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Centre for Trophoblast Research


List by authors


Burton, Graham


Majali-Martinez, A., Velicky, P., Pollheimer, J., Knöfler, M., Yung, H.W., Burton, G.J., Tabrizi-Wizsy, N.G., Lang, U., Hiden, U., Desoye, G. and Dieber-Rotheneder, M. (2017). Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B: implications for trophoblast invasion and pre-eclampsia. Human Reproduction, 32, 46-54.


Burton, G.J., Yung, H.W. and Murray, A.J. (2017) Mitochondrial – endoplasmic reticulum interactions in the trophoblast; stress and senescence. Placenta, 52, 146-155.


Lu, L., Kingdom, J., Burton, G.J. and Cindrova-Davies, T. (2017) Placental stem villus arterial remodeling associated with reduced hydrogen sulfide synthesis contributes to human fetal growth restriction. American Journal of Pathology, 187, 908-920.


Burton, G.J., Yung, H.W. and Murray, A.J. (2017) Oxygen and placental development; parallels and differences with tumour biology. Placenta, 56, 14-18.


Kato, Y., Oyen, M.L. and Burton, G.J. (2017) Villous tree model with active contractions for estimating blood flow conditions in the human placenta. The Open Biomedical Engineering Journal, 11, 36-48.


Turco, M.Y., Gardner, L., Hughes, J., Cindrova-Davies, T., Gomez, M.J., Farrell, L., Hollinshead, M., Marsh, S.G.E., Brosens, J.J., Critchley, H.O., Simons, B.D., Hemberger, M., Koo, B-K., Moffett, A. and Burton, G.J. (2017) Long-term, hormone-responsive organoid cultures of human endometrium in a chemically-defined medium. Nature Cell Biology, 19, 568-577.


Turco, M.Y., Gardner, L., Koo, B-K., Moffett, A. and Burton, G.J. (2017) Derivation and long-term expansion of human endometrial and decidual organoids. Nature Protocol Exchange, doi:10.1038/protex.2017.030


Cindrova-Davies, T., Jauniaux, E., Elliot, M.G., Gong, S., Burton, G.J. and Charnock-Jones, D.S. (2017) RNA-Seq reveals conservation of function among the yolk sacs of human, mouse and chicken. Proceedings of National Academy of Sciences USA, 114(24):E4753-E4761.


Burton, G.J. and Jauniaux, E. (2017) The cytotrophoblastic shell and complications of pregnancy. Placenta, 60, 134-139.


Roberts, V.H.J., Morgan, T.K., Bednarek, P., Morita, M., Burton, G.J., Lo, J.O. and Frias, A.E. (2017) Early first trimester uteroplacental flow and the progressive disintegration of spiral artery plugs: new insights from contrast-enhanced ultrasound and tissue histopathology. Human Reproduction, 32, 2382-2393.


Burton, G.J. and Jauniaux, E.R.M. (2017) Hemochorial Development. In: Early Pregnancy (eds. R.G. Farquharson and M.D. Stephenson). 2nd Edition, 18-26. CUP, Cambridge.


Jauniaux, E., Bidhe, A. and Burton, G.J. (2017) Pathophysiology of accreta. In: Placenta Accreta Syndrome (ed. R. M. Silver), 13-28. CRC Press, Boca Raton, Florida.


Reijnders, I.F., Mulders, A.G.M.G.J., Koster, M.P.H., Koning, A.H.J., Frudiger, A., Willemsen, S.P., Jauniaux, E., Burton, G.J., Steegers-Theunissen, R.P.M. and Steegers, E.A.P. (2018) New imaging markers for preconceptional and first-trimester utero-placental vascularization. Placenta, 61, 96-102.


Jauniaux, E., Collins, S. and Burton, G.J. (2018) The placenta accreta spectrum: pathophysiology and evidence-based anatomy for prenatal ultrasound imaging. American Journal of Obstetrics and Gynecology, 218,75-87.


Burton, G.J. and Jauniaux, E. (2018) Pathophysiology of Placental-Derived Fetal Growth Restriction. American Journal of Obstetrics and Gynecology, 218(2S), S745-S761.


Burton, G.J. and Jauniaux, E. (2018) Development of the Human Placenta and Fetal Heart: Synergic or independent? Frontiers in Physiology, 9, 373.


Colledge, William (CTR member)


 d'Anglemont de Tassigny, X., Jayasena, C., Murphy, K.G., Dhillo, W.S. and Colledge, W.H. (2017). Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo. PLOS ONE.


