco, MR, Reik, W (2019). Correction to: Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data. Genome Biology 20(1). doi:101186/s13059-019-1656-9

Linker, SM, Urban, L, Clark, SJ, Chhatriwala, M, Amatya, S, McCarthy, DJ, Ebersberger, I, Vallier, L, Reik, W, Stegle, O, Bonder, MJ (2019). Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity. Genome Biology 20(1). https://doi.org/10.1186/s13059-019-1644-0

Messmer, T, von Meyenn, F, Savino, A, Santos, F, Mohammed, H, Lun, ATL, Marioni, JC, Reik, W (2019). Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution. Cell Reports 26(4). doi:101016/jcelrep201812099

Eckersley-Maslin M, Alda-Catalinas C, Blotenburg M, Kreibich E, Krueger C & Reik W (2019). Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program. Genes & Development 33: 194-208.

Bell CG, Lowe R, Adams PD, Baccarelli AA, Beck S, Bell JT, Christensen BC, Gladyshev VN, Heijmans BT, Horvath S, Ideker T, Issa JJ, Kelsey KT, Marioni RE, Reik W, Relton CL, Schalkwyk LC, Teschendorff AE, Wagner W, Zhang K, Rakyan VK (2019). DNA methylation aging clocks: challenges and recommendations. Genome Biol. 25 Nov;20(1):249. doi:10.1186/s13059-019-1824-y. Review. PubMed PMID: 31767039; PubMed Central PMCID: PMC6876109

Santiago M, Antunes C, Guedes M, Iacovino M, Kyba M, Reik W, Sousa N, Pinto L, Branco MR, Marques CJ (2019). Tet3 regulates cellular identity and DNA methylation in neural progenitor cells. Cell Mol Life Sci. doi:10.1007/s00018-019- 03335-7

Alda-Catalinas C, Bredikhin D, Hernando-Herraez I, Kubinyecz O, Santos F, Eckersley-Maslin MA, Stegle O & Reik W (2020). A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of zygotic genome activation. Cell Systems 11:25-41.

Eckersley-Maslin M, Parry A, Blotenburg M, Krueger C, Ito Y, Franklin VNR, Narita M, D’Santos CS & Reik W (2020). Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Nature Structural and Molecular Biology 27: 696-705.

Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X (2019). Voices in methods development. Nature Methods 16(10): 945-951. doi:10.1038/s41592-019-0585-6

Hernando-Herraez I, Evano B, Stubbs T, Commere PH, Jan Bonder M, Clark S, Andrews S, Tajbakhsh S, Reik W (2019). Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells. Nat Commun. 25 Sep;10(1):4361. doi:10.1038/s41467-019-12293-4. PubMed PMID: 31554804; PubMed Central PMCID: PMC6761124

Stuart HT, Stirparo GG, Lohoff T, Bates LE, Kinoshita M, Lim CY, Sousa EJ, Maskalenka K, Radzisheuskaya A, Malcolm AA, Alves MRP, Lloyd RL, Nestorowa S, Humphreys P, Mansfield W, Reik W, Bertone P, Nichols J, Göttgens B, Silva JCR (2019). Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell 25(3). doi:10.1016/j. stem.2019.07.009

Peter Rugg-Gunn

Ortmann, Daniel; Brown, Stephanie; Czechanski, Anne; Aydin, Selcan; Muraro, Daniele; Huang, Yuanhua; Tomaz, Rute A; Osnato, Anna; Canu, Giovanni; Wesley, Brandon T; Skelly, Daniel A; Stegle, Oliver; Choi, Ted; Churchill, Gary A; Baker,

Christopher L; Rugg-Gunn, Peter J; Munger, Steven C; Reinholdt, Laura G; Vallier, Ludovic (2020). Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation. Cell Stem Cell 27(3). ISSN: 1934-5909, 1875- 9777; DOI: 10.1016/j.stem.2020.07.019

Wojdyla, Katarzyna; Collier, Amanda J; Fabian, Charlene; Nisi, Paola S; Biggins, Laura; Oxley, David; Rugg-Gunn, Peter J (2020). Cell-Surface Proteomics Identifies Differences in Signaling and Adhesion Protein Expression between Naive and Primed Human Pluripotent Stem Cells. Stem Cell Reports, 2020, 14(5): 972-988. ISSN: 2213-6711; doi:10.1016/j. stemcr.2020.03.017

Goodwin, Jacob; Laslett, Andrew L; Rugg-Gunn, Peter J (2020). The application of cell surface markers to demarcate distinct human pluripotent states. Experimental Cell Research, 387(1): 111749. ISSN: 0014-4827, 1090-2422; doi:10.1016/j.yexcr.2019.111749

