Current PhD Projects on Offer for 2021/2022
Understanding mechanisms underlying the impact of metformin on placental, fetal and maternal health
Supervisors: Prof Susan Ozanne & Dr Catherine Aiken
Investigating the role for epigenetic modifier MLL2 in placental development
Supervisors: Dr Courtney Hanna & Dr Miguel Constancia
Maternal Obesity: Translatable Programmed Cardiovascular Dysfunction in Offspring
Supervisors: Prof Dino Giussani & Prof Susan Ozanne
Defining the contribution of parental obesity to feto-placental dynamics and offspring health
Supervisors: Dr Amanda Sferruzzi-Perri & Dr Gavin Kelsey
Previous Projects Offered
Placental hormones and pregnancy health in obese mothers.
Supervisor: Dr Amanda Sferruzzi-Perri
Epigenetic regulation of cell fate decisions in mammalian development. Supervisor: Professor Wolf Reik
Metabo-Devo of the placenta: Understanding the metabolic determinants of early placental development. Supervisors: Dr Irving Aye, Professor Stephen Charnock-Jones
Trophoblast cell migration into maternal tissues. Supervisor: Thorsten Boroviak
Multivariate statistical modelling to characterise phenotypes of human placental dysfunction. Supervisor: Professor Gordon Smith
Making sense of complexity: how do tissue lymphocytes work in the uterus? Supervisor: Francesco Colucci
Tissue innate immunity in the womb and reproduction Supervisor: Francesco Colucci. Co-supervisors: Francesca Gaccioli and Irving Aye
How to build a primate: towards a synthetic model for primate embryogenesis Supervisor: Dr Thorsten Boroviak
Developmental origins of heart disease Supervisor: Professor Dino A. Giussani, Department of Physiology Development and Neuroscience
Embryonic and extraembryonic partnership: requisite for successful pregnancy
Supervisor: Professor Magdalena Zernicka-Goetz
An Evolutionary Approach to Understanding Transcriptional Control in the Human Placenta
Supervisor: Professor Steve Charnock-Jones.
Co-supervised by Dr Paul Flicek, European Bioinformatics Institute (EBI, Hinxton)
Single cell sequencing of the placenta
Supervisor: Professor Steve Charnock-Jones
Understanding the nature and role of placental endocrine function in materno-fetal resource allocation during pregnancy
Supervisor: Dr Amanda Sferruzzi-Perri
Genetic and molecular mechanisms of placental angiogenesis
Supervisor: Dr Miguel Constância
Improving placental energy metabolism and obstetric outcome in pathological pregnancies – lessons from high-altitude populations
Supervisor: Dr Andrew Murray
Deciphering the role of the imprinted gene Rtl1/Peg11 in the placenta
Supervisor: Professor Anne Ferguson-Smith & Dr Mitsuteru Ito
Placento-fetal hypoxia and preeclampsia
Supervisor: Professor Dino Giussani
Manipulating epigenetic reprogramming in vivo and its role in extraembryonic tissue function
Supervisor: Professor Wolf Reik
Developmental Regulation of the Placental Prolactin-Growth Hormone Gene Families in the Placenta
Supervisors: Amanda Sferruzzi-Perri