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Centre for Trophoblast Research



  1. Benirschke, K., Burton, G.J. and Baergen, R. (2012) Pathology of the Human Placenta, 6th edition. Springer, Berlin, pp. 941.
  2. Michael J. Booth*, Miguel R. Branco*, Gabriella Ficz, David Oxley, Felix Krueger, Wolf Reik, and Shankar Balasubramanian. Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution, Science Published online 26 April 2012 [DOI:10.1126/science.1220671] *Equal authorship
  3. Burton, G.J. & Fowden, A.L. (2012). The placenta and developmental programming: balancing fetal nutrient demands and maternal resource allocation. Placenta 33 Suppl A Trophoblast Research S23-S27.
  4. Burton, G.J., Sibley, C.P. and Jauniaux, E. (2012) Placental anatomy and physiology. In; Obstetrics: Normal and Problem Pregnancies (eds S.G. Gabbe, J.R. Niebyl, J.L. Simpson, M.B. Landon, H.L. Galan, E.R.M. Jauniaux and D.A. Driscoll). 6th Edition. Elsevier, Amsterdam.
  5. Colleoni, F., Morash, A.J., Ashmore, T., Monk, M., Burton, G.J. and Murray, A.J. (2012) Cryopreservation of placental biopsies for mitochondrial respiratory analysis.Placenta, 33, 122-123.
  6. Constancia, M. & Fowden, A. (Eds). Maternal Fetal Resource AllocationPlacenta 33Suppl 2, published online November 2012.
  7. Giussani, D.A., Camm, E.J., Niu, Y., Richter, H.G., Blanco, C.E., Gottschalk, R., Blake, E.Z., Horder, K.A., Thakor, A.S., Hansell, J.A., Kane, A.D., Wooding, F.B.P., Cross C.M. & Herrera. E.A (2012).  Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress.  PLoS ONE. In Press.
  8. Gutierrez-Marcos, J.F., Constancia, M. and Burton, G.J. (2012) Maternal to offspring resource allocation in plants and mammals. Placenta, 33, Suppl 2: e3-e10.
  9. Griffiths A., ter Haar, G.R., Rivens, I.H., Giussani, D.A. & Lees, C.C. (2012).  High Intensity Focused Ultrasound in obstetrics and gynaecology: the birth of a new era of non-invasive surgery? European Journal of Ultrasound.  In  Press.
  10. Hemberger M. (2012). Health during pregnancy and beyond: Fetal trophoblast cells as chief co-ordinators of intrauterine growth and reproductive success. Annals of Medicine, 44: 325-337.
  11. Herrera, E.A., Camm, E.J., Cross, C.M., Mullender, J.L., Wooding, F.B.P. & Giussani, D.A. (2012). Morphological and functional alterations in the aorta of the chronically-hypoxic fetal rat.  Journal of Vascular Research 49(1), 50-8.
  12. *Herrera, E.A., *Kane, A. D., Hansell, J.A., Thakor, A.S., Allison, B.J., Niu, Y. & Giussani, D.A. (2012).  The role of xanthine oxidase in the control of ovine fetal cardiovascular function. *Authors contributed equally. J. Physiol.In Press.
  13. Jain, A., Olovsson, M., Burton, G.J. and Yung, H.W. (2012) Endothelin-1 induces endoplasmic reticulum stress by activating the PLC/IP3 pathway; implications for placental autocrine signaling in the pathophysiology of pre-eclampsia. Am J Pathol, 180, 2309-2320.
  14. John R.M. and Hemberger M. (2012). A Placenta for Life. Reprod. Biomed. Online, 25: 5-11. This is the introductory article to a special Symposium on Trophoblast Differentiation for which I was the lead guest co-editor on invitation by Prof. Martin Johnson.
  15. Kane, A. D., Herrera, E.A., J.A. Hansell & Giussani, D.A. (2012).  Statin treatment depresses the fetal defense to acute hypoxia via increasing nitric oxide bioavailability.J Physiol. 590(Pt 2), 323-34.
  16. Latos P.A.*, Helliwell C., Mosaku O., Dudzinska D.A., Stubbs B., Berdasco M., Esteller M., Hendrich B.*, “NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate”, Biology Open 2012: 1(4):341-52
    *corresponding author
  17. Latos P.A.*, Pauler F.M.*, Koerner M.V.*, Senergin B.H, Hudson Q.J., Stocsits R.R., Allhoff W., Stricker S.H., Klement R.M., Warczok K.E., Aumayr K., Pasierbek P., Barlow D.P., “Airn transcriptional overlap but not its lncRNA product induces imprinted Igf2r silencing”, Science 2012 Dec 14;338(6113):1469-72. *equal contribution.
  18. Male V, Gardner L, Moffett A  (2012) Isolation of cells from the feto-maternal interface. Curr Protoc Immunol Chapter 7:Unit 7 40 1.
  19. Reynolds N., Latos P.A., Hynes-Allen A., Loos R., Leaford D., O’Shaughnessy A., Mosaku O., Signolet J., Brennecke P., Kalkan T., Costello I., Humphreys P., Mansfield B., Nakagawa K., I. John Strouboulis I.J., Behrens A., Bertone P., Hendrich B., “NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment”, Cell Stem Cell 2012;10(5):583-94.
  20. Richter, H.G., Camm, E.J., Modi, B.N., Naeem, F., Cross, C.M., Cindrova-Davies, T., Spasic-Boskovic, O., Dunster, C., Mudway, I.A., Kelly, F.J., Burton, G.J., Poston, L. & Giussani, D.A. (2012). Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats. Journal of Physiology. In Press.
  21. Seisenberger S, Andrews S, Krueger F, Arand J, Walter J, Santos F, Popp C, Thienpont B, Dean W, Reik W. The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.  Mol Cell. 2012 Dec 28;48(6):849-62. doi: 10.1016/j.molcel.2012.11.001. Epub 2012 Dec 6.
  22. Senner C.E., Krueger F., Oxley D., Andrews S. and Hemberger M. (2012). DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary. Stem Cells, 30: 2732-2745.
  23. Senner C.E., Krueger F., Oxley D., Andrews S. and Hemberger M. (2012). DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary. Stem Cells, 30: 2732-2745.
  24. Vaughan, O.R., Sferruzzi-Perri A.N., Coan, P.M. & Fowden, A.L. (2012). Environmental regulation of placental phenotype: implications for fetal growth. Reprod. Fert. Develop. 24 80-96.
  25. Yung, H.W., Cox, M., Tissot van Patot, M. and Burton, G.J. (2012) Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude. FASEB J, 26, 1970-1981.
