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Centre for Trophoblast Research



  1. Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA. (2016) Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. FASEB J. May:30(5):1968-75.
  2. Allison BJ, Brain KL, Niu Y, Kane AD, Herrera EA, Thakor AS, Botting KJ, Cross CM, Itani N, Skeffington KL, Beck C, Giussani DA. (2016) Fetal in vivo continuous cardiovascular function during chronic hypoxia. J Physiol. Mar 1;594(5):1247-64.
  3. Angermueller, C., Clark, S. J., Lee, H. J., Macaulay, I., Hu, T., Krueger, F., Smallwood, S. A., Ponting, C., Voet, T., Kelsey, G., Stegle, O. and Reik, W. (2016) Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity. Nat. Methods 13, 229-232.
  4. Blake G.E.T. and Watson E.D. (2016) Unravelling the complex mechanisms of transgenerational epigenetic inheritance.  Current Opin Chem Biol 33: 101-107.
  5. De Blasio, M.J., Boije, M., Kempster, S.L., Smith, G.C., Charnock-Jones, D.S., Denyer, A., Hughes, A., Wooding, F.B., Blache, D., Fowden, A.L. and Forhead, A.J. (2016) Leptin matures aspects of lung structure and function in the ovine fetus. Endocrinology, 157, 395-404.
  6.  Bolton H, Graham SJ, Van der Aa N, Kumar P, Theunis K, Fernandez Gallardo E, Voet T, Zernicka-Goetz M. (2016) Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential. Nat Commun. 2016 Mar 29;7:
  7. Boulenouar, S., Doisne, J-M., Sferruzzi-Perri, A., Gaynor, L.M., Kieckbusch, J., Balmas, E., Yung, H.W., Javadzadeh, S., Volmer, L., Hawkes, D.A., Phillips, K., Brady, H.J.M., Fowden, A.L., Burton, G.J., Moffett, A. and Colucci, F. (2016) The residual innate lymphoid cells in NFIL3-deficient mice support suboptimal maternal adaptations to pregnancy. Frontiers in Immunology, 7, 43.
  8. Branco M.R., King M., Perez-Garcia V., Bogutz A.B., Caley M., Fineberg E., Lefebvre L., Cook S.J., Dean W., Hemberger M.* and Reik W.* (2016). Maternal DNA methylation regulates early trophoblast  development.  Dev Cell. 2016 Jan 25;36(2):152-63.  *Co-senior authors.
  9. Burton, G.J., Yung, H.W. and Murray, A.J. (2016) Mitochondrial – endoplasmic reticulum interactions in the trophoblast; stress and senescence. Placenta, pii: S0143-4004(16)30052-2
  10. Burton, G.J., Fowden, A.L. & Thornburg, K. (2016). Placental origins of chronic disease. Physiol. Rev. 94 1509-1565.
  11. Butcher L, Ito M, Bimpari M, Morris T, Soares FAC, Carey N, Vallier* L, Ferguson-Smith AC*, Beck S*. (2016) Non-CG DNA methylation is a biomarker for pluripotent stem cell differentiation capacity Nature Communications 7:10458. *(joint senior authors)
  12. Chong HP, Cordeaux Y, Sri Ranjan Y, Richardson S, Liquet B, Smith GCS*, Charnock-Jones DS* [*Joint last author] (2016) Age-related changes in murine myometrial transcript profile are mediated by exposure to the female sex hormones. Aging Cell;15:177-80.  Epub 21 Oct 2015.
  13. Cleaton MA, Corish J, Howard M, Gutteridge I, Sovio U, Gaccioli F, Takahashi N, Bauer S, Charnock-Jones DS, Powell T, Smith GCS, Ferguson-Smith AC, Charalambous M. (2016) Fetus-derived Delta-like  homologue-1 (DLK1) is required for maternal metabolic adaptations to pregnancy and predicts birthweight and fetal growth restriction.  Nature Genetics 48(12):1473-1480.
  14. Collinson A., Collier A.J., Morgan N.P., Sienerth A.R., Chandra T., Andrews S. and Rugg-Gunn P.J. (2016). Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells. Cell Reports 17:2700-2714
  15. Dalgaard, K., Landgraf, K., Heyne, S., Lempradl, A., Longinotto, J., Gossens, K., . . .Pospisilik, J. A. (2016). Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell, 164(3), 353-364.
  16. Deglincerti A, Croft GF, Pietila LN, Zernicka-Goetz M, Siggia ED, Brivanlou AH. (2016) Self-organization of the in vitro attached human embryo. Nature. 2016 May 4;533(7602):251-4.
  17. Eckersley-Maslin MA, Svensson V, Krueger C, Stubbs TM, Giehr P, Krueger F, Miragaia RJ, Kyriakopoulos C, Berrens RV, Milagre I, Walter J, Teichmann SA, Reik W.   MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.  Cell Rep. 2016 Sep 27;17(1):179-92.
  18. Elliot, M.G. (2016) Oxidative stress and the evolutionary origins of preeclampsia. Journal of Reproductive Immunology 114: 75-80
  19. Flenady, V., Wojcieszek, A. M., Middleton, P., Ellwood, D., Erwich, J. J., Coory, M., . . . Lancet . (2016). Stillbirths: recall to action in high-income countries..Lancet, 387(10019), 691-702.
  20. Fowden, A.L., Valenzuela, O.A., Vaughan, O.R., Jellyman, J.K. and Forhead, A.J. (2016) Glucocorticoid programming of intrauterine development. Domestic Animal Endocrinology, 56 Suppl, S121-32.
  21. Gaccioli F, Lager S. Placental Nutrient Transport and Intrauterine Growth Restriction.  Front Physiol. 2016 Feb 16;7:40.
  22. Gaccioli,F.  Lager, S. Sovio U.,  Charnock-Jones, D.S.  Smith, GCS.  The pregnancy outcome prediction (POP) study: Investigating the relationship between serial prenatal ultrasonography, biomarkers, placental phenotype and adverse pregnancy outcomes.   Placenta, in press
  23.  Gilbert-Kawai, E., Coppel, J., Bountziouka, V., Ince, C., Martin, D., & Caudwell Xtreme Everest and Xtreme Everest 2 Research Groups. (2016). A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes.. BMC Med Imaging, 16,
  24. Giussani DA, Bennet L, Sferruzzi-Perri AN, Vaughan OR, Fowden AL (2016) Hypoxia, Fetal & Neonatal Physiology: 100 years on from Sir Joseph Barcroft. Journal of Physiology 594(5):1105-11.
  25. Giussani DA. (2016) The fetal brain sparing response to hypoxia: physiological mechanisms. J Physiol. Mar 1;594(5):1215-30.
  26. Goolam M, Scialdone A, Graham SJ, Macaulay IC, Jedrusik A, Hupalowska A, Voet T, Marioni JC, Zernicka-Goetz M. (2016) Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos. Cell. Mar 24;165(1):61-74.
