2019-2020 Publications

2019-2020 Publications

Nick Burton, NGF

Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection.  Nature Communications,  April 2020 10.1038/s41467-020-15555-8

Courtney Hanna, NGF

Hanna CW (2020). Placental imprinting: Emerging mechanisms and functions. PLoS Genetics; 16(4): e1008709.
Hemberger M, Hanna CW, Dean W (2020). Mechanisms of early placental development in mouse and humans. Nature Reviews Genetics; 21(1):27-43.
Argelaguet R, Clark SJ, Mohammed H, Stapel LC, Krueger C, Kapourani CA, Imaz-Rosshandler I, Lohoff T, Xiang Y, Hanna CW, Smallwood S, Ibarra-Soria X, Buettner F, Sanguinetti G, Xie W, Krueger F, Göttgens B, Rugg-Gunn PJ, Kelsey G, Dean W, Nichols J, Stegle O, Marioni JC, Reik W (2019). 
Multi-omics profiling of mouse gastrulation at single cell resolution. Nature, 576(7787):487-491.

Hanna CW*, Pérez-Palacios R, Gahurova L, Schubert M, Krueger F, Biggins L, Andrews S, Colomé-Tatché M, Bourc’his D, Dean W, Kelsey G* (2019). Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues. Genome Biology; 20(1):225. *Co-corresponding authors.

Vicente Perez Garcia, NGF

Woods L, Morgan N, Zhao X, Dean W, Perez-Garcia V, Hemberger M. Epigenetic changes occur at decidualisation genes as a function of reproductive ageing in mice. Development, Mar 17;147(6) (2020).

López-Tello J, Pérez-García V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernández de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN. Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice. Elife. Jun 26; 8 (2019). 

Claire Senner, NGF

Senner C. E., Chrysanthou S., Burge S,, Lin H-Y., Branco M. R., and Hemberger M. (2020) TET1 and 5-hydroxymethylation preserve the stem cell state of mouse trophoblast. Stem Cell Reports. May 2020 doi.org/10.1016/j.stemcr.2020.04.009

Irving Aye, NGF

(no publications)

Simon Tunster, NGF

Bethany R. L. Aykroyd, Simon J. Tunster and Amanda N. Sferruzzi-Perri, Igf2 deletion affects the endocrine capacity of the mouse placenta in a sexually dimorphic manner. J. Endocrinol. dx.doi.org/10.1530/JOE-20-0128

S. Tunster*, E. Watson, A. Fowden, G.J. Burton, Placental glycogen stores and fetal growth: insights from genetic mouse models, Reproduction 159(6) (2020) R213-235 (invited review; *corresponding author)

A.P. Sowton, N. Padmanabhan, S.J. Tunster, B.D. McNally, A. Murgia, A. Yusuf, J.L. Griffin, A.J. Murray, E.D. Watson, Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice, Molecular Genetics and Metabolism Reports 23 (2020)

K. Menelaou, M. Prater, S. Tunster, G. Blake, C. Geary Joo, J.C. Cross, R. Hamilton, E. Watson, Blastocyst transfer in mice alters the placental transcriptome and growth, Reproduction 159(2) (2020) 115-132.

G.A.G. Roberts and S. J. Tunster*, Characterising the dynamics of placental glycogen stores in the mouse. Under review at Placenta. (*corresponding author)

Graham Burton 

Plitman May, R., Abbas, Y., Charnock-Jones, D.S., Burton, G.J. and Marom, G. (2019) Three-dimensional morphological analysis of placental terminal villi. Interface Focus, 9, 20190037.

Burton, G.J., Redman, C.W., Roberts, J.M. and Moffett, A. (2019) Pre-eclampsia: pathophysiology and clinical implications. British Medical Journal, 366, l2381. 

Abbas, Y., Carnicer-Lombarte, A., Gardner, L., Thomas, J., Brosens, J.J., Moffett, A., Sharkey, A., Franze, K., Burton, G.J. and Oyen, M.L. (2019) Tissue stiffness at the human maternal-fetal interface. Human Reproduction, 4, 1999-2008.

Jauniaux, E. and Burton, G.J. (2019) From Etiopathology to Management of Accreta Placentation. Current Obstetrics and Gynecology Reports. Epub ahead of print.

Yung, H.W., Colleoni, F., Dommett, E., Cindrova-Davies, T.C., Kingdom, J., Murray, A.J. and Burton, G.J. (2019) Non-canonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset pre-eclampsia. Proceedings of National Academy of Sciences USA, 116, 18109-18118.
Abbas, Y., Brunel, L.G., Hollinshead, M.S., Fernando, R., Gardner, L., Duncan, I., Moffett, A., Best, S., Turco, M.Y., Burton, G.J. and Cameron, R.E. (2019) Generation of a three-dimensional collagen scaffold-based model of the human endometrium. Interface Focus, 10, 20190079.

Jauniaux, E., Hussein, A.H., Zosmer, N., Elbarmelgy, R.M., MD, Elbarmelgy, R.A., Shaikh, H. and Burton, G.J. (2020) A new methodologic approach for clinico-pathologic correlations in invasive placenta previa accreta. American Journal of Obstetrics and Gynecology, 222, 379.e1-11.

Jauniaux, E., Moffett, A. and Burton, G.J. (2020) Placental Implantation Disorders. Obstetrics and Gynecology Clinics of North America, 7, 117-132.

Lorenzon-Ojea, A.R., Yung, H.W., Burton, G.J. and Bevilacqua, E. (2020) The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866, 165386.

Burton, G.J., Cindrova-Davies, T. and Turco, M.Y. (2020) Histotrophic nutrition and the placental-endometrial dialogue during human early pregnancy. Placenta Epub ahead of print. https://doi.org/10.1016/j.placenta.2020.02.008

Tunster, S.J., Watson, E.D., Fowden, A.L. and Burton, G.J. (2020) Placental glycogen stores and fetal growth: insights from genetic mouse models. Reproduction, Epub ahead of print. PMID: 32191912.

Jauniaux, E., Bidhe, A. and Burton, G.J. (2020) The placenta. In: The Oxford Textbook of Obstetrics and Gynaecology (eds. S. Arulkurmaran, L. Denny, S. Doumouchtsis, and W. Ledger). Oxford University Press, Oxford.

