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Regina Hoo

Regina Hoo

Postdoctoral Fellow, Wellcome Sanger Institute


Research Interests

I am interested how host-pathogen interaction can define the outcome of infection in different tissue environments. My previous experience in paediatric infections such as pertussis and malaria motivate me to understand how infection can be transmitted from mother to child during pregnancy. The maternal-fetal interface represents the most intriguing environment during pregnancy, but it is not entirely clear how cells within this environment response against different infections. My work involves using single-cell genomics, imaging and computational tools to study placental infections in large cohorts of individuals and in trophoblast organoids (collaboration with Dr. Margherita Turco, CTR). I am a team member from Dr. Roser Vento-Tormo laboratory at the Wellcome Sanger Institute.

Key Publications

Hoo R, Bruske E, Dimonte S, Zhu L, Mordmüller B, Sim BKL, Kremsner PG, Hoffman SL, Bozdech Z, Frank M, Preiser PR. Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies. EBioMedicine. 2019 Oct;48:442-452.

 

Fraschka SA*, Filarsky M*, Hoo R, Niederwieser I, Yam XY, Brancucci NMB, Mohring F, Mushunje AT, Huang X, Christensen PR, Nosten F, Bozdech Z, Russell B, Moon RW, Marti M, Preiser PR, Bártfai R, Voss TS. Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites. Cell Host Microbe. 2018 Mar 14;23(3):407-420.*Co-first author

 

Hoo R, Zhu L, Anburaj A, Mok S, Natalang O, Lapp SA, Hu G, Ramadoss R, Liew K, Galinski MR, Bozdech Z, Preiser PR. Integrated analysis of the Plasmodium species transcriptome. EBioMedicine 2016 May;7:255-66.

 

Hoo R, Lam JH, Huot L, Pant A, Li R, Hot D, Alonso S. Evidence for a role of the polysaccharide capsule transport proteins in pertussis pathogenesis. PLoS One. 2014 Dec 12;9(12):e115243.