  27. Graham, S. J., & Zernicka-Goetz, M. (2016).The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous? Curr Top Dev Biol, 117, 671-695.
  28. Hanna, C. W., Peñaherrera, M. S., Saadeh, H., Andrews, S., McFadden, D. E., Kelsey, G. and Robinson, W. P. (2016) Pervasive polymorphic imprinted methylation in the human placenta. Genome Research 26, 756-767.
  29. Hawkes RA, Patterson AJ, Priest AN, Harrison G, Hunter S, Pinney J, Set P, Hilliard N, Graves MJ, Smith GCS, Lomas DJ. Uterine artery pulsatility and resistivity indices in pregnancy: comparison of MRI and Doppler US. Placenta 2016;43:35-40.
  30. Herrera EA, Rojas RT, Krause BJ, Ebensperger G, Reyes RV, Giussani DA, Parer JT, Llanos AJ. (2016) Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano. J Physiol. 2016 Mar 1;594(5):1231-45.
  31. Higgins JS, Vaughan OR, Fernandez De Liger E, Fowden AL, Sferruzzi-Perri AN (2016) Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy. Journal of Physiology, 594:1341-56.
  32. Holtzmann K, Gautier HOB, Christ AF, Guck J, Karadottir RT, Franze K. Brain tissue stiffness is a sensitive marker for acidosis. Journal of Neuroscience Methods 271:50-54 (2016)
  33. Hore TA, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, Santos F, Balasubramanian S, Jurkowski TP, Reik W.  Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.  Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12202-12207.
  34. Jauniaux, E. and Burton, G.J. (2016) The role of oxidative stress in placental-related diseases of pregnancy. Journal de Gynécologie Obstétrique et Biologie de la Reproduction (Paris), 45, 775-785.
  35. Jauniaux, E., Collins, S.L., Jurkovic, D. and Burton, G.J. (2016) Accreta Placentation: A systematic review of Prenatal Ultrasound Imaging and Grading of Villous Invasiveness. American Journal of Obstetrics and Gynecology, 215, 712-721.
  36. Jones, D. C., Hewitt, C. R., López-Álvarez, M. R., Jahnke, M., Russell, A. I., Radjabova, V., . . . Trowsdale, J. (2016). Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8-associated ligand on necrotic glandular epithelial cells..Oncotarget, 7(13), 15618-15631.
  37. Juan, A.H., Wang, S., Ko, K.D., Zare, H., Tsai, P.-F., Feng, X., Vivanco, K.O., Ascoli, A.M., Gutierrez-Cruz, G., Krebs, J. Sidoli S., Knight A.L., Pedersen R.A., Garcia B.A., Casellas R., Zou J. and Sartorelli V. (2016). Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells. Cell Rep. 17, 1369–1382.
  38. Kennedy PR, Chazara O, Gardner L, Ivarsson MA, Farrell LE, Xiong S, Hiby SE, Colucci F, Sharkey AM, Moffett A.   Activating KIR2DS4 Is Expressed by Uterine NK Cells andContributes to Successful Pregnancy.  J Immunol. 2016 Dec 1;197(11):4292-4300.
  39. Knight HW, van der Meulen JH,Gurol-Urganci I, Smith GCS, Kiran A, Thornton S, Richmond D, Cameron A, Cromwell DA. Birth 'out-of-hours': an evaluation of obstetric practice and outcome according to the presence of senior obstetricians on the labour ward. PLoS Medicine 2016;13:e1002000.
  40. Koser DE, Thompson AJ, Foster SK, Dwivedy A, Pillai EK, Sheridan GK, Svoboda H, Viana M, Costa LdF, Guck J, Holt CE, Franze K. Mechanosensing is critical for axon growth in the developing brain. Nature Neuroscience 19(12):1592-1598 (2016)
  41. Koucký M, Malíčková K, Cindrová-Davies T, Smíšek J, Vráblíková H, Černý A, Šimják P, Slováčková M, Pařízek A, Zima T (2016). Prolonged progesterone administration is associated with less frequent cervicovaginal colonization by Ureaplasma urealyticum during pregnancy - Results of a pilot study. J Reprod Immunol. 2016; 116:35-41
  42. Kurlak, L.O., Mistry, H.D., Cindrova-Davies, T., Burton, G.J. and Broughton-Pipkin, F. (2016) Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. The Journal of Physiology, 594.5, 1327-1340.
  43. Lakisic G, Lebreton A, Wendling O, Libertini E, Radford EJ, Paliwal A, Le Guillou M, Champy MF, Wattenhoffer-Donze M, Soubigou G, Ait-Si-Ali S, Feunteun J, Sorg T, Coppee JY, Ferguson-Smith AC, Cossart P, Bierne H.  (2016) Role of the BAHD1 chromatin-repressive complex in placental development and regulation of steroid metabolism.  PLoS Genetics 12(3):e1005898.
  44.  Lee, C. Q., Gardner, L., Turco, M., Zhao, N., Murray, M. J., Coleman, N., . . . Moffett, A. (2016). What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast..Stem Cell Reports, 6(2), 257-272.
  45. Iurlaro M, McInroy GR, Burgess HE, Dean W, Raiber EA, Bachman M, Beraldi D, Balasubramanian S, Reik W.  In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine.  Genome Biol. 2016 Jun 29;17(1):141.
  46. Mascetti, V. L., & Pedersen, R. A. (2016).Human-Mouse Chimerism Validates Human Stem Cell Pluripotency. Cell Stem Cell, 18(1), 67-72.
  47. Mascetti VL and Pedersen RA (2016b) Contributions of mammalian chimeras to pluripotent stem cell research. Cell Stem Cell 19: 163-175.
  48. Matheson, H., Veerbeek, J.H.W., Charnock-Jones, D.S., Burton, G.J. and Yung, H.W. (2016) Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy. The Journal of Physiology, 594.5, 1371-1388.
  49. McCarthy FP, Adetoba A, Gill C, Bramham K, Bertolaccini M, Burton GJ, Girardi G, Seed PT, Poston L, Chappell LC  Urinary congophilia in women with hypertensive disorders of pregnancy and pre-existing Proteinuria or hypertension. Am J Obstet Gynecol. 2016 Apr 29. pii: S0002-9378(16)30139-9.
  50. Miska EA, Ferguson-Smith AC. (2016) Transgenerational inheritance: Models and mechanisms of non-DNA sequence-based inheritance. Science 353:59-63.
  51.  Mizuuchi, M., Cindrova-Davies, T., Olovsson, M., Charnock-Jones, D. S., Burton, G. J., & Yung, H. W. (2016).Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β: implications for the pathophysiology of human pregnancy complications..J Pathol, 238(4), 550-561.
  52. Moffett A, Hartley JD, Ferguson BJ.   Reply: Am J Obstet Gynecol. 2016 Apr;214(4):548-9.  No abstract available. 
  53. Moffett A, Shreeve N.  Reply: First do no harm: continuing the uterine NK cell debate.  Hum Reprod. 2016 Jan;31(1):218-9.