 Derangeon, M., Montnach, J., Ore-Cerpa, C., Jagu, B., Patin, J., Toumaniantz, G., Girardeau, A., Huang, C.L.H., Colledge, W.H., Grace, A.A., Baró, I. and Charpentier F. (2017). Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease. Cardiovascular Research. 113(5):464-474.


 Clarkson, J., Hana, S.Y., Piet, R., McLennan, T., Kane, G.M., Ng, J., Porteous, R.W., Kim, J.S., Colledge, W.H., Iremonger, K.J. and Allan E. Herbison. (2017). Definition of the hypothalamic GnRH pulse generator in mice. Proc Natl Acad Sci doi: 10.1073/pnas.1713897114.


 Mendonça, P., Kyle, V., Yeo, S-H., Colledge, W.H. and Robinson, H. (2018). Kv4.2 channel activity controls intrinsic firing dynamics of arcuate kisspeptin neurons. J. Physiol. 596(5):885-899. doi: 10.1113/JP274474.


 Adekunbi, D.A., Li, X.F., Lass, G., Shetty, K., Adegoke, O.A., Yeo, S.H., Colledge, W.H., Lightman, S.L. and O'Byrne, K.T. (2018. Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice. (2018). J Neuroendocrinol. 30(3):e12572. doi: 10.1111/jne.12572.


 Hellier, V., Brock, O., Candlish, M., Desroziers, E., Aoki, M., Mayer, C., Piet, R., Herbison, A., Colledge, W.H., Prévot, V., Boehm, U. and Bakker, J. Female sexual behavior in mice is controlled by kisspeptin neurons. (2018) Nat Commun. 9(1):400. doi: 10.1038/s41467-017-02797-2.


Giussani, Dino (CTR member)


Itani, N., Skeffington, K.L., Beck, C. & Giussani, D.A. (2017). Sildenafil therapy for fetal cardiovascular dysfunction during hypoxic development:  Studies in the chick embryo.  The Journal of Physiology 595(5), 1563-1573.


McGillick, E.V., Orgeig, S., Allison, B.J., Brain, K.L., Niu, Y., Itani, N., Skeffington, K.L., Kane, A.D., Herrera, E.A., Giussani, D.A. & Morrison, J.L. (2017). Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation.  The Journal of Physiology 595(13), 4329-4350.


Lobmaier, S.M, Ortiz, J.U., Sewald, M., Muller, A., Schmidt, G., Haller, B., Obedrhoffer, R., Scheider, K.T., Giussani, D.A. & Wacker-Gussmann, A. (2017). Influence of gestational diabetes on the fetal autonomic nervous system: A study using phase-rectified signal averaging analysis. Ultrasound in Obstetrics and Gynecology. doi: 10.1002/uog.18823. In Press.


Mohammed, R., Salinas, C.E., Giussani, D.A., Blanco, C.E., Cogolludo, A.L. & Villamor, E. (2017).  Acute hypoxia-reoxygenation and vascular oxygen sensing in the chicken embryo. Physiol Rep. 5(22).pii, e13501.


McGillick, E.V., Orgeig, S., Giussani, D.A. & Morrison, J.L. (2017). Chronic hypoxaemia as a molecular regulator of fetal lung development: implications for risk of respiratory complications at birth. Paediatr Respir Rev. 21, 3-10.


Botting, K.L. & Giussani, D.A. (2017).  At the heart of accelerated old matter. The Journal of Physiology 595(4), 1009-1010.


Itani, N., Salinas, C.E., Villena, M., Skeffington, K.L., Beck, C., Villamor, E., Blanco, C.E. & Giussani, D.A. (2017). The highs and lows of programmed heart disease by isolated developmental hypoxia: Studies in the chick embryo. The Journal of Physiology. doi: 10.1113/JP274111. In Press.


Reyes, R.V., Díaz, M., Ebensperger, G., Herrera, E.A., Quezada, S.A., Hernandez, I., Sanhueza, E.M., Parer, J.T., Giussani, D.A. & Llanos, A.J (2018). The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas. The Journal of Physiology. doi: 10.1113/JP274340. [Epub ahead of print].


Shaw CJ, Allison BJ, Itani N, Botting KJ, Niu Y, Lees CC, Giussani DA (2018). Altered autonomic control of heart rate variability in the chronically hypoxic fetus. J Physiol. 2018 Mar 31. doi: 10.1113/JP275659. [Epub ahead of print].