  26. Yung H.-W., Hemberger M., Watson E.D., Senner C.E., Jones C.P., Kaufman R.J., Charnock-Jones D.S. and Burton G.J. (2012). Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction. J. Pathology, doi: 10.1002/path.4068. [Epub ahead of print]. 


  1. Ackerman WEt, Bulmer JN, Carter AM, Chaillet JR, Chamley L, Chen CP, Chuong EB, Coleman SJ, Collet GP, Croy BA, de Mestre AM, Dickinson H, Ducray J, Enders AC, Fogarty NM, Gauster M, Golos T, Haider S, Heazell AE, Holland OJ, Huppertz B, Husebekk A, John RM, Johnsen GM, Jones CJ, Kalionis B, Konig J, Lorenzon AR, Moffett A, Moreira de Mello JC, Nuzzo AM, Parham P, Parolini O, Petroff MG, Pidoux G, Ramirez-Pinilla MP, Robinson WP, Rolfo A, Sadovsky Y, Soma H, Southcombe JH, Tilburgs T, Lash GE.   IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta 33 Suppl:S15.
  2. Ajduk A, Ilozue T, Windsor S,  Yu Y, Seres KB, Bomphrey RJ, Tom BD, Swann K,  Thomas A, Graham C and Zernicka-Goetz M (2011). Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability Nature Communications 2, Article number: 417 doi:10.1038/ncomms1424.
  3. Angiolini, E., Coan, P.M., Sandovici, I., Unuigbe, O.H., Peck, G., Burton, G.J., Sibley, C.P., Reik, W., Fowden, A.L. and Constância, M. (2011) Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowthFASEB J25 1737-1745.
  4. Angioloni, E., Smith, R.J., Sandovici, I., Yung, H-W., Komfortova, G., Burton, G.J., Constancia, M. and Kelsey, G. The imprinted amino acid transporter SNAT4 controls fetal growth by regulating uptake of amino acids required for placental growth. Developmental Cell, Submitted.
  5. Apps R, Sharkey A, Gardner L, Male V, Kennedy P, Masters L, Farrell L, Jones D, Thomas R, Moffett A. (2011). Ex vivo functional responses to HLA-G differ between blood and decidual NK cells. Mol Hum Reprod. 2011 Sep;17(9):577-86. Epub 2011 Apr 5.
  6. Bernardo A.S., Faial T., Niakan K.K., Ortmann D., Gardner L., Senner C.E., Callery E.M., Trotter M.W., Hemberger M., Smith J.C., Moffett A., Bardwell L. and Pedersen R.A. (2011). BRACHYURY and CDX2 mediate BMP-induced differentiation of human embryonic and mouse epiblast stem cells into embryonic and extraembryonic mesoderm. Cell Stem Cell, 9: 144-155.
  7. Graham Burton, David Barker, Ashley Moffett, Kent Thornburg (Editors).The Placenta and Human Developmental Programming. (Cambridge University Press, ISBN 987-0-521-19945-2).
  8. Burton, G.J. (2011) Deportation of syncytial sprouts from the term human placentaPlacenta, 32, 96-98.
  9. Graham J. Burton, Hong-Wa Yung. Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsiaPregnancy Hypertension: An International Journal of Women's Cardiovascular Health 1(2011)72-78.
  10. Burton, G.J and Jauniaux, E. (2011) Oxidative stressBest Practice & Research Clinical Obstetrics & Gynaecology Epub ahead of print.
  11. Burton, G.J., Scioscia, M. and Rademacher, T.W. (2011) Endometrial secretions; creating a stimulatory microenvironment within the early human placenta. Implications for the etiopathogenesis of pre-eclampsia. Journal of Reproductive Immunology, in press.
  12. Camm, E.J., Martin-Gronert, M.S., Wright, N., Hansell, J.A., Ozanne, S.E. & Giussani, D.A. (2011). Prenatal hypoxia independent of undernutrition promotes molecular markers of insulin resistance in adult offspring. FASEB J.25(1), 420-7.
  13. Camm, E.J., Tijsseling, D., Richter, H.G., Adler, A., Hansell, J.A., Derks, J.B., Cross, C.M. & Giussani, D.A. (2011). Oxidative stress in the developing brain:  Effects of postnatal glucocorticoid therapy and antioxidants. PLoS ONE 6(6), e21142. Doi:10.1371/journal.pone.0021142.
  14. Cindrova-Davies, T., Sanders, D.A., Burton, G.J. and Charnock-Jones, D.S. (2011) Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonising VEGF receptor-mediated signallingCardiovascular Research, 89, 671-679.
  15. Cetin, I., Huppertz, B., Burton, G., Cuckle, H. Gonen, R., Lapaire, O., Mandia, L., Nicolaides, K., Redman, C., Soothill, P., Spencer, K., Thilaganathan, B., Williams, D. and Meiri, H. (2011) Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies? Placenta, Suppl., S4-S16.
  16. Coan, P.M., Vaughan, O.R., McCarthy, J., Mactier, C., Burton, G.J., Constancia, M. & Fowden, A.L. (2011). Dietary composition programs placental phenotype in mice. J. Physiol. 589 3659-3670.
  17. F Colleoni, AJ Morash, T Ashmore, M Monk, GJ Burton, AJ Murray. Cryopreservation of placental biopsies for mitochondrial respiratory analysis. Placenta. 2012 Feb;33(2):122-3. Epub 2011 Dec 10.
  18. Colucci F, Boulenouar S, Kieckbusch J, Moffett A. How does variability of immune system genes affect placentation? Placenta. 2011 Aug;32(8):539-45. Epub 2011 Jun 12.
  19. Doisne JM, Tan TC, Colucci F.Guardian of the genome turns on genes that alert natural killer cells Cell Cycle.2011 Nov 15;10(22):3822. Epub 2011 Nov 15.
  20. Evans, P., Cindrova-Davies, T., Muttukrishna, S., Burton, G.J., Porter, J. and Jauniaux, E. (2011) Hepcidin and iron species distribution inside the first trimester human gestational sacMolecular Human Reproduction, 17, 227-232.
  21. Ferguson-Smith, A (2011). Genomic imprinting: the emergence of an epigenetic paradigm. Genetics Vol. 12 pp565-575.
  22. Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S, Reik W. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation Nature. 2011 May 19;473(7347):398-402
  23. Fogarty NME, Mayhew TM, Ferguson-Smith AC and Burton GJ. A quantitative analysis of transcriptionally active syncytiotrophoblast nuclei across human gestation. J Anat. 2011 Aug 24. doi: 10.1111/j.1469-7580.2011.01417.x. [Epub ahead of print]
  24. R.L. Gardner and M.H. Johnson: Bob Edwards and the first decade of Reproductive BioMedicine Online. Reproductive BioMedicine Online 22, 103- 121.