Burton, G.J., Sibley, C.P. and Jauniaux, E. (2020) Placental anatomy and physiology. In: Obstetrics: Normal and Problem Pregnancies, 8th Edition (eds M.B. Landon, H.L. Galan, E.R.M. Jauniaux and D.A. Driscoll, V. Berghella, W.A. Grobman, S.J. Kilpatrick and A.G. Cahill). Elsevier, Amsterdam.

Yassen Abbas, Margherita Y Turco, Graham J Burton, Ashley Moffett (2020) Investigation of human trophoblast invasion in vitro. Human Reproduction Update, dmaa017, May 2020 doi.org/10.1093/humupd/dmaa017

Burton, G.J., Cindrova-Davies, T., Yung, H.W. and Jauniaux, E. (2020) Oxygen and human placental development. Reproduction, May 1:REP-20-0153.R1. doi: 10.1530/REP-20-0153. Online ahead of print.

Lorenzon, A.R., Moreli, J.B., de Macedo Melo, R., Namba, F.Y., Staff, A.C., Yung, H.W., Burton,G.J. and Bevilacqua, E. (2020) Stromal cell-derived Factor (SDF) 2 and the endoplasmic reticulum stress response of trophoblast cells in gestational diabetes mellitus and in vitro hyperglycaemic condition. Current Vascular Pharmacology, 2020 Jun 6. doi: 10.2174/1570161118666200606222123. Online ahead of print.

Steve Charnock Jones

Albrecht, C., Chamley, L., Charnock-Jones, D. S., Collins, S., Fujiwara, H., Golos, T., et al. (2019). IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery. Placenta, 1–0. doi.org/10.1016/j.placenta.2019.02.006

Jordan H. Cater, Janet R. Kumitac, Rafaa Zeineddine Abdallah, Guomao Zhao, Ana Bernardo-Gancedo, Amanda Henry, Wendy Winata, Mengna Chi, Brin S. F. Grenyer, Michelle L. Townsend, Marie Ranson, Catalin S. Buhimschi, D. Stephen Charnock-Jones, Christopher M. Dobson, Mark R. Wilson, Irina A. Buhimschi, and Amy R. Wyatt (2019). Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide. Proceedings of the National Academy of Sciences of the United States of America, 116(13), 201817298–6110. doi.org/10.1073/pnas.1817298116

Romina Plitman Mayo, Yassen Abbas, D. Stephen Charnock-Jones, Graham J. Burton and Gil Marom.  2019  Three-dimensional morphological analysis of placental terminal villi. (2019). Three-dimensional morphological analysis of placental terminal villi. Interface Focus, 9, 20190037–9. http://doi.org/10.1098/rsfs.2019.0037

Jayasuriya, N. A., Hughes, A. E., Sovio, U., Cook, E., Charnock-Jones, D. S., & Smith, G. C. S. (2019). A lower maternal cortisol to cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks. The Journal of Clinical Endocrinology and Metabolism. doi.org/10.1210/jc.2018-02312

Ulla Sovio, Nancy McBride, Angela M Wood, Katya L Masconi, Emma Cook, Francesca Gaccioli, D Stephen Charnock-Jones, Debbie A Lawlor and Gordon CS Smith (2019). 4-Hydroxyglutamate is a novel predictor of pre-eclampsia. International Journal of Epidemiology, 388, 1775. doi.org/10.1093/ije/dyz098

Hughes AE, Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Smith GCS. The association between first trimester AFP to PAPP-A ratio and placentally-related adverse pregnancy outcome.  Placenta. 2019 81:25–31 doi:10.1016/j.placenta.2019.04.005.

Lawera, Aleksandra, Zhen Tong, Midory Thorikay, Rachael E Redgrave, Jie Cai, Maarten van Dinther, Nicholas W Morrell, Gijs B. Afink, D. Stephen Charnock-Jones, Helen M. Arthur, Peter ten Dijke, and Wei Li.  Role of soluble endoglin in BMP9 signaling. P Natl Acad Sci USA. 2019 Sep 3;116(36):17800–8. doi:10.1073/pnas.1816661116

de Goffau, Marcus C, Susanne Lager, Ulla Sovio, Francesca Gaccioli, Emma Cook, Sharon J Peacock, Julian Parkhill, D Stephen Charnock-Jones*, and Gordon C S Smith*. Human Placenta Has No Microbiome but Can Contain Potential Pathogens Nature 572, no. 7769: 329–34. doi:10.1038/s41586-019-1451-5.

Ulla Sovio, Neil Goulding, Nancy McBride, Emma Cook, Francesca Gaccioli, D Stephen Charnock-Jones, Debbie A Lawlor and Gordon C S Smith. A maternal serum metabolite ratio predicts fetal growth restriction at term.  2020 Nature Medicine, 26(3), 348–353. doi.org/10.1038/s41591-020-0804-9

Furse, S., Fernandez-Twinn, D. S., Jenkins, B., Meek, C. L., Williams, H. E. L., Smith, G. C. S., et al. (2020). A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Analytical and Bioanalytical Chemistry, 91(15), 1–12. doi.org/10.1007/s00216-020-02511-0

Fetal inheritance of chromosomally integrated HHV-6 predisposes to preeclampsia in the mother.  Francesca Gaccioli, Susanne Lager, Marcus C de Goffau, Ulla Sovio, Justyna Dopierala, Sungsam Gong, Emma Cook, Andrew Sharkey, Ashley Moffett, Wai Kwong Lee, Christian Delles, Cristina Venturini, Judith Breuer, Julian Parkhill, Sharon J Peacock, D Stephen Charnock-Jones* and Gordon CS Smith*. 2020 Nature Microbiology, In Press
*Joint senior author
Francesco Colucci

Microbes, immunity and cancer in Capri: Another successful course of the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology founded by Serafino Zappacosta.
Colucci F, Carbone E. Eur J Immunol. 2019 Dec;49(12):2123-2126. doi: 10.1002/eji.201970125. No abstract available. PMID: 31814128

The immunological code of pregnancy.Colucci F. Science. 2019 Aug 30;365(6456):862-863. doi: 10.1126/science.aaw1300. No abstract available. PMID: 31467207

Placentation and antitumor immunity regulated by a scaffolding protein in NK cells.
Colucci F. Sci Immunol. 2019 Aug 2;4(38). pii: eaax9589. doi: 10.1126/sciimmunol.aax9589. Review.
PMID: 31375527

