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Centre for Trophoblast Research

 

Catherine Aiken

  1. Schoonejans JM, Blackmore HL, Ashmore TJ, Pantaleão LC, Pellegrini Pisani L, Dearden L, Tadross JA, Aiken CE, Fernandez-Twinn DS, Ozanne SE. Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring. Diabetologia. 2022 Dec;65(12):2132-2145. doi: 10.1007/s00125-022-05789-0. Epub 2022 Sep 16. PMID: 36112170; PMCID: PMC9630251.
  2. Hufnagel A, Grant ID, Aiken CEM. Glucose and oxygen in the early intrauterine environment and their role in developmental  bnormalities. Semin Cell Dev Biol. 2022 Nov;131:25-34. doi: 10.1016/j.semcdb.2022.03.041. Epub 2022 Apr 8. PMID: 35410716.
  3. Eggleton EJ, McMurrugh KJ, Aiken CE. Cardiomyopathy confers increased risks of maternal adverse outcomes. Am J Obstet Gynecol. 2022 Jun 28:S0002-9378(22)00524-5. doi: 10.1016/j.ajog.2022.06.048. Epub ahead of print. PMID: 35777429.
  4. Eggleton EJ, McMurrugh KJ, Aiken CE. Maternal pregnancy outcomes in women with cardiomyopathy: a systematic review and meta-analysis. Am J Obstet Gynecol. 022 Oct;227(4):582-592. doi: 10.1016/j.ajog.2022.05.039. Epub 2022 May 21. PMID: 35609641.
  5. Stock SJ, Aiken CE. Barriers to progress in pregnancy research: How can we break through? Science. 2023 Apr 14;380(6641):150-153.doi:10.1126/science.adf9347. Epub 2023 Apr 13. PMID: 37053324.
  6. Crump A, Aiken C, Cunningham EM, Arnott G. Short-Term Microplastic Exposure Impairs Cognition in Hermit Crabs. Animals (Basel). 2023 Mar 14;13(6):1055. doi: 10.3390/ani13061055. PMID: 36978596; PMCID: PMC10044271.
  7. Eggleton EJ, McMurrugh KJ, Aiken CE. Perinatal outcomes in pregnancies complicated by maternal cardiomyopathy: a systematic review and meta-analysis. Am J Obstet Gynecol. 2023 Mar;228(3):283-291. doi: 10.1016/j.ajog.2022.09.025. Epub 2022 Sep 20. PMID: 36150520.
  8. Eggleton EJ, McMurrugh KJ, Aiken CE. Maternal cardiomyopathy increases the risk of perinatal adverse outcomes: a response. Am J Obstet Gynecol. 2023 Apr;228(4):486-487. doi: 10.1016/j.ajog.2022.11.1311. Epub 2022 Dec 5. PMID: 36473504.
  9. Namagembe I, Chukwuma SM, Nakimuli A, Kiwanuka N, Byamugisha J, Moffett A, Aiken CE. Learning from maternal deaths due to uterine rupture: review of cases from peri-urban Uganda. AJOG Glob Rep. 2022 Jun 11;2(3):100063. doi: 10.1016/j.xagr.2022.100063. PMID: 36276797; PMCID: PMC9563662.
  10. Eggleton EJ, Bhagra CJ, Patient CJ, Belham M, Pickett J, Aiken CE. Maternal left ventricular function and adverse neonatal outcomes in women with cardiac disease. Arch Gynecol Obstet. 2023 May;307(5):1431-1439. doi: 10.1007/s00404-022-06635-9. Epub 2022 Jun 3. PMID: 35657407; PMCID: PMC10110658.
  11. Cristian A, Tarry-Adkins JL, Aiken CE. The Uterine Environment and Childhood Obesity Risk: Mechanisms and Predictions. Curr Nutr Rep. 2023 Jun 20. doi:10.1007/s13668-023-00482-z. Epub ahead of print. PMID: 37338777.
  12. Olga L, Sovio U, Wong H, Smith G, Aiken C. Association between antenatal diagnosis of late fetal growth restriction and educational outcomes in mid-childhood: A UK prospective cohort study with long-term data linkage study. PLoS Med. 2023 Apr  4;20(4):e1004225. doi: 10.1371/journal.pmed.1004225. PMID:37093852; PMCID: PMC10166482.

Irving Aye

  1. Avellino G, Deshmukh R, Rogers SN, Charnock-Jones DS, Smith GCS, Tardito S, Aye ILMH. Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function. American Journal of Physiology: Cell Physiology. 2023 Apr 1;324(4):C878-C885
  2. Tarry-Adkins JL, Robinson IG, Reynolds RM, Aye ILMH, Charnock-Jones DS, Jenkins B, Koulmann A, Ozanne SE, Aiken CE. Impact of metformin treatment on human placental energy production and oxidative stress. Frontiers in Cell & Developmental Biology. 2022;10:935403.
  3. Aye ILMH, Gong S, Avellino G, Barbagallo R, Gaccioli F, Jenkins BJ, Koulman A, Murray AJ, Stephen Charnock-Jones D, Smith GCS. Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation. Communications Biology. 2022 Jun 15;5(1):586.
  4. Aye ILMH, Aiken CE, Charnock-Jones DS, Smith GCS. Placental energy metabolism in health and disease-significance of development and implications for preeclampsia. American Journal of Obstetrics and Gynecology. 2022 Feb;226(2S):S928-S944
  5. Aye ILMH, Rosario FJ, Kramer A, Kristiansen O, Michelsen TM, Powell TL, Jansson T. Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity. Journal of Clinical Endocrinology & Metabolism. 2022 Jan 1;107(1):53-66.

Thorsten Boroviak

  1. Bergmann S, Penfold CA, Slatery E, Siriwardena D, Drummer C, Clark S, Strawbridge SE, Kishimoto K, Vickers A, Tewary M, Kohler TN, Hollfelder F, Reik W, Sasaki E, Behr R, Boroviak TE. Spatial profiling of early primate gastrulation in utero. Nature. 2022 Sep;609(7925):136-143. doi: 10.1038/s41586-022-04953-1. Epub 2022 Jun 16. PMID: 35709828; PMCID: PMC7614364.
  2. Siriwardena D, Boroviak TE. Evolutionary divergence of embryo implantation in primates. Philos Trans R Soc Lond B Biol Sci. 2022 Dec 5;377(1865):20210256. doi: 10.1098/rstb.2021.0256. Epub 2022 Oct 17. PMID: 36252209; PMCID: PMC9574630.
  3. Castillo-Venzor A, Penfold CA, Morgan MD, Tang WW, Kobayashi T, Wong FC, Bergmann S, Slatery E, Boroviak TE, Marioni JC, Surani MA. Origin and segregation of the human germline. Life Sci Alliance. 2023 May 22;6(8):e202201706. doi: 10.26508/lsa.202201706. PMID: 37217306; PMCID: PMC10203729.
  4. Sheng G, Boroviak TE, Schmidt-Ott U, Srinivas S. Extraembryonic tissues: exploring concepts, definitions and functions across the animal kingdom. Philos Trans R Soc Lond B Biol Sci. 2022 Dec 5;377(1865):20210250. doi: 10.1098/rstb.2021.0250. Epub 2022 Oct 17. PMID: 36252213; PMCID: PMC9574640.
  5. Chen Y, Siriwardena D, Penfold C, Pavlinek A, Boroviak TE. An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells. Development. 2022 Jul 1;149(13):dev200171. doi: 10.1242/dev.200171. Epub 2022 Jul 6. PMID: 35792865; PMCID: PMC9340556.
  6. Munger C, Kohler TN, Slatery E, Ellermann AL, Bergmann S, Penfold CA, Ampartzidis I, Chen Y, Hollfelder F, Boroviak TE. Microgel culture and spatial identity mapping elucidate the signalling requirements for primate epiblast and amnion formation. Development. 2022 Oct 15;149(20):dev200263. doi:10.1242/dev.200263. Epub 2022 Sep 20. PMID: 36125063; PMCID: PMC7614365.
  7. Kraunsoe S, Azami T, Pei Y, Martello G, Jones K, Boroviak T, Nichols J.Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro. Biol Open. 2023 Jan 1;12(1):bio059650. doi:  0.1242/bio.059650. Epub 2023 Jan 17. PMID: 36504370