  54. Moffett A, Chazara O, Colucci F, Johnson MH.  Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention.  Reprod Biomed Online. 2016 Dec;33(6):763-769.
  55. Moreau T, Evans A, Vasquez L, Tijssen MR, Yan Y, Trotter MW, Howard D, Colzani M, Arumugam M, Wu WH, Dalby A, Lampela R, Bouet G, Hobbs CM, Pask DC, Payne H, Ponomaryov T, Brill A, Soranzo N, Ouwehand WH, Pedersen RA, and Ghevaert G. (2016) Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Nature Communications, 7:11208.
  56. Murakami, K., Günesdogan, U., Zylicz, J. J., Tang, W. W., Sengupta, R., Kobayashi, T., . . . Surani, M. A. (2016). NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers. Nature, 529(7586), 403-407. doi:10.1038/nature16480
  57. Murray A., Sienerth A. and Hemberger M. (2016). Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation. Sci Rep. 2016 Apr 28;6:25112.
  58. Musial B, Fernandez-Twinn, Vaughan OR, Ozanne SE, Voshol P, Sferruzzi-Perri AN, Fowden AL (2016) Proximity to delivery alters insulin sensitivity and glucose metabolism in pregnant mice. Diabetes. 65: 851-60:
  59. Novo CL , Tang C, Ahmed K, Djuric U, Fussner E, Mullin NP, Morgan NP, Hayre J, Sienerth AR, Elderkin S, Nishinakamura R, Chambers I, Ellis J, Bazett-Jones DP, Rugg-Gunn PJ.  The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.  Genes Dev. 2016 May 1;30(9):1101-15.
  60. Panamarova M, Cox A, Wicher KB, Butler R, Bulgakova N, Jeon S, Rosen B, Seong RH, Skarnes W, Crabtree G, Zernicka-Goetz M. (2016) The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. Development. 2016 Apr 15;143(8):1271-83.
  61.  Papanikos, F., Daniel, K., Goercharn-Ramlal, A., Fei, J. F., Kurth, T., Wojtasz, L., . . . Toth, A. (2016). The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice.. Chromosoma.
  62. Partap U, Sovio U, Smith GCS. Fetal growth and the risk of spontaneous preterm birth in a prospective cohort study of nulliparous women. Am J Epidemiol 2016;184(2):110-119.
  63.  Pearson, J. R., Zurita, F., Tomás-Gallardo, L., Díaz-Torres, A., Díaz de la Loza, M. D. E. L. C., Franze, K., . . . González-Reyes, A. (2016). ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary.. PLoS Genet, 12(1),
  64. Penman BS, Moffett A, Chazara O, Gupta S, Parham P.   Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution.   Immunogenetics. 2016 Nov;68(10):755-764.
  65. Plitman Mayo, R., Charnock-Jones, D.S., Burton, G.J. and Oyen, M.L. (2016) Three-dimensional modelling of human placental villi. Placenta, 43, 54-60.
  66. Plitman R, Olsthoorn J,  Charnock-Jones D.S,  Burton G.J.,  Oyen M.L.,   Computational modeling of the structure-function relationship in human placental terminal villi.  Journal of Biomechnics.  Volume 49, Issue 16, Pages 3780–3787
  67.  Rhodes, D. A., Reith, W., & Trowsdale, J. (2016). Regulation of Immunity by Butyrophilins.. Annu Rev Immunol, 34, 151-172.
  68. Salvatari N, Sovio U, Plitman Mayo R, Charnock-Jones DS, Smith GCS. The relationship between human placental morphometry and ultrasonic measurements of utero-placental blood flow and fetal growth. Placenta 2016;38:41-8. 
  69. Sandovici, I., Hammerle, C.M., Cooper, W.N., Smith, N.H., Tarry-Adkins, J.L., Dunmore, B.J., Bauer, J., Andrews, S.R., Yeo, G.S., Ozanne, S.E., Constância, M. (2016) Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets. Diabetologia, 59, 502-511.
  70. Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, Henriques da Costa AS, Gaude E, Vercauteren Drubbel A, Theobald SJ, Abbo S, Tran M, Rajeeve V, Cardaci S, Foster S, Yun H, Cutillas P, Warren A, Gnanapragasam V, Gottlieb E, Franze K, Huntly B, Maher ER, Maxwell PH, Saez-Rodriguez J, Frezza C. The oncometabolite fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature 537(7621):544-547 (2016)
  71. Sferruzzi-Perri AN, Camm EJ. (2016) The programming power of the placenta. Frontiers in Physiology 7:33.
  72. Sferruzzi-Perri AN, López-Tello J, Fowden AL, Constancia M. Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation.  Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11255-11260.
  73. Shahbazi, M. N., Jedrusik, A., Vuoristo, S., Recher, G., Hupalowska, A., Bolton, V., . . . Zernicka-Goetz, M. (2016). Self-organization of the human embryo in the absence of maternal tissues. Nat Cell Biol. Doi :10.1038/ncb3347
  74. Shahbazi MN Jedrusik A, Vuoristo S, Recher G, Hupalowska A, Bolton V, Fogarty N, CampbelA, Gasparini LD, Ilic D, Khalaf Y Niakan KK, Fishel S and Zernicka-Goetz M. (2016).  Human embryo implantation morphogenesis and self-organization in the absence of maternal tissues. Nature Cell Biology18(6):700-8.
  75. Skeffington, K.L., Higgins, J., Mahmoud, A., Evans, A.M., Sferruzzi-Perri, A.N., Fowden, A.L., Yung, H.W., Burton, G.J., Giussani, D.A. and Moore, L.G. (2016) Hypoxia, AMPK activation and uterine artery vasoreactivity. The Journal of Physiology, 594.5, 1357-1369.
  76. Smith, G. C. (2016). Quantifying the Risk of Different Types of Perinatal Death in Relation to Gestational Age: Researchers at Risk of Causing Confusion. Paediatr Perinat Epidemiol, 30(1), 18-19.
  77. Sovio U, Murphy HR, Smith GCS. Accelerated fetal growth prior to diagnosis of gestational diabetes mellitus: a prospective cohort study of nulliparous women. Diabetes Care ePub ahead of print, April 7, 2016:
  78. Surani A.  Breaking the germ line–soma barrier. Nature Reviews Molecular Cell Biology17, 136 (2016)
  79. Valenzuela, O.A., Jellyman, J.K., Allen, V.L., Holdstock, N.B. & Fowden, A.L. (2016). Effects of maternal dexamethasone treatment on pancreatic β cell function in the pregnant mare and postnatal foal. Equine Vet. J.
  80.  Vaughan, O.R., Davies, K.L., Ward, J.W., de Blasio, M.J. & Fowden, A.L. (2016). A physiological increase in maternal cortisol alters uteroplacental metabolism in pregnant ewes. J. Physiol 594 6407-6418.
  81.  Vaughan, O.R. & Fowden, A.L. (2016). Placental metabolism: substrate requirements and the response to stress. Reprod. Dom. Anim. 51 (Suppl 2) 25-35.
