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Dr Vicente Perez-Garcia

Research Interests

I am researching on the reproductive decline in advanced maternal age focusing my attention in the specific role of the uterus sustaining the correct embryo development.  In parallel, as part of the WT "Deciphering the Mechanisms of Developmental Disorders" consortium, I am conducting a systematic screen for placental defects in embryonic lethal mouse mutants.  This will, for the first time, provide a global overview of the collection of genes that are jointly necessary to make a functional placenta.

Key Publications

Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W. Maternal DNA Methylation Regulates Early rophoblast Development.  Dev Cell.  2016 Jan 25;36(2):152-63

Perez-Garcia V, Redondo-Muoz J, Kumar A, Carrera AC.  Cell activation-inducted phosphoinositide 3-kinase alpha/beta demerzation regulates PTEN activity.  Mol Cell Biol. 2014 Sep 15;34(18):3359-73. doi: 10.1128/MCB.00167-14

Recondo-Munoz J, Rodriguez MJ, Silio V, Perez-Garcia V, Valpuesta JM, Carerra Ac.  Phosphoinositide 3-Kinase beta controls replication factor C assembly and function.  Nucleic Acids Res. 2013 Jan:4192):855-68