Argelaguet, Ricard; Clark, Stephen J; Mohammed, Hisham; Stapel, L Carine; Krueger, Christel; Kapourani, Chantriolnt- Andreas; Imaz-Rosshandler, Ivan; Lohoff, Tim; Xiang, Yunlong; Hanna, Courtney W; Smallwood, Sebastien; Ibarra-Soria, Ximena; Buettner, Florian; Sanguinetti, Guido; Xie, Wei; Krueger, Felix; Göttgens, Berthold; Rugg-Gunn, Peter J; Kelsey, Gavin; Dean, Wendy (2019). Multi-omics profiling of mouse gastrulation at single-cell resolution. Nature, 2019, 576(7787): 487-491. ISSN: 0028-0836, 1476-4687; doi:10.1038/s41586-019-1825-8

Peter J Rugg-Gunn (2019). Transcription factors make the right contacts. Nature Cell Biology, 21(10): 1,173-1,174. ISSN: 1465-7392, 1476-4679; doi:10.1038/s41556-019-0399-x

Claire Senner

Senner CE, Chrysanthou S, Burge S, Lin H-Y, Branco MR, and Hemberger M (2020). TET1 and 5-hydroxymethylation preserve the stem cell state of mouse trophoblast. Stem Cell Reports. May. doi:10.1016/j.stemcr.2020.04.009

Amanda Sferruzzi-Perri

Christoforou, ER, Sferruzzi-Perri, AN (2020). Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress. Cellular and Molecular Life Sciences 77(23). doi:101007/s00018-020-03566-z

Napso, T, Hung, Y-P, Davidge, ST, Care, AS, Sferruzzi-Perri, AN (2020). Author Correction: Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats. Scientific Reports 10(1). doi:101038/s41598-020-59769-8

Sferruzzi-Perri, AN, Lopez-Tello, J, Napso, T, Yong, HEJ (2020). Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: Lessons from animal models. Placenta 98. doi:101016/ jplacenta202001015

Lopez-Tello J and Sferruzzi-Perri AN (2020). Fused placentas: Till birth do us part. Placenta 103: 177-9. Zhang Y, Hu M, Jia W, Liu G, Zhang J, Wang B, Li J, Cui P, Li X, Lager S, Sferruzzi-Perri AN, Han Y, Liu S, Wu X,

Brännström M, Linus Shao L, Billig H (2020). Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats. Journal of Endocrinology 246:247-263. doi:10.1530/JOE-20-0155

Aykroyd BRL, Tunster ST, Sferruzzi-Perri AN (2020). Igf2 deletion alters mouse placenta endocrine capacity in a sexually-dimorphic manner. Journal of Endocrinology 246: 93-108.

De Clercq K*, Lopez-Tello J*, Vriens J, Sferruzzi-Perri AN (2020). Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology. Placenta 94: 44-47. *Contributed equally.

Kaitu’u-Lino TJ, MacDonald TM, Cannon P, Nguyen TV, Hiscock RJ, Haan N, Hastie R, Dane KM, Middleton AL, Bittar I, Sferruzzi-Perri AN, Pritchard N, Harper A, Hannan AJ, Kyritsis V, Crinis N, HuiL, Walker SP, Tong S (2020). Circulating SPINT1 is a marker of placental insufficiency and fetal growth restriction. Nature Comms 11(1): 2,411.

Napso T, Hung Y-P, Davidge S, Care A, Sferruzzi-Perri AN (2019). Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats. Scientific Reports 9(1): 16,916.

Sandovici I, Georgopoulou A, Hufnagel AS, Schiefer SN, Santos F, Hoelle K, Lam BYH, Yeo GSH, Burling K, López-Tello J, Reiterer M, Fowden AL, Burton GJ, Sferruzzi-Perri AN, Branco CM, Constância M (2019). The imprinted Igf2–Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. https://www.biorxiv.org/content/ early/2019/01/16/520536

Musial B, Fernandez-Twinn, Duque-Guimaraes D, Carr SK, Fowden AL, Ozanne SE*, Sferruzzi-Perri AN* (2019). Exercise alters the molecular pathways of insulin signalling and lipid handling in maternal tissues of obese pregnant mice. Physiological Reports 7(16). doi:1014814/phy214202

Lopez-Tello J, Perez-Garcia V, Khaira J, Kusinski L, Andreani, A, Grant I, Fernandez De Liger E, Cooper W, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN (2019) Interplay between fetal and trophoblast phosphoinositol 3-kinase (PI3K) p110α signalling modifies resource allocation to the growing fetus. eLIFE 8. pii: e45282.