Steve Charnock-Jones

  1. Stephens K, Charnock-Jones DS, Smith GCS. Group B Streptococcus and the risk of perinatal morbidity and mortality following term labor. Am J Obstet Gynecol. 2023 May;228(5S):S1305-S1312. doi: 10.1016/j.ajog.2022.07.051. Epub 2023 Mar 23. Review. PubMed PMID: 37164497.
  2. Avellino G, Deshmukh R, Rogers SN, Charnock-Jones DS, Smith GCS, Tardito S, Aye ILMH. Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function. Am J Physiol Cell Physiol. 2023 Apr 1;324(4):C878-C885. doi: 10.1152/ajpcell.00581.2022. Epub 2023 Mar 6. PubMed PMID: 36878843; PubMed Central PMCID: PMC10069969.
  3. Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Smith GCS. Maternal serum levels of soluble fms-like tyrosine kinase-1 and placental growth factor at 20 and 28 weeks of gestational age and the risk of spontaneous preterm birth. Am J Obstet Gynecol. 2023 Feb 8;. doi: 10.1016/j.ajog.2023.02.001. [Epub ahead of print] PubMed PMID: 36758709.
  4. Gaccioli F, Sovio U, Gong S, Cook E, Charnock-Jones DS, Smith GCS. Increased Placental sFLT1 (Soluble fms-Like Tyrosine Kinase Receptor-1) Drives the Antiangiogenic Profile of Maternal Serum Preceding Preeclampsia but Not Fetal Growth Restriction. Hypertension. 2023 Feb;80(2):325-334. doi: 10.1161/HYPERTENSIONAHA.122.19482. Epub 2022 Jul 22. PubMed PMID: 35866422; PubMed Central PMCID: PMC9847691.
  5. Yung HW, Zhao X, Glover L, Burrin C, Pang PC, Jones CJP, Gill C, Duhig K, Olovsson M, Chappell LC, Haslam SM, Dell A, Burton GJ, Charnock-Jones DS. Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism. iScience. 2023 Jan 20;26(1):105911. doi: 10.1016/j.isci.2022.105911. eCollection 2023 Jan 20. PubMed PMID: 36660474; PubMed Central PMCID: PMC9843443.
  6. Sovio U, Clayton GL, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS. Metabolomic Identification of a Novel, Externally Validated Predictive Test for Gestational Diabetes Mellitus. J Clin Endocrinol Metab. 2022 Jul 14;107(8):e3479-e3486. doi: 10.1210/clinem/dgac240. PubMed PMID: 35436338; PubMed Central PMCID: PMC9282248.

William Colledge

  1. Ramos-Pittol JM, Fernandes-Freitas I, Milona A, Manchishi SM, Rainbow K, Lam BYH, Tadross JA, Beucher A, Colledge WH, Cebola I, Murphy KG, Miguel-Aliaga I, Yeo GSH, Dhillo WS, Owen BM. Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice. Nat Commun. 2023 May 29;14(1):3076. doi: 10.1038/s41467-023-38618-y. PubMed PMID: 37248237; PubMed Central PMCID: PMC10227040.
  2. Lass G, Li XF, Voliotis M, Wall E, de Burgh RA, Ivanova D, McIntyre C, Lin XH, Colledge WH, Lightman SL, Tsaneva-Atanasova K, O'Byrne KT. GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice. J Neuroendocrinol. 2022 Nov;34(11):e13207. doi: 10.1111/jne.13207. Epub 2022 Oct 28. PubMed PMID: 36305576; PubMed Central PMCID: PMC10078155.
  3. Göcz B, Takács S, Skrapits K, Rumpler É, Solymosi N, Póliska S, Colledge WH, Hrabovszky E, Sárvári M. Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations. Front Endocrinol (Lausanne). 2022;13:960769. doi: 10.3389/fendo.2022.960769. eCollection 2022. PubMed PMID: 36093104; PubMed Central PMCID: PMC9454256.
  4. Göcz B, Rumpler É, Sárvári M, Skrapits K, Takács S, Farkas I, Csillag V, Trinh SH, Bardóczi Z, Ruska Y, Solymosi N, Póliska S, Szőke Z, Bartoloni L, Zouaghi Y, Messina A, Pitteloud N, Anderson RC, Millar RP, Quinton R, Manchishi SM, Colledge WH, Hrabovszky E. Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2113749119. doi: 10.1073/pnas.2113749119. Epub 2022 Jun 28. PubMed PMID: 35763574; PubMed Central PMCID: PMC9271166.

Francesco Colucci

  1. Cazzetta V, Depierreux D, Colucci F, Mikulak J, Mavilio D. NKG2A Immune Checkpoint in Vδ2 T Cells: Emerging Application in Cancer Immunotherapy. Cancers (Basel). 2023 Feb 16;15(4). doi: 10.3390/cancers15041264. Review. PubMed PMID: 36831606; PubMed Central PMCID: PMC9954046.
  2. Colucci F. Uterine NK Cells Ace an "A" in Education: NKG2A Sets Up Crucial Functions at the Maternal-Fetal Interface. J Immunol. 2022 Oct 15;209(8):1421-1425. doi: 10.4049/jimmunol.2200384. Review. PubMed PMID: 36192118; PubMed Central PMCID: PMC7613701.

Miguel Constância

  1. Sandovici I, Reiterer M, Constância M, Branco CM. Protocol to isolate and culture primary mouse feto-placental endothelial cells. STAR Protoc. 2022 Dec 16;3(4):101721. doi: 10.1016/j.xpro.2022.101721. Epub 2022 Sep 24. PubMed PMID: 36153734; PubMed Central PMCID: PMC9513276.

Priscilla Day-Walsh

  1. Day-Walsh PE, Keeble B, Pirabagar G, Fountain SJ, Kroon PA. Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory Stimuli. Int J Mol Sci. 2022 Aug 3;23(15). doi: 10.3390/ijms23158646. PubMed PMID: 35955781; PubMed Central PMCID: PMC9369439.
  2. Shehata E, Parker A, Suzuki T, Swann JR, Suez J, Kroon PA, Day-Walsh P. Microbiomes in physiology: insights into 21st-century global medical challenges. Exp Physiol. 2022 Apr;107(4):257-264. doi: 10.1113/EP090226. Epub 2022 Feb 14. Review. PubMed PMID: 35081663; PubMed Central PMCID: PMC9304168.