  25. Giussani, D.A. (2011).  The vulnerable developing brain. Proc Natl Acad Sci U S A. 108(7), 2641-2. (Featured in the March 2011 issue of the North American Vascular Biology Organization (NAVBO) Vascular Biology Publications Alert).
  26. Giussani, D.A., Flecther, A.J.W. & Gardner, D.S. (2011).  Sex differences in the cortisol response to stress before birth. Pediatric Research 69(2), 118-22.
  27. Hemberger M., Moffett A. and Colucci F. (2011). Reply to Lenz: Parental MHC disparity may affect offspring fitness via uterine NK cells. Proc. Natl. Acad. Sci. U.S.A., 108: E254.M.H. Johnson: Bob Edwards: The trail that led to the Nobel Prize. The Galton Institute Newsletter 75, 1-3.
  28. M.H Johnson: The Biology of Donation. In: (Eds. J. Appleby, G. Pennings and `M. Richards) Reproductive Donation: Bioethics, Policy and Practice. CUP, Cambridge.
  29. M.H. Johnson: Robert Edwards: the path to IVF. Reproductive BioMedicine Online, in press.
  30. M.H Johnson  and A.A. Theodosiou: PGD and the making of the 'genetic embryo' as a political tool: A historical analysis. In: (Ed. Sheila McLean) Regulating PGD: A Comparative and Theoretical Analysis. Hart Publishing, Oxford.
  31. Kerr WG, Colucci F. Inositol phospholipid signaling and the biology of natural killer cells J Innate Immun. 2011;3(3):249-57. Epub 2011 Mar 22. Review.
  32. Llanos, A.J., Ebensperger, G., Herrera, E.A., Reyes, R.V., Pulgar, V.M., Serón-Ferré, M., Díaz, M., Parer, J.T., Giussani, D.A., Moraga, F.A. &  Riquelme, R.A. (2011). Fetal and postnatal pulmonary circulation in the Alto Andino.Placenta 32 Suppl 2, S100-3. Epub 2011 Feb 3.
  33. Male V, Sharkey A, Masters L, Kennedy PR, Farrell LE, Moffett A. (2011). The effect of pregnancy on the uterine NK cell KIR repertoire. Eur J Immunol. 2011 Oct;41(10):3017-27. doi: 10.1002/eji.201141445. Epub 2011 Aug 30. PMID: 21739430 [PubMed - indexed for MEDLINE] Free PMC Article Related Citations.
  34. Zofia Madeja, Hakim Yadi, Richard Apps, Selma Boulenouar, Stephen J. Roper, Lucy Gardner, Ashley Moffett, Francesco Colucci, and Myriam Hemberger.Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth. PNAS, 2011 March, Vol 108 No 10 4012-4017.
  35. Moraga, F.A., Reyes, R.V., Herrera, E.A., Riquelme, R.A., Ebensperger, G., Pulgar, V.M., Parer, J.T., Giussani, D.A. & Llanos, A.J. (2011).  The role of the a-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep:  A comparative study between highland and lowland species. American Journal of Physiology301(4), R1153-60.
  36. Nelson, D.M. and Burton, G.J. (2011) A technical note to improve the reporting of studies of the human placentaPlacenta, 32, 195-196.
  37. Nesterova T.B., Senner C.E., Schneider J., Alcayna-Stevens T., Tattermusch A., Hemberger M. and Brockdorff N. (2011). Pluripotency factor binding and Tsixexpression act synergistically to repress Xist in undifferentiated ES cells. Epigenetics & Chromatin, 4: 17.
  38. Niakan K.K., Han, J., Pedersen, R.A., Simon C. and Riejo Pera R.A. Human pre-implantation embryo development. Development, in press. (Primer)
  39. Novakovic B, Gordon L, Wong NC, Moffett A, Manuelpillai U, Craig JM, Sharkey A, Saffery R. (2011). Wide-ranging DNA methylation differences of primary trophoblast cell populations and derived cell lines: implications and opportunities for understanding trophoblast function. Mol Hum Reprod. 2011 Jun;17(6):344-53. doi: 10.1093/molehr/gar005. Epub 2011 Feb 2.
  40. Novakovic B, Yuen RK, Gordon L, Penaherrera MS, Sharkey A, Moffett A, Craig JM, Robinson WP, Saffery R. (2011). Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors. BMC Genomics. 2011 Oct 28;12:529.
  41. Ohhata T., Senner C.E., Hemberger M. and Wutz A. (2011). Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice. Genes & Dev., 25: 1702-1715.
  42. Rugg-Gunn, P.J., Cox, B.J., Lanner, F., Sharma, P., Ignatchenko, V., McDonald, A.C.H., Garner, J., Gramolini, A.O., Rossant, J. and Kislinger, T. Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Developmental Cell, in press.
  43. Rugg-Gunn, P.J. Epigenetic features of mouse trophoblast. Reproductive BioMedicine Online, in press.
  44. Salinas, C.E., Villena, Blanco, C.E.  & Giussani, D.A. (2011).  Adrenocortical suppression in highland chick embryos is restored during incubation at sea level.   High Altitude Medicine & Biology 12(1), 79-87.
  45. Salker MS, Christian M, Steel JH, Nautiyal J, Lavery S, Trew G, Webster Z, Al-Sabbagh M, Puchchakayala G, Föller M, Landles C, Sharkey AM, Quenby S, Aplin JD, Regan L, Lang F, Brosens JJ. (2011) Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med. 17:1509-13.
  46. Ionel Sandovici, Noel H. Smith, Marloes Dekker Nitert, Matthew Ackers-Johnson, Santiago Uribe-Lewis, Yoko Ito, R. Huw Jones, Victor E. Marquez, William Cairns, Mohammed Tadayyon, Laura P. O'Neill, Adele Murrell, Charlotte Ling, Miguel Constância, and Susan E. Ozanne. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. (News article).
  47. Sferruzzi-Perri, A.N., Vaughan, O.R., Coan, P.M., Suciu, M.C., Darbyshire, R., Constancia, M., Burton, G.J. & Fowden, A.L. (2011). Placental specific Igf2 deficiency alters developmental adaptations to undernutrition in mice. Endocrinol. 152 3202-3212.
  48. Smallwood, S.A., Tomizawa, S., Krueger, F., Ruf, N, Carli, N., Sato, S., Hata, K., Andrews, S. and Kelsey, G. (2011) Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nature Genetics Vol 43, pp811–814.
  49. A.A. Theodosiou and M.H Johnson: The politics of human embryo research and the motivation to achieve PGD. Reproductive BioMedicine 22, 457-471.
  50. Tomizawa, S., Kobayashi, H., Watanabe, T., Hata, K., Kelsey, G. and Sasaki, H. (2011) Dynamic stage-specific changes of imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes. Development Vol 138, pp811-820.