Sharing Knowledge With Young and Established Students of Immunology by the Neapolitan Gulf at the Ruggero Ceppellini Advanced School.
Colucci F. Front Immunol. 2020 Jan 28;11:43. doi: 10.3389/fimmu.2020.00043. eCollection 2020. No abstract available. PMID: 32047501 

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.Huhn O, Ivarsson MA, Gardner L, Hollinshead M, Stinchcombe JC, Chen P, Shreeve N, Chazara O, Farrell LE, Theorell J, Ghadially H, Parham P, Griffiths G, Horowitz A, Moffett A, Sharkey AM, Colucci F. Nat Commun. 2020 Jan 20;11(1):381. doi: 10.1038/s41467-019-14123-z.  PMID: 3195975

Alison Forhead

Valenzuela OA, Jellyman JK, Allen V, Niu Y, Forhead AJ, Giussani DA, Fowden AL & Herrera EA (2020) Neonatal glucocorticoid overexposure alters cardiovascular function in young adult horses in a sex-linked manner. Journal of Developmental Origins of Health and Disease (in press).

Davies KL, Camm JE, Atkinson EV, Lopez T, Forhead AJ, Murray AJ & Fowden AL (2020) Development and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth. Journal of Physiology (in press).

Harris SE, De Blasio MJ, Zhao X, Ma M, Davies KL, Wooding FBP, Hamilton RS, Blache D, Meredith D, Murray AJ, Fowden AL & Forhead AJ
(2020) Thyroid deficiency before birth modifies the adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity. Thyroid (in press).
Fowden AL, Giussani DA & Forhead AJ (2020) Developmental physiology of the equine fetus during late gestation. Equine Veterinary Journal 52: 
165-173.

Forhead AJ (2019) Breathing for two: maternal asthma and lung development in the fetus. Journal of Physiology 597: 4125-4126.

Abby Fowden

Sferruzzi-Perri, A.N., Higgins, J.S., Vaughan, O.R., Murray, A.J. & Fowden, A.L. (2019). Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth. PNAS 116 1621-1626.

Musial, B., Fernandez-Twinn, D.S., Duque-Guimaraes, D., Carr, S.K., Fowden, A.L., Ozanne, S.E. & Sferruzzi-Perri, A.N. (2019). Exercise alters the molecular pathways of insulin signalling and lipid handling in tissues of obese pregnant mice. Physiol. Reports 7 e14202.  

Hardwick, L.J.A., Phythain, C.J., Fowden, A.L. & Hughes, K. (2020). Size of supernumerary teats in sheep correlated with complexity of the anatomy and microenvironment. J. Anat. DOI: 10.1111/joa.13149. 

Harris, S., De Blasio, M., Zhao, X., Ma, M., Davies, K.L., Wooding, F.B.P., Hamilton, R., Blache, D., Meredith, D., Murray, A.J., Fowden, A.L. & Forhead A.J. (2020). Thyroid deficiency before birth modifies adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity. Thyroid DOI: 10.1089/thy2019.0749. 

Davies, K.L., Camm, E.J., Atkinson, E.V., Lopez, T., Forhead, A.J., Murray, A.J. & Fowden, A.L. (2020). Developmental and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth. J. Physiol. DOI: 10.1113/JP279194.

Fowden, A.L., Giussani, D.A., & Forhead, A.J. (2020). Physiological  development of the equine fetus during late gestation. Equine Vet. J. 52 165-173.

Tunster, S.J., Watson, E.D., Fowden, A.L. & Burton, G.J. (2020). Placental glycogen function and fetal growth: insights from genetic mouse models. Reproduction. 159 R213-R235.

Fowden, A.L., Giussani, D.A., & Forhead, A.J. (2020). Physiological development of the equine fetus during late gestation. Equine Vet. J. 52 165-173.

Tunster, S.J., Watson, E.D., Fowden, A.L. & Burton, G.J. (2020). Placental glycogen function and fetal growth: insights from genetic mouse models. Reproduction doi.org/10.1530/REP-20-0007.

Kristian Franze

Jakobs MAH, Dimitracopoulos A, Franze K: KymoButler, a deep learning software for automated kymograph analysis. eLife 8:e42288 (2019)

Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez G, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KF: Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature 573:130–134 (2019)

Caglar M, Pandya R, Xiao J, Foster SK, Divitini G, Chen RYS, Greenham NC, Franze K, Rao A, Keyser UF: All-optical detection of neuronal membrane depolarization in live cells using colloidal quantum dots. Nano Letters 19(12):8539-8549 (2019)
Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey A, Franze K, Burton GJ, Oyen ML: Tissue stiffness at the human maternal-fetal interface. Human Reproduction 34(10):1999-2008 (2019)
Pocaterra A, Santinon G, Romani P, Brian I, Dimitracopoulos A, Ghisleni A, Carnicer-Lombarte A, Forcato M, Braghetta P, Montagner M, Galuppini F, Aragona M, Pennelli G, Bicciato S, Gauthier N, Franze K, Dupont S: F-actin dynamics regulates mammalian organ growth and cell fate maintenance. J Hepatol S0168-8278(19)30144-8 (2019)

Jakobs M, Franze K, Zemel A: Mechanical regulation of neurite polarization and growth - A computational study. Biophys J accepted (2020)

Kulenkampff K, Lippert AH, McColl J, Santos AM, Ponjavic A, Jenkins E, Humphrey J, Winkel A, Franze K, Lee SF, Davis SJ, Klenerman D: The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale. Biophys J doi: 10.1016/j.bpj.2020.01.019 (2020) 

Kjell J, Fischer-Sternjak J, Thompson AJ, Friess C, Sticco MJ, Salinas F, Cox J, Martinelli DC, Ninkovic J, Franze K*, Schiller HB*, Götz M*: Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis.  Cell Stem Cell 26(2):277-293 (2020)

Johannes Rheinlaender, Andrea Dimitracopoulos, Bernhard Wallmeyer, Nils M. Kronenberg, Kevin J. Chalut, Malte C. Gather, Timo Betz, Guillaume Charras & Kristian Franze. Cortical cell stiffness is independent of substrate mechanics. Nature Materials (2020) doi.org/10.1038/s41563-020-0684-x

Dino Giusanni

Tay, J., Masini, G., McEniery, C., Giussani, D.A., Shaw, C.J., Wilkinson, I.B., Bennett, P.R. & Lees, C.C. (2019).  Maternal Cardiac Output and Vascular Resistance are associated with maternal uterine and fetal umbilical artery but not cerebral Doppler changes. American Journal of Obstetrics & Gyecology. 220(1), 96.e1-96.e8.