Anne Ferguson-Smith

  1. Edwards CA, Watkinson WMD, Telerman SB, Hulsmann LC, Hamilton RS, Ferguson-Smith AC. Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions. Elife. 2023 Mar 14;12. doi: 10.7554/eLife.83364. PubMed PMID: 36916665; PubMed Central PMCID: PMC10097420.
  2. Weinberg-Shukron A, Ben-Yair R, Takahashi N, Dunjić M, Shtrikman A, Edwards CA, Ferguson-Smith AC, Stelzer Y. Balanced gene dosage control rather than parental origin underpins genomic imprinting. Nat Commun. 2022 Jul 29;13(1):4391. doi: 10.1038/s41467-022-32144-z. PubMed PMID: 35906226; PubMed Central PMCID: PMC9338321.
  3. Wolf JB, Ferguson-Smith AC, Lorenz A. Mendel's laws of heredity on his 200th birthday: What have we learned by considering exceptions?. Heredity (Edinb). 2022 Jul;129(1):1-3. doi: 10.1038/s41437-022-00552-y. Epub 2022 Jul 1. PubMed PMID: 35778507; PubMed Central PMCID: PMC9273789

Abby Fowden

  1. Young R, Lewandowska D, Long E, Wooding FBP, De Blasio MJ, Davies KL, Camm EJ, Sangild PT, Fowden AL, Forhead AJ. Hypothyroidism impairs development of the gastrointestinal tract in the ovine fetus. Front Physiol. 2023;14:1124938. doi: 10.3389/fphys.2023.1124938. eCollection 2023. PubMed PMID: 36935746; PubMed Central PMCID: PMC10020222.
  2. Davies KL, Camm EJ, Smith DJ, Miles J, Forhead AJ, Murray AJ, Fowden AL. Developmental programming of mitochondrial substrate metabolism in skeletal muscle of adult sheep by cortisol exposure before birth. J Dev Orig Health Dis. 2023 Feb;14(1):77-87. doi: 10.1017/S204017442200040X. Epub 2022 Jul 13. PubMed PMID: 35822505.
  3. Lopez-Tello J, Salazar-Petres E, Webb L, Fowden AL, Sferruzzi-Perri AN. Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy. Front Cell Dev Biol. 2022;10:928210. doi: 10.3389/fcell.2022.928210. eCollection 2022. PubMed PMID: 35846351; PubMed Central PMCID: PMC9283861

Dino Giussani

  1. Tong W, Ganguly E, Villalobos-Labra R, Quon A, Spaans F, Giussani DA, Davidge ST. Sex-Specific Differences in the Placental Unfolded Protein Response in a Rodent Model of Gestational Hypoxia. Reprod Sci. 2023 Jun;30(6):1994-1997. doi: 10.1007/s43032-022-01157-w. Epub 2022 Dec 27. PubMed PMID: 36574145; PubMed Central PMCID: PMC10229681.
  2. Garrud TAC, Teulings NEWD, Niu Y, Skeffington KL, Beck C, Itani N, Conlon FG, Botting KJ, Nicholas LM, Tong W, Derks JB, Ozanne SE, Giussani DA. Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system. FASEB J. 2023 Jun;37(6):e22887. doi: 10.1096/fj.202200676RR. PubMed PMID: 37132324.
  3. Kane AD, Herrera EA, Niu Y, Camm EJ, Allison BJ, Tijsseling D, Lusby C, Derks JB, Brain KL, Bronckers IM, Cross CM, Berends L, Giussani DA. Combined Statin and Glucocorticoid Therapy for the Safer Treatment of Preterm Birth. Hypertension. 2023 Apr;80(4):837-851. doi: 10.1161/HYPERTENSIONAHA.122.19647. Epub 2023 Feb 1. PubMed PMID: 36724801; PubMed Central PMCID: PMC10017302.
  4. Galli GLJ, Lock MC, Smith KLM, Giussani DA, Crossley DA 2nd. Effects of Developmental Hypoxia on the Vertebrate Cardiovascular System. Physiology (Bethesda). 2023 Mar 1;38(2):0. doi: 10.1152/physiol.00022.2022. Epub 2022 Nov 1. Review. PubMed PMID: 36317939.
  5. Sacco A, Cornish EF, Marlow N, David AL, Giussani DA. The effect of antenatal corticosteroid use on offspring cardiovascular function: A systematic review. BJOG. 2023 Mar;130(4):325-333. doi: 10.1111/1471-0528.17316. Epub 2022 Oct 27. Review. PubMed PMID: 36209465; PubMed Central PMCID: PMC10092187.
  6. Brombach C, Tong W, Giussani DA. Maternal obesity: new placental paradigms unfolded. Trends Mol Med. 2022 Oct;28(10):823-835. doi: 10.1016/j.molmed.2022.05.013. Epub 2022 Jun 24. Review. PubMed PMID: 35760668.
  7. Smith KLM, Swiderska A, Lock MC, Graham L, Iswari W, Choudhary T, Thomas D, Kowash HM, Desforges M, Cottrell EC, Trafford AW, Giussani DA, Galli GLJ. Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex-dependent manner. J Pineal Res. 2022 Oct;73(3):e12821. doi: 10.1111/jpi.12821. Epub 2022 Aug 17. PubMed PMID: 35941749; PubMed Central PMCID: PMC9540814.
  8. Tong W, Allison BJ, Brain KL, Patey OV, Niu Y, Botting KJ, Ford SG, Garrud TA, Wooding PFB, Shaw CJ, Lyu Q, Zhang L, Ma J, Cindrova-Davies T, Yung HW, Burton GJ, Giussani DA. Chronic Hypoxia in Ovine Pregnancy Recapitulates Physiological and Molecular Markers of Preeclampsia in the Mother, Placenta, and Offspring. Hypertension. 2022 Jul;79(7):1525-1535. doi: 10.1161/HYPERTENSIONAHA.122.19175. Epub 2022 May 9. PubMed PMID: 35534925; PubMed Central PMCID: PMC9172902

Courtney Hanna

  1. Thomas JR, Appios A, Calderbank EF, Yoshida N, Zhao X, Hamilton RS, Moffett A, Sharkey A, Laurenti E, Hanna CW*, McGovern N* (2023). Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR. Nature Communications, 14(1):1764. *Co-corresponding authors.
  2. Andrews S, Krueger C, Mellado-Lopez M, Hemberger M, Dean W, Perez-Garcia V, Hanna CW (2023). Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B. Nature Communications,14(1):371.
  3. Demond H, Hanna CW, Castillo-Fernandez J, Santos F, Papachristou EK, Segonds-Pichon A, Kishore K, Andrews S, D’Santos CS, Kelsey G (2023). Multi-omics analyses demonstrates a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis. Genome Research, 33(1):18-31.
  4. Hanna CW (2023). Mouse models of epigenetic inheritance: Classification, Mechanisms, and Experimental Strategies. In “Handbook of Epigenetics” Tollefsbol (Ed). Elsevier Inc., New York.