  51. Watson ED, Hughes M, Natale DRC, Simmons DG, Natale DRC, Sutherland AE and Cross JC. Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development. 2011 Development Dynamics (In press).
  52. Vaughan, O.R. Forhead, A.J. & Fowden, A.L. (2011). Glucocorticoids and placental programming. In The Placenta and Human Developmental Programming Eds. Burton, G.J., Barker, D.J.P., Moffett, A., & Thornburg, K.L. pp 175-186. Cambridge University Press, Cambridge.
  53. Wossidlo M, Lepikhov K, Marques CJ, Zakhartchenko V, Boiani M, Reik W, Walter J. Dynamics of 5-hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.2011Nature Communications 2:241.
  54. Yung, H.W., Charnock-Jones, D.S. and Burton, G.J. (2011) Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent mannerPLoS One. 6, e17894.
  55. Zernicka-Goetz M. (2011) Proclaiming fate in the early mouse embryo. Nat Cell Biol. 13(2):112-4.

Reviews 2011

  1. Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2011 Nov 15;13(1):7-13.
  2. Fowden, A.L., Coan, P.M., Angiolini, E., Burton, G.J. & Constancia, M. (2011). Imprinted genes and the epigenetic regulation of placental phenotype. Prog. Biophy. Mol. Biol. 106 281-288.

CTR member citations

  1. Erlebacher A with reference to the work of CTR members Francesco Colucci, Ashley Moffett and Myriam Hemberger. Strangers no more: Uterine NK cell recognition of the placenta in mice. Published online before print March 3, 2011, doi: 10.1073/pnas.1101509108 PNAS March 3, 2011



  1. Adler, A., Camm, E.J., Hansell, J.A., Richter, H.G. & Giussani, D.A. (2010). An investigation of the use of antioxidants diminish adverse effects of postnatal glucocorticoid treatment in the newborn rat. Neonatology 98 (1), 73-83.
  2. Ali, K.Z., Burton, G.J., Khalid, M.E., Moosa, R. and Abd-Alla, S. (2010) Concentrations of free vascular endothelial growth factor in the maternal and fetal circulations during pregnancy; a cross-sectional study. Journal of Maternal-Fetal & Neonatal Medicine.
  3. Apps R, Sharkey A, Gardner L, Male V, Kennedy P, Masters L, Farrell L, Jones D, Kulkarni S and Moffett A. Stimulation of decidual NK cells by the different conformations of HLA-G expressed on fetal extravillous trophoblast cells (submitted).
  4. Apps R, Sharkey A, Gardner L, Male V, and Moffett A. Microarray-based expression analysis of first trimester human trophoblast cells. In press at Placenta.
  5. Richard Apps, Andrew Sharkey, Lucy Gardner, Victoria Male, Matthew Trotter, Nigel Miller, Robyn North, Sandra Founds and Ashley Moffett. Genome-wide expression profile of first trimester villous and extravillous human trophoblast cells. Placenta In press.
  6. Belteki, G.,  Kempster, S.L., Forhead, A.J., Giussani, D.A., Fowden, A.L., Charnock-Jones, S.G. & Smith, G.C.S. Paraoxonase-3 is systemically up-regulated in late gestation in the fetal rat, sheep and human. Journal of Clinical Endocrinology & Metabolism 95(8), 3798-805.
  7. Bruce AW and Zernicka-Goetz M (2010). Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate. Curr Opin Genet Dev. 2010
  8. Burke S, Laksmikanth T, Colucci F, Carbone E (2010) New views on natural killer cell-based immunotherapy for melanoma treatment Trends Immunol, 31:339-345.
  9. Burton, G.J., Jauniaux, E. and Charnock-Jones, D.S. (2010). The influence of the intrauterine environment on human placental development. International Journal of Developmental Biology ;54:303-312.
  10. Camm, E.J., Hansell, J.A., Kane, A.D., Herrera, E.A., Lewis, C., Wong, S., Morrell, N.W. & Giussani, D.A. (2010). Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function. American Journal of Obstetrics & Gynecology 203(5), 495.e24-34.
  11. Coan, P.M., Vaughan, O.R., Sekita, Y., Finn, S.L., Burton, G.B., Constancia, M. & Fowden, A.L. (2010). Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice. J. Physiol 588 527-538.
  12. Derks, J.B., Oudijk, M.A., Torrance, H.L. Rademaker, C.M.A., Benders, M.J., Rosen, K.G., Cindrova-Davies, T., Thakor, A.S., Visser, G.H.A., Burton, G.J., van Bel, F. &Giussani, D.A. (2010). Allopurinol reduces oxidative stress in the ovine fetal cardiovascular system following repeated episodes of ischemia-reperfusion. Pediatric Research 68(5), 374-80.
  13. Dilworth M, Kusinski, L, Cowley E, Ward S, Husain S, Constancia M, Sibley C and Glazier J (2010) Placental-specific Igf2 knockout mice exhibit hypocalcaemia and adaptive changes in placental calcium transport Proc Natl Acad Sci USA 107:3894-3899.
  14. Francesco Colucci, Corrado M. Cilio. Taming killer cells may halt diabetes progression. Nat Immunol. 2010 Feb;11(2):111-2.
  15. Fowden, A.L., Ward, J.W., Wooding, F.B.P. & Forhead, A.J. (2010). Developmental programming of the ruminant placenta. In Reproduction in Domestic Ruminants Editors: Lucy, M.C., Pate, J.L., Smith, M.F. & Spencer, T.E. pp 41-57. Nottingham University Press.
  16. Hemberger M. (2010). Genetic-epigenetic intersection in trophoblast differentiation: Implications for extraembryonic tissue function. Epigenetics, 5: 1-6.
  17. Hemberger M., Udayashankar R. Tesar P., Moore H. and Burton G.J. (2010). ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta. Hum. Mol. Gen., 19: 2456-2467.
  18. Herrera, E.A., Riquelme, R.A., Ebensperger, G., Reyes, R.V., Ulloa, C.E., Cabello, G., Krause, B.J., Parer, J.T., Giussani, D.A. & Llanos, A.J. (2010). Long term exposure to high altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level. American Journal of Physiology 299(6), R1676-84.
  19. Herrera, E.A., Verkerk, M.M., Derks, J.B. & Giussani, D.A. (2010). Antioxidants improve peripheral vascular dysfunction induced by postnatal glucocorticoid therapy in rats. PLoS ONE 5(2), e9250.
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  16. Cordeaux, Y., Missfelder-Lobos, H., Charnock-Jones, D. S. and Smith, G. C. (2008) Stimulation of Contractions in Human Myometrium by Serotonin is Unmasked by Smooth Muscle Relaxants. Reprod Sci, 15, 727-734.
