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Centre for Trophoblast Research


 Current PhD projects.

Listed below are the current PhD projects available:








Placental hormones and pregnancy health in obese mothers.
Supervisor: Dr Amanda Sferruzzi-Perri

Epigenetic regulation of cell fate decisions in mammalian development. Supervisor: Professor Wolf Reik

Metabo-Devo of the placenta: Understanding the metabolic determinants of early placental development. Supervisors: Dr Irving Aye, Professor Stephen Charnock-Jones

Functional role of non-CpG methylation in human placenta. Supervisors: Russell Hamilton and Miguel Constancia

Trophoblast cell migration into maternal tissues. Supervisor: Thorsten Boroviak

Analysis of epigenetic and genomic stability in model of abnormal folate metabolism. Co-Supervisors: Dr Erica Watson and Dr Russell Hamilton. Department of Physiology, Development and Neuroscience

Multivariate statistical modelling to characterise phenotypes of human placental dysfunction. Supervisor: Professor Gordon Smith

The effects of abnormal folate metabolism on placenta form and function Supervisors: Dr Erica Watson and Dr Margherita Turco, Dept of Physiology, Development and Neuroscience

Making sense of complexity: how do tissue lymphocytes work in the uterus? Supervisor: Francesco Colucci

Early development of the human placenta; potential role of the endometrial gland secretions Supervisor: Professor Graham Burton

Uncovering epigenetic regulation in the human placenta Supervisor: Dr Russell Hamilton

Stem cell biology of the fetal-maternal interface Supervisor: Dr. Margherita Yayoi Turco

Tissue innate immunity in the womb and reproduction Supervisor: Francesco Colucci. Co-supervisors: Francesca Gaccioli and Irving Aye

How to build a primate: towards a synthetic model for primate embryogenesis Supervisor: Dr Thorsten Boroviak

Maternal signalling to oocytes and programming of offspring development and physiology  Supervisors: Dr Nick Burton (CTR Research Fellow) and Dr. Eric Miska (Department of Genetics) 

Developmental origins of heart disease Supervisor: Professor Dino A. Giussani, Department of Physiology Development and Neuroscience

Embryonic and extraembryonic partnership: requisite for successful pregnancy
Supervisor: Professor Magdalena Zernicka-Goetz 

An Evolutionary Approach to Understanding Transcriptional Control in the Human Placenta
Supervisor: Professor Steve Charnock-Jones.
Co-supervised by Dr Paul Flicek, European Bioinformatics Institute (EBI, Hinxton)

Single cell sequencing of the placenta
Supervisor: Professor Steve Charnock-Jones

Understanding the nature and role of placental endocrine function in materno-fetal resource allocation during pregnancy
Supervisor: Dr Amanda Sferruzzi-Perri

Genetic and molecular mechanisms of placental angiogenesis 
Supervisor: Dr Miguel Constância

Improving placental energy metabolism and obstetric outcome in pathological pregnancies – lessons from high-altitude populations
Supervisor: Dr Andrew Murray

Deciphering the role of the imprinted gene Rtl1/Peg11 in the placenta
Supervisor: Professor Anne Ferguson-Smith & Dr Mitsuteru Ito

Placento-fetal hypoxia and preeclampsia
Supervisor: Professor Dino Giussani

Manipulating epigenetic reprogramming in vivo and its role in extraembryonic tissue function
Supervisor:   Professor Wolf Reik

Developmental Regulation of the Placental Prolactin-Growth Hormone Gene Families in the Placenta
Supervisors:   Amanda Sferruzzi-Perri