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Read more at: Review on oxygen and development of the human placenta just published in Reproduction

Review on oxygen and development of the human placenta just published in Reproduction

29 May 2020

The review, writen by Burton GJ, Cindrova-Davies T, Yung HW, Jauniaux E. has just been published in Reproduction. You can read the full article here


Read more at: Professor Wolf Reik FRS appointed Acting Director of the Babraham Institute
Professor Wolf Reik FRS appointed Acting Director of the Babraham Institute

Professor Wolf Reik FRS appointed Acting Director of the Babraham Institute

27 May 2020

Professor Wolf Reik has been appointed the Institute’s Acting Director with immediate effect, following the sad loss of Professor Michael Wakelam at the end of March. Professor Reik is an internationally renowned expert in the field of epigenetics and has led the Institute’s Epigenetics research programme since 2008. He...


Read more at: Living cells adapt their stiffness to that of their surroundings, or not?

Living cells adapt their stiffness to that of their surroundings, or not?

26 May 2020

Living cells adapt their stiffness to that of their surroundings, or not? New study by the Franze lab published in Nature Materials could have disproven a central dogma of mechanobiology: that living cells adapt their stiffness to the stiffness of their microenvironment. Scientists have developed a new method that allows...


Read more at: Investigation of human trophoblast invasion in vitro, just published in Human Reproduction Update

Investigation of human trophoblast invasion in vitro, just published in Human Reproduction Update

26 May 2020

The paper by Yassen Abbas, Margherita Y Turco, Graham J Burton and Ashley Moffett b rings together engineering skills in microfluidics with a biological question that is central to placental development. You can read the full article here Abstract BACKGROUND In humans, inadequate trophoblast invasion into the decidua is...


Read more at: TET1 and 5-Hydroxymethylation Preserve the Stem Cell State of Mouse Trophoblast, just published in Cell.com

TET1 and 5-Hydroxymethylation Preserve the Stem Cell State of Mouse Trophoblast, just published in Cell.com

22 May 2020

The ten-eleven translocation factor TET1 and its conferred epigenetic modification 5-hydroxymethylcytosine (5hmC) have important roles in maintaining the pluripotent state of embryonic stem cells (ESCs). We previously showed that TET1 is also essential to maintain the stem cell state of trophoblast stem cells (TSCs). Here...


Read more at: A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues, just published in Analytical and Bioanalytical Chemistry

A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues, just published in Analytical and Bioanalytical Chemistry

13 May 2020

Lipidomics is of increasing interest in studies of biological systems. However, high-throughput data collection and processing remains non-trivial, making assessment of phenotypes difficult. We describe a platform for surveying the lipid fraction for a range of tissues. These techniques are demonstrated on a set of seven...


Read more at: Roser Vento-Tormo receives Chan Zuckerberg Initiative support for COVID-19 study

Roser Vento-Tormo receives Chan Zuckerberg Initiative support for COVID-19 study

11 May 2020

Roser, Group Leader at the Wellcome Sanger Institute and Member of the Loke CTR, will use single-cell technologies to understand human immune response to SARS-CoV-2 infection and the progression of the disease. Joint project leader with Esteban Ballestar from the Josep Carreras Institute, Roser and her collaborators will...


Read more at: Igf2 deletion alters mouse placenta endocrine capacity in a sexually-dimorphic manner, just published in Journal of Endocrinology

Igf2 deletion alters mouse placenta endocrine capacity in a sexually-dimorphic manner, just published in Journal of Endocrinology

11 May 2020

Igf2 deletion alters mouse placenta endocrine capacity in a sexually-dimorphic manner, just published in Journal of Endocrinology Paper by Bethany R L Aykroyd 1 , Simon J Tunster 2 and Amanda N Sferruzzi-Perri 3 . You can read it in full here


Read more at: Basement membrane remodelling regulates development, just published in Nature
Basement membrane remodelling regulates development, just published in Nature

Basement membrane remodelling regulates development, just published in Nature

7 May 2020

New study by Zernicka-Goetz lab published on Nature on the mechanism of membrane perforation during the development of the mouse embryo During development the mouse embryo implants in the mother’s uterus and undergoes a dramatic transformation. The resulting post-implantation embryo has an elongated morphology and is thus...


Read more at: Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia, just published in Nature Microbiology

Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia, just published in Nature Microbiology

7 May 2020

Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia. Gaccioli F, Lager S, de Goffau MC, Sovio U, Dopierala J, Gong S, Cook E, Sharkey A, Moffett A, Lee WK, Delles C, Venturini C, Breuer J, Parkhill J, Peacock SJ, Charnock-Jones DS, Smith GCS. Nat Microbiol. 2020 May 4...