 

Gavin Kelsey

  1. Hanna CW, Huang J, Belton C, Reinhardt S, Dahl A, Andrews S, Stewart AF, Kranz A, Kelsey G. (2022) Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation. Nucl. Acids Res. 50:1993-2004.
  2. Rodríguez-Ubreva J, Arutyunyan A, Jan Bonder M, Del Pino-Molina L, Clark SJ, de la Calle-Fabregat C, Garcia-Alonso L, Handfield L-F, Ciudad L, Andrés-Leon E, Krueger F, Català-Moll F, Rodríguez-Cortez VC, Polanski K, Mamanova L, van Dongen S, Kiselev V, Martinez-Saavedra MT, Heyn H, Martin J, Warnatz K, López-Granados E, Rodríguez-Gallego C, Stegle O, Kelsey G, Vento-Tormo R, Ballestar E. (2022) Single-cell atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses. Nat. Communs. 13:1779.
  3. Van de Pette M, Dimond A, Galvao A, Millership SJ, To W, Prodani C, McNamara G, Bruno L, Sardini A, Webster Z, McGinty J, French PMW, Uren GA, Castillo-Fernandez J, Watkinson W, Ferguson-Smith AC, Merkenschlager M, John RM, Kelsey G, Fisher AG. (2022) Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice. Nat. Communs. 13:2464.
  4. Claxton M, Pulix M, Seah M, Bernardo R, Zhou P, Aljuraysi S, Liloglou T, Arnaud P, Kelsey G, Messerschmidt D, Plagge A. (2022) Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells. Front. Cell Dev. Biol. 10:1022422.
  5. Lopes JS, Ivanova E, Ruiz S, Andrews S, Kelsey G, Coy P. (2022) Effect of superovulation treatment on oocyte’s DNA methylation. Int. J. Mol. Sci. 23:16158.
  6. Saucedo-Cuevas L, Ivanova E, Herta A-C, Krueger F, Billooye K, Smitz J, Kelsey G, Anckaert E. (2023) Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts. Clin. Epigenet. 15:9.
  7. Demond H, Hanna CW, Castillo-Fernandez J, Santos F, Papachristou EK, Segonds-Pichon A, Kishore K, Andrews S, D’Santos CS, Kelsey G. (2023) Multi-omics analyses demonstrate a critical role for GLP methyltransferase in transcriptional repression during oogenesis. Genome Res. 33:18-31.
  8. Mora JRH, Buhigas C, Clark S, Bonilla RDG, Daskeviciute D, Monteagudo-Sánchez A, Poo-Llanillo ME, Medrano JV, Simón C, Meseguer M, Kelsey G, Monk D. (2023) Single-cell multi-omic analysis reveals defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrest. Cell Rep. 42:112100
  9. Rogerson C, Sciacovelli M, Maddelena L, Valcarel L, Yang M, Schmidt I, Ivanova E, Kent J, Cheeseman D, Carroll J, Kelsey G, Frezza C. FOXA2 controls the anti-oxidant response in FH-deficient cells. bioRxiv 2022.07.04.498412; deposited 14.10.22

Marta Shahbazi

  1. Miroshnikova YA, Shahbazi MN, Negrete J, Chalut KJ, Smith A. “Cell state transitions: catch them if you can”. Development. Mar, 2023; 150 (6): dev201139
  2. Sharma K, Uraji J, Ammar OF, Ali ZE, Liperis G, Modi D, Ojosnegros S, Shahbazi MN, Fraire-Zamora JJ. “#ESHREjc report: renewing the old: novel stem cell research for unsolved ART problems”. Hum Reprod. Aug, 2022; 37 (9): 2224-2227.
  3. Moris N, Shahbazi MN. “Unravelling the mysteries of human embryogenesis”. Semin Cell Dev Biol. Nov, 2022; 131: 1-3.
  4. Shahbazi MN. “Size matters”. Nat Rev Mol Cell Biol. Jul, 2022; doi: 10.1038/s41580-022-00521-7

Naomi McGovern

  1. Thomas JR, Appios A, Calderbank EF, Yoshida N, Zhao X, Hamilton RS, Moffett A, Sharkey A, Laurenti E, Hanna CW, McGovern N. Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR. Nat Commun. 2023 Mar 30;14(1):1764. doi: 10.1038/s41467-023-37383-2. PubMed PMID: 36997537; PubMed Central PMCID: PMC10063560.
  2. Nabweyambo S, Kanyerezi S, Petterson JH, Katabazi FA, Ssekagiri A, Mwesigwa S, Mboowa G, Nakazzi F, Keesiga A, Adroma M, Bwanga F, McGovern N, Sande OJ, Nakimuli A. No association of a Vascular endothelial growth factor A (VEGFA) gene polymorphism with pre-eclampsia among pregnant women in Uganda. BMC Genomics. 2023 Mar 20;24(1):132. doi: 10.1186/s12864-023-09213-8. PubMed PMID: 36941544; PubMed Central PMCID: PMC10029258.
  3. Stewart H, Palmulli R, Johansen KH, McGovern N, Shehata OM, Carnell GW, Jackson HK, Lee JS, Brown JC, Burgoyne T, Heeney JL, Okkenhaug K, Firth AE, Peden AA, Edgar JR. Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic. bioRxiv. 2022 Dec 22;. doi: 10.1101/2021.01.06.425396. PubMed PMID: 33442692; PubMed Central PMCID: PMC7805449.

Ashley Moffett

  1. Thomas JR, Appios A, Calderbank EF, Yoshida N, Zhao X, Hamilton RS, Moffett A, Sharkey A, Laurenti E, Hanna CW, McGovern N.  Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR. Nat Commun. 2023;14(1):1764. PMID: 36997537
  2. Arutyunyan A, Roberts K, Troulé K, Wong FCK, Sheridan MA, Kats I, Garcia-Alonso L, Velten B, Hoo R, Ruiz-Morales ER, Sancho-Serra C, Shilts J, Handfield LF, Marconato L, Tuck E, Gardner L, Mazzeo CI, Li Q, Kelava I, Wright GJ, Prigmore E, Teichmann SA, Bayraktar OA, Moffett A*, Stegle O*, Turco MY*, Vento-Tormo R*. Spatial multiomics map of trophoblast development in early pregnancy.  Nature. 2023 616(7955):143-151. PMID: 36991123. *joint last author
  3. Male V, Moffett A. Natural Killer Cells in the Human Uterine Mucosa. Annu Rev Immunol. 2023 Jan 11. Epub ahead of print. PMID: 36630598.
  4. Namagembe I, Kiwanuka N, Byamugisha JK, Ononge S, Beyeza-Kashesya J, Kaye DK, Moffett A, Aiken CE, Nakimuli A. Why mothers die at a busy tertiary urban hospital in Kampala, Uganda: a comprehensive review of maternal deaths 2016-2018 and implications for quality improvement to reduce deaths. Afr Health Sci. 2022 22(2):489-499. PMID: 36407335
  5. Namagembe I, Chukwuma SM, Nakimuli A, Kiwanuka N, Byamugisha J, Moffett A, Aiken CE.  Learning from maternal deaths due to uterine rupture: review of cases from peri-urban Uganda. AJOG Glob Rep. 2022 2(3):100063. PMID: 36276797
  6. Moffett A, Shreeve N. Local immune recognition of trophoblast in early human pregnancy: controversies and questions.  Nat Rev Immunol. 2023 Apr;23(4):222-235. PMID: 36192648
  7. Garcia-Alonso L, Lorenzi V, Mazzeo CI, Alves-Lopes JP, Roberts K, Sancho-Serra C, Engelbert J, Marečková M, Gruhn WH, Botting RA, Li T, Crespo B, van Dongen S, Kiselev VY, Prigmore E, Herbert M, Moffett A, Chédotal A, Bayraktar OA, Surani A, Haniffa M, Vento-Tormo R. Single-cell roadmap of human gonadal development. Nature. 2022 Jul;607(7919):540-547. PMID: 35794482
  8. Namagembe I, Nakimuli A, Byamugisha J, Moffett A, Aiken A, Aiken C.  Preventing death following unsafe abortion: a case series from urban Uganda.  AJOG Glob Rep. 2022 Feb;2(1):100039. PMID: 35252906 
  9. Moffett A. Miracle Mayonnaise Babies, London Review of Books. November 18th 2021. https://www.lrb.co.uk/the-paper/v43/n22/ashley-moffett/short-cuts
  10. ESHRE Add-ons working group: Lundin K., Bozdag G., Ebner T., Gasseholm Bentzen J., Harper J., Le Clef N., Moffett A., Norcross S., Polyzos N.P., Rautakallio-Hokkanen S, Sfontouris I., Sermon K., Vermeulen N. and Pinborg A. Good practice recommendations for add-ons in reproductive medicine. Human Reproduction (in press)