  17. Durcova-Hills G., Tang F., Doody G., Tooze R., Surani M.A. (2008) Reprogramming primordial germ cells into pluripotent stem cells. Plos One 3, e3531.
  18. Farthing CR, Ficz G, Ng RK, Chan CF, Andrews S, Dean W, Hemberger M, Reik W. Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet 2008;4:e1000116.
  19. Fowden AL, Forhead AJ, Coan PM, Burton GJ. The placenta and intrauterine programming. J Neuroendocrinol 2008;20:439-50.
  20. Hemberger M., Yang W., Natale D., Brown T.L., Dunk C., Gargett C.E. and Tanaka S. (2008). Stem cells from fetal membranes – A Workshop Report. Placenta, 29S: 17-19.
  21. Hemberger M. (2008). IFPA award in placentology lecture – Characteristics and significance of trophoblast giant cells. Placenta, 29S: 4-9.
  22. Hajkova P., Ancelin K., Waldmann T., Lacoste N., Lange U.C., Cesari F., Lee C., Almouzni G., Schneider R., Surani M.A. (2008) Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature 452, 877-881
  23. Hayashi K., Chuva de Sousa Lopes S.M., Tang F., Surani M.A. (2008) Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states . Cell Stem Cell 3, 391-401
  24. Hayashi K., Chuva de Sousa Lopes S.M., Kaneda M., Tang F., Hajkova P., Lao K., O'Carroll D., Das P.P., Tarakhovsky A., Miska E.A., Surani M.A. (2008) MicroRNA Biogenesis is required for mouse primordial germ cell development and Spermatogenesis Plos One 3, e1738
  25. Hiby SE, Regan L, Lo W, Farrell L, Carrington M, Moffett A. Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage. Hum Reprod 2008;23:972-6.
  26. Hirose, O., Yoshida, R., Imoto, S., Yamaguchi, R., Higuchi, T., Charnock-Jones, D. S., Print, C. and Miyano, S. (2008) Statistical inference of transcriptional module-based gene networks from time course gene expression profiles by using state space models. Bioinformatics, 24, 932-942.
  27. Holmes, K., Charnock Jones, S. D., Forhead, A. J., Giussani, D. A., Fowden, A. L., Licence, D., Kempster, S. and Smith, G. C. (2008) Localization and Control of Expression of VEGF-A and the VEGFR-2 Receptor in Fetal Sheep Intestines. Pediatr Res, 63, 143-148.
  28. Hull, M. L., Escareno, C. R., Godsland, J. M., Doig, J. R., Johnson, C. M., Phillips, S. C., Smith, S. K., Tavare, S., Print, C. G. and Charnock-Jones, D. S. (2008) Endometrial-peritoneal interactions during endometriotic lesion establishment. Am J Pathol, 173, 700-715.
  29. Jauniaux E, Burton GJ. Placental circulations. In: Yagel S, Gembruch U,Silverman NH editor. Fetal Cardiology:Embryology, Genetics, Physiology, Echocardiographic Evaluation, Diagnosis and Perinatal Management of Cardiac Diseases. London: Informa Healthcare; 2008, pp. 41-56.
  30. Jedrusik A, Parfitt DE, Guo G, Skamagki M, Grabarek JB, Johnson MH, Robson P and Zernicka-Goetz M. (2008). Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 22(19):2692-706.
  31. M.H. Johnson and K. Petersen: Public Interest or Public Meddling? Towards an objective framework for the regulation of Assisted Reproductive Technologies. Human Reproduction (2008) 23, 716-728.
  32. M.H. Johnson: Human ES cells and a blastocyst from one Embryo: exciting science but conflicting ethics? (2008) Cell Stem Cell 2, 103-104
  33. Lykke-Andersen K, Gilchrist MJ, Grabarek JB, Das P, Miska E, Zernicka-Goetz M. (2008). Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition. Mol Biol Cell. 19(10):4383-92.
  34. AJ Murray, MA Cole, CA Lygate, CA Carr, DJ Stuckey, SE Little, S Neubauer, K Clarke. Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart. J Mol Cell Cardiol 44:694-700, 2008.
  35. Ng RK, Dean W, Dawson C, Lucifero D, Madeja Z, Reik W, Hemberger M. Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5. Nat Cell Biol 2008;10:1280-90.
  36. Pasupathy, D., Dacey, A., Cook, E., Charnock-Jones, D. S., White, I. R. and Smith, G. C. (2008) Study protocol. A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction study. BMC Pregnancy Childbirth, 8, 51.
  37. Screen M, Dean W, Cross JC, Hemberger M. Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling. Development 2008;135:3311-20.
  38. Sharkey AM, Gardner L, Hiby S, Farrell L, Apps R, Masters L, Goodridge J, Lathbury L, Stewart CA, Verma S, Moffett A. Killer Ig-like receptor expression in uterine NK cells is biased toward recognition of HLA-C and alters with gestational age. J Immunol 2008;181:39-46.
  39. Sharkey AM, Gardner L, Hiby S, Farrell L, Apps R, Masters L, Goodridge J, Lathbury L, Stewart CA, Verma S, Moffett A. KIR expression in uterine NK cells is biased towards recognition of HLA-C and alters with gestational age. J Immunol. 2008 181:39-46.
  40. Smith, G. C., Cordeaux, Y., White, I. R., Pasupathy, D., Missfelder-Lobos, H., Pell, J. P., Charnock-Jones, D. S. and Fleming, M. (2008) The Effect of Delaying Childbirth on Primary Cesarean Section Rates. PLoS Med, 5, e144.
  41. Smith GCS, Celik E, To M, Khouri O, Nicolaides KH. Cervical length at mid-pregnancy and the risk of primary cesarean delivery during labor at term. New England Journal of Medicine 2008;358:1346-1353.
  42. Soares ML, Torres-Padilla ME, Zernicka-Goetz M. (2008). Bone morphogenetic protein 4 signalling regulates development of the anterior visceral endoderm in the mouse embryo. Dev Growth Differ. 50(7):615-21.
  43. Sowpati D.T., Thiagarajan D., Sharma S., Sultana H., John R., Surani A., Mishra R.K., Khosla S. (2008) An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila . Mech Dev 125, 963-973
  44. Surani M.A., Durcova-Hills G., Hajkova P., Hayashi K., Tee W.W. (2008) Germ Line, Stem Cells and Epigenetic Reprogramming . In 73rd Cold Spring Harbor Symposium on Stem Cells Quant Biol 73, 9-15
  45. Tian G., Singh U., Yu Y., Ellsworth B.S., Hemberger M., Geyer R., Stewart M.D., Behringer R.R. and Fundele R. (2008). Expression and function of the LIM-homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Dev. Dyn., 237: 1517-1525.