Lee CQR, Bailey A, Lopez-Tello J, Sferruzzi-Perri AN, Okkenhaug K, Moffett A, Hemberger M, Rossant J (2019). Inhibition of phosphatidylinositol-3-kinase signaling promotes the stem cell state of trophoblast. Stem Cells 37: 1,307-1,318

Zhang Y, Zhao W, Xu H, Hu M, Guo X, Jia W, Liu G, Li J, Cui P, Lager SM, Sferruzzi-Perri AN, Li W, Wu X, Brännström M, Shao LR, Billig H (2019) Hyperandrogenism and insulin resistance-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome. J Physiol 597: 3,927-3,950.

De Clercq, K, Persoons, E, Napso, T, Luyten, C, Parac-Vogt, TN, Sferruzzi-Perri, AN, Kerckhofs, G, Vriens, J (2019). High- resolution contrast-enhanced microCT reveals the true three-dimensional morphology of the murine placenta.

Proceedings of the National Academy of Sciences of the United States of America 116(28): 13,927-13,936. doi:101073/ pnas1902688116

De Clercq K, Persoons E, Napso T, Luyten C, Parac-Vogt TN, Sferruzzi-Perri AN, Kerckhofs G and Vriens J (2019). Simultaneous 3D morphological analysis of the mature murine placenta and its vasculature using contrast enhanced microCT. PNAS 116: 13,927-13,936.

Hu M, Zhang Y, Guo X, Jia W, Liu G, Zhang J, Li J, Cui P, Sferruzzi-Perri AN, Han Y, Wu X, Ma H, Brännström M, Shao LR and Billig H (2019). Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant ROS production. American Journal of Physiology Endocrinology and Metabolism 316: E794-E809.

Sferruzzi-Perri AN, Higgins J, Vaughan OR, Murray AJ, Fowden AL (2019). Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth. PNAS 116(5): 1,621-1,626.

López-Tello J, Arias-Álvarez M, González-Bulnes A, Sferruzzi-Perri AN (2019). Rabbit models for studying intrauterine growth restriction and fetal programming. Molecular Reproduction & Development 86(12): 1,781-1,809.

Andrew Sharkey

chromosomally integrated HHV-6 predisposes to preeclampsia in the mother. Nat Microbiol., in press. doi:10.1038/ s41564-020-0711-3

Ben Simmons

Sznurkowska, MK, Hannezo, E, Azzarelli, R, Chatzeli, L, Ikeda, T, Yoshida, S, Philpott, A, Simons, BD (2020). Tracing the cellular basis of islet specification in mouse pancreas. Nature Communications 11(1).

doi:101038/s41467-020-18837-3

Aragona, M, Sifrim, A, Malfait, M, Song, Y, Van Herck, J, Dekoninck, S, Gargouri, S, Lapouge, G, Swedlund, B, Dubois, C, Baatsen, P, Vints, K, Han, S, Tissir, F, Voet, T, Simons, BD, Blanpain, C (2020). Mechanisms of stretch-mediated skin expansion at single-cell resolution. Nature 584(7820). doi:101038/s41586-020-2555-7

Corominas-Murtra, B, Scheele, CLGJ, Kishi, K, Ellenbroek, SIJ, Simons, BD, Van Rheenen, J, Hannezo, E (2020). Stem cell lineage survival as a noisy competition for niche access. Proceedings of the National Academy of Sciences of the United States of America 117(29). DOI: 101073/pnas1921205117

Chatzeli, L, Simons, BD (2020). Tracing the dynamics of stem cell fate Cold Spring Harbor. Perspectives in Biology 12(6). doi:101101/cshperspecta036202

Dekoninck, S, Hannezo, E, Sifrim, A, Miroshnikova, YA, Aragona, M, Malfait, M, Gargouri, S, de Neunheuser, C, Dubois, C, Voet, T, Wickström, SA, Simons, BD, Blanpain, C (2020). Defining the Design Principles of Skin Epidermis Postnatal Growth. Cell 181(3). doi:101016/jcell202003015

Than-Trong, E, Kiani, B, Dray, N, Ortica, S, Simons, B, Rulands, S, Alunni, A, Bally-Cuif, L (2020). Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells. Science Advances 6(18). doi:101126/ sciadvaaz5424

