News

Mapping cells of the reproductive tract across the lifespan will help fill critical gaps in our knowledge about health

20 April 2021

0_tsi06wu9v1xoqygd.jpg A typical fallopian tube epithelium stained to highlight cell membranes (red), nuclei (blue), and PAX8 genes (green). Photo provided by Ernst Lengyel, University of Chicago. 1 of 10 women in reproductive age suffer from endometriosis, but we don’t have a diagnostic tool and we don’t have a treatment...

Investigation of infertility using endometrial organoids review just published in Repro Journal

20 April 2021

Konstantina Nikolakopoulou, Margherita Y Turco Abstract Infertility is a common problem in modern societies with significant socio-psychological implications for women. Therapeutic interventions are often needed which, depending on the cause, can either be medical treatment, surgical procedures or assisted reproductive...

Frequent loss-of-heterozygosity in CRISPR-Cas9–edited early human embryos

12 April 2021

Gregorio Alanis-Lobato , Jasmin Zohren , Afshan McCarthy , Norah M. E. Fogarty , Nada Kubikova , Emily Hardman , Maria Greco , Dagan Wells , James M. A. Turner , and Kathy K. Niakan Abstract CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles...

Fetal umbilical artery Doppler as a tool for universal third trimester screening: A systematic review and meta-analysis of diagnostic test accuracy

12 April 2021

Alexandros A. Moraitis , Thomas Bainton, Ulla Sovio, Peter Brocklehurst, Alexander EP. Heazell, Jim G. Thornton, Stephen C. Robson, Aris Papageorghiou, Gordon CS. Smith Abstract The objective of this study was to investigate the accuracy of universal third trimester umbilical artery (UA) Doppler to predict adverse...

Developmental programming of the female reproductive system — a review

12 April 2021

Sijia Yao , Jorge Lopez-Tello , Amanda N Sferruzzi-Perri Abstract Exposures to adverse conditions in utero can lead to permanent changes in the structure and function of key physiological systems in the developing fetus, increasing the risk of disease and premature aging in later postnatal life. When considering the...

Professor Bob Moor FRS

11 March 2021

We are saddened to hear of the passing of Professor Bob Moor FRS, a great scientist and colleague. Bob identified many of the factors underpinning reproduction in ungulates during his time at the Babraham Institute, and also worked on generating transgenic animals and stem cells. His wisdom and collegiality will be sorely...

Inherent mosaicism and extensive mutation of human placentas - just published in Nature

11 March 2021

Tim H. H. Coorens, Thomas R. W. Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D. Young, Raheleh Rahbari, Neil Sebire, Peter J. Campbell, D. Stephen Charnock-Jones, Gordon C. S. Smith & Sam Behjati. Abstract Placentas can exhibit chromosomal aberrations that are absent from...

The final version of Sovio and Smith:Comparison of estimated fetal weight percentiles near term for predicting extremes of birthweight percentile is now available

24 February 2021

Background The INTERGROWTH-21st estimated fetal weight percentiles are recommended for predicting extremes of birthweight percentile, although evidence for their superiority over the widely employed Hadlock method is lacking. Objective This study aimed to compare the ability of estimated fetal weight percentiles calculated...

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy just published in Science Immunology

24 February 2021

Benedikt Strunz 1 , Jonna Bister 1 , Hanna Jönsson 1 , Iva Filipovic 1 , Ylva Crona-Guterstam 1 , 2 , 3 , Egle Kvedaraite 1 , 4 , Natalie Sleiers 1 , Bogdan Dumitrescu 5 , Mats Brännström 6 , Antonio Lentini 7 , Björn Reinius 7 , Martin Cornillet 1 , Tim Willinge Sebastian Gidlöf 2 , 3 , 8 , Russell S. Hamilton 9 , 10 ...

Interesting perspective on "Placental mitochondria central to gestational diabetes pathogenesis?"

24 February 2021

Gestational diabetes (GDM) affects up to ∼1 in 6 pregnancies worldwide, representing ∼18 million births each year. It causes excessively big babies and difficult deliveries. There is also a strong link with the development of type 2 diabetes in the mother in later life. A failure of the mother to produce enough insulin and...

Mapping cells of the reproductive tract across the lifespan will help fill critical gaps in our knowledge about health

Investigation of infertility using endometrial organoids review just published in Repro Journal

Frequent loss-of-heterozygosity in CRISPR-Cas9–edited early human embryos

Fetal umbilical artery Doppler as a tool for universal third trimester screening: A systematic review and meta-analysis of diagnostic test accuracy

Developmental programming of the female reproductive system — a review

Professor Bob Moor FRS

Inherent mosaicism and extensive mutation of human placentas - just published in Nature

The final version of Sovio and Smith:Comparison of estimated fetal weight percentiles near term for predicting extremes of birthweight percentile is now available

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy just published in Science Immunology

Interesting perspective on "Placental mitochondria central to gestational diabetes pathogenesis?"

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