Our research

The placenta is essential for a healthy pregnancy and has lasting effects on the health of both mother and child. Problems with placental development and function can contribute to miscarriage, stillbirth, pre-eclampsia, fetal growth restriction and preterm birth. The placenta also shapes the environment in which the fetus develops, with effects that may extend into later life for both the child and pregnant individual.

However, many aspects of how the placenta develops and functions, and how placental dysfunction contributes to complications of fertility and pregnancy, remain poorly understood.

Our approach

Our research centres on the trophoblast, the first cell lineage to form as the embryo develops and the main cell type of the placenta. Trophoblast cells form the interface between maternal and fetal tissues. They help establish the maternal blood supply to the placenta, exchange nutrients and signals, produce hormones and interact with the maternal immune system.

Placental biology brings together developmental biology, immunology, physiology, genetics and clinical research. The Loke CTR connects researchers from across these disciplines so that fundamental discoveries can inform questions about fertility, pregnancy and lifelong health.

Our research priorities 

Our research spans three interconnected priorities: Development, Modifiers, and Disease. Together, these define the Centre’s research remit and guide the projects, fellowships and studentships we support.