  46. Trowsdale J, Moffett A. NK receptor interactions with MHC class I molecules in pregnancy. Semin Immunol 2008;20:317-20.
  47. Watanabe T., Totoki Y., Toyoda A., Kaneda M., Kuramochi-Miyagawa S., Obata Y., Chiba H., Kohara Y., Kono T., Nakano T., Surani M.A., Sakaki Y., Sasaki H. (2008) Endogenous SiRNAs from naturally formed dsRNAs regulate transcripts in mouse Oocytes Nature 453, 539-543.
  48. Yadi H, Burke S, Madeja Z, Hemberger M, Moffett A, Colucci F. Unique receptor repertoire in mouse uterine NK cells. J Immunol 2008;181:6140-7.
  49. Yung HW, Calabrese S, Hynx D, Hemmings BA, Cetin I, Charnock-Jones DS, Burton GJ. Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction. Am J Pathol 2008;173:451-62.



  1. Affara, M., Dunmore, B., Savoie, C., Imoto, S., Tamada, Y., Araki, H., Charnock-Jones, D. S., Miyano, S. and Print, C. (2007) Understanding Endothelial Cell Apoptosis: What can the transcriptome, glycome and proteome reveal? Philos Trans R Soc Lond B Biol Sci, 362, 1469-1487.
  2. Andrews S.C., Wood M.D., Tunster S.J., Barton S.C., Surani M.A., John R.M. (2007) Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. BMC Dev Biol 7, 53.
  3. Apps R, Gardner L, Sharkey AM, Holmes N, Moffett A. A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1. Eur J Immunol. 2007 37:1924-37.
  4. Bukowski R, Smith GCS, Malone F, et al for the FASTER Consortium. Human sexual size dimorphism in early pregnancy. American Journal of Epidemiology2007;165:1216-1218.
  5. Bukowski R, Smith GCS, Malone F, et al for the FASTER Consortium. Early pregnancy fetal growth and the risk of delivering a low birth weight infant. BMJ2007;334:836.
  6. Burdon, C., Mann, C., Cindrova-Davies, T., Ferguson-Smith A.C. and Burton, G.J. (2007) Oxidative stress and the induction of cyclooxygenase enzymes and apoptosis in the murine placenta. Placenta, 28, 724-733.
  7. Burton, G. J., Jauniaux, E. and Charnock-Jones, D. S. (2007) Human early placental development: potential roles of the endometrial glands. Placenta, 28 Suppl A, S64-69.
  8. Catalano, R. D., Critchley, H. O., Heikinheimo, O., Baird, D. T., Hapangama, D., Sherwin, J. R., Charnock-Jones, D. S., Smith, S. K. and Sharkey, A. M. (2007) Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod, 13, 641-654.
  9. Cheng, C. W., Bielby, H., Licence, D., Smith, S. K., Print, C. G. and Charnock-Jones, D. S. (2007) Quantitative cellular and molecular analysis of the effect of progesterone withdrawal in a murine model of decidualization. Biol Reprod, 76, 871-883.
  10. Cindrova-Davies, T., Spasic-Boskovic, O., Jauniaux, E., Charnock-Jones, D. S. and Burton, G. J. (2007) Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitamins. Am J Pathol, 170, 1511-1520.
  11. Cindrova-Davies, T., Yung, H. W., Johns, J., Spasic-Boskovic, O., Korolchuk, S., Jauniaux, E., Burton, G. J. and Charnock-Jones, D. S. (2007) Oxidative Stress, Gene Expression, and Protein Changes Induced in the Human Placenta during Labor. Am J Pathol, 171, 1168-1178.
  12. Derks, J.B., Torrance, H.L., Oudijk, M.A., Thakor, A.S., Rademaker C.M.A., Benders, M.J., Rosen, K.G., Cindrova-Davies, T., Visser, G.H.A., Burton, G.J., van Bel, F. and Giussani, D.A. (2010) Allopurinol reduces oxidative stress in the ovine fetal cardiovascular system following repeated episodes of ischemia-reperfusion. Pediatric Research, 68, 374-380.
  13. Duval, H., Johnson, N., Li, J., Evans, A., Chen, S., Licence, D., Skepper, J., Charnock-Jones, D. S., Smith, S. and Print, C. (2007) Vascular development is disrupted by endothelial cell-specific expression of the anti-apoptotic protein Bcl-2. Angiogenesis, 10, 55-68.
  14. Evans, A. L., Bryant, J., Skepper, J., Smith, S. K., Print, C. G. and Charnock-Jones, D. S. (2007) Vascular development in embryoid bodies: quantification of transgenic intervention and antiangiogenic treatment. Angiogenesis.
  15. Frankenberg S, Smith L, Greenfield A, and Zernicka-Goetz M (2007). Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. BMC Dev Biol 15;7(1):8.
  16. Hayashi K., De Sousa Lopes S.M., Surani M.A. (2007) Germ cell specification in mice Science 316, 394-396
  17. Hemberger M. (2007). Epigenetic landscape required for placental development. Cell. and Mol. Life Sciences, 64: 2422-2436.
  18. Hemberger M. and Dean W. (2007). Epigenetic arbitration of cell fate decisions: Tipping the bias. Dev. Cell, 12: 176-178.
  19. OJ How, TS Larsen, AD Hafstad, A Khalid, ES Myhre, AJ Murray, NT Boardman, M Cole, K Clarke, DL Severson, E Aasum. Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice.Arch Physiol Biochem 113:211-20, 2007.
  20. Jauniaux, E. and Burton, G.J. (2007) Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit. Early Human Development, 83, 699-706.
  21. Jauniaux, E., Johns, J., Gulbis, B., Spasic-Boskovic, O. and Burton, G.J. (2007) Transfer of folic acid inside the first trimester gestational sac and the effect of maternal smoking. American Journal of Obstetrics and Gynecology, 197, 58.e1-6.
  22. Jauniaux, E., van Oppenraaij, R.H.F. and Burton, G.J. (2010) Obstetric outcome after early placental complications. Current Opinion in Obstetrics and Gynecology, 22, 452-457.
  23. Jones, C.J., Aplin, J. D. and Burton, G.J. (2010) First trimester histiotrophe shows altered sialylation compared with secretory phase glycoconjugates in human endometrium. Placenta, 31, 576-580.
  24. Moffett A, Hiby SE. (2007) How Does the Maternal Immune System Contribute to the Development of Pre-eclampsia? Placenta 28 Supplement A S51-S56
  25. AJ Murray, LM Edwards, K Clarke. Mitochondria in heart failure. Curr Opin Clin Nutr Metab Care 10: 704-711, 2007.
  26. Perea-Gomez A, Meilhac SM, Piotrowska-Nitsche K, Gray D, Collignon J, Zernicka-Goetz M (2007.) Regionalisation of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder. BMC Dev Biol. 16, 7(1), 96.
