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View mouse pre-implantation blastocyst immunostained for DNA in blue and microtubules in green. Some cells in both the trophectoderm and the inner cell mass are undergoing mitosis. Imaged by Nadia Capatina CTR PhD student

last modified Feb 22, 2018 02:03 PM

Mouse pre-implantation blastocyst immunostained for DNA in blue and microtubules in green. Some cells in both the trophectoderm and the inner cell mass are undergoing mitosis. Imaged by Nadia Capatina CTR PhD student.

 

Infertility, miscarriage, preeclampsia, and fetal growth restriction are devastating conditions for which at present there are no effective solutions. I study the connections between cell stress and placental development. The endoplasmic reticulum (ER) is the point of convergence of many cell stressors. My preliminary data support the hypothesis that induction of ER stress leads to precocious trophoblast cell differentiation at the blastocyst stage. This may impact adversely on the stem cell pool, compromising placental development and hence pregnancy outcome.