Loche E, Blackmore HL, Carpenter AAM, Beeson JH, Pinnock A, Ashmore TJ, Aiken CE, de Almeida-Faria J, Schoonejans J, Giussani DA, Fernandez-Twinn DS, Ozanne SE (2018). Maternal Diet-Induced Obesity Programmes Cardiac Dysfunction in Male Mice Independently of Post-Weaning Diet. Cardiovasc Res. 2018 Apr 4. doi: 10.1093/cvr/cvy082. [Epub ahead of print].


Skeffington KL, Beck C, Itani N, Giussani DA (2018). Isolating the direct effects of adverse developmental conditions on in vivo cardiovascular function at adulthood: the avian model. J Dev Orig Health Dis. 2018 Apr 25:1-7. doi: 10.1017/S2040174418000247. [Epub ahead of print]


 Hamilton, Russell (CTR Bioinformatician)


Ong, C-K & Hamilton, R.S.* (2018) Constructing Computational Pipelines, Encyclopedia of Bioinformatics and Computational Biology, In Reference Module in Life Sciences, Elsevier, ISBN 9780128096338,


Prater, M. & Hamilton, R.S.* (2018) Epigenetics: Analysis of Cytosine Modifications at Single Base Resolution, Encyclopedia of Bioinformatics and Computational Biology, In Reference Module in Life Sciences, Elsevier, 2018, ISBN 9780128096338,


Taylor, W.R. & Hamilton, R.S. (2017) Exploring RNA conformational space under sparse distance restraints. Scientific Reports, 7, 44074


Hanna, Courtney (CTR New Generation Research Fellow started June 2018)


Del Gobbo GF, Price EM, Hanna CW, Robinson WP (2018). No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation. Clinical Epigenetics, 10(34):1-16.


Hanna CW, Taudt A, Huang J, Gahurova L, Kranz A, Andrews S, Dean W, Stewart AF, Colomé-Tatché M, Kelsey G (2018). MLL2 conveys transcription-independent H3K4 trimethylation in the oocyte. Nature Structural and Molecular Biology, 25(1):73-82.


Hanna CW, Kelsey G (2017). Genomic imprinting beyond DNA methylation: a role for maternal histones. Genome Biology, 18:177.


Kelsey, Gavin (Babraham Institute, CTR member)


Brici, D., Zhang, Q., Reinhardt, S., Dahl, A., Hartmann, H., Schmidt, K., Goveas, N., Huang, J., Gahurova, L.., Kelsey, G., Anastassiadis, K., Stewart, A. F. and Kranz, A. (2017) Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program. Development 144:2606-2617.


 Fonseca-Balvís, N., Garcia-Martinez, S., Ivanova, E., Gomez-Redondo, I., Hamdi, M., Rizos, D., Coy, P., Kelsey, G. and Gutierrez-Adan, A. (2017) Cultured bovine embryo biopsy conserves methylation marks from original embryo. Biology of Reproduction 97:189-196.


 Hanna, C. W., Taudt, A., Huang, J., Gahurova, L., Kranz, A., Andrews, S., Dean, W., Stewart, A. F., Colomé-Tatché, M., Kelsey, G. (2018) MLL2 conveys transcription-independent H3K4me3 in the oocyte. Nature Structural and Molecular Biology 25:73-82.


 Clark, S. J., Argelaguet, R., Kapourani, C.-A., Stubbs, T. M., Lee, H. J., Alda, C., Krueger, F., Sanguinetti, G., Kelsey, G., Marioni, J. C., Stegle, O. and Reik, W. (2018) Joint profiling of chromatin accessibility, DNA methylation and transcription in single cells. Nature Communications 9:781.


 Canovas, S., Ross, P. J., Kelsey, G. and Coy P. (2017) DNA methylation in embryo development: Epigenetic impact of ART (Assisted Reproductive Technologies). BioEssays doi: 10.1002/bies.201700106.


 Kelsey, G., Stegle, O. and Reik, W. (2017) Single-cell epigenomics: recording the past and predicting the future. Science 358:69-75.


Hanna, C. W. and Kelsey, G. (2017) “Research highlight”: Genomic imprinting beyond DNA methylation: a role for maternal histones. Genome Biology 18:177


Rugg-Gunn, Peter (CTR Associate Babraham Institute)


 Collier AJ, Rugg-Gunn PJ. Identifying Human Naïve Pluripotent Stem Cells -Evaluating State-Specific Reporter Lines and Cell-Surface Markers. Bioessays.2018 40(5):e1700239. doi: 10.1002/bies.201700239. PubMed PMID: 29574793.