McCarthy, DJ, Rostom, R, Huang, Y, Kunz, DJ, Danecek, P, Bonder, MJ, Hagai, T, Lyu, R, Kilpinen, H, Goncalves, A, Leha, A, Afzal, V, Alasoo, K, Ashford, S, Bala, S, Bensaddek, D, Jan Bonder, M, Casale, FP, Culley, OJ, Cuomo, A, Faulconbridge, A, Harrison, PW, Kathuria, A, McCarthy, SA, Meleckyte, R, Memari, Y, Mirauta, B, Moens, N, Soares, F, Mann, A, Seaton, D, Streeter, I, Agu, CA, Alderton, A, Nelson, R, Harper, S, Patel, M, White, A, Patel, SR, Clarke, L,

Halai, R, Kirton, CM, KolbKokocinski, A, Beales, P, Birney, E, Danovi, D, Lamond, AI, Ouwehand, WH, Vallier, L, Watt, FM, Durbin, R, Stegle, O, Gaffney, DJ, Wang, W, Simons, BD, Teichmann, SA (2020). Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes. Nature Methods 17(4). doi:101038/s41592-020-0766-3

Krieger, TG, Moran, CM, Frangini, A, Visser, WE, Schoenmakers, E, Muntoni, F, Clark, CA, Gadian, D, Chong, WK, Kuczynski, A, Dattani, M, Lyons, G, Efthymiadou, A, Vargha-Khadem, F, Simons, BD, Chatterjee, K, Livesey, FJ (2020). Erratum: Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development. Proceedings of the National Academy of Sciences of the United States of America 117(13). doi:101073/pnas2003767117

Georgakopoulos, N, Prior, N, Angres, B, Mastrogiovanni, G, Cagan, A, Harrison, D, Hindley, CJ, Arnes-Benito, R, Liau, S-S, Curd, A, Ivory, N, Simons, BD, Martincorena, I, Wurst, H, Saeb-Parsy, K, Huch, M (2020). Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids. BMC Developmental Biology 20(1). doi:101186/s12861-020-0209-5

Hannezo, E, Simons, BD (2019). Multiscale dynamics of branching morphogenesis. Current Opinion in Cell Biology 60. doi:101016/jceb201904008

Han, S, Fink, J, Jörg, DJ, Lee, E, Yum, MK, Chatzeli, L, Merker, SR, Josserand, M, Trendafilova, T, Andersson-Rolf, A, Dabrowska, C, Kim, H, Naumann, R, Lee, J-H, Sasaki, N, Mort, RL, Basak, O, Clevers, H, Stange, DE, Philpott, A, Kim, JK, Simons, BD, Koo, B-K (2019). Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Cell Stem Cell 25(3). doi:101016/jstem201907008

Li, Z, Solomonidis, EG, Meloni, M, Taylor, RS, Duffin, R, Dobie, R, Magalhaes, MS, Henderson, BEP, Louwe, PA, D’Amico, G, Hodivala-Dilke, KM, Shah, AM, Mills, NL, Simons, BD, Gray, GA, Henderson, NC, Baker, AH, Brittan, M (2019). Single- cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction. European Heart Journal 40(30). doi:101093/eurheartj/ehz305

Andersen, MS, Hannezo, E, Ulyanchenko, S, Estrach, S, Antoku, Y, Pisano, S, Boonekamp, KE, Sendrup, S, Maimets, M, Pedersen, MT, Johansen, JV, Clement, DL, Feral, CC, Simons, BD, Jensen, KB (2019). Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states. Nature Cell Biology 21(8). doi:101038/s41556-019- 0362-x

Guiu, J, Hannezo, E, Yui, S, Demharter, S, Ulyanchenko, S, Maimets, M, Jørgensen, A, Perlman, S, Lundvall, L, Mamsen, LS, Larsen, A, Olesen, RH, Andersen, CY, Thuesen, LL, Hare, KJ, Pers, TH, Khodosevich, K, Simons, BD, Jensen, KB (2019). Tracing the origin of adult intestinal stem cells. Nature 570(7759). doi:101038/s41586-019-1212-5

Prior, N, Hindley, CJ, Rost, F, Meléndez, E, Lau, WWY, Göttgens, B, Rulands, S, Simons, BD, Huch, M (2019). Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool. Development (Cambridge) 146(12). doi:101242/dev174557

Baker, A-M, Cereser, B, Melton, S, Fletcher, AG, Rodriguez-Justo, M, Tadrous, PJ, Humphries, A, Elia, G, McDonald, SAC, Wright, NA, Simons, BD, Jansen, M, Graham, TA (2019). Erratum: Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon. doi:101016/jcelrep201905035

Jörg, DJ, Caygill, EE, Hakes, AE, Contreras, EG, Brand, AH, Simons, BD (2019). The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism. eLife 8. doi:107554/eLife40919