Brain, K.L., Allison, B.J., Niu, Y., Cross, C.M., Itani, N., Kane, A.D., Herrera, E.A., Skeffington, K.L., Botting, K.J. & Giussani, D.A. (2019). Intervention against hypertension in the next generation programmed by developmental hypoxia PLoS Biology 17(1): e2006552. 

Aiken, C.E., Tarry-Adkins, J.L., Spiroski, A.M., Nuzzo, A.M., Ashmore, T.J., Rolfo, A., Sutherland, M.J., Camm, E.J., Giussani, D.A. & Ozanne, S.E. (2019).  Chronic fetal hypoxia disrupts the peri-conceptual environment in adult female rats. The Journal of Physiology 597(9), 2391-2401.

Manuscript chosen for an Editorial Focus by Nathanielsz, P.W.  Maternal programming by hypoxia alters the molecular composition of the oviduct of her offspring, the first pathway her grandchildren will transit: a potential novel pathway for intergenerational programming? J Physiol. 2019; 597(9):2325-2326.

Aiken C.E., Tarry-Adkins, J.L., Spiroski A.M., Nuzzo A.M., Ashmore T., Giussani D.A. & Ozanne, S.E. (2019).  Chronic gestational hypoxia induces low ovarian reserve in adult female rats. FASEB J.  33(6), 7758-7766.

Snelling, E.P., Seymour, R.S., Giussani, D.A., Fuller, A., Maloney, S.K., Farrell, A.P., Mitchell, D., George, K., Kamerman, P.R., Mitchell, G., Dzialowski, E.M., Jonker, S.S., Wube, T (2019). Scaling of heart mass is interrupted by birth in the developing sheep Ovis aries.   The Journal of Anatomy. 235(1), 96-105. 

Shaw C.J., Rivens, I., Civale, J., Botting, K.J., Allison, B.J., Brain, K.L., Niu, Y., Ter Haar, G., Giussani, D.A. & Lees, C.C. (2019). Maternal and fetal cardiometabolic recovery following ultrasound-guided high-intensity focused ultrasound placental vascular occlusion. J R Soc Interface 16(154), 20190013. 

Fratelli, N., Prefumo, F., Wolf, H., Hecher, K., Visser, G.H.A., Giussani, D.A., Derks, J.B., Shaw, C.J., Frusca, T., Ghi, T., Ferrazzi, E., Lees, C.C.; TRUFFLE Group; TRUFFLE Group authors; TRUFFLE Group collaborating authors (2019). Effects of Antenatal Betamethasone on Fetal Doppler Indices and Short Term Fetal Heart Rate Variation in Early Growth Restricted Fetuses. Ultraschall Med. Sep 2. doi: 10.1055/a-0972-1098. [Epub ahead of print].

Garrud, T.A.C. & Giussani, D.A. (2019). Combined glucocorticoid and antioxidant therapy for the safer treatment of preterm birth.  Trends in Endocrinology & Metabolism 30(4), 258-269.

Tong, W. & Giussani, D.A. (2019).  Preeclampsia link to gestational hypoxia. The Journal of Developmental Origins of Helath and Disease 10(3), 322-333. 

Giussani, D.A. (2019). Fatty vessels shed tonnes on programmed cardiovascular risk. The Journal of Physiology 597.22, 5317-5318.

Frasch, M.G., Herry, C.L., Niu, Y. & Giussani, D.A (2020).  First evidence that intrinsic fetal heart rate variability exists and is affected by hypoxic pregnancy. J Physiol. 598(2), 249-263.

Cetin, I., Taricco, E., Mandò, C., Radelli, T. Boito, S. Nuzzo, A.M. & Giussani, D.A. (2020). Fetal oxygen and glucose consumption in human pregnancy complicated by fetal growth restriction.  Hypertension 75(3),748-754. 

Valenzuela, O.A., Jellyman, J.K., Allen, V.L., Niu, Y., Holdstock, N.B., Forhead, A.J., Giussani, D.A., Fowden, A.L. & Herrera EA. Neonatal glucocorticoid overexposure alters cardiovascular function in young adult horses in a sex-linked manner. J Dev Orig Health Dis. 2020 Jun 3:1-10. 
doi: 10.1017/S2040174420000446. Online ahead of print. PMID: 32489168.

Fowden, A.L., Giussani, D.A. & Forhead, A.J. (2020). Physiological development of the equine fetus during late gestation. Equine Vet J. 52(2), 165-173.

Jellyman, J.K., Fletcher, A.J.W., Fowden, A.L. & Giussani, D.A. (2020).  Glucocorticoid Maturation of Fetal Cardiovascular Function. Trends Mol Med. 26(2), 170-184.

Kane, A.D., Kothmann, E. & Giussani, D.A. (2020). Detection and response to acute systemic hypoxia. BJA Education 20(2), 58-64.

Frasch, M.G. & Giussani, D.A. (2020). Impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development.  Cells 9(3), pii: E733. 

Reyes, R., Herrera, E.A., Ebensperger, G., Sanhueza, E., Giussani, D.A. & Llanos, A.J. (2020). Perinatal cardiopulmonary adaptation to the thin air of the Alto Andino by a native Altiplano dweller, the llama. Journal of Applied Physiology.  In Press. 

Teulings, N.E.W.D., Garrud, T.A.C., Niu, Y., Skeffington, K.L., Beck, C., Itani, N., Conlon, F., Botting, K.J., Nicholas, L.M., Ashmore, T.J., Blacknmore, H.L., Tong, W., Camm, E.J., Derks, J.B., Logan, A., Murphy, M.P., Ozanne, S.E. & Giussani, D.A. (2020). Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system.  FASEB J. In press. Jun 5. doi: 10.1096/fj.202000697R. Online ahead of print. PMID: 32502311

Skeffington, K.L., Beck, C., Itani, N., Niu, Y., Shaw, C.J. & Giussani, D.A. (2020).  Hypertension programmed in adult hens by isolated effects of developmental hypoxia in ovo. Hypertension. In Press.

