Research
My research focuses on uncovering the molecular mechanisms underlying human infertility in both males and females. In male infertility, I have investigated novel centrosome-associated proteins to elucidate their roles during spermatocyte meiosis, particularly in chromosomal recombination during prophase I, accurate chromosome segregation, and sperm flagellum formation. These studies aim to identify key factors essential for proper spermatogenesis and male fertility. In female infertility, I combine the basic molecular research with clinical studies to identify and characterize functional genes that regulate oocyte meiosis. Findings are validated in patient samples to establish clinical relevance, bridging molecular mechanisms with reproductive outcomes. Overall, my work seeks to advance understanding of the genetic and cellular bases of infertility, providing insights that could inform the development of diagnostic markers and therapeutic strategies for individuals experiencing reproductive challenges.
Publications
I. He SW, Gillies JP, Zang JL, C6rdoba-Beldad CM, Yamamoto I, Fujiwara Y, Grantham J,DeSantis ME, Shibuya H. Distinct dynein complexes defined by DYNLRBl and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. Nature communications. doi.org/10.1038/s41467-023-37370-7.
2. He SW, Xu BH, Liu Y, Wang YL, Chen MH, Xu L, Liao BQ, Lui R, Li FP, Lin YH, Fu XP, Fu BB,Hong ZW, Liu YX, Qi ZQ, Wang HL. SKAP2 regulates Arp2/3 complex for actin-mediated asymmetric cytokinesis by interacting with WA VE2 in mouse oocytes. Cell Cycle. doi: 10.1080/15384101.