Tischler, J, Gruhn, WH, Reid, J, Allgeyer, E, Buettner, F, Marr, C, Theis, F, Simons, BD, Wernisch, L, Surani, MA (2019). Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate. EMBO Journal 38(1). doi:1015252/ embj201899518

Kitadate, Y, Jörg, DJ, Tokue, M, Maruyama, A, Ichikawa, R, Tsuchiya, S, Segi-Nishida, E, Nakagawa, T, Uchida, A, Kimura-Yoshida, C, Mizuno, S, Sugiyama, F, Azami, T, Ema, M, Noda, C, Kobayashi, S, Matsuo, I, Kanai, Y, Nagasawa, T,

Sugimoto, Y, Takahashi, S, Simons, BD, Yoshida, S (2019). Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche. Cell Stem Cell 24(1). doi:101016/jstem201811013

Aztekin, C, Hiscock, TW, Marioni, JC, Gurdon, JB, Simons, BD, Jullien, J (2019). Identification of a regeneration- organizing cell in the Xenopus tail. Science 364(6441). doi:10.1126/science.aav9996

Baker, A-M, Gabbutt, C, Williams, MJ, Cereser, B, Jawad, N, Rodriguez-Justo, M, Jansen, M, Barnes, CP, Simons, BD, McDonald, SAC, Graham, TA, Wright, NA (2019). Crypt fusion as a homeostatic mechanism in the human colon. Gut 68(11). doi:101136/gutjnl-2018-317540

Krieger, TG, Moran, CM, Frangini, A, Visser, WE, Schoenmakers, E, Muntoni, F, Clark, CA, Gadian, D, Chong, WK, Kuczynski, A, Dattani, M, Lyons, G, Efthymiadou, A, Varga-Khadem, F, Simons, BD, Chatterjee, K, Livesey, FJ (2019). Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development. Proceedings of the National Academy of Sciences of the United States of America 116 (45). doi:101073/pnas1908762116

Hoffman, M, Gillmor, AH, Kunz, DJ, Johnston, MJ, Nikolic, A, Narta, K, Zarrei, M, King, J,Ellestad, K, Dang, NH, Cavalli, FMG, Kushida, MM, Coutinho, FJ, Zhu, Y, Luu, B, Ma, Y,Mungall, A, Moore, R, Marra, MA, Taylor, MD, Pugh, TJ, Dirks, PB, Strother, D, Lafay-Cousin, L, Resnick, AC, Scherer, S, Senger, DL, Simons, BD, Chan, JA, Morrissy, AS, Gallo,

M (2019). Intratumoral genetic and functional heterogeneity in pediatric glioblastoma. Cancer Research 79(9). doi:101158/0008-5472CAN-18-3441

Gordon Smith

Teulings NEWD, Wood AM, Sovio U, Ozanne SE, Smith GCS, Aiken CE (2020). Independent influences of maternal obesity and fetal sex on maternal cardiovascular adaptation to pregnancy: a prospective cohort study. International Journal of Obesity

Smith GCS, Moraitis AA, Wastlund D, Thornton JG, Papageorghiou A, Sanders J, Heazell AEP, Robson SC, Sovio U, Brockelhurst P, Wilson ECF (2020). A systematic review and cost-effectiveness analysis of the case for screening nulliparous women in late pregnancy using ultrasound. Health Technology Assessment

Iliodromiti S, Smith GCS, Lawlor DA, Pell JP, Nelson SM (2020). UK stillbirth trends in over 11 million births provide no evidence to support effectiveness of Growth Assessment Protocol program. Ultrasound in Obstetrics & Gynaecology.

Gaccioli F, Lager S, de Goffau MC, Sovio U, Dopierala J, Gong S, Cook E, Sharkey A, Moffett A, Lee WK, Delles C, Venturini C, Breuer J, Parkhill J, Peacock SJ, Charnock-Jones DS, Smith GCS (2020). Fetal inheritance of chromosomally integrated HHV-6 predisposes to preeclampsia in the mother. Nature Microbiology

Furse S, Fernandez-Twinn D, Jenkins B, Meek CL, Williams HE, Smith GCS, Charnock-Jones DS, Ozanne SE, Koulman A (2020). A high throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Analytical and Bioanalytical Chemistry

Sovio U, Goulding N, McBride N, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS (2020). A maternal serum metabolite ratio predicts term fetal growth restriction. Nature Medicine 26:348-353

de Goffau MC, Lager SM, Sovio U, Gaccioli F, Cook E, Peacock SJ, Parkhill J, Charnock-Jones DS, Smith GCS (2019).

