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Gregorio Alanis-Lobato, Jasmin Zohren, Afshan McCarthy, Norah M. E. Fogarty, Nada Kubikova, Emily Hardman, Maria Greco, Dagan Wells, James M. A. Turner, and Kathy K. NiakanAbstractCRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this appr…

Alexandros A.Moraitis, ThomasBainton, UllaSovio, Peter Brocklehurst, Alexander EP.Heazell,Jim G.Thornton, Stephen C.Robson,Aris Papageorghiou,Gordon CS.SmithAbstractThe objective of this study was to investigate the accuracy of universal third trimester umbilical artery (UA) Doppler to predict adverse pregnancy outcome at term. We searched Medline,…

Sijia Yao, Jorge Lopez-Tello, Amanda N Sferruzzi-PerriAbstractExposures to adverse conditions in utero can lead to permanent changes in the structure and function of key physiological systems in the developing fetus, increasing the risk of disease and premature aging in later postnatal life. When considering the systems that could be affected by an…

We are saddened to hear of the passing of Professor Bob Moor FRS, a great scientist and colleague. Bob identified many of the factors underpinning reproduction in ungulates during his time at the Babraham Institute, and also worked on generating transgenic animals and stem cells. His wisdom and collegiality will be sorely missed.

Tim H. H. Coorens, Thomas R. W. Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D. Young, Raheleh Rahbari, Neil Sebire, Peter J. Campbell, D. Stephen Charnock-Jones, Gordon C. S. Smith & Sam Behjati.AbstractPlacentas can exhibit chromosomal aberrations that are absent from the fetus1. The basis of this g…

BackgroundThe INTERGROWTH-21st estimated fetal weight percentiles are recommended for predicting extremes of birthweight percentile, although evidence for their superiority over the widely employed Hadlock method is lacking.ObjectiveThis study aimed to compare the ability of estimated fetal weight percentiles calculated using the Hadlock method and…

Benedikt Strunz1,Jonna Bister1, Hanna Jönsson1, Iva Filipovic1, Ylva Crona-Guterstam1,2,3, Egle Kvedaraite1,4, Natalie Sleiers1, Bogdan Dumitrescu5, Mats Brännström6, Antonio Lentini7, Björn Reinius7, Martin Cornillet1, Tim WillingeSebastian Gidlöf2,3,8, Russell S. Hamilton9,10, Martin A. Ivarsson1 and Niklas K. Björkström1,*1Center for Infectious …

Gestational diabetes (GDM) affects up to ∼1 in 6 pregnancies worldwide, representing ∼18 million births each year. It causes excessively big babies and difficult deliveries. There is also a strong link with the development of type 2 diabetes in the mother in later life. A failure of the mother to produce enough insulin and/or respond to insulin and…

Congratulations toOisín Huhn, Martin A. Ivarsson, Lucy Gardner, Mike Hollinshead, Jane C Stinchcombe, Puran Chen, Norman Shreeve, Olympe Chazara, Lydia E. Farrell, Jakob Theorell, Hormas Ghadially, Peter Parham, Gillian Griffiths, Amir Horowitz, Ashley Moffett, Andrew M. Sharkey and Francesco Coluccion their paper “Distinctive phenotypes and functi…

Zhu M, Cornwall-Scoones J, Wang P, Handford CE, Na J, Thomson M,Zernicka-Goetz M.During the early stages of the pregnancy, the cells of the mammalian embryos differentiate into trophectoderm (TE), the progenitors of the placenta; and inner cell mass (ICM), the clump of cells that will give rise to embryonic tissues and yolk sac. A key event that me…

Elizabeth Bearblock,Catherine E.Aiken,Graham J.BurtonAbstractIntroductionAir pollution has significant negative health impacts, particularly on the cardiovascular system. The aims of this narrative review were to identify whether there is an association between air pollution and the incidence of pre-eclampsia, and the potential mechanisms by which …

Sijia Yao, Jorge Lopez-Tello, Amanda N Sferruzzi-PerriAbstractExposures to adverse conditions in utero can lead to permanent changes in the structure and function of key physiological systems in the developing fetus, increasing the risk of disease and premature aging in later postnatal life. When considering the systems that could be affected by an…

Graham J Burton,Tereza Cindrova-Davies, Hong wa Yung and Eric JauniauxAbstractDevelopment of the human placenta takes place in contrasting oxygen concentrations at different stages of gestation, from ~20 mmHg during the first trimester rising to ~60 mmHg at the start of the second trimester before gradually declining to ~40 mmHg at term. In view of…

Professor Anne Ferguson-Smith, a Fellow of Darwin College and Head of the Department of Genetics at the University, has been appointed as Acting Pro-Vice-Chancellor for Research for one year from 1 January 2021. She takes over the role from Professor Chris Abell, who died suddenly in October. Professor Ferguson-Smith is the Arthur Balfour Professor…

Abnormal placental CD8+ T‐cell infiltration is a feature of fetal growth restriction and pre‐eclampsiaSusanne Lager, Ulla Sovio, Elizabeth Eddershaw, Margaretha W. van der Linden, Cansu Yazar, Emma Cook, Lisa Happerfield, Flora A. Jessop, Neil J. Sebire, D. Stephen Charnock‐Jones, Gordon C. S. SmithAbstractFetal growth restriction (FGR) and pre‐ecl…