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Read more at: Placental hypoxia: What have we learnt from small animal models?

Placental hypoxia: What have we learnt from small animal models?

1 June 2021

Emma Siragher, Amanda Sferruzzi-Perri Abstract Intrauterine hypoxia is a feature of pregnancy complications, both at high altitude and sea level. To understand the placental response to reduced oxygen availability, small animal models of maternal inhalation hypoxia (MIH) or reduced uterine perfusion pressure (RUPP) may be...


Read more at: Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

1 June 2021

genes_cover_with_credits_resized.png Image credit: Image acquired by Ionel Sandovici using a Philips XL30 FEG microscope at the Cambridge Advanced Imaging Centre, University of Cambridge In a recent study, Miguel Constância’s group, in collaboration with colleagues from the Loke Centre for Trophoblast Research and...


Read more at: Congratulations to Sue Ozanne and colleages for their review listed as one of the most cited articles published since 2018

Congratulations to Sue Ozanne and colleages for their review listed as one of the most cited articles published since 2018

20 May 2021

Congratulations to Sue Ozanne and colleages for their review "Sex and gender differences in developmental programming of metabolism" listed as one of the most cited articles published since 2018. Dearden, L, Bouret, S. G, Ozanne, S.E. (2018). Sex and gender differences in developmental programming of metabolism. Molecular...


Read more at: Cambridge scientists and CTR members awarded £1.3m to unravel how cardiovascular disease is programmed by obese pregnancy

Cambridge scientists and CTR members awarded £1.3m to unravel how cardiovascular disease is programmed by obese pregnancy

13 May 2021

Congratulations to Loke CTR members Professor Dino Giussani and Professor Sue Ozanne who have, with Professor Mike Murphy (MRC Mitochrondrial Biology Unit), been awarded a £1.3m grant from the Medical Research Council (MRC) to study the relationship between obesity in pregnancy and cardiovascular effects in the offspring...


Read more at: The RNA landscape of the human placenta in health and disease

The RNA landscape of the human placenta in health and disease

13 May 2021

Sungsam Gong, Francesca Gaccioli, Justyna Dopierala, Ulla Sovio, Emma Cook, Pieter-Jan Volders, Lennart Martens, Paul D. W. Kirk, Sylvia Richardson, Gordon C. S. Smith & D. Stephen Charnock-Jones Abstract The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term...


Read more at: Slowing of fetal growth and elevated maternal serum sFLT1:PlGF are associated with early term spontaneous labor

Slowing of fetal growth and elevated maternal serum sFLT1:PlGF are associated with early term spontaneous labor

27 April 2021

Ulla Sovio, Francesca Gaccioli, Emma Cook, Stephen Charnock-Jones, Gordon Smith Background The physiological control of human parturition at term is unknown. Objective To test the hypothesis that slowing of fetal growth or elevated maternal serum levels of markers of placental hypoxia in late gestation will be associated...


Read more at: Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

27 April 2021

Emily Angiolini, Ionel Sandovici, Philip M. Coan, Graham J. Burton, Colin P. Sibley, Abigail L. Fowden, Miguel Constância Abstract Genomic imprinting, an epigenetic phenomenon that causes the expression of a small set of genes in a parent-of-origin-specific manner, is thought to have co-evolved with placentation. Many...


Read more at: Mapping the expression of transient receptor potential channels across murine placental development

Mapping the expression of transient receptor potential channels across murine placental development

23 April 2021

Katrien De Clercq · Vicente Pérez‑García · Rieta Van Bree · Federica Pollastro · Karen Peeraer · Thomas Voets · Joris Vriens Abstract Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is governed by the processes of trophoblast...


Read more at: The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice

The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice

23 April 2021

Summary The conserved CD94/NKG2A inhibitory receptor is expressed by nearly all human and ∼50% of mouse uterine natural killer (uNK) cells. Binding human HLA-E and mouse Qa-1, NKG2A drives NK cell education, a process of unknown physiological importance influenced by HLA-B alleles. Here, we show that NKG2A genetic ablation...


Read more at: Anti-oxidant supplements during pregnancy may protect against the link between low oxygen in the womb and impaired memory function in adult offspring, a study using laboratory rats and led by Professor Dino Giussani shows.

Anti-oxidant supplements during pregnancy may protect against the link between low oxygen in the womb and impaired memory function in adult offspring, a study using laboratory rats and led by Professor Dino Giussani shows.

22 April 2021

A new study in laboratory rats has discovered a direct link between low oxygen in the womb and impaired memory function in the adult offspring. It also finds that anti-oxidant supplements during pregnancy may protect against this. Low oxygen in the womb - known as chronic fetal hypoxia - is one of the most common...