  82. von Meyenn F, Berrens RV, Andrews S, Santos F, Collier AJ, Krueger F, Osorno R, Dean W, Rugg-Gunn PJ, Reik W.  Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.  Dev Cell. 2016 Oct 10;39(1):104-115.
  83. von Meyenn F, Iurlaro M, Habibi E, Liu NQ, Salehzadeh-Yazdi A, Santos F, Petrini E, Milagre I, Yu M,  Xie Z, Kroeze LI, Nesterova TB, Jansen JH, Xie H, He C  ,Reik W, Stunnenberg HG.  Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.  Mol Cell. 2016 Jun 16;62(6):848-61.
  84. Walker KF, Bugg GJ, Macpherson M, McCormick C, Grace N, Wildsmith C, Bradshaw L, Smith GCS, Thornton JG. A randomized trial of labor induction in women 35 years of age or over. New England Journal of Medicine 2016;374:813-822.
  85. Watson ED.   Transferring Fragments of Paternal Metabolism to the Offspring.Cell Metab. 2016 Mar 8;23(3):401-2.
  86. Watson, E.D. and Rakoczy J. (2016) Fat eggs shape offspring health. Nat Genet 48(5): 478-9.
  87. Yung, H.W., Alnæs-Katjavivi, P., Jones, C.J.P., El-Bacha, T., Golic, M., Staff, A.C. and Burton, G.J. (2016) Placental endoplasmic reticulum stress in gestational diabetes:  the potential for therapeutic intervention with chemical chaperones and antioxidants. Diabetologia, 59, 2240-2250. Accompanied by Invited Commentary.

Book chapters

  1. Burton, G.J., Sibley, C.P. and Jauniaux, E. (2016) Placental anatomy and physiology. In: Obstetrics: Normal and Problem Pregnancies, 7th Edition (eds S.G. Gabbe, J.R. Niebyl, J.L. Simpson, M.B. Landon, H.L. Galan, E.R.M. Jauniaux and D.A. Driscoll), 2-25. Elsevier, Amsterdam.
  2. Jauniaux, E. and Burton, G.J. (2015) Implantation and placentation. In: Gray’s Anatomy, 41st Ed. (ed. S Standring), 171-180. Elsevier, Amsterdam.
  3. Jauniaux, E., Bidhe, A. and Burton, G.J. (2016) The placenta. In: The Oxford Textbook of Obstetrics and Gynaecology (eds. S. Arulkurmaran, L. Denny, S. Doumouchtsis, and W. Ledger). Oxford University Press, Oxford.
  4. Yung, H.W. and Burton, G.J. (2016) Placental endoplasmic reticulum stress in the determination of pregnancy outcome: from homeostasis to pathophysiology. In: Endoplasmic Reticulum Stress: Regulation, Function and Role in Health and Disease. Nova Science Publishers.


  1. Arand J, Wossidlo M, Lepikhov K, Peat JR, Reik W, Walter J. (2015) Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo. Epigenetics Chromatin 8(1):1 2015. Doi: 10.1186/1756-8935-8-1.
  2. Bedzhov I, Zernicka-Goetz M. (2015) Cell death and morphogenesis during early mouse development: are they interconnected? Bioessays 37(4):372-378 Apr 2015. doi: 10.1002/bies.201400147.
  3. Bedzhov I, Bialecka M, Zielinska A, Kosalka J, Antonica F, Thompson AJ, Franze K, Zernicka-Goetz M. (2015) Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo.Cell Res. 2015 Sep 4. doi: 10.1038/cr.2015.104. [Epub ahead of print]
  4. Berrens RV, Reik W. (2015) Prmt5: a guardian of the germline protects future generations. EMBO J 16 Feb 2015. Doi: 10.15252/embj.201591054.
  5. Burton G.J. and Jauniaux E. (2015) What is the placenta? American Journal of Obstetrics and Gynecology, 213(4 Suppl):S6.e1-4.
  6. Burton GJ, Moffett A, Keverne B. (2015) Human evolution: brain, birthweight and the immune system. Philosophical Transactions B of the Royal Society of London. doi: 10.1098/rstb.2014.0061.
  7. Burton GJ, Fowden AL.  (2015) The placenta: a multifaceted, transient organ. Philosophical Transactions B of the Royal Society of London. doi:10.1098/rstb.2014.0066.
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  32. Teoh PJ, Menzies FM, Hansell CA, Clarke M, Waddell C, Burton GJ, Nelson SM, Nibbs RJ. (2014) Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice. J Immunol 193(10):5218-5228. doi: 10.4049/jimmunol.1401096.
  33. Yung HW, Colleoni F, Atkinson D, Cook E, Murray AJ, Burton GJ, Charnock-Jones DS. (2014) Influence of speed of sample processing on placental energetics and signalling pathways: implications for tissue collection. Placenta 35,103-108.
  35. Yung HW, Atkinson D, Campion-Smith T, Olovsson M, Charnock-Jones DS and Burton GJ. (2014) Differential activation of placental Unfolded Protein Response pathways implies heterogeneity of causation of early- and late-onset pre-eclampsia. Journal of Pathology, in press.


  1. Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, Del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, Heckerman D, Stein JL, Soderberg KA, Moody MA, Denny TN, Zeng X, Fang J, Moffett A, Lifson JD, Goedert JJ, Buchbinder S, Kirk GD, Fellay J, McLaren P, Deeks SG, Pereyra F, Walker B, Michael NL, Weintrob A, Wolinsky S, Liao W, Carrington M. (2013) Influence of HLA-C expression level on HIV control. Science.  Apr 5;340(6128):87-91. doi: 10.1126 PMID: 23559252.
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  4. Burke KA, Jauniaux E, Burton GJ, Cindrova-Davies T. (2013) Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation. Placenta, 34, 1105-1109.
  5. Cindrova-Davies T, Herrera E.A, Niu Y, Kingdom J, Giussani DA, Burton GJ. (2013) Reduced cystathionine g-lyase and increased miR-21 are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator. Am J Pathol, 182, 1448-1458.
  6. Colleoni F, Padmanabhan N, Yung H-W, Watson ED, Cetin I, Tissot van Patot MC, Burton GJ, Murray AJ. (2013) Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miR-210 and protein synthesis inhibition. PLoS One, 8, e55194.
  7. Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S, Levasseur DN, Li Z, Xu M, Reik W, Silva JC, Wang J. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013 Mar 21;495(7441):370-4. doi: 10.1038/nature11925. Epub 2013 Feb 10.
  8. Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D, Paul YL, Walter J, Cook SJ, Andrews S, Branco MR, Reik W. FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency. Cell Stem Cell. 2013 Jul 10. doi:pii: S1934-5909(13)00262-2. 10.1016/j.stem.2013.06.004. [Epub ahead of print]
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  10. Fogarty NM, Ferguson-Smith AC, Burton GJ. Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage. Am J Pathol. 2013 Jul;183(1):144-52.