Botting, K.J., Skeffington, K.L., Niu, Y., Allison, B.J., Brain, K.L., Itani, N., Beck, C., Logan, A., Murray, A.J., Murphy, M.P. & Giussani, D.A. (2020). Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction. Science Advances.  In Press.

Shaw, C.J., Botting, K.J., Niu, Y., Lees, C.C. & Giussani, D.A. (2020).  Maternal and fetal cardiovascular and metabolic effects of intra-operative uterine handling under general anesthesia during pregnancy in sheep.  Scientific Reports.  In Press.

Itani, N., Skeffington, K.L., Beck, C., Niu, Y., Katzilieris-Petras, G., Smith, N. & Giussani, D.A. (2020).  Protective effects of pravastatin on the embryonic cardiovascular system suring hypoxic development.  Hypertension.  In Press.

Allison, B.J., Brain, K.L., Niu, Y., Kane, A.D., Herrera, E.A., Thakor, A.S., Botting, K.J., Cross, C.M., Itani, N., Shaw, C.J., Skeffington, K.L., Beck, C. & Giussani, D.A. (2020).  Weak Cardiovascular Defence to Hypotensive Stress in the Chronically Hypoxic Fetus. Hypertension.  In Press.

Hess, R.M., Niu, Y., Garrud, T.A., Botting, K.J., Ford, S.G. & Giussani, D.A. (2020). Cardioprotective action of hydrogen sulphide in the embryonic heart. The Journal of Physiology. In Press.

Martin Johnson

M.H. Johnson: IVF: The women who helped make it happen (2019). Reprod Biomed Soc  8, 1-6.

M.H. Johnson:  The Significance of Cell Polarity in Early Mammalian Development.  Reference Module in Biomedical Sciences. Elsevier. 22-Jan-2019 doi:10.1016/B978-0-12-801238-3.99504-7.

P.R. Braude, M.H. Johnson: Reflections on 40 years of IVF (2019). BJOG 126, 135-137.
Fauser, B., Alikani, M., Anderson, R., Franklin, S., Johnson, M.H., Garcia Velasco, J.  Another new year. (2019). RBMO  38, 5-6.

M.H. Johnson: A short history of in vitro fertilization (IVF) (2019).  Int. J. Dev. Biol. 63, 83-92.

M. H. Johnson: Human in vitro fertilisation and developmental biology: a mutually influential history (2019) Development 146, doi:10.1242/dev.183145

C. Aiken, M. H. Johnson: A mouse model for the effects of IVF procedures on the development of embryos (2019). RB MO 39 355-356. 

S Franklin, M.H. Johnson: Editorial. Reproductive BioMedicine and Society Online (2018) 7, 158–159  

K Williams, M. H. Johnson: Adapting the 14-day rule for embryo research to encompass evolving technologies.(2020)  RBMS 10, 1-9.

Gavin Kelsey 

Saenz-de-Juano, M. D., Ivanova, E., Romero, S., Lolicato, F., Sanchez, F., Van Ranst, H., Krueger, F., Segonds-Pichon, A., De Vos, M., Andrews, S., Smitz, J., Kelsey, G. and Anckaert, E. (2019) DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved IVM method for oocytes from small antral follicles in PCOS patients. Human Reproduction 34, 1640-1649.

Hanna, C. W., Pérez-Palacios, R., Gahurova, L., Schubert, M., Krueger, F., Biggins, L., Andrews, S., Colomé-Tatché, M., Bourc’his, D., Dean, W. and Kelsey, G. (2019) Non-canonical imprinting in extra-embryonic tissues is driven by endogenous retroviral insertions. Genome Biology 20, 225.

Argelaguet, R., Mohammed, H., Clark, S. J., Stapel, L. C., Krueger, C., Kapourani, C.-A., Xiang, Y., Hanna, C., Smallwood, S., Ibarra-Soria, X., Buettner, F., Sanguinetti, G., Krueger, F., Xie, W., Rugg-Gunn, P., Kelsey, G., Dean, W., Nichols, J., Stegle, O., Marioni, J. C., Reik, W. (2019) Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification. Nature 576, 487-491.

Demond, H., Anvar, Z., Jahromi, B. N., Sparago, A., Verma, A., Davari, M., Calzari, L., Russo, S., Jahromi, M. A., Monk, D., Andrews, S., Riccio, A. and Kelsey, G. (2019) A KHDC3L mutation resulting in recurrent hydatidiform mole causes genome-wide DNA methylation loss in oocytes and persistent imprinting defects post-fertilisation. Genome Medicine 11, 84.

Saenz-de-Juano, M. D., Ivanova, E., Billooye, K., Herta, A. C., Smitz, J., Kelsey, G. and Anckaert, A. (2019) Genome-wide DNA methylation assessment in mouse oocytes reveals effects associated with in vitro growth, superovulation, and sexual immaturity. Clinical Epigenetics 11, 197.

Olsen, K. W., Castillo-Fernandez, J., Zedeler, A., Freiesleben, N. C., Bungum, M., Chan, A. C., Cardona, A., Perry, J. R. B., Skouby, S. O., Borup, R., Hoffmann, E. R., Kelsey, G. and Grøndahl, M. L. (2020) A distinctive epigenetic ageing profile in granulosa cells. Human Reproduction accepted March 2020.

Wołodko, K., Walewska, E., Adamowski, M., Castillo-Fernandez, J., Kelsey, G. and Galvão, A. Leptin resistance in the ovary of obese mice is associated with profound changes in the transcriptome of cumulus ells. Cellular Physiology and Biochemistry 54, 417-437.

Ivanova, E., Canovas, S., Garcia-Martinez, S., Romar, R., Lopes, J. S., Rizos, D., Sanchez-Calabuig, M. J., Krueger, F., Andrews, S., Perez-Sanz, F., Kelsey, G. and Coy, P. (2020) DNA methylation changes during preimplantation development reveal interspecies differences and reprogramming events at imprinted genes. Clinical Epigenetics 12, 64.

Sendžikaitė, G. and Kelsey, G. (2019) The role and mechanisms of DNA methylation in the oocyte. Essays in Biochemistry EBC20190043 doi.org/10.1042/EBC20190043.
Demond, H. and Kelsey, G. (2020) The enigma of DNA methylation in oocytes. F1000 Research 9, 146.