Andrew Murray

  1. Lindsay RT, Ambery P, Jermutus L, Murray AJ. Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart. Physiol Rep. 2023 Mar;11(6):e15597. doi: 10.14814/phy2.15597. PubMed PMID: 36946315; PubMed Central PMCID: PMC10031586.
  2. Davies KL, Camm EJ, Smith DJ, Miles J, Forhead AJ, Murray AJ, Fowden AL. Developmental programming of mitochondrial substrate metabolism in skeletal muscle of adult sheep by cortisol exposure before birth. J Dev Orig Health Dis. 2023 Feb;14(1):77-87. doi: 10.1017/S204017442200040X. Epub 2022 Jul 13. PubMed PMID: 35822505.
  3. Verma N, Velmurugan GV, Winford E, Coburn H, Kotiya D, Leibold N, Radulescu L, Despa S, Chen KC, Van Eldik LJ, Nelson PT, Wilcock DM, Jicha GA, Stowe AM, Goldstein LB, Powel DK, Walton JH, Navedo MF, Nystoriak MA, Murray AJ, Biessels GJ, Troakes C, Zetterberg H, Hardy J, Lashley T, Despa F. Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas. Commun Biol. 2023 Jan 3;6(1):2. doi: 10.1038/s42003-022-04398-2. PubMed PMID: 36596993; PubMed Central PMCID: PMC9810597.
  4. Ronzano R, Skarlatou S, Barriga BK, Bannatyne BA, Bhumbra GS, Foster JD, Moore JD, Lancelin C, Pocratsky AM, Özyurt MG, Smith CC, Todd AJ, Maxwell DJ, Murray AJ, Pfaff SL, Brownstone RM, Zampieri N, Beato M. Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled. Elife. 2022 Dec 13;11. doi: 10.7554/eLife.81976. PubMed PMID: 36512397; PubMed Central PMCID: PMC9844990.
  5. Moore LG, Wesolowski SR, Lorca RA, Murray AJ, Julian CG. Why is human uterine artery blood flow during pregnancy so high?. Am J Physiol Regul Integr Comp Physiol. 2022 Nov 1;323(5):R694-R699. doi: 10.1152/ajpregu.00167.2022. Epub 2022 Sep 12. PubMed PMID: 36094446; PubMed Central PMCID: PMC9602899.

Kathy Niakan

  1. Regin M, Essahib W, Demtschenko A, Dewandre D, David L, Gerri C, Niakan KK, Verheyen G, Tournaye H, Sterckx J, Sermon K, Van De Velde H. Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1. Hum Reprod. 2023 Jun 9;. doi: 10.1093/humrep/dead107. [Epub ahead of print] PubMed PMID: 37295962.
  2. Gerri C, McCarthy A, Mei Scott G, Regin M, Stamatiadis P, Brumm S, Simon CS, Lee J, Montesinos C, Hassitt C, Hockenhull S, Hampshire D, Elder K, Snell P, Christie L, Fouladi-Nashta AA, Van de Velde H, Niakan KK. A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals. Development. 2023 Apr 15;150(8). doi: 10.1242/dev.201112. Epub 2023 Apr 20. PubMed PMID: 36971487; PubMed Central PMCID: PMC10263151.
  3. Barry DJ, Gerri C, Bell DM, D'Antuono R, Niakan KK. GIANI - open-source software for automated analysis of 3D microscopy images. J Cell Sci. 2022 May 15;135(10). doi: 10.1242/jcs.259511. Epub 2022 May 17. PubMed PMID: 35502739; PubMed Central PMCID: PMC9189431.

Sue Ozanne

  1. Garrud TAC, Teulings NEWD, Niu Y, Skeffington KL, Beck C, Itani N, Conlon FG, Botting KJ, Nicholas LM, Tong W, Derks JB, Ozanne SE, Giussani DA. Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system. FASEB J. 2023 Jun;37(6):e22887. doi: 10.1096/fj.202200676RR. PubMed PMID: 37132324.
  2. Metcalfe NB, Bellman J, Bize P, Blier PU, Crespel A, Dawson NJ, Dunn RE, Halsey LG, Hood WR, Hopkins M, Killen SS, McLennan D, Nadler LE, Nati JJH, Noakes MJ, Norin T, Ozanne SE, Peaker M, Pettersen AK, Przybylska-Piech A, Rathery A, Récapet C, Rodríguez E, Salin K, Stier A, Thoral E, Westerterp KR, Westerterp-Plantenga MS, Wojciechowski MS, Monaghan P. Solving the conundrum of intra-specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit: New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species: New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species. Bioessays. 2023 Jun;45(6):e2300026. doi: 10.1002/bies.202300026. Epub 2023 Apr 12. PubMed PMID: 37042115.
  3. Parra-Vargas M, Bouret SG, Bruning JC, de Moura EG, Garland T Jr, Lisboa PC, Ozanne SE, Patti ME, Plagemann A, Speakman JR, Tena-Sempere M, Vergely C, Zeltser LM, Jiménez-Chillarón JC. The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology. Mol Metab. 2023 May;71:101707. doi: 10.1016/j.molmet.2023.101707. Epub 2023 Mar 16. PubMed PMID: 36933618; PubMed Central PMCID: PMC10074241.
  4. White SL, Koulman A, Ozanne SE, Furse S, Poston L, Meek CL. Towards precision medicine in gestational diabetes: pathophysiology and glycemic patterns in pregnant women with obesity. J Clin Endocrinol Metab. 2023 Mar 23;. doi: 10.1210/clinem/dgad168. [Epub ahead of print] PubMed PMID: 36950879.
  5. Justulin LA, Zambrano E, Ong TP, Ozanne SE. Editorial: Early Life Epigenetic Programming of Health and Disease through DOHaD Perspective. Front Cell Dev Biol. 2023;11:1139283. doi: 10.3389/fcell.2023.1139283. eCollection 2023. PubMed PMID: 36846583; PubMed Central PMCID: PMC9950751.
  6. Dearden L, Ozanne SE. Considerations for designing and analysing inter-generational studies in rodents. Nat Metab. 2023 Jan;5(1):1-4. doi: 10.1038/s42255-022-00721-7. PubMed PMID: 36609721.
  7. Schoonejans JM, Blackmore HL, Ashmore TJ, Pantaleão LC, Pellegrini Pisani L, Dearden L, Tadross JA, Aiken CE, Fernandez-Twinn DS, Ozanne SE. Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring. Diabetologia. 2022 Dec;65(12):2132-2145. doi: 10.1007/s00125-022-05789-0. Epub 2022 Sep 16. PubMed PMID: 36112170; PubMed Central PMCID: PMC9630251.
  8. Muglia LJ, Benhalima K, Tong S, Ozanne S. Maternal factors during pregnancy influencing maternal, fetal, and childhood outcomes. BMC Med. 2022 Nov 1;20(1):418. doi: 10.1186/s12916-022-02632-6. PubMed PMID: 36320027; PubMed Central PMCID: PMC9623926.
  9. Inzani I, Ozanne SE. Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring. Proc Nutr Soc. 2022 Sep;81(3):227-242. doi: 10.1017/S0029665122001914. Epub 2022 Jul 29. Review. PubMed PMID: 35974421; PubMed Central PMCID: PMC7613838.
  10. Giakoumaki I, Pollock N, Aljuaid T, Sannicandro AJ, Alameddine M, Owen E, Myrtziou I, Ozanne SE, Kanakis I, Goljanek-Whysall K, Vasilaki A. Postnatal Protein Intake as a Determinant of Skeletal Muscle Structure and Function in Mice-A Pilot Study. Int J Mol Sci. 2022 Aug 8;23(15). doi: 10.3390/ijms23158815. PubMed PMID: 35955948; PubMed Central PMCID: PMC9369224.