Novo CL, Javierre BM, Cairns J, Segonds-Pichon A, Wingett SW, Freire-PritchettP, Furlan-Magaril M, Schoenfelder S, Fraser P, Rugg-Gunn PJ. Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition. Cell Rep. 2018 22(10):2615-2627. doi:10.1016/j.celrep.2018.02.040. PubMed PMID: 29514091.


 Lupo G, Nisi PS, Esteve P, Paul YL, Novo CL, Sidders B, Khan MA, Biagioni S,Liu HK, Bovolenta P, Cacci E, Rugg-Gunn PJ. Molecular profiling of aged neuralprogenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline. Aging Cell. 2018 doi: 10.1111/acel.12745. PubMed PMID: 29504228.


Rugg-Gunn PJ. Naive pluripotent stem cells as a model for studying humandevelopmental epigenomics: opportunities and limitations. Epigenomics. 2017 9(12):1485-1488. doi: 10.2217/epi-2017-0115. PubMed PMID: 29106295.


Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN. Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports. 2017 11;9(1):1-4. doi: 10.1016/j.stemcr.2017.05.029. PubMed PMID: 28700896.


Hassan-Zadeh V, Rugg-Gunn P, Bazett-Jones DP. DNA methylation is dispensable for changes in global chromatin architecture but required for chromocentre formation in early stem cell differentiation. Chromosoma. 2017126(5):605-614. doi: 10.1007/s00412-017-0625-x. PubMed PMID: 28084535.


Santos, Fatima (CTR member, Babraham Institute)

Berrens RV, Andrews S, Spensberger D, Santos F, Dean W, Gould P, Sharif J, Olova N, Chandra T, Koseki H, von Meyenn F, Reik W. An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells. Cell Stem Cell. 2017 Nov 2; 21 (5):694-703.e7. doi: 10.1016/j.stem.2017.10.004.


Sferruzi-Perri, Amanda (CTR member)


Camm EJ, Botting KJ, Sferruzzi-Perri AN Near to one’s heart: the intimate relationship between the placenta and fetal heart. Invited Review. Frontiers in Physiology. In Press


Sferruzzi-Perri AN (2018) Balancing needs; Exploring the role of IGF2 signalling in materno-fetal resource allocation. Invited Review. Placenta. 64 Suppl 1:S16-S22.


Sferruzzi-Perri AN Assessment of placental transport function in studies of disease programming (2018). Invited Review. Methods in Molecular Biology 1735:239-250


Decato BE, Lopez-Tello J, Sferruzzi-Perri AN, Smith AD, Dean MD (2017) DNA methylation divergence and tissue specialization in the developing mouse placenta. Molecular Biology and Evolution 34:1702-1712.


Musial B, Vaughan OR, Ozanne SE, Fowden AL, Sferruzzi-Perri AN (2017) A Western-style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice. Journal of Physiology 595:4875-4892.


Sferuzzi-Perri AN, Sandovici I, Constancia M, Fowden AL (2017) Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. Journal of Physiology 595:5057-5093.


Fernandez-Twinn D, Gascoin G, Musial B, Carr S, Duque-Guimaraes D, Blackmore H, Zahra M Alfaradhi, Loche E, Ferland-McCollough D, Bushell M, Sferuzzi-Perri AN, Fowden AL, Ozanne SE (2017) Exercise rescues obese mothers' insulin sensitivity, placental function and her offsprings' insulin sensitivity. Scientific Reports 14;7:44650.


Smith, Gordon (CTR Manager)


Pritchard N, Kaitu'u-Lino T, Gong S, Dopierala J, Smith GCS, Charnock-Jones DS, Tong S. ELABELA levels are not decreased in the maternal circulation or placenta among women with preeclampsia. American Journal of Pathology 2018 In press.


Gaccioli F, Sovio U, Cook E, Hund M, Charnock-Jones DS, Smith GCS. Screening for fetal growth restriction using ultrasound and the sFLT1:PlGF ratio in a prospective cohort study of nulliparous women. The Lancet Child and Adolescent Health 2018, In press


Gong S, Johnson MD, Dopierala J, Gaccioli F, Sovio U, Constância M, Smith GCS, Charnock-Jones DS. Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placenta. Epigenetics 2018 Feb 21:1-12. doi: 10.1080/15592294.2018.1429857. [Epub ahead of print].


