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Susanne Lager