  27. K Petersen and M.H. Johnson: SmARTest regulation? Comparing the regulatory structures for ARTs in the UK and Australia. (2007)Reproductive BioMedicine 15, 236-244.
  28. Roberts CT, Owens JA, Sferruzzi-Perri AN (2007) Distinct actions of insulin-like growth factors (IGFs) on placental development and fetal growth. Placenta 29 Suppl A:S42-7.
  29. Schlabritz-Loutsevitch, N., Ballesteros, B., Dudley, C., Jenkins, S., Hubbard, G., Burton, G.J. and Nathanielsz, P. (2007) Moderate maternal nutrient restriction, but not glucocorticoid administration, leads to placental morphological changes in the baboon (Papio sp.). Placenta 28, 783-793.
  30. Sengupta, J., Lalitkumar, P. G., Najwa, A. R., Charnock-Jones, D. S., Evans, A. L., Sharkey, A. M., Smith, S. K. and Ghosh, D. (2007) Immunoneutralization of vascular endothelial growth factor inhibits pregnancy establishment in the rhesus monkey (Macaca mulatta). Reproduction, 133, 1199-1211.
  31. Smith GCS, Crossley JA, Aitken DA, Jenkins N, Lyall F, Cameron AD, Connor JM, Dobbie R Circulating angiogenic factors in early pregnancy and the risk of pre-eclampsia, intra-uterine growth restriction, spontaneous preterm birth and stillbirth. Obstetrics & Gynecology 2007;109:1316-24.
  32. Smith GCS, Fleming K, White IR. Birth order of twins and the risk of delivery-related perinatal death in England, Northern Ireland and Wales, 1994-2003. BMJ2007;334:576
  33. Smith GCS, Fretts R. Seminar: Stillbirth. Lancet 2007;370: 1715-25.
  34. Smith GCS, Shah I, Pell JP, Crossley JA, Dobbie R. Maternal obesity and the risk of spontaneous and elective preterm birth: a retrospective cohort study. American Journal of Public Health 2007;97:157-162.
  35. Smith GCS, Shah I, White I, Pell JP, Crossley JA, Dobbie R. Maternal and biochemical predictors of antepartum stillbirth among nulliparous women in relation to gestational age of fetal death. BJOG 2007;114:705-714.
  36. Smith GCS, Shah I, White IR, Pell JP, Dobbie R. Previous pre-eclampsia, preterm delivery and delivery of a small for gestational age infant and the risk of unexplained stillbirth in the second pregnancy: a retrospective cohort study. American Journal of Epidemiology 2007;165:194-202.
  37. Smith GCS, Yu CKH, Papageorghiou AT, Cacho AM, Nicolaides KM, for the Fetal Medicine Foundation Second Trimester Screening Group Maternal uterine artery Doppler flow velocimetry and the risk of stillbirth. Obstetrics & Gynecology 2007;109:144-151.
  38. Surani M.A., Hayashi K., Hajkova P. (2007) Genetic and Epigenetic Regulators of Pluripotency. Cell 128, 747-762
  39. Surani, M. A. (2007). Germ cells: The eternal link between generations. The Pontifical Academy of Sciences, Vatican City
  40. Tang F., Kaneda M., O'Carroll D., Hajkova P., Barton S.C., Sun Y.A., Lee C., Tarakhovsky A., Lao K., Surani M.A. (2007) Maternal microRNAs are essential for mouse Zygotic development. Genes Dev. 21, 644-648
  41. Torres-Padilla ME, Parfitt DE, Kouzarides T and Zernicka-Goetz M (2007). Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 445, 214-218.
  42. Torres-Padilla ME, Richardson L, Kolasinska P, Meilhac SM, Luetke-Eversloh MV, Zernicka-Goetz M (2007). The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation. Dev Biol 309, 97-11.
  43. Yung, H. W., Korolchuk, S., Tolkovsky, A. M., Charnock-Jones, D. S. and Burton, G. J. (2007) Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells. Faseb J, 21, 872-884.



  1. Angiolini, E., Fowden, A., Coan, P., Sandovici, I., Ferguson-Smith, A., Smith, P., Dean, W., Burton, G., Tycko, B., Reik, W., Sibley, C.  and M Constância, M. (2006) Regulation of placental efficiency for nutrient transport by imprinted genes. Placenta, 27 Suppl A, S98-S102.
  2. Bell, S.E., Sanchez, M.J.,  Spasic-Boskovic, O., Santalucia, T., Burton, G.J., Murphy, J.J., Norton, J.D., Clark, A.R.  and Turner, M. (2006) The RNA binding proteinZfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Developmental Dynamics, 235, 3144-3155.
  3. E.A. Campbell, L. O'Hara, R.D. Catalano, A.M. Sharkey, T.C. Freeman and M.H. Johnson: Temporal expression profiling of the uterine luminal epithelium of the pseudo-pregnant mouse suggests receptivity to the fertilised egg is associated with complex transcriptional changes. Human Reproduction 21, 2495-2513.
  4. Coan, P.M., Conroy, N., Burton, G.J. and Ferguson-Smith, A.C. (2006) Origin and characteristics of glycogen cells in the developing murine placenta. Developmental Dynamics, 235, 3280-3294.
  5. H. Dolatshad, E.A. Campbell, L. O'Hara, E.S. Maywood, M.H. Hastings and M.H. Johnson: Developmental and reproductive performance in circadian mutant mice. Human Reproduction 21, 68-79.
  6. Hung, T-H. and Burton, G.J. (2006) Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwanese Journal of Obstetrics and Gynecology, 45, 189-200.
  7. Huppertz, B. Burton G., Cross, J.C. and Kingdom, J.C.P. (2006) Placental morphology: From molecule to mother – A dedication to Peter Kaufmann. Placenta, 27 Suppl A, S3-S8.
  8. Jauniaux, E. and Burton, G.J. (2006) Villous histomorphometry and placental bed biopsy investigation in Type I diabetic pregnancies. Placenta, 27, 468-474.
  9. Jauniaux, E., Poston, L and Burton G.J. (2006) Placental-related diseases of pregnancy, human evolution and oxygen. Human Reproduction Update, 12, 747-755.
  10. Johns, J. Jauniaux, E. and Burton, G.J. (2006) Factors affecting the early embryonic environment. Reviews in Gynaecological and Perinatal Practice, 6, 199-210.
  11. M.H. Johnson: Escaping the tyranny of the embryo? A new approach to ART regulation based on UK and Australian experiences. Human Reproduction 21, 2756-2765.