Ashley Moffett

Abbas Y, Turco MY, Burton GJ, Moffett A. Investigation of human trophoblast invasion in vitro.
Hum Reprod Update. 2020 May 22:dmaa017. doi: 10.1093/humupd/dmaa017. Online ahead of print.PMID: 32441309

Gaccioli F, Lager S, de Goffau MC, Sovio U, Dopierala J, Gong S, Cook E, Sharkey A, Moffett A, Lee WK, Delles C, Venturini C, Breuer J, Parkhill J, Peacock SJ, Charnock-Jones DS, Smith GCS. Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia.
Nat Microbiol. 2020 May 4. doi: 10.1038/s41564-020-0711-3. Online ahead of print.PMID: 32367053

Nakimuli A, Starling JE, Nakubulwa S, Namagembe I, Sekikubo M, Nakabembe E, Scott JG, Moffett A, Aiken CE. Relative impact of pre-eclampsia on birth weight in a low resource setting: A prospective cohort study. Pregnancy Hypertens. 2020 Apr 7;21:1-6. doi: 10.1016/j.preghy.2020.04.002. Online ahead of print.PMID: 32330863

Abbas Y, Brunel LG, Hollinshead MS, Fernando RC, Gardner L, Duncan I, Moffett A, Best S, Turco MY, Burton GJ, Cameron RE. Generation of a three-dimensional collagen scaffold-based model of the human endometrium. Interface Focus. 2020 Apr 6;10(2):20190079. doi: 10.1098/rsfs.2019.0079. Epub 2020 Feb 14.PMID: 32194932 Free PMC article.

Jauniaux E, Moffett A, Burton GJ. Placental Implantation Disorders.
Obstet Gynecol Clin North Am. 2020 Mar;47(1):117-132. doi: 10.1016/j.ogc.2019.10.002. Epub 2019 Dec 18.PMID: 32008663 Review.

Huhn O, Ivarsson MA, Gardner L, Hollinshead M, Stinchcombe JC, Chen P, Shreeve N, Chazara O, Farrell LE, Theorell J, Ghadially H, Parham P, Griffiths G, Horowitz A, Moffett A, Sharkey AM, Colucci
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy. F.Nat Commun. 2020 Jan 20;11(1):381. doi: 10.1038/s41467-019-14123-z.PMID: 31959757 Free PMC article.

Lensen S, Shreeve N, Barnhart KT, Gibreel A, Ng EHY, Moffett A. In vitro fertilization add-ons for the endometrium: it doesn't add-up. Fertil Steril. 2019 Dec;112(6):987-993. doi: 10.1016/j.fertnstert.2019.10.011.PMID: 31843098 Review.

Turco MY, Moffett A. Development of the human placenta. Development. 2019 Nov 27;146(22):dev163428. doi: 10.1242/dev.163428.PMID: 31776138 Free article. Review.

Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey AM, Franze K, Burton GJ, Oyen ML. Tissue stiffness at the human maternal-fetal interface.
Hum Reprod. 2019 Oct 2;34(10):1999-2008. doi: 10.1093/humrep/dez139.PMID: 31579915 Free PMC article.

Burton GJ, Redman CW, Roberts JM, Moffett A. Pre-eclampsia: pathophysiology and clinical implications. BMJ. 2019 Jul 15;366:l2381. doi: 10.1136/bmj.l2381.PMID: 31307997 Review.

Lee CQE, Bailey A, Lopez-Tello J, Sferruzzi-Perri AN, Okkenhaug K, Moffett A, Rossant J, Hemberger . Inhibition of Phosphoinositide-3-Kinase Signaling Promotes the Stem Cell State of Trophoblast.
M.Stem Cells. 2019 Oct;37(10):1307-1318. doi: 10.1002/stem.3052. Epub 2019 Jul 18.PMID: 31233251

Wolf Reik

Thompson O, von Meyenn F, Hewitt Z, Alexander J, Wood A, Weightman R, Gregory S, Krueger F, Andrews S, Barbaric I, Gokhale PJ, Moore HD, Reik W, Milo M, Nik-Zainal S, Yusa K, Andrews PW. Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions. Nat Commun. 2020 Mar 23;11(1):1528. doi: 10.1038/s41467-020-15271-3. PubMed PMID: 32251294; PubMed Central PMCID: PMC7089967.

Antunes C, Da Silva JD, Guerra-Gomes S, Alves ND, Ferreira F, Loureiro-Campos E, Branco MR, Sousa N, Reik W, Pinto L, Marques CJ. Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice. Mol Psychiatry  2020. 
Feb 26. doi: 10.1038/s41380-020-0695-7. [Epub ahead of print] PubMed PMID: 32103150.

Argelaguet R, Clark SJ, Mohammed H, Stapel LC, Krueger C, Kapourani CA, Imaz-Rosshandler I, Lohoff T, Xiang Y, Hanna CW, Smallwood S, Ibarra-Soria X, Buettner F, Sanguinetti G, Xie W, Krueger F, Göttgens B, Rugg-Gunn PJ, Kelsey G,  Dean W, Nichols J, Stegle O, Marioni JC, Reik W. Multi-omics profiling of mouse gastrulation at single-cell resolution. Nature. 2019 Dec;576(7787):487-491. doi: 
10.1038/s41586-019-1825-8. Epub 2019 Dec 11. PubMed PMID: 31827285; PubMed Central PMCID: PMC6924995.
Bell CG, Lowe R, Adams PD, Baccarelli AA, Beck S, Bell JT, Christensen BC, Gladyshev VN, Heijmans BT, Horvath S, Ideker T, Issa JJ, Kelsey KT, Marioni RE, Reik W, Relton CL, Schalkwyk LC, Teschendorff AE, Wagner W, Zhang K, Rakyan VK. DNA methylation aging clocks: challenges and recommendations. Genome Biol. 2019 Nov 25;20(1):249. doi: 10.1186/s13059-019-1824-y. Review. PubMed PMID: 31767039; PubMed Central PMCID: PMC6876109.
Santiago M, Antunes C, Guedes M, Iacovino M, Kyba M, Reik W, Sousa N, Pinto L, Branco MR, Marques CJ. Tet3 regulates cellular identity and DNA methylation in neural progenitor cells. Cell Mol Life Sci. 2019 Oct 23. doi: 10.1007/s00018-019-03335-7. [Epub ahead of print] Erratum in: Cell Mol Life Sci. 2020 Jan 9;:. PubMed PMID: 31646359.

Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X. Voices in methods development. Nat Methods. 2019 Oct;16(10):945-951. doi: 10.1038/s41592-019-0585-6. PubMed PMID: 31562479; PubMed
Central PMCID: PMC7075469.

Hernando-Herraez I, Evano B, Stubbs T, Commere PH, Jan Bonder M, Clark S, Andrews S, Tajbakhsh S, Reik W. Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells. Nat Commun. 2019 Sep 25;10(1):4361. doi: 10.1038/s41467-019-12293-4. PubMed PMID: 31554804; PubMed Central PMCID: PMC6761124.

Stuart HT, Stirparo GG, Lohoff T, Bates LE, Kinoshita M, Lim CY, Sousa EJ, Maskalenka K, Radzisheuskaya A, Malcolm AA, Alves MRP, Lloyd RL, Nestorowa S, Humphreys P, Mansfield W, Reik W, Bertone P, Nichols J, Göttgens B, Silva JCR. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem  Cell. 2019 Sep 5;25(3):388-406.e8. doi: 10.1016/j.stem.2019.07.009. Epub 2019 Aug 15. PubMed PMID: 31422912; PubMed Central PMCID: PMC6731995.

Gao X, Nowak-Imialek M, Chen X, Chen D, Herrmann D, Ruan D, Chen ACH, Eckersley-Maslin MA, Ahmad S, Lee YL, Kobayashi T, Ryan D, Zhong J, Zhu J, Wu J,  Lan G, Petkov S, Yang J, Antunes L, Campos LS, Fu B, Wang S, Yong Y, Wang X, Xue SG, Ge L, Liu Z, Huang Y, Nie T, Li P, Wu D, Pei D, Zhang Y, Lu L, Yang F, KimberSJ, Reik W, Zou X, Shang Z, Lai L, Surani A, Tam PPL, Ahmed A, Yeung WSB, Teichmann SA, Niemann H, Liu P. Establishment of porcine and human expanded potential stem cells. Nat Cell Biol. 2019 Jun;21(6):687-699. doi: 10.1038/s41556-019-0333-2. Epub 2019 Jun 3. PubMed PMID: 31160711; PubMed Central PMCID: PMC7035105.

Andrew Sharkey

Tissue stiffness at the human maternal-fetal interface.
Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey AM, Franze K, Burton GJ, Oyen ML. Hum Reprod. 2019 Oct 2;34(10):1999-2008. doi: 10.1093/humrep/dez139.    PMID: 31579915

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.Huhn O, Ivarsson MA, Gardner L, Hollinshead M, Stinchcombe JC, Chen P, Shreeve N, Chazara O, Farrell LE, Theorell J, Ghadially H, Parham P, Griffiths G, Horowitz A, Moffett A, Sharkey AM, Colucci F. Nat Commun. 2020 Jan 20;11(1):381. doi: 10.1038/s41467-019-14123-z.  PMID: 31959757

Fetal inheritance of chromosomally integrated HHV-6 predisposes to preeclampsia in the mother.  Francesca Gaccioli, Susanne Lager, Marcus C de Goffau, Ulla Sovio, Justyna Dopierala, Sungsam Gong, Emma Cook, Andrew Sharkey, Ashley Moffett, Wai Kwong Lee, Christian Delles, Cristina Venturini, Judith Breuer, Julian Parkhill, Sharon J Peacock, D Stephen Charnock-Jones, Gordon CS Smith. Nat Microbiol. 2020 May,  in press.    Doi: 10.1038/s41564-020-0711-3

Gordon Smith

Teulings NEWD, Wood AM, Sovio U, Ozanne SE, Smith GCS, Aiken CE. Independent influences of maternal obesity and fetal sex on maternal cardiovascular adaptation to pregnancy: a prospective cohort study.  International Journal of Obesity 2020 In press.

Smith GCS, Moraitis AA, Wastlund D, Thornton JG, Papageorghiou A, Sanders J, Heazell AEP, Robson SC, Sovio U, Brockelhurst P, Wilson ECF. A systematic review and cost-effectiveness analysis of the case for screening nulliparous women in late pregnancy using ultrasound. Health Technology Assessment 2020 In press.

Iliodromiti S, Smith GCS, Lawlor DA, Pell JP, Nelson SM. UK stillbirth trends in over 11 million births provide no evidence to support effectiveness of Growth Assessment Protocol program. Ultrasound in Obstetrics & Gynaecology 2020 In press.

Gaccioli F, Lager S, de Goffau MC, Sovio U, Dopierala J, Gong S, Cook E, Sharkey A, Moffett A, Lee WK, Delles C, Venturini C, Breuer J, Parkhill J, Peacock SJ, Charnock-Jones DS, Smith GCS. Fetal inheritance of chromosomally integrated HHV-6 predisposes to preeclampsia in the mother. Nature Microbiology 2020 In press.

Furse S, Fernandez-Twinn D, Jenkins B, Meek CL,  Williams HE, Smith GCS, Charnock-Jones DS, Ozanne SE, Koulman A. A high throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Analytical and Bioanalytical Chemistry 2020, In press.

Ulla Sovio U, Goulding N, McBride N, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA,  Smith GCS. A maternal serum metabolite ratio predicts term fetal growth restriction. Nature Medicine 2020;26:348-353.

de Goffau MC, Lager SM, Sovio U, Gaccioli F, Cook E, Peacock SJ, Parkhill J, Charnock-Jones DS, Smith GCS. Article: Human placenta has no microbiome but can contain potential pathogens. Nature 2019;572:329-334.

Hughes AE, Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Lawlor DA, Smith GCS. The association between first trimester AFP to PAPP-A ratio and placentally-related adverse pregnancy outcome. Placenta 2019;81:25-31.

Sovio U, McBride M, Wood AM, Masconi KL, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS. 4-hydroxyglutamate is a novel predictor of preeclampsia. International Journal of Epidemiology 2019 May 16. pii: dyz098. doi: 10.1093/ije/dyz098. [Epub ahead of print]. 

Wastlund D, Moraitis AA, , Thornton JG, Sanders J, White IR, Brockelhurst P, Smith GCS, Wilson ECF. The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women: a decision-analysis. BJOG 2019 May 8. doi: 10.1111/1471-0528.15809. [Epub ahead of print].

