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Claire Senner

Claire  Senner

2019 Next Generation Fellow


Research Interests

I am interested in the many facets of epigenetic regulation within the trophoblast lineage. In the lab, I use trophoblast stem cells and mouse models to investigate the contribution of epigenetic mechanisms such as X Chromosome Inactivation, DNA methylation dynamics, and the action of long non-coding RNAs to the identity and developmental potential of the trophoblast stem cell compartment.

Key Publications

Senner C.E., Chrysanthou S., Burge S., Lin H-Y., Branco M. and Hemberger M. (2020). TET1 and 5-hydroxymethylation preserve the stem cell state of mouse trophoblast. Stem Cell Reports. In press (co-corresponding)

Schoenfelder S., Mifsud B., Senner C.E., Todd C.D., Chrysanthou S., Darbo E., Hemberger M., and Branco M.R. (2018). Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages. Nat Commun. 9, 4189.

Chrysanthou S., Senner C.E., Woods L., Fineberg E., Okkenhaug H., Burge S., Perez-Garcia V. and Hemberger M. (2018). A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells. Stem Cell Reports. 10, 1355-1368.

Kubaczka C., Senner C.E., Cierlitza M., Araúzo-Bravo M.J., Kuckenberg P., Peitz M., Hemberger M. and Schorle H. (2015). Direct induction of trophoblast stem cells from murine fibroblasts. Cell Stem Cell 17, 557-568.

Kubaczka, C., Senner, C., Araúzo-Bravo, M.J., Sharma, N., Kuckenberg, P., Becker, A., Zimmer, A., Brüstle, O., Peitz, M., Hemberger, M., and Schorle, H. (2014). Derivation and Maintenance of Murine Trophoblast Stem Cells under Defined Conditions. Stem Cell Reports 30, 232-242.

Senner, C.E., Krueger, F., Oxley, D., Andrews, S., and Hemberger, M. (2012). DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary. Stem Cells 30, 2732-2745.

Nesterova, T.B.*, Senner, C.E.*, Schneider, J., Alcayna-Stevens, T., Tattermusch, A., Hemberger, M., and Brockdorff N. (2011). Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells.  Epigenetics Chromatin 4, 17. *equal contribution

Ohhata, T., Senner, C.E., Hemberger, M., and Wutz, A. (2011). Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice. Genes Dev. 25, 1702-1715.

Senner, C.E. (2011). The role of DNA methylation in mammalian development. Reprod. Biomed. Online 22, 529-535.

Senner, C.E., Nesterova, T.B., Norton, S., Dewchand, H., Godwin, J., Mak, W., and Brockdorff N. (2011). Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation. Development 138, 1541-1550.

Senner, C.E., and Hemberger, M. (2010). Regulation of early trophoblast differentiation - lessons from the mouse. Placenta 31, 944-950.

Senner, C.E., and Brockdorff, N. (2009) Xist gene regulation at the onset of X inactivation. Curr. Opin. Genet. Dev. 19, 122-126.