  12. M.H. Johnson: Defining the human embryo: A way with words? BioNews (July, 2006) 366.
  13. M.H. Johnson: Regulating the Science and Therapeutic Application of Human Embryo Research: Managing the Tension Between Biomedical Creativity and Public Concern. Chap. 10 in: Freedom and Responsibility in Reproductive Choice. Editors A.L. Pedain and J.R. Spencer. Hart Publishing, Oxford and Portland, pp.91-106.
  14. Raijmakers, M.T.M., Burton, G.J., Jauniaux, E., Seed, P.T., Peters, W.H.M., Steegers, E.A.P. and Poston, L. (2006) Placental NAD(P)H oxidase mediated superoxide generation in early pregnancy. Placenta, 27, 158-163.
  15. L. Selwood and M.H. Johnson: Trophoblast and hypoblast in the monotreme, marsupial and eutherian mammal: evolution and origins. BioEssays 28, 128-145.
  16. Tjoa, M.L., Cindrova-Davies, T., Spasic-Boskovic, O., Bianchi, D.W. and Burton, G.J. (2006) Trophoblastic oxidative stress and the release of cell-free feto-placental DNA. American Journal of Pathology, 169, 400-404.
  17. Varanou, A., Withington, S.L., Lakasing, L., Williamson, C., Burton, G.J. and Hemberger, M. (2006) The importance of cysteine cathepsin proteases for placental development. Journal of Molecular Medicine, 84, 305-317. (Featured by Editorial)
  18. Zusterzeel, P.L.M., Peters, W.H.M., Burton, G.J., Visser, W., Roelofs, H.M.J. and Steegers, E.A.P. (2006) Multiple genetic polymorphisms in maternal biotransformation enzymes and susceptibility to preeclampsia. Gynecologic and Obstetric Investigation, 63, 209-213.



  1. Smith GCS, Wood A, Pell JP, Dobbie R. Sudden infant death syndrome and complications in other pregnancies. Lancet 2005;366:2107-2111.

Book Chapters

  1. Burton, G.J., Charnock-Jones, D.S and Jauniaux, E. (2006) Working with oxygen and oxidative stress in vitro. In: Placenta and Trophoblast: Methods and Protocols, Vol. II (eds. M.J. Soares and J.S. Hunt), pp 413-425. Methods in Molecular Medicine Series, Vol. 122. Humana Press Inc., Totowa, NJ.
  2. G. Burton, E. Jauniaux, 2009 Early placental development and pregnancy outcome In: Textbook of Periconceptional Medicine (eds. N.S. Macklon, I.A. Greer & E.A.P. Steegers) (ISBN 978-0-203-09220-0).
  3. Burton, G.J. and Jauniaux, E. (2006) Trophoblast and the first trimester environment. In: Biology and Pathology of the Trophoblast (eds. A. Moffett, C. Loke and A. McClaren), pp 111-131. Cambridge University Press, Cambridge.
  4. Burton, G.J. and Jauniaux, E. (2010) The maternal circulation and placental shape: villus remodelling induced through haemodynamics and oxidative and endoplasmic reticulum stress In: The Placenta and Human Developmental Programming (eds. G.J. Burton, D.J.P. Barker, A. Moffett and K. Thornburg), 161-171. Cambridge University Press.
  5. Burton, G.J., Hung, T-H. and Jauniaux, E. (2007) Placental hypoxia, hyperoxia and ischaemia-reperfusion injury in pre-eclampsia In: Pre-eclampsia – Etiology and Clinical Practice (eds. F. Lyall and M. Belfort), 138-151. Cambridge University Press, Cambridge.
  6. Burton, G.J., Kaufmann, P. and Huppertz, B. (2006) Anatomy and Genesis of the Placenta. In: Knobil and Neill’s Physiology of Reproduction (ed. J.D. Neill). 3rd Edition, 189-243. Academic Press, Amsterdam.
  7. Graham Burton, Colin Sibley and Eric Jauniaux (2007). Placental Anatomy and Physiology (Chapter 1) In: Obstetrics: Normal and Problem Pregnancies (Steven G. Gabbe, Jennifer R. Niebyl, Joe Leigh Simpson) (ISBN 978-0-443-06930-7, Churchill Livingstone Elsevier, Nov 08).
  8. Anne Croy, Jianhong Zhang, Chandrakant Tayade, Francesco Colucci, Hakim Yadi, and Aureo T. Yamada 2009. Analysis of Uterine Natural Killer Cells in Mice In: Natural Killer Cell Protocols: Cellular and Molecular Methods. Methods in Molecular Biology Series, Humana Press. Kerry Campbell and Marco Colonna, Editors.
  9. Jauniaux E, Burton GJ. In: Pijnenborg R, Brosens I, Romero R editor. (2009) Oxygen delivery at the deciduo-placental interfacePlacental Bed Vascular Failure: Basic Science & Clinical Management. Cambridge: Cambridge University Press; pp. in press.
  10. Jauniaux, E. and Burton, G.J. (2008) Placental circulations In: Fetal Cardiology: Embryology, Genetics, Physiology, Echocardiographic Evaluation, Diagnosis and Perinatal Management of Cardiac Diseases (eds. S Yagel, U. Gembruch and N.H. Silverman), 41-56. Informa Healthcare, London.
  11. Jauniaux, E. and Burton, G.J. (2010) Maternofetal transport pathways during embryogenesis and organogenesis In: The Placenta and Human Developmental Programming (eds. G.J. Burton, D.J.P. Barker, A. Moffett and K. Thornburg), 47-54. Cambridge University Press.
  12. M.H. Johnson and K, Petersen. Instruments for ART regulation: what are the most appropriate mechanisms for achieving smart regulation? In: Regulating Autonomy: Sex, Reproduction and Fertility. Edited by F Ebtehaj, E Jackson, M Richards & S Day Sclater, Hart Publishing, Oxford and Portland, in press.
  13. M. Richards and M.H. Johnson. Introduction: Death writes In: Death Rites and Rights. Editors B. Brooks-Gordon, F. Ebtehaj, J Herring, M.H. Johnson and M Richards. Hart Publishing, Oxford and Portland, pp.1-10.
  14. Saudemont A, Burke S, Colucci F. A simple method to measure NK cell cytotoxicity in vivo In: Methods Mol Biol. 2010;612:325-34.


  1. The Placenta and Human Developmental Programming (Cambridge University Press, ISBN 987-0-521-19945-2) Graham Burton, David Barker, Ashley Moffett, Kent Thornburg (Editors).
  2. Comparative Placentation (Springer-Verlag Berlin Heidelberg, ISBN 978-3-540-78796-9) Peter Wooding, Graham Burton, Aug-08.