  11. Hemberger M. and Dean W. (2013). First cell fate decisions in early development – towards establishment of the trophoblast lineage. In The Guide of Investigations of Mouse Pregnancy, Elsevier Press 2013. 
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  15. Lu L, Burton GJ, Cindrova-Davies T. (2013) P26 Placental stem villus arteries undergo dedifferentiation via reduced hydrogen sulfide production by cystathionine-γ-lyase upon exposure to oxidative stress. United States. Nitric Oxide. 31 Suppl 2: S46. 01 Sep 2013. Doi: 10.1016/j.niox.2013.06.088.
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  17. Mohun TJ, Adams DJ, Baldock R, Bhattacharya S, Copp AJ, Hemberger M, Houart C, Hurles ME, Robertson E, Smith JC, Weaver T, Weninger W. (2013). Deciphering the Mechanisms of Developmental Disorders (DMDD): A new programme for phenotyping embryonic lethal mice. Disease Models & Mechanisms, 6: 562-566.
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  19. Naicker T, Dorsamy E, Ramsuran D, Burton GJ, Moodley J. (2013) The role of apoptosis on trophoblast cell invasion in the placental bed of normotensive and hypertensive pregnancies. Hypertension in Pregnancy, 32, 245-256.
  20. Nakimuli A, Chazara O, Byamugisha J, Elliott AM, Kaleebu P, Mirembe F, Moffett A. (2013) Pre-eclampsia, Pregnancy and Parturition in Women of African Ancestry.American Journal of Obstetrics and Gynecology doi: 10.1016/j.ajog. 2013.10.879
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  37. Van Uitert, E.M., Exalto, N., Burton, G.J., Willemsen, S.P., Koning, A.H.J., Eilers, P.H.C., Laven, J.S.E., Steegers, E.A.P. and Steegers-Theunissen, R.P.M. (2013) Human embryonic growth trajectories and associations with fetal growth and birthweight. Human Reproduction, 28, 1753-1761.
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  1. Benirschke, K., Burton, G.J. and Baergen, R. (2012) Pathology of the Human Placenta, 6th edition. Springer, Berlin, pp. 941.
  2. Michael J. Booth*, Miguel R. Branco*, Gabriella Ficz, David Oxley, Felix Krueger, Wolf Reik, and Shankar Balasubramanian. Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution, Science Published online 26 April 2012 [DOI:10.1126/science.1220671] *Equal authorship
  3. Burton, G.J. & Fowden, A.L. (2012). The placenta and developmental programming: balancing fetal nutrient demands and maternal resource allocation. Placenta 33 Suppl A Trophoblast Research S23-S27.
  4. Burton, G.J., Sibley, C.P. and Jauniaux, E. (2012) Placental anatomy and physiology. In; Obstetrics: Normal and Problem Pregnancies (eds S.G. Gabbe, J.R. Niebyl, J.L. Simpson, M.B. Landon, H.L. Galan, E.R.M. Jauniaux and D.A. Driscoll). 6th Edition. Elsevier, Amsterdam.
  5. Colleoni, F., Morash, A.J., Ashmore, T., Monk, M., Burton, G.J. and Murray, A.J. (2012) Cryopreservation of placental biopsies for mitochondrial respiratory analysis.Placenta, 33, 122-123.
  6. Constancia, M. & Fowden, A. (Eds). Maternal Fetal Resource AllocationPlacenta 33Suppl 2, published online November 2012.
  7. Giussani, D.A., Camm, E.J., Niu, Y., Richter, H.G., Blanco, C.E., Gottschalk, R., Blake, E.Z., Horder, K.A., Thakor, A.S., Hansell, J.A., Kane, A.D., Wooding, F.B.P., Cross C.M. & Herrera. E.A (2012).  Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress.  PLoS ONE. In Press.
  8. Gutierrez-Marcos, J.F., Constancia, M. and Burton, G.J. (2012) Maternal to offspring resource allocation in plants and mammals. Placenta, 33, Suppl 2: e3-e10.
  9. Griffiths A., ter Haar, G.R., Rivens, I.H., Giussani, D.A. & Lees, C.C. (2012).  High Intensity Focused Ultrasound in obstetrics and gynaecology: the birth of a new era of non-invasive surgery? European Journal of Ultrasound.  In  Press.
  10. Hemberger M. (2012). Health during pregnancy and beyond: Fetal trophoblast cells as chief co-ordinators of intrauterine growth and reproductive success. Annals of Medicine, 44: 325-337.
  11. Herrera, E.A., Camm, E.J., Cross, C.M., Mullender, J.L., Wooding, F.B.P. & Giussani, D.A. (2012). Morphological and functional alterations in the aorta of the chronically-hypoxic fetal rat.  Journal of Vascular Research 49(1), 50-8.
  12. *Herrera, E.A., *Kane, A. D., Hansell, J.A., Thakor, A.S., Allison, B.J., Niu, Y. & Giussani, D.A. (2012).  The role of xanthine oxidase in the control of ovine fetal cardiovascular function. *Authors contributed equally. J. Physiol.In Press.
  13. Jain, A., Olovsson, M., Burton, G.J. and Yung, H.W. (2012) Endothelin-1 induces endoplasmic reticulum stress by activating the PLC/IP3 pathway; implications for placental autocrine signaling in the pathophysiology of pre-eclampsia. Am J Pathol, 180, 2309-2320.
  14. John R.M. and Hemberger M. (2012). A Placenta for Life. Reprod. Biomed. Online, 25: 5-11. This is the introductory article to a special Symposium on Trophoblast Differentiation for which I was the lead guest co-editor on invitation by Prof. Martin Johnson.
  15. Kane, A. D., Herrera, E.A., J.A. Hansell & Giussani, D.A. (2012).  Statin treatment depresses the fetal defense to acute hypoxia via increasing nitric oxide bioavailability.J Physiol. 590(Pt 2), 323-34.
  16. Latos P.A.*, Helliwell C., Mosaku O., Dudzinska D.A., Stubbs B., Berdasco M., Esteller M., Hendrich B.*, “NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate”, Biology Open 2012: 1(4):341-52
    *corresponding author
  17. Latos P.A.*, Pauler F.M.*, Koerner M.V.*, Senergin B.H, Hudson Q.J., Stocsits R.R., Allhoff W., Stricker S.H., Klement R.M., Warczok K.E., Aumayr K., Pasierbek P., Barlow D.P., “Airn transcriptional overlap but not its lncRNA product induces imprinted Igf2r silencing”, Science 2012 Dec 14;338(6113):1469-72. *equal contribution.
  18. Male V, Gardner L, Moffett A  (2012) Isolation of cells from the feto-maternal interface. Curr Protoc Immunol Chapter 7:Unit 7 40 1.
  19. Reynolds N., Latos P.A., Hynes-Allen A., Loos R., Leaford D., O’Shaughnessy A., Mosaku O., Signolet J., Brennecke P., Kalkan T., Costello I., Humphreys P., Mansfield B., Nakagawa K., I. John Strouboulis I.J., Behrens A., Bertone P., Hendrich B., “NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment”, Cell Stem Cell 2012;10(5):583-94.
