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Centre for Trophoblast Research

 

Current PhD Projects on Offer for 2021/2022

 

Understanding mechanisms underlying the impact of metformin on placental, fetal and maternal health

Supervisors: Prof Susan Ozanne & Dr Catherine Aiken

 

Investigating the role for epigenetic modifier MLL2 in placental development

Supervisors: Dr Courtney Hanna & Dr Miguel Constancia

 

Maternal Obesity: Translatable Programmed Cardiovascular Dysfunction in Offspring

Supervisors: Prof Dino Giussani & Prof Susan Ozanne

 

Previous Projects Offered

Placental hormones and pregnancy health in obese mothers.
Supervisor: Dr Amanda Sferruzzi-Perri

Epigenetic regulation of cell fate decisions in mammalian development. Supervisor: Professor Wolf Reik

Metabo-Devo of the placenta: Understanding the metabolic determinants of early placental development. Supervisors: Dr Irving Aye, Professor Stephen Charnock-Jones

Trophoblast cell migration into maternal tissues. Supervisor: Thorsten Boroviak

Multivariate statistical modelling to characterise phenotypes of human placental dysfunction. Supervisor: Professor Gordon Smith

Making sense of complexity: how do tissue lymphocytes work in the uterus? Supervisor: Francesco Colucci

Tissue innate immunity in the womb and reproduction Supervisor: Francesco Colucci. Co-supervisors: Francesca Gaccioli and Irving Aye

How to build a primate: towards a synthetic model for primate embryogenesis Supervisor: Dr Thorsten Boroviak

Developmental origins of heart disease Supervisor: Professor Dino A. Giussani, Department of Physiology Development and Neuroscience

Embryonic and extraembryonic partnership: requisite for successful pregnancy
Supervisor: Professor Magdalena Zernicka-Goetz 

An Evolutionary Approach to Understanding Transcriptional Control in the Human Placenta
Supervisor: Professor Steve Charnock-Jones.
Co-supervised by Dr Paul Flicek, European Bioinformatics Institute (EBI, Hinxton)

Single cell sequencing of the placenta
Supervisor: Professor Steve Charnock-Jones

Understanding the nature and role of placental endocrine function in materno-fetal resource allocation during pregnancy
Supervisor: Dr Amanda Sferruzzi-Perri

Genetic and molecular mechanisms of placental angiogenesis 
Supervisor: Dr Miguel Constância

Improving placental energy metabolism and obstetric outcome in pathological pregnancies – lessons from high-altitude populations
Supervisor: Dr Andrew Murray

Deciphering the role of the imprinted gene Rtl1/Peg11 in the placenta
Supervisor: Professor Anne Ferguson-Smith & Dr Mitsuteru Ito

Placento-fetal hypoxia and preeclampsia
Supervisor: Professor Dino Giussani

Manipulating epigenetic reprogramming in vivo and its role in extraembryonic tissue function
Supervisor:   Professor Wolf Reik

Developmental Regulation of the Placental Prolactin-Growth Hormone Gene Families in the Placenta
Supervisors:   Amanda Sferruzzi-Perri