Reinebrant HE, Leisher SH, Coory M, Henry S, Wojcieszek AM, Gardener G, Lourie R, Ellwood D, Teoh Z, Allanson E, Blencowe H, Draper ES, Erwich JJ, Frøen JF, Gardosi J, Gold K, Gordijn S, Gordon A, Heazell A, Khong TY, Korteweg F, Lawn JE, McClure EM, Oats J, Pattinson R, Pettersson K, Siassakos D, Silver RM, Smith GCS, Tunçalp Ö, Flenady V. Making stillbirths visible: a systematic review of globally reported causes of stillbirth. BJOG 2018;125:212-224.


Aye ILM, Moraitis AM, Stanislaus, Charnock-Jones DS, Smith GCS. Retosiban prevents stretch-induced human myometrial contractility and delays labor in Cynomolgus monkeys. Journal of Clinical Endocrinology & Metabolism 2017 Dec 26. doi: 10.1210/jc.2017-02195. [Epub ahead of print].


Sovio U, Smith GCS. The effect of customization and use of a fetal growth standard on the association between birth weight percentile and adverse perinatal outcome. American Journal of Obstetrics & Gynaecology 2017 Dec 1. doi: 10.1016/j.ajog.2017.11.563. [Epub ahead of print]


Salvatari N, Gordijn SJ, Sovio U, Zill-E-Huma R, Gebril A, Charnock-Jones DS, Scherjon SA,  Smith GCS. Birth weight to placenta weight ratio and its relationship to ultrasonic measurements, maternal and neonatal morbidity: a prospective cohort study of nulliparous women. Placenta 2018;63:45-52.


Chong HP, Froen F, Richardson S, Liquet B, Charnock-Jones DS, Smith GCS.  Age at menarche and the risk of operative delivery. Journal of Maternal-Fetal & Neonatal Medicine 2017. Sep 28:1-8. doi:

10.1080/14767058.2017.1381823. [Epub ahead of print]


Knight HW, Cromwell DA, Gurol-Urganci I, Harron K, van der Meulen JH, Smith GCS, Perinatal mortality associated with induction of labour versus expectant management in nulliparous women aged 35 years or over: a national cohort study. PLoS Medicine 2017;14: e1002425.


Smith GCS. Universal screening for fetal growth restriction. Best Practice & Research Clinical Obstetrics & Gynaecology 2018, In press.


Gaccioli F, Charnock-Jones DS, Smith GCS. Screening for Fetal Growth Restriction using Fetal Biometry Combined with Maternal Biomarkers. American Journal of Obstetrics and Gynecology. 2017 Dec 22. doi: 10.1016/j.ajog.2017.12.002. [Epub ahead of print]


Smith GCS. Commentary: The STRIDER trial: one step forwards, one step back. Lancet Child & Adolescent Health 2018;2:80-81


Smith GCS. Commentary: Should we implement universal screening with late pregnancy ultrasound to prevent stillbirth? BJOG 2017. Jun 12. doi: 10.1111/1471-0528.14782. [Epub ahead of print].


Smith GCS, Rowitch D, Mol BW. The role of prenatal steroids at 34-36 weeks of gestation. Archives of Diseases of Childhood 2017;102:F284-F285.


Gacciolo F, Lager S, Sovio U, Charnock-Jones DS, Smith GCS. The Pregnancy Outcome Prediction (POP) study: investigating the relationship between serial prenatal ultrasonography, biomarkers, placental phenotype and adverse pregnancy outcome. Placenta 2017, 59, Supplement 1, Trophoblast Research, Vol. 31, S17-S25


Smith GCS. Screening and prevention of stillbirth. Best Practice & Research Clinical Obstetrics & Gynecology 2017; 38:71-82


Sovio, Ulla (Dept of Obstetrics and Gynaecology, CTR member)


Gong S, Johnson MD, Dopierala J, Gaccioli F, Sovio U, Constancia M, Smith GCS, Charnock-Jones DS. Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placenta. Epigenetics 2018 (Epub ahead of print:


Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS. Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers. Am J Obstet Gynecol. 2018;218(2);S725-S737.


Sovio U, Smith GCS. The effect of customization and use of a fetal growth standard on the association between birthweight percentile and adverse perinatal outcome. Am J Obstet Gynecol. 2018;218(2);S738-S744.