Human placenta has no microbiome but can contain potential pathogens. Nature 572:329-334

Hughes AE, Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Lawlor DA, Smith GCS (2019). The association between first trimester AFP to PAPP-A ratio and placentally-related adverse pregnancy outcome. Placenta 81:25-31

Sovio U, McBride M, Wood AM, Masconi KL, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS (2019).

4-hydroxyglutamate is a novel predictor of preeclampsia. International Journal of Epidemiology. 16 May. pii: dyz098. doi:10.1093/ije/dyz098. [Epub ahead of print]

Wastlund D, Moraitis AA, Thornton JG, Sanders J, White IR, Brockelhurst P, Smith GCS, Wilson ECF (2019). The cost- effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women: a decision-analysis. BJOG. 8 May. doi:10.1111/1471-0528.15809. [Epub ahead of print]

Wastlund D, Moraitis AA, Dacey A, Wilson ECF, Sovio U, Smith GCS (2019). Screening for breech presentation using universal late pregnancy ultrasonography: A prospective cohort study and cost-effectiveness analysis. PLoS Medicine 6(4):e1002778

Sovio U, Smith GCS (2019). Evaluation of a simple risk score to predict preterm preeclampsia using maternal characteristics: a prospective cohort study. BJOG. 126:963–970

Consortium of Metabolomics Studies. Smith GCS et al (author 57 out of 74) (2019). The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. American Journal of Epidemiology. 188:991- 1012

Jayasuriya N, Hughes AE, Sovio U, Cook E, Charnock-Jones DS, Smith GCS (2019). A lower maternal cortisol to cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks. Journal of Clinical Endocrinology & Metabolism. 104:2355-2366

Smith GCS, Nakimuli A (2020). Ultrasonic estimation of gestational age in late pregnancy in low income countries: made to measure or off-the-peg? Lancet Global Health. 8:e462-e463

Smith GCS (2019). Screening and intervention for late fetal growth restriction. BJOG 23 Dec. doi:10.1111/1471- 0528.16072. [Epub ahead of print]

Smith GCS (2019). The risk of perinatal death at term. BJOG 126:1258

Azim Surani

Eli Y Adashi, I Glenn Cohen, Jacob H Hanna, Azim M Surani, Katsuhiko Hayashi (2019). Stem Cell-Derived Human Gametes: The Public Engagement Imperative. https://doi.org/10.1016/j.molmed.2019.01.005

John Trowsdale

Alicata C, Ashouri E, Nemat-Gorgani N, Guethlein LA, Marin WM, Tao S, Moretta L, Hollenbach JA, Trowsdale J, Traherne JA, Ghaderi A, Parham P, Norman PJ (2020). KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors. Front Immunol. Apr 2;11:556.

Cossarizza A et al (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. Oct;49(10):1457-1973

Simon Tunster

Aykroyd BRL, Tunster SJ and Sferruzzi-Perri AN (2020). Igf2 deletion affects the endocrine capacity of the mouse placenta in a sexually dimorphic manner. J Endocrinol. doi:10.1530/JOE-20-0128

Tunster S*, Watson E, Fowden A, Burton GJ (2020). Placental glycogen stores and fetal growth: insights from genetic mouse models. Reproduction 159(6): R213-235 (invited review; *corresponding author).

Sowton AP, Padmanabhan N, Tunster SJ, McNally BD, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED (2020). Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Molecular Genetics and Metabolism Reports 23.

Menelaou K, Prater M, Tunster S, Blake G, Geary Joo C, Cross JC, Hamilton R, Watson E (2020). Blastocyst transfer in mice alters the placental transcriptome and growth. Reproduction. 159(2): 115-132.

Roberts GAG and Tunster SJ*. Characterising the dynamics of placental glycogen stores in the mouse. Placenta 99: 131-140. doi:10.1016/j.placenta.2020.07.010. Epub 22 Jul 2020 [*corresponding author]

Margherita Turco

Abbas Y, Turco MY, Burton GJ, Moffett M (2020). Investigation of human trophoblast invasion in vitro. Human Reproduction Update, doi:10.1093/humup/dmaa017

Burton GJ, Cindrova-Davies T, Turco MY (2020). Histotrophic nutrition and the placental-endometrial dialogue during human early pregnancy. Placenta 14 February. doi:10.1016/j.placenta.2020.02.008

Abbas Y, Brunel LG, Hollinshead MS, Fernando R, Gardner L, Duncan I, Moffett A, Best S, Turco MY, Burton GJ, Cameron RE (2020). Generation of a three-dimensional collagen scaffold-based model of the human endometrium. Interface Focus. doi:10.1098/rsfs.2019.0079

Turco MY & Moffett A (2019). The Development of the Human Placenta. Development 146: dev163428.

