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Centre for Trophoblast Research



Increasingly, women are delaying childbearing until later in life, and in the UK average maternal age now exceeds 30 years. Advanced maternal age at first pregnancy is linked to an increased risk of obstetric complications such as miscarriage, and fetal growth restriction.

The underlying causes of poor pregnancy outcomes in older mothers can be due to aging of the oocyte; however uterine aging also seems to play a role, leading to abnormal placental development. This project is using aging female mice to investigate age related uterine changes, which may underlie abnormal placentation.

Not available for consultancy