Wastlund D, Moraitis AA, Dacey A, Wilson ECF, Sovio U, Smith GCS. Screening for breech presentation using universal late pregnancy ultrasonography: A prospective cohort study and cost-effectiveness analysis. PLoS Medicine 2019 6(4):e1002778. 

Sovio U, Smith GCS. Evaluation of a simple risk score to predict preterm preeclampsia using maternal characteristics: a prospective cohort study. BJOG 2019;126:963–970.

Consortium of Metabolomics Studies. Smith GCS (author 57 out of 74). The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. American Journal of Epidemiology 2019;188:991-1012.
Jayasuriya N, Hughes AE, Sovio U, Cook E, Charnock-Jones DS, Smith GCS.  A lower maternal cortisol to cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks. Journal of Clinical Endocrinology & Metabolism 2019;104:2355-2366.

Smith GCS Nakimuli A. Ultrasonic estimation of gestational age in late pregnancy in low income countries: made to measure or off-the-peg? Lancet Global Health 2020;8:e462-e463.

Smith GCS. Screening and intervention for late fetal growth restriction. BJOG 2019 Dec 23. doi: 10.1111/1471-0528.16072. [Epub ahead of print]

Smith GCS. The risk of perinatal death at term. BJOG 2019;126:1258.

John Trowsdale

KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors. Alicata C, Ashouri E, Nemat-Gorgani N, Guethlein LA, Marin WM, Tao S, Moretta L, Hollenbach JA, Trowsdale J, Traherne JA, Ghaderi A, Parham P, Norman PJ. Front Immunol. 2020 Apr 2;11:556.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Cossarizza A et al Eur J Immunol. 2019. Oct;49(10):1457-1973

Margherita Turco

Abbas Y, Turco MY, Burton GJ, Moffett M. Investigation of human trophoblast invasion in vitro. Human Reproduction Update, (2020), doi:10.1093/humup/dmaa017

Burton GJ, Cindrova-Davies T, Turco MY. Histotrophic nutrition and the placental-endometrial dialogue during human early pregnancy. Placenta (2020) 14 February doi.org/10.1016/j.placenta.2020.02.008

Abbas Y, Brunel LG, Hollinshead MS, Fernando R, Gardner L, Duncan I, Moffett A, Best S, Turco MY, Burton GJ, Cameron RE. Generation of a three-dimensional collagen scaffold-based model of the human endometrium, Interface Focus (2020), 14 February doi.org/10.1098/rsfs.2019.0079

Turco MY & Moffett A. The Development of the Human Placenta. Development (2019), Nov; 146: dev163428 

Erica Watson

Sowton A, Padmanabhan N, Tunster SJ, McNally B, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED. (2020) Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Molecular Genetics and Metabolism Reports 23: 100580

Tunster SJ, Watson ED, Fowden AL, Burton GJ. Placenta glycogen stores and fetal growth: evidence from genetic mouse models. (2020) Reproduction 159(6): R213-2R35

Menelaou K, Prater M, Tunster SJ, Blake GET, Geary-Joo C, Cross JC, Hamilton RS, Watson ED. (2020) Blastocyst transfer in mice alters the placental transcriptome and growth. Reproduction 159(2): 115-132.
Blake GET, Hall J, Petkovic GE, Watson ED. (2019) Analysis of spermatogenesis and fertility in adult mice with a hypomorphic mutation in the Mtrr gene. Reproduction, Fertility and Development 31(11): 1730-1741.

Blake GET, Zhao X, Yung HW, Burton GJ, Ferguson-Smith AC, Hamilton RS, Watson ED. (2020) Disruption of folate metabolism causes germline epigenetic instability and distinguishes HIRA as a biomarker of maternal transgenerational epigenetic inheritance. bioRxiv doi.org/10.1101/2020.05.21.109256.

Magda Zernicka-Goetz

Kyprianou C, Christodoulou, N. and Zernicka-Goetz, M. (2020). Basement membrane remodelling regulates mouse embryogenesis. Nature, in press. 

Zhu M, Zernicka-Goetz M. Living a Sweet Life: Glucose Instructs Cell Fate in the Mouse Embryo. Dev Cell. 2020 Apr 6;53(1):1-2. doi: 10.1016/j.devcel.2020.03.012. PMID: 32259489

Zhu M, Zernicka-Goetz M. Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives. Curr Opin Cell Biol. 2020 Feb;62:144-149. doi: 10.1016/j.ceb.2019.11.005. Epub 2019 Dec 21.PMID: 31869760 Review.

Molè MA, Weberling A, Zernicka-Goetz M. Comparative analysis of human and mouse development: From zygote to pre-gastrulation. Curr Top Dev Biol. 2020;136:113-138. doi: 10.1016/bs.ctdb.2019.10.002. Epub 2019 Dec 26.PMID: 31959285

Sozen B, Cox AL, De Jonghe J, Bao M, Hollfelder F, Glover DM, Zernicka-Goetz . Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid. M.Dev Cell. 2019 Dec 16;51(6):698-712.e8. doi: 10.1016/j.devcel.2019.11.014.PMID: 31846649

Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA, Huch M. Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration. Nat Cell Biol. 2019 Nov;21(11):1321-1333. doi: 10.1038/s41556-019-0402-6. Epub 2019 Nov 4.PMID: 31685987 

Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X. Voices in methods development.
Nat Methods. 2019 Oct;16(10):945-951. doi: 10.1038/s41592-019-0585-6.PMID: 31562479 

Christodoulou N, Weberling A, Strathdee D, Anderson KI, Timpson P, Zernicka-Goetz M. Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation. Nat Commun. 2019 Aug 7;10(1):3557. doi: 10.1038/s41467-019-11482-5.PMID: 31391456 

Shahbazi MN, Siggia ED, Zernicka-Goetz . Self-organization of stem cells into embryos: A window on early mammalian development. M.Science. 2019 Jun 7;364(6444):948-951. doi: 10.1126/science.aax0164.PMID: 31171690

Antonica F, Orietti LC, Mort RL, Zernicka-Goetz M.Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. Dev Biol. 2019 Jun 15;450(2):132-140. doi: 10.1016/j.ydbio.2019.03.016. Epub 2019 Mar 30.PMID: 30940540