Salavati N, Gordijn SJ, Sovio U, Zill-E-Huma R, Gebril A, Charnock-Jones DS, Scherjon SA, Smith GCS. Birth weight to placenta weight ratio and its relationship to ultrasonic measurements, maternal and neonatal morbidity: A prospective cohort study of nulliparous women. Placenta. 2018;63:45-52.


Sovio U, Smith GCS. Blinded ultrasonic fetal biometry at 36 weeks and the risk of emergency caesarean delivery: a prospective cohort study of 3,047 low risk nulliparous women. Ultrasound Obstet Gynecol. 2017 (Epub ahead of print:


Sovio U, Moraitis AA, Wong HS, Smith GCS. Universal versus selective ultrasonography to screen for large for gestational age infants and associated morbidity. Ultrasound Obstet Gynecol. 2017 (Epub ahead of print:


Gaccioli F, Lager S, Sovio U, Charnock-Jones DS, Smith GCS. The pregnancy outcome prediction (POP) study: Investigating the relationship between serial prenatal ultrasonography, biomarkers, placental phenotype and adverse pregnancy outcomes. Placenta 2017;59(Suppl 1):S17-S25.


Tunster, Simon (CTR New Generation Research Fellow)


Genetic sex determination of mice by simplex PCR. Biology of Sex Differences. 8:31 (2017) 


Chloe Duval, Mark R. Dilworth, Simon J. Tunster, Susan J. Kimber and Jocelyn D. Glazier. PTHrP is essential for normal morphogenetic and functional development of the murine placenta. Dev Biol 430(2) (2017) 325-336. (work conducted in Cardiff)


Watson, Erica (CTR manager)


Blake GET, Rakoczy J, and Watson ED. (2018) Epigenetics of transgenerational inheritance of disease in Epigenetics in Human Disease, 2nd Ed. Tollefsbol T. (in press)


Padmanabhan N, Rakoczy J, Kondratowicz M, Menelaou K, Blake GET, and Watson ED. (2017) Multigenerational analysis of sex-specific phenotypic differences at midgestation caused by abnormal folate metabolism. Environmental Epigenetics 3(4): 1-17.


Rakoczy J, Padmanabhan N, Krzak AM, Kieckbusch J, Cindrova-Davies T, and Watson ED. (2017) Dynamic expression of TET1, TET2, and TET3 dioxygenases in mouse and human placentas throughout gestation. Placenta 59: 46-56.


Zernicka-Goetz, Magdalena (CTR member)


 Shahbazi MN, Scialdone A, Skorupska N, Weberling A, Recher G, Zhu M, Jedrusik A, Devito LG, Noli L, Macaulay IC, Buecker C, Khalaf Y, Ilic D, Voet T, Marioni JC, Zernicka-Goetz M. (2017). Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature 14;552(7684):239-243.  PMID: 29186120


Strauss B, Harrison A, Coelho PA, Yata K, Zernicka-Goetz M, Pines J. (2018). Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis. J Cell Biol. 2018 Jan 2;217(1):179-193. doi: 10.1083/jcb.201612147. PMID: 29074707


Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, Vlahov N, Grawenda A, Haider S, Chauhan J, Buti L, Kanapin A, Lu X, Buffa F, Dianov G, von Kriegsheim A, Matallanas D, Samsonova A, Zernicka-Goetz M, O'Neill E (2018). RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Nature Commun. Jan 30;9(1):424. doi: 10.1038/s41467-017-02786-5. PMID: 2938281


Harrison SE, Sozen B, Christodoulou N, Kyprianou C and Zernicka-Goetz M (2017). Assembly of embryonic and extra-embryonic stem cells to mimic embryogenesis in vitro. Science. Mar 2. pii: eaal1810. doi: 10.1126/science.aal1810. 


Zhu M, Leung CY, Shahbazi MN and Zernicka-Goetz M. (2017). Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo. Nature Commun. Oct 13;8(1):921. doi: 10.1038/s41467-017-00977-8. PMID:29030553  


Bury L, Coelho PA, Simeone A, Ferries S, Eyers CE, Eyers PA, Zernicka-Goetz M and Glover DM (2017). Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes. J Cell Biol. Sep 28. pii: jcb.201606077. doi: 10.1083/jcb.201606077. PMID: 28972102 


Ajduk A, Strauss B, Pines J and Zernicka-Goetz M. (2017). Delayed APC/C activation extends the first mitosis of mouse embryos. Sci Rep. Aug 29;7(1):9682. doi: 10.1038/s41598-017-09526-1. PMID:28851945