  20. Richter, H.G., Camm, E.J., Modi, B.N., Naeem, F., Cross, C.M., Cindrova-Davies, T., Spasic-Boskovic, O., Dunster, C., Mudway, I.A., Kelly, F.J., Burton, G.J., Poston, L. & Giussani, D.A. (2012). Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats. Journal of Physiology. In Press.
  21. Seisenberger S, Andrews S, Krueger F, Arand J, Walter J, Santos F, Popp C, Thienpont B, Dean W, Reik W. The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.  Mol Cell. 2012 Dec 28;48(6):849-62. doi: 10.1016/j.molcel.2012.11.001. Epub 2012 Dec 6.
  22. Senner C.E., Krueger F., Oxley D., Andrews S. and Hemberger M. (2012). DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary. Stem Cells, 30: 2732-2745.
  23. Senner C.E., Krueger F., Oxley D., Andrews S. and Hemberger M. (2012). DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary. Stem Cells, 30: 2732-2745.
  24. Vaughan, O.R., Sferruzzi-Perri A.N., Coan, P.M. & Fowden, A.L. (2012). Environmental regulation of placental phenotype: implications for fetal growth. Reprod. Fert. Develop. 24 80-96.
  25. Yung, H.W., Cox, M., Tissot van Patot, M. and Burton, G.J. (2012) Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude. FASEB J, 26, 1970-1981.
  26. Yung H.-W., Hemberger M., Watson E.D., Senner C.E., Jones C.P., Kaufman R.J., Charnock-Jones D.S. and Burton G.J. (2012). Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction. J. Pathology, doi: 10.1002/path.4068. [Epub ahead of print]. 


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  3. Angiolini, E., Coan, P.M., Sandovici, I., Unuigbe, O.H., Peck, G., Burton, G.J., Sibley, C.P., Reik, W., Fowden, A.L. and Constância, M. (2011) Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowthFASEB J25 1737-1745.
  4. Angioloni, E., Smith, R.J., Sandovici, I., Yung, H-W., Komfortova, G., Burton, G.J., Constancia, M. and Kelsey, G. The imprinted amino acid transporter SNAT4 controls fetal growth by regulating uptake of amino acids required for placental growth. Developmental Cell, Submitted.
  5. Apps R, Sharkey A, Gardner L, Male V, Kennedy P, Masters L, Farrell L, Jones D, Thomas R, Moffett A. (2011). Ex vivo functional responses to HLA-G differ between blood and decidual NK cells. Mol Hum Reprod. 2011 Sep;17(9):577-86. Epub 2011 Apr 5.
  6. Bernardo A.S., Faial T., Niakan K.K., Ortmann D., Gardner L., Senner C.E., Callery E.M., Trotter M.W., Hemberger M., Smith J.C., Moffett A., Bardwell L. and Pedersen R.A. (2011). BRACHYURY and CDX2 mediate BMP-induced differentiation of human embryonic and mouse epiblast stem cells into embryonic and extraembryonic mesoderm. Cell Stem Cell, 9: 144-155.
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  9. Graham J. Burton, Hong-Wa Yung. Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsiaPregnancy Hypertension: An International Journal of Women's Cardiovascular Health 1(2011)72-78.
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  11. Burton, G.J., Scioscia, M. and Rademacher, T.W. (2011) Endometrial secretions; creating a stimulatory microenvironment within the early human placenta. Implications for the etiopathogenesis of pre-eclampsia. Journal of Reproductive Immunology, in press.
  12. Camm, E.J., Martin-Gronert, M.S., Wright, N., Hansell, J.A., Ozanne, S.E. & Giussani, D.A. (2011). Prenatal hypoxia independent of undernutrition promotes molecular markers of insulin resistance in adult offspring. FASEB J.25(1), 420-7.
  13. Camm, E.J., Tijsseling, D., Richter, H.G., Adler, A., Hansell, J.A., Derks, J.B., Cross, C.M. & Giussani, D.A. (2011). Oxidative stress in the developing brain:  Effects of postnatal glucocorticoid therapy and antioxidants. PLoS ONE 6(6), e21142. Doi:10.1371/journal.pone.0021142.
  14. Cindrova-Davies, T., Sanders, D.A., Burton, G.J. and Charnock-Jones, D.S. (2011) Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonising VEGF receptor-mediated signallingCardiovascular Research, 89, 671-679.
  15. Cetin, I., Huppertz, B., Burton, G., Cuckle, H. Gonen, R., Lapaire, O., Mandia, L., Nicolaides, K., Redman, C., Soothill, P., Spencer, K., Thilaganathan, B., Williams, D. and Meiri, H. (2011) Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies? Placenta, Suppl., S4-S16.
  16. Coan, P.M., Vaughan, O.R., McCarthy, J., Mactier, C., Burton, G.J., Constancia, M. & Fowden, A.L. (2011). Dietary composition programs placental phenotype in mice. J. Physiol. 589 3659-3670.
  17. F Colleoni, AJ Morash, T Ashmore, M Monk, GJ Burton, AJ Murray. Cryopreservation of placental biopsies for mitochondrial respiratory analysis. Placenta. 2012 Feb;33(2):122-3. Epub 2011 Dec 10.
  18. Colucci F, Boulenouar S, Kieckbusch J, Moffett A. How does variability of immune system genes affect placentation? Placenta. 2011 Aug;32(8):539-45. Epub 2011 Jun 12.
  19. Doisne JM, Tan TC, Colucci F.Guardian of the genome turns on genes that alert natural killer cells Cell Cycle.2011 Nov 15;10(22):3822. Epub 2011 Nov 15.
  20. Evans, P., Cindrova-Davies, T., Muttukrishna, S., Burton, G.J., Porter, J. and Jauniaux, E. (2011) Hepcidin and iron species distribution inside the first trimester human gestational sacMolecular Human Reproduction, 17, 227-232.
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Reviews 2011

  1. Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2011 Nov 15;13(1):7-13.
  2. Fowden, A.L., Coan, P.M., Angiolini, E., Burton, G.J. & Constancia, M. (2011). Imprinted genes and the epigenetic regulation of placental phenotype. Prog. Biophy. Mol. Biol. 106 281-288.

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  20. Jauniaux, E. and Burton, G.J. (2007) Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit. Early Human Development, 83, 699-706.
  21. Jauniaux, E., Johns, J., Gulbis, B., Spasic-Boskovic, O. and Burton, G.J. (2007) Transfer of folic acid inside the first trimester gestational sac and the effect of maternal smoking. American Journal of Obstetrics and Gynecology, 197, 58.e1-6.
  22. Jauniaux, E., van Oppenraaij, R.H.F. and Burton, G.J. (2010) Obstetric outcome after early placental complications. Current Opinion in Obstetrics and Gynecology, 22, 452-457.
