System A is an amino acid transporter that plays an important role in fetal growth and development. My work involves using genetic models of the System A transporter genes to examine the following:
- Understand the role of system A activity in the mouse placenta.
- Study the role of system A activity in fetal tissues.
- Establish cell signalling pathways involved in system A activity.
- Analyse the effects of nutrient supplementation in rescuing the growth restricted phenotype.
I am a member of Miguel Constancia’s group.
Kusinski LC, Stanley JL, Dilworth MR, Hirt CJ, Andersson IJ, Renshall LJ, Baker BC, Baker PN, Sibley CP, Wareing M, Glazier JD (2012). eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype. Am J Physiol Regul Integr Comp Physiol.[Epub ahead of print].
Kusinski LC, Dilworth MR, Baker PN, Sibley CP, Wareing M, Glazier JD (2011).System A activity and vascular function in the placental-specific Igf2 knockout mouse. Placenta.32 (11):871-6.
Kusinski LC, Jones CJ, Baker PN, Sibley CP, Glazier JD. Isolation of plasma membrane vesicles from mouse placenta at term and measurement of system A and system beta amino acid transporter activity. Placenta. 2010 Jan;31(1):53-9.