Dr Wolfram Gruhn

In multicellular eukaryotes, the epigenome forms a key regulatory layer for controlling transcription and defining cellular identity and developmental potential. In mammals, the development of germ cells into sperm or eggs involves profound changes to this regulatory layer, collectively termed epigenetic reprogramming, which are essential for normal gametogenesis and embryonic development.

My research focuses on understanding the molecular mechanisms that govern the first phase of epigenetic reprogramming in the human germline, which takes place in embryonic primordial germ cells (PGCs). In particular, my team aims to understand: What mechanisms drive human PGC development? How do these mechanisms determine which epigenetic information to erase or maintain? And how environmental factors may influence this process?

To address these questions, my lab uses human embryonic stem cell-based models to recapitulate early germline development, combined with approaches to monitor and manipulate transcriptional and epigenetic states.

Ultimately, our research aims to advance our understanding of human germline development and identify risk factors for reproductive health.