  23. Jones, C.J., Aplin, J. D. and Burton, G.J. (2010) First trimester histiotrophe shows altered sialylation compared with secretory phase glycoconjugates in human endometrium. Placenta, 31, 576-580.
  24. Moffett A, Hiby SE. (2007) How Does the Maternal Immune System Contribute to the Development of Pre-eclampsia? Placenta 28 Supplement A S51-S56
  25. AJ Murray, LM Edwards, K Clarke. Mitochondria in heart failure. Curr Opin Clin Nutr Metab Care 10: 704-711, 2007.
  26. Perea-Gomez A, Meilhac SM, Piotrowska-Nitsche K, Gray D, Collignon J, Zernicka-Goetz M (2007.) Regionalisation of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder. BMC Dev Biol. 16, 7(1), 96.
  27. K Petersen and M.H. Johnson: SmARTest regulation? Comparing the regulatory structures for ARTs in the UK and Australia. (2007)Reproductive BioMedicine 15, 236-244.
  28. Roberts CT, Owens JA, Sferruzzi-Perri AN (2007) Distinct actions of insulin-like growth factors (IGFs) on placental development and fetal growth. Placenta 29 Suppl A:S42-7.
  29. Schlabritz-Loutsevitch, N., Ballesteros, B., Dudley, C., Jenkins, S., Hubbard, G., Burton, G.J. and Nathanielsz, P. (2007) Moderate maternal nutrient restriction, but not glucocorticoid administration, leads to placental morphological changes in the baboon (Papio sp.). Placenta 28, 783-793.
  30. Sengupta, J., Lalitkumar, P. G., Najwa, A. R., Charnock-Jones, D. S., Evans, A. L., Sharkey, A. M., Smith, S. K. and Ghosh, D. (2007) Immunoneutralization of vascular endothelial growth factor inhibits pregnancy establishment in the rhesus monkey (Macaca mulatta). Reproduction, 133, 1199-1211.
  31. Smith GCS, Crossley JA, Aitken DA, Jenkins N, Lyall F, Cameron AD, Connor JM, Dobbie R Circulating angiogenic factors in early pregnancy and the risk of pre-eclampsia, intra-uterine growth restriction, spontaneous preterm birth and stillbirth. Obstetrics & Gynecology 2007;109:1316-24.
  32. Smith GCS, Fleming K, White IR. Birth order of twins and the risk of delivery-related perinatal death in England, Northern Ireland and Wales, 1994-2003. BMJ2007;334:576
  33. Smith GCS, Fretts R. Seminar: Stillbirth. Lancet 2007;370: 1715-25.
  34. Smith GCS, Shah I, Pell JP, Crossley JA, Dobbie R. Maternal obesity and the risk of spontaneous and elective preterm birth: a retrospective cohort study. American Journal of Public Health 2007;97:157-162.
  35. Smith GCS, Shah I, White I, Pell JP, Crossley JA, Dobbie R. Maternal and biochemical predictors of antepartum stillbirth among nulliparous women in relation to gestational age of fetal death. BJOG 2007;114:705-714.
  36. Smith GCS, Shah I, White IR, Pell JP, Dobbie R. Previous pre-eclampsia, preterm delivery and delivery of a small for gestational age infant and the risk of unexplained stillbirth in the second pregnancy: a retrospective cohort study. American Journal of Epidemiology 2007;165:194-202.
  37. Smith GCS, Yu CKH, Papageorghiou AT, Cacho AM, Nicolaides KM, for the Fetal Medicine Foundation Second Trimester Screening Group Maternal uterine artery Doppler flow velocimetry and the risk of stillbirth. Obstetrics & Gynecology 2007;109:144-151.
  38. Surani M.A., Hayashi K., Hajkova P. (2007) Genetic and Epigenetic Regulators of Pluripotency. Cell 128, 747-762
  39. Surani, M. A. (2007). Germ cells: The eternal link between generations. The Pontifical Academy of Sciences, Vatican City
  40. Tang F., Kaneda M., O'Carroll D., Hajkova P., Barton S.C., Sun Y.A., Lee C., Tarakhovsky A., Lao K., Surani M.A. (2007) Maternal microRNAs are essential for mouse Zygotic development. Genes Dev. 21, 644-648
  41. Torres-Padilla ME, Parfitt DE, Kouzarides T and Zernicka-Goetz M (2007). Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 445, 214-218.
  42. Torres-Padilla ME, Richardson L, Kolasinska P, Meilhac SM, Luetke-Eversloh MV, Zernicka-Goetz M (2007). The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation. Dev Biol 309, 97-11.
  43. Yung, H. W., Korolchuk, S., Tolkovsky, A. M., Charnock-Jones, D. S. and Burton, G. J. (2007) Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells. Faseb J, 21, 872-884.



  1. Angiolini, E., Fowden, A., Coan, P., Sandovici, I., Ferguson-Smith, A., Smith, P., Dean, W., Burton, G., Tycko, B., Reik, W., Sibley, C.  and M Constância, M. (2006) Regulation of placental efficiency for nutrient transport by imprinted genes. Placenta, 27 Suppl A, S98-S102.
  2. Bell, S.E., Sanchez, M.J.,  Spasic-Boskovic, O., Santalucia, T., Burton, G.J., Murphy, J.J., Norton, J.D., Clark, A.R.  and Turner, M. (2006) The RNA binding proteinZfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Developmental Dynamics, 235, 3144-3155.
  3. E.A. Campbell, L. O'Hara, R.D. Catalano, A.M. Sharkey, T.C. Freeman and M.H. Johnson: Temporal expression profiling of the uterine luminal epithelium of the pseudo-pregnant mouse suggests receptivity to the fertilised egg is associated with complex transcriptional changes. Human Reproduction 21, 2495-2513.
  4. Coan, P.M., Conroy, N., Burton, G.J. and Ferguson-Smith, A.C. (2006) Origin and characteristics of glycogen cells in the developing murine placenta. Developmental Dynamics, 235, 3280-3294.
  5. H. Dolatshad, E.A. Campbell, L. O'Hara, E.S. Maywood, M.H. Hastings and M.H. Johnson: Developmental and reproductive performance in circadian mutant mice. Human Reproduction 21, 68-79.
  6. Hung, T-H. and Burton, G.J. (2006) Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwanese Journal of Obstetrics and Gynecology, 45, 189-200.
  7. Huppertz, B. Burton G., Cross, J.C. and Kingdom, J.C.P. (2006) Placental morphology: From molecule to mother – A dedication to Peter Kaufmann. Placenta, 27 Suppl A, S3-S8.
  8. Jauniaux, E. and Burton, G.J. (2006) Villous histomorphometry and placental bed biopsy investigation in Type I diabetic pregnancies. Placenta, 27, 468-474.
  9. Jauniaux, E., Poston, L and Burton G.J. (2006) Placental-related diseases of pregnancy, human evolution and oxygen. Human Reproduction Update, 12, 747-755.