Peter Rugg-Gunn

  1. Rugg-Gunn PJ, Moris N, Tam PPL. Technical challenges of studying early human development. Development. 2023 Jun 1;150(11). doi: 10.1242/dev.201797. Epub 2023 Jun 1. PubMed PMID: 37260362.
  2. Rosspopoff O, Cazottes E, Huret C, Loda A, Collier AJ, Casanova M, Rugg-Gunn PJ, Heard E, Ouimette JF, Rougeulle C. Species-specific regulation of XIST by the JPX/FTX orthologs. Nucleic Acids Res. 2023 Mar 21;51(5):2177-2194. doi: 10.1093/nar/gkad029. PubMed PMID: 36727460; PubMed Central PMCID: PMC10018341.
  3. Maskalenka K, Alagöz G, Krueger F, Wright J, Rostovskaya M, Nakhuda A, Bendall A, Krueger C, Walker S, Scally A, Rugg-Gunn PJ. NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells. Development. 2023 Jan 15;150(2). doi: 10.1242/dev.201155. Epub 2023 Jan 18. PubMed PMID: 36621005; PubMed Central PMCID: PMC10110494.
  4. von Meyenn F, Berrens RV, Andrews S, Santos F, Collier AJ, Krueger F, Osorno R, Dean W, Rugg-Gunn PJ, Reik W. Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification. Dev Cell. 2022 Dec 5;57(23):2669-2671. doi: 10.1016/j.devcel.2022.11.009. PubMed PMID: 36473463; PubMed Central PMCID: PMC9746669.
  5. Novo CL, Wong EV, Hockings C, Poudel C, Sheekey E, Wiese M, Okkenhaug H, Boulton SJ, Basu S, Walker S, Kaminski Schierle GS, Narlikar GJ, Rugg-Gunn PJ. Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells. Nat Commun. 2022 Jun 20;13(1):3525. doi: 10.1038/s41467-022-31198-3. PubMed PMID: 35725842; PubMed Central PMCID: PMC9209518.
  6. Zijlmans DW, Talon I, Verhelst S, Bendall A, Van Nerum K, Javali A, Malcolm AA, van Knippenberg SSFA, Biggins L, To SK, Janiszewski A, Admiraal D, Knops R, Corthout N, Balaton BP, Georgolopoulos G, Panda A, Bhanu NV, Collier AJ, Fabian C, Allsop RN, Chappell J, Pham TXA, Oberhuemer M, Ertekin C, Vanheer L, Athanasouli P, Lluis F, Deforce D, Jansen JH, Garcia BA, Vermeulen M, Rivron N, Dhaenens M, Marks H, Rugg-Gunn PJ, Pasque V. Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nat Cell Biol. 2022 Jun;24(6):858-871. doi: 10.1038/s41556-022-00932-w. Epub 2022 Jun 13. PubMed PMID: 35697783; PubMed Central PMCID: PMC9203278.
  7. Rostovskaya M, Andrews S, Reik W, Rugg-Gunn PJ. Amniogenesis occurs in two independent waves in primates. Cell Stem Cell. 2022 May 5;29(5):744-759.e6. doi: 10.1016/j.stem.2022.03.014. Epub 2022 Apr 18. PubMed PMID: 35439430; PubMed Central PMCID: PMC9627701.
  8. Collier AJ, Bendall A, Fabian C, Malcolm AA, Tilgner K, Semprich CI, Wojdyla K, Nisi PS, Kishore K, Roamio Franklin VN, Mirshekar-Syahkal B, D'Santos C, Plath K, Yusa K, Rugg-Gunn PJ. Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming. Sci Adv. 2022 Mar 25;8(12):eabk0013. doi: 10.1126/sciadv.abk0013. Epub 2022 Mar 25. PubMed PMID: 35333572; PubMed Central PMCID: PMC8956265.
  9. Rugg-Gunn PJ. Induction of Human Naïve Pluripotency Using Chemical Resetting. Methods Mol Biol. 2022;2416:29-37. doi: 10.1007/978-1-0716-1908-7_3. PubMed PMID: 34870828.
  10. Tomimatsu K, Bihary D, Olan I, Parry AJ, Schoenfelder S, Chan ASL, Slater GSC, Ito Y, Rugg-Gunn PJ, Kirschner K, Bermejo-Rodriguez C, Seko T, Kugoh H, Shiraishi K, Sayama K, Kimura H, Fraser P, Narita M, Samarajiwa SA, Narita M. Locus-specific induction of gene expression from heterochromatin loci during cellular senescence. Nat Aging. 2022 Jan;2(1):31-45. doi: 10.1038/s43587-021-00147-y. Epub 2021 Dec 23. PubMed PMID: 37118356.
  11. Rugg-Gunn PJ. Flow Cytometry Analysis of Cell-Surface Markers to Identify Human Naïve Pluripotent Stem Cells. Methods Mol Biol. 2022;2416:257-265. doi: 10.1007/978-1-0716-1908-7_16. PubMed PMID: 34870841.

Amanda Sferruzzi-Perri

  1. Yong HEJ*, Maksym K*, Yusoff MAB, Salazar-Petres E, Nazarenko T, Zaikin A, David AL, Hillman SL, Sferruzzi-Perri AN (2023) Integrated placental modelling of histology with gene expression to identify functional impact in health and disease. Cells 12(7):1093 and Available on medRxiv:  https://medrxiv.org/cgi/content/short/2022.05.31.22275522v1. * joint first author. Joint senior author.
  2. Musa E*, Salazar-Petres E*, Arowolo A, Levitt N, Matjila M*, Sferruzzi-Perri AN* (2023) Obesity and gestational diabetes independently and collectively, induce specific impacts on placental structure, inflammation, and endocrine function. J Physiol 601(7):1287-1306. A feature by the journal: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284407 and much media attention (featured on 23 outlets): https://wiley.altmetric.com/details/142967245/news
  3. Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN (2023) Maternal and intrauterine influences on feto-placental growth are accompanied by sexually dimorphic changes in placental mitochondrial respiration, and metabolic signalling pathways.Joint senior author. Cells 12:797 and on Bioarchive server https://www.biorxiv.org/content/10.1101/2023.01.24.525377v1?rss=1
  4. Sferruzzi-Perri AN, Lopez-Tello J, Salazar-Petres E. Placental adaptations supporting fetal growth during normal and adverse gestational environments. Exp Physiol. 2023 Mar;108(3):371-397. doi: 10.1113/EP090442. Epub 2022 Dec 9. Review. PubMed PMID: 36484327.
  5. Candia AA, Jiménez T, Navarrete Á, Beñaldo F, Silva P, García-Herrera C, Sferruzzi-Perri AN, Krause BJ, González-Candia A, Herrera EA. Developmental Ultrasound Characteristics in Guinea Pigs: Similarities with Human Pregnancy. Vet Sci. 2023 Feb 10;10(2). doi: 10.3390/vetsci10020144. PubMed PMID: 36851448; PubMed Central PMCID: PMC9963037.
  6. Lopez-Tello J, Sferruzzi-Perri AN. Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age. Front Endocrinol (Lausanne). 2023;14:1116770. doi: 10.3389/fendo.2023.1116770. eCollection 2023. PubMed PMID: 36843585; PubMed Central PMCID: PMC9950515.
  7. Cindrova-Davies T, Sferruzzi-Perri AN. Human placental development and function. Semin Cell Dev Biol. 2022 Nov;131:66-77. doi: 10.1016/j.semcdb.2022.03.039. Epub 2022 Apr 4. Review. PubMed PMID: 35393235.
  8. Lean SC, Candia AA, Gulacsi E, Lee GCL, Sferruzzi-Perri AN (2022) Obesogenic diet in mice compromises maternal metabolic physiology and lactation ability leading to reductions in neonatal viability. Acta Physiologica 236(2):e13861.
    Much media attention e.g. https://mcginleysbar.com/western-style-diet-high-in-fat-and-sugar-can-ne....
  9. Pereira-Carvalho D, Salazar-Petres E, Lopez-Tello J, Sferruzzi-Perri AN. Maternal and Fetal PI3K-p110α Deficiency Induces Sex-Specific Changes in Conceptus Growth and Placental Mitochondrial Bioenergetic Reserve in Mice. Vet Sci. 2022 Sep 13;9(9). doi: 10.3390/vetsci9090501. PubMed PMID: 36136716; PubMed Central PMCID: PMC9506205.
  10. Lopez-Tello J, Salazar-Petres E, Webb L, Fowden AL, Sferruzzi-Perri AN. Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy. Front Cell Dev Biol. 2022;10:928210. doi: 10.3389/fcell.2022.928210. eCollection 2022. PubMed PMID: 35846351; PubMed Central PMCID: PMC9283861.
  11. Lopez-Tello J, Schofield Z, Kiu R, Dalby MJ, van Sinderen D, Le Gall G, Sferruzzi-Perri AN, Hall LJ. Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice. Cell Mol Life Sci. 2022 Jun 28;79(7):386. doi: 10.1007/s00018-022-04379-y. PubMed PMID: 35760917; PubMed Central PMCID: PMC9236968.