Roser Vento-Tormo

Hoo R, Nakimuli A, Vento-Tormo R (2020). Innate immune mechanisms to protect against infection at the human maternal-fetal interface. Front Immunol. 11: 2070.

Davidson S, Efremova M, Riedel A, Mahata B, Pramanik J, Huuhtanen J, Kar G, Vento-Tormo R, Hagai T, Chen X, Haniffa MA, Shields JD, Teichmann SA (2020). Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. Cell Rep. 31(7):107628. doi:10.1016/j.celrep.2020.107628

Efremova M, Vento-Tormo M, Teichmann SA, Vento-Tormo R (2020). CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand-receptor complexes. Nature Protocols. 15(4): 1,484-1,506. https:// doi.org/10.1038/s41596-020-0292-x

Park JE, Botting RA, Domínguez Conde C, Popescu DM, Lavaert M, Kunz DJ, Goh I, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Roberts K, Kedlian VR, Ferdinand JR, He X, Webb S, Maunder D, Vandamme N, Mahbubani KT, Polanski K, Mamanova L, Bolt L, Crossland D, de Rita F, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Bayraktar OA, Barker RA, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T, Haniffa M, Teichmann SA (2020). A cell atlas of human thymic development defines T cell repertoire formation. Science 367(6480). pii: eaay3224. doi:10.1126/science.aay3224

Efremova M*, Vento-Tormo R*, Park JP*, Teichmann SA and James K (2020). Immunology in the era of single-cell technologies. Annu Rev Immunol. 38: 727-757. https://doi.org/10.1146/annurev-immunol-090419-020340

Stewart BJ, Ferdinand JR, Young MD, Mitchell TJ, Loudon KW, Riding AM, Richoz N, Frazer GL, Staniforth JUL, Vieira Braga FA, Botting RA, Popescu DM, Vento-Tormo R, Stephenson E, Cagan A, Farndon SJ, Polanski K, Efremova M, Green K, Del Castillo Velasco-Herrera M, Guzzo C, Collord G, Mamanova L, Aho T, Armitage JN, Riddick ACP, Mushtaq I, Farrell S, Rampling D, Nicholson J, Filby A, Burge J, Lisgo S, Lindsay S, Bajenoff M, Warren AY, Stewart GD, Sebire N, Coleman N, Haniffa M, Teichmann SA, Behjati S, Clatworthy MR (2019). Spatiotemporal immune zonation of the human kidney. Science 365(6460): 1,461-1,466. doi:10.1126/science.aat5031

Popescu DM, Botting RA, Stephenson E, Green K, Webb S, Jardine L, Calderbank EF, Polanski K, Goh I, Efremova M, Acres M, Maunder D, Vegh P, Gitton Y, Park JE, Vento-Tormo R, Miao Z, Dixon D, Rowell R, McDonald D, Fletcher J, Poyner E, Reynolds G, Mather M, Moldovan C, Mamanova L, Greig F, Young MD, Meyer KB, Lisgo S, Bacardit J, Fuller A, Millar B, Innes B, Lindsay S, Stubbington MJT, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper

M, Rozenblatt-Rosen O, Filby A, Carey P, Villani AC, Roy A, Regev A, Chédotal A, Roberts I, Göttgens B, Behjati S, Laurenti E, Teichmann SA, Haniffa M (2019). Decoding human fetal liver haematopoiesis. Nature 574(7778): 365-371. doi: 10.1038/s41586-019-1652-y

Ramachandran P, Dobie R, Wilson-Kanamori JR, Dora EF, Henderson BEP, Luu NT, Portman JR, Matchett KP, Brice M, Marwick JA, Taylor RS, Efremova M, Vento-Tormo R, Carragher NO, Kendall TJ, Fallowfield JA, Harrison EM, Mole DJ, Wigmore SJ, Newsome PN, Weston CJ, Iredale JP, Tacke F, Pollard JW, Ponting CP, Marioni JC, Teichmann SA,

Henderson NC (2019). Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature 575(7783): 512- 518. doi:10.1038/s41586-019-1631-3

Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA (2019). A cellular census of human lungs identifies novel cell states in health and in asthma. Nature Medicine 25(7): 1,153-1,163. https://doi.org/10.1038/ s41591-019-0468-5

Taylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, Jaiswal JK, Whitsett J, Hamilton KE, MacParland SA, Kelsen J, Heuckeroth RO, Potter SS, Vella LA, Terry NA, Ghanem LR, Kennedy BC, Helbig I, Sullivan KE, Castelo-Soccio L, Kreigstein A, Herse F, Nawijn MC, Koppelman GH, Haendel M, Harris NL, Rokita JL, Zhang Y, Regev A, Rozenblatt-Rosen O, Rood JE, Tickle TL, Vento-Tormo R, Alimohamed S, Lek M, Mar JC, Loomes KM, Barrett DM, Uapinyoying P, Beggs AH, Agrawal PB, Chen YW, Muir AB, Garmire LX, Snapper SB, Nazarian J, Seeholzer SH, Fazelinia H, Singh LN, Faryabi RB, Raman P, Dawany N, Xie HM, Devkota B, Diskin SJ, Anderson SA, Rappaport EF, Peranteau W, Wikenheiser-Brokamp KA, Teichmann S, Wallace D, Peng T, Ding YY, Kim MS, Xing Y, Kong SW, Bönnemann CG, Mandl KD, White PS (2019). The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Dev Cell 49(1): 10-29. doi:10.1016/j.devcel.2019.03.001

Erica Watson

Sowton A, Padmanabhan N, Tunster SJ, McNally B, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED (2020). Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Molecular Genetics and Metabolism Reports. 23: 100580

Tunster SJ, Watson ED, Fowden AL, Burton GJ (2020). Placenta glycogen stores and fetal growth: evidence from genetic mouse models. Reproduction. 159(6): R213-2R35

Menelaou K, Prater M, Tunster SJ, Blake GET, Geary-Joo C, Cross JC, Hamilton RS, Watson ED (2020). Blastocyst transfer in mice alters the placental transcriptome and growth. Reproduction. 159(2): 115-132

Blake GET, Hall J, Petkovic GE, Watson ED (2019). Analysis of spermatogenesis and fertility in adult mice with a hypomorphic mutation in the Mtrr gene. Reproduction, Fertility and Development. 31(11): 1730-1741

Magda Zernicka-Goetz

Zhu, M, Zernicka-Goetz, M (2020). Principles of Self-Organization of the Mammalian Embryo. Cell 183(6): 1,467-1,478.

Orietti, LC, Rosa, VS, Antonica, F, [...], Shahbazi, MN, Zernicka-Goetz, M (2020). Embryo Size Regulates the Timing and Mechanism of Pluripotent Tissue Morphogenesis. Stem Cell Reports.

Kyprianou C, Christodoulou, N and Zernicka-Goetz, M (2020). Basement membrane remodelling regulates mouse embryogenesis. Nature.

Zhu M, Zernicka-Goetz M (2020). Living a Sweet Life: Glucose Instructs Cell Fate in the Mouse Embryo. Dev Cell. 6 Apr;53(1):1-2. doi:10.1016/j.devcel.2020.03.012. PMID: 32259489

Zhu M, Zernicka-Goetz M (2020). Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives. Curr Opin Cell Biol. Feb;62:144-149. doi:10.1016/j.ceb.2019.11.005. Epub 21 Dec 2019. PMID: 31869760. Review

Molè MA, Weberling A, Zernicka-Goetz M (2020). Comparative analysis of human and mouse development: From zygote to pre-gastrulation. Curr Top Dev Biol. 136:113-138. doi:10.1016/bs.ctdb.2019.10.002. Epub 26 Dec 2019. PMID: 31959285

Sozen B, Cox AL, De Jonghe J, Bao M, Hollfelder F, Glover DM, Zernicka-Goetz (2019). Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid. M Dev Cell. 16 Dec;51(6):698-712.e8. doi:10.1016/j. devcel.2019.11.014. PMID: 31846649

Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA, Huch M (2019).

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration. Nat Cell Biol. Nov;21(11):1321-1333. doi:10.1038/s41556-019-0402-6

Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X (2019). Voices in methods development. Nat Methods 16(10): 945-951. doi:10.1038/s41592-019-0585-6

Christodoulou N, Weberling A, Strathdee D, Anderson KI, Timpson P, Zernicka-Goetz M (2019). Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation. Nat Commun. 10(1): 3,557. doi:10.1038/s41467-019-11482-5

Shahbazi MN, Siggia ED, Zernicka-Goetz (2019). Self-organization of stem cells into embryos: A window on early mammalian development. M Science 364(6444): 948-951. doi:10.1126/science.aax0164

Antonica F, Orietti LC, Mort RL (2019). Zernicka-Goetz M.Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. Dev Biol. 450(2): 132-140. doi:10.1016/j.ydbio.2019.03.016

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Research at Cambridge