  10. Johns, J. Jauniaux, E. and Burton, G.J. (2006) Factors affecting the early embryonic environment. Reviews in Gynaecological and Perinatal Practice, 6, 199-210.
  11. M.H. Johnson: Escaping the tyranny of the embryo? A new approach to ART regulation based on UK and Australian experiences. Human Reproduction 21, 2756-2765.
  12. M.H. Johnson: Defining the human embryo: A way with words? BioNews (July, 2006) 366.
  13. M.H. Johnson: Regulating the Science and Therapeutic Application of Human Embryo Research: Managing the Tension Between Biomedical Creativity and Public Concern. Chap. 10 in: Freedom and Responsibility in Reproductive Choice. Editors A.L. Pedain and J.R. Spencer. Hart Publishing, Oxford and Portland, pp.91-106.
  14. Raijmakers, M.T.M., Burton, G.J., Jauniaux, E., Seed, P.T., Peters, W.H.M., Steegers, E.A.P. and Poston, L. (2006) Placental NAD(P)H oxidase mediated superoxide generation in early pregnancy. Placenta, 27, 158-163.
  15. L. Selwood and M.H. Johnson: Trophoblast and hypoblast in the monotreme, marsupial and eutherian mammal: evolution and origins. BioEssays 28, 128-145.
  16. Tjoa, M.L., Cindrova-Davies, T., Spasic-Boskovic, O., Bianchi, D.W. and Burton, G.J. (2006) Trophoblastic oxidative stress and the release of cell-free feto-placental DNA. American Journal of Pathology, 169, 400-404.
  17. Varanou, A., Withington, S.L., Lakasing, L., Williamson, C., Burton, G.J. and Hemberger, M. (2006) The importance of cysteine cathepsin proteases for placental development. Journal of Molecular Medicine, 84, 305-317. (Featured by Editorial)
  18. Zusterzeel, P.L.M., Peters, W.H.M., Burton, G.J., Visser, W., Roelofs, H.M.J. and Steegers, E.A.P. (2006) Multiple genetic polymorphisms in maternal biotransformation enzymes and susceptibility to preeclampsia. Gynecologic and Obstetric Investigation, 63, 209-213.



  1. Smith GCS, Wood A, Pell JP, Dobbie R. Sudden infant death syndrome and complications in other pregnancies. Lancet 2005;366:2107-2111.

Book Chapters

  1. Burton, G.J., Charnock-Jones, D.S and Jauniaux, E. (2006) Working with oxygen and oxidative stress in vitro. In: Placenta and Trophoblast: Methods and Protocols, Vol. II (eds. M.J. Soares and J.S. Hunt), pp 413-425. Methods in Molecular Medicine Series, Vol. 122. Humana Press Inc., Totowa, NJ.
  2. G. Burton, E. Jauniaux, 2009 Early placental development and pregnancy outcome In: Textbook of Periconceptional Medicine (eds. N.S. Macklon, I.A. Greer & E.A.P. Steegers) (ISBN 978-0-203-09220-0).
  3. Burton, G.J. and Jauniaux, E. (2006) Trophoblast and the first trimester environment. In: Biology and Pathology of the Trophoblast (eds. A. Moffett, C. Loke and A. McClaren), pp 111-131. Cambridge University Press, Cambridge.
  4. Burton, G.J. and Jauniaux, E. (2010) The maternal circulation and placental shape: villus remodelling induced through haemodynamics and oxidative and endoplasmic reticulum stress In: The Placenta and Human Developmental Programming (eds. G.J. Burton, D.J.P. Barker, A. Moffett and K. Thornburg), 161-171. Cambridge University Press.
  5. Burton, G.J., Hung, T-H. and Jauniaux, E. (2007) Placental hypoxia, hyperoxia and ischaemia-reperfusion injury in pre-eclampsia In: Pre-eclampsia – Etiology and Clinical Practice (eds. F. Lyall and M. Belfort), 138-151. Cambridge University Press, Cambridge.
  6. Burton, G.J., Kaufmann, P. and Huppertz, B. (2006) Anatomy and Genesis of the Placenta. In: Knobil and Neill’s Physiology of Reproduction (ed. J.D. Neill). 3rd Edition, 189-243. Academic Press, Amsterdam.
  7. Graham Burton, Colin Sibley and Eric Jauniaux (2007). Placental Anatomy and Physiology (Chapter 1) In: Obstetrics: Normal and Problem Pregnancies (Steven G. Gabbe, Jennifer R. Niebyl, Joe Leigh Simpson) (ISBN 978-0-443-06930-7, Churchill Livingstone Elsevier, Nov 08).
  8. Anne Croy, Jianhong Zhang, Chandrakant Tayade, Francesco Colucci, Hakim Yadi, and Aureo T. Yamada 2009. Analysis of Uterine Natural Killer Cells in Mice In: Natural Killer Cell Protocols: Cellular and Molecular Methods. Methods in Molecular Biology Series, Humana Press. Kerry Campbell and Marco Colonna, Editors.
  9. Jauniaux E, Burton GJ. In: Pijnenborg R, Brosens I, Romero R editor. (2009) Oxygen delivery at the deciduo-placental interfacePlacental Bed Vascular Failure: Basic Science & Clinical Management. Cambridge: Cambridge University Press; pp. in press.
  10. Jauniaux, E. and Burton, G.J. (2008) Placental circulations In: Fetal Cardiology: Embryology, Genetics, Physiology, Echocardiographic Evaluation, Diagnosis and Perinatal Management of Cardiac Diseases (eds. S Yagel, U. Gembruch and N.H. Silverman), 41-56. Informa Healthcare, London.
  11. Jauniaux, E. and Burton, G.J. (2010) Maternofetal transport pathways during embryogenesis and organogenesis In: The Placenta and Human Developmental Programming (eds. G.J. Burton, D.J.P. Barker, A. Moffett and K. Thornburg), 47-54. Cambridge University Press.
  12. M.H. Johnson and K, Petersen. Instruments for ART regulation: what are the most appropriate mechanisms for achieving smart regulation? In: Regulating Autonomy: Sex, Reproduction and Fertility. Edited by F Ebtehaj, E Jackson, M Richards & S Day Sclater, Hart Publishing, Oxford and Portland, in press.
  13. M. Richards and M.H. Johnson. Introduction: Death writes In: Death Rites and Rights. Editors B. Brooks-Gordon, F. Ebtehaj, J Herring, M.H. Johnson and M Richards. Hart Publishing, Oxford and Portland, pp.1-10.
  14. Saudemont A, Burke S, Colucci F. A simple method to measure NK cell cytotoxicity in vivo In: Methods Mol Biol. 2010;612:325-34.


  1. The Placenta and Human Developmental Programming (Cambridge University Press, ISBN 987-0-521-19945-2) Graham Burton, David Barker, Ashley Moffett, Kent Thornburg (Editors).
  2. Comparative Placentation (Springer-Verlag Berlin Heidelberg, ISBN 978-3-540-78796-9) Peter Wooding, Graham Burton, Aug-08.