Claire Senner

  1. Senner C.E.*, Dong Z., Prater M., Branco M.R. and Watson E.D.* (2023). One-carbon metabolism is required for epigenetic stability in the mouse placenta. Front Cell Dev Biol. In press.

Gordon Smith

  1. Stephens K, Charnock-Jones DS, Smith GCS. Group B Streptococcus and the risk of perinatal morbidity and mortality following term labor. American Journal of Obstetrics & Gynecology 2022, in press.
  2. Kennedy KM, de Goffau M, Elisa Perez-Muñoz ME, Arrieta MC, Bäckhed F, Bork P, Braun T, Bushman FD, Doré J, de Vos W , Earl A, Eisen J, Elovitz M, Ganal-Vonarburg S, Gänzle M, Garrett M, Hall L, Hornef M, Huttenhower C, Konnikova L, Lebeer S, Macpherson A, Massey R, McHardy A, Koren O, Lawley T, Ley R, O'Mahony L, O'Toole P, Pamer E, Parkhill J, Raes J,  Rattei T, Salonen A, Segal E, Segata N, Shanahan F, Sloboda D, Smith GCS, Sokol H, Spector T,  Surette M, Tannock G, Walker A, Yassour M, Walter J. Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Nature 2023;613:639-649.
  3. Olga L, Sovio U, Wong H, Smith GCS, Aiken CE. Association between antenatal diagnosis of late fetal growth restriction and educational outcomes in mid-childhood: A UK prospective cohort study with long-term data-linkage study. PLoS Medicine 2023, in press.
  4. Burden CA, Smith GCS, Sovio U, Clayton GL, Fraser A. Maternal hemoglobin levels and adverse pregnancy outcomes: individual patient data analysis from 2 prospective UK pregnancy cohorts. American Journal of Clinical Nutrition 2023:117:616-624.
  5. Avellino G, Deshmukh R, Charnock-Jones DS, Smith GCS, Tardito S, Aye ILMH. Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function. American Journal of Physiology (Cell Physiology) 2023, In press.
  6. Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Smith GCS. Maternal serum levels of sFlt-1 and PlGF at 20 and 28 weeks of gestational age and the risk of spontaneous preterm birth. American Journal of Obstetrics & Gynecology 2023, Feb 7:S0002-9378(23)00077-7. doi: 10.1016/j.ajog.2023.02.001. Online ahead of print.
  7. Adanikin A, Lawlor DA, Pell JP, Nelson SM, Smith GCS, Iliodromiti S. Association of birthweight centiles and early childhood development: A population-based cohort study of singleton infants born from 37 weeks of gestation in Scotland. PLoS Medicine 2022;19:e1004108.
  8. Been JV, Smith GCS, Cooper SA, Pell JP, Mackay D. Time of birth and additional support need at school age: national cohort study of 865 409 children. Journal of Perinatology 2022 Oct 8. doi: 10.1038/s41372-022-01524-0. Online ahead of print.
  9. Gaccioli F, Sovio U, Song S, Cook E, Charnock-Jones DS, Smith GCS. Increased Placental sFLT1 (Soluble fms-Like Tyrosine Kinase Receptor-1) Drives the Antiangiogenic Profile of Maternal Serum Preceding Preeclampsia but Not Fetal Growth Restriction. Hypertension 2023;80:325-334.

Azim Surani

  1. Castillo-Venzor A, Penfold CA, Morgan MD, Tang WW, Kobayashi T, Wong FC, Bergmann S, Slatery E, Boroviak TE, Marioni JC, Surani MA. Origin and segregation of the human germline. Life Sci Alliance. 2023 Aug;6(8). doi: 10.26508/lsa.202201706. Print 2023 Aug. PubMed PMID: 37217306; PubMed Central PMCID: PMC10203729.
  2. Zhang J, Zhao L, Fu Y, Liu F, Wang Z, Li Y, Zhao G, Sun W, Wu B, Song Y, Li S, Hao C, Wuyun B, Wu R, Liu M, Cao G, Nashun B, Surani MA, Sun Q, Bao S, Liu P, Li X. Reprogramming efficiency and pluripotency of mule iPSCs over its parents†. Biol Reprod. 2023 Jun 9;108(6):887-901. doi: 10.1093/biolre/ioad041. PubMed PMID: 37040346; PubMed Central PMCID: PMC10266948.
  3. Fulka H, Loi P, Czernik M, Surani A, Fulka J. Omne vivum ex ovo: the oocyte reprogramming and remodeling activities. Reproduction. 2023 Mar 1;165(3):R75-R89. doi: 10.1530/REP-22-0124. Print 2023 Mar 1. Review. PubMed PMID: 36449538.
  4. Alves-Lopes JP, Wong FCK, Tang WWC, Gruhn WH, Ramakrishna NB, Jowett GM, Jahnukainen K, Surani MA. Specification of human germ cell fate with enhanced progression capability supported by hindgut organoids. Cell Rep. 2023 Jan 31;42(1):111907. doi: 10.1016/j.celrep.2022.111907. Epub 2023 Jan 5. PubMed PMID: 36640324.Gruhn WH, Tang WWC, Dietmann S, Alves-Lopes JP, Penfold CA, Wong FCK, Ramakrishna NB, Surani MA. Epigenetic resetting in the human germ line entails histone modification remodeling. Sci Adv. 2023 Jan 18;9(3):eade1257. doi: 10.1126/sciadv.ade1257. Epub 2023 Jan 18. PubMed PMID: 36652508; PubMed Central PMCID: PMC9848478.
  5. Floros VI, Pyle A, Dietmann S, Wei W, Tang WWC, Irie N, Payne B, Capalbo A, Noli L, Coxhead J, Hudson G, Crosier M, Strahl H, Khalaf Y, Saitou M, Ilic D, Surani MA, Chinnery PF. Author Correction: Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos. Nat Cell Biol. 2023 Jan;25(1):194. doi: 10.1038/s41556-022-01046-z. PubMed PMID: 36522542.
  6. Ramakrishna NB, Battistoni G, Surani MA, Hannon GJ, Miska EA. Mouse primordial germ-cell-like cells lack piRNAs. Dev Cell. 2022 Dec 5;57(23):2661-2668.e5. doi: 10.1016/j.devcel.2022.11.004. PubMed PMID: 36473462.
  7. Garcia-Alonso L, Lorenzi V, Mazzeo CI, Alves-Lopes JP, Roberts K, Sancho-Serra C, Engelbert J, Marečková M, Gruhn WH, Botting RA, Li T, Crespo B, van Dongen S, Kiselev VY, Prigmore E, Herbert M, Moffett A, Chédotal A, Bayraktar OA, Surani A, Haniffa M, Vento-Tormo R. Single-cell roadmap of human gonadal development. Nature. 2022 Jul;607(7919):540-547. doi: 10.1038/s41586-022-04918-4. Epub 2022 Jul 6. PubMed PMID: 35794482; PubMed Central PMCID: PMC9300467.

