Research
I am interested in deciphering the common molecular mechanisms shared between trophoblast and cancer cells. Trophoblast cells share some key similarities with metastatic cancer cells, in particular with regard to cell invasiveness and the capacity to breach basement membranes. During my NGF, I am applying CRISPR/Cas9 genome editing systems to genetically manipulate trophoblast stem cells and organoids and study the role of tumour suppressor genes in regulating trophoblast differentiation and invasiveness.
Publications
Perez-Garcia V*, Fineberg E*, Wilson R, Murray A, Icoresi C, Tudor C, Sienerth A, White JK, E Tuck E, Ryder E, Gleeson D, Siragher E, Wardle-Jones H, Collins J, Geyer S, Busch E, Galli A, Smith JC, Robertson E, Adams DJ, Weninger WJ, Mohun T, Hemberger M. Placental malformations are highly prevalent in embryonic lethal mouse mutants. Nature, 555(7697):463-468 (2018). * Equal contribution.
Woods L*, Perez-Garcia V*, Kieckbusch J, Wang X, DeMayo F, Colucci F, Hemberger M. Decidualisation and placentation defects are a major cause of age-related reproductive decline. Nat Commun. 8(1):352 (2017). * Equal contribution
Woods L, Perez-Garcia V*, Hemberger M*. Regulation of Placental Development and Its Impact on Fetal Growth-New Insights From Mouse Models. Front Endocrinol. 27;9:570 (2018). *Equal contribution.
Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W. Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 36(2):152-63 (2016).
Perez-Garcia V, Turco MY. Keep calm and the placenta will carry on. Dev Cell. in press.
Wang Z, Monteiro CD, Jagodnik KM, Fernandez NF, Gundersen GW, Rouillard AD, Jenkins SL, Feldmann AS, Hu KS et al. Pérez-García V, Ma'ayan A. Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd. Nat Commun. 7:128462 (2016)
Lopez-Tello J, Pérez-García V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernández de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M,Sferruzzi-Perri AN. Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice. Elife. Jun 26; 8 (2019)
Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W. Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 36(2):152-63 (2016).
Perez-Garcia V, Redondo-Muñoz J, Kumar A, Carrera AC. Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity Mol Cell Biol. 34(18): 3359-3373 (2014).