Roser Vento-Tormo

  1. Arutyunyan A, Roberts K, Troulé K, Wong FCK, Sheridan MA, Kats I, Garcia-Alonso L, Velten B, Hoo R, Ruiz-Morales ER, Sancho-Serra C, Shilts J, Handfield LF, Marconato L, Tuck E, Gardner L, Mazzeo CI, Li Q, Kelava I, Wright GJ, Prigmore E, Teichmann SA, Bayraktar OA, Moffett A, Stegle O, Turco MY, Vento-Tormo R*. Spatial multiomics map of trophoblast development in early pregnancy. Nature. 2023 Apr;616(7955):143-151.
  2. Suo C, Polanski K, Dann E, Lindeboom RGH, Vilarrasa-Blasi R, Vento-Tormo R, Haniffa M, Meyer KB, Dratva LM, Tuong ZK, Clatworthy MR, Teichmann SA. Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins. Nat Biotechnol. 2023 Apr 13.
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Erica Watson

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Mathew Van de Pette

  1. Dimond A, Van de Pette M, Taylor-Bateman V, Brown K, Sardini A, Whilding C, Feytout A, Prinjha RK, Merkenschlager M, Fisher AG. Drug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c. Sci Rep. 2023 Apr 6;13(1):5626. doi: 10.1038/s41598-023-32747-6. PubMed PMID: 37024615; PubMed Central PMCID: PMC10079848.
  2. Gleneadie HJ, Fernandez-Ruiz B, Sardini A, Van de Pette M, Dimond A, Prinjha RK, McGinty J, French PMW, Bagci H, Merkenschlager M, Fisher AG. Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition. Commun Biol. 2023 Mar 25;6(1):318. doi: 10.1038/s42003-023-04666-9. PubMed PMID: 36966198; PubMed Central PMCID: PMC10039851.
  3. Van de Pette M, Dimond A, Galvão AM, Millership SJ, To W, Prodani C, McNamara G, Bruno L, Sardini A, Webster Z, McGinty J, French PMW, Uren AG, Castillo-Fernandez J, Watkinson W, Ferguson-Smith AC, Merkenschlager M, John RM, Kelsey G, Fisher AG. Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice. Nat Commun. 2022 May 5;13(1):2464. doi: 10.1038/s41467-022-30022-2. PubMed PMID: 35513363; PubMed Central PMCID: PMC9072353.

Magdalena Zernicka-Goetz

  1. Handford CE, Panda P, Mohammad Choudhury IB, Amadei G, Zernicka-Goetz M. Generation of Stem Cell-Based Mouse Embryo-Like Structures. Methods Mol Biol. 2023 Jun 8;. doi: 10.1007/7651_2023_493. [Epub ahead of print] PubMed PMID: 37284940.
  2. Bao M, Cornwall-Scoones J, Sanchez-Vasquez E, Cox AL, Chen DY, De Jonghe J, Shadkhoo S, Hollfelder F, Thomson M, Glover DM, Zernicka-Goetz M. Author Correction: Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension. Nat Cell Biol. 2023 Jun;25(6):917. doi: 10.1038/s41556-023-01157-1. PubMed PMID: 37221392; PubMed Central PMCID: PMC10264236.
  3. Lamba A, Zernicka-Goetz M. The role of polarization and early heterogeneities in the mammalian first cell fate decision. Curr Top Dev Biol. 2023;154:169-196. doi: 10.1016/bs.ctdb.2023.02.006. Epub 2023 Mar 21. Review. PubMed PMID: 37100517.
  4. Apostolou E, Blau H, Chien K, Lancaster MA, Tata PR, Trompouki E, Watt FM, Zeng YA, Zernicka-Goetz M. Progress and challenges in stem cell biology. Nat Cell Biol. 2023 Feb;25(2):203-206. doi: 10.1038/s41556-023-01087-y. PubMed PMID: 36788378.
  5. Liang X, Weberling A, Hii CY, Zernicka-Goetz M, Buckley CE. E-cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities. EMBO J. 2022 Dec 15;41(24):e111021. doi: 10.15252/embj.2022111021. Epub 2022 Aug 22. PubMed PMID: 35993232; PubMed Central PMCID: PMC9753465.
  6. Lau KYC, Rubinstein H, Gantner CW, Hadas R, Amadei G, Stelzer Y, Zernicka-Goetz M. Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development. Cell Stem Cell. 2022 Oct 6;29(10):1445-1458.e8. doi: 10.1016/j.stem.2022.08.013. Epub 2022 Sep 8. PubMed PMID: 36084657; PubMed Central PMCID: PMC9648694.
  7. Amadei G, Handford CE, Qiu C, De Jonghe J, Greenfeld H, Tran M, Martin BK, Chen DY, Aguilera-Castrejon A, Hanna JH, Elowitz MB, Hollfelder F, Shendure J, Glover DM, Zernicka-Goetz M. Embryo model completes gastrulation to neurulation and organogenesis. Nature. 2022 Oct;610(7930):143-153. doi: 10.1038/s41586-022-05246-3. Epub 2022 Aug 25. PubMed PMID: 36007540; PubMed Central PMCID: PMC9534772.
  8. Bao M, Cornwall-Scoones J, Zernicka-Goetz M. Stem-cell-based human and mouse embryo models. Curr Opin Genet Dev. 2022 Oct;76:101970. doi: 10.1016/j.gde.2022.101970. Epub 2022 Aug 18. Review. PubMed PMID: 35988317.
  9. Bao M, Cornwall-Scoones J, Sanchez-Vasquez E, Cox AL, Chen DY, De Jonghe J, Shadkhoo S, Hollfelder F, Thomson M, Glover DM, Zernicka-Goetz M. Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension. Nat Cell Biol. 2022 Sep;24(9):1341-1349. doi: 10.1038/s41556-022-00984-y. Epub 2022 Sep 13. PubMed PMID: 36100738; PubMed Central PMCID: PMC9481465
  10. Shen C, Lamba A, Zhu M, Zhang R, Zernicka-Goetz M, Yang C (2022). Stain-free detection of embryo polarization using deep learning. Sci Rep. 12(1):2404. doi: 10.1038/s41598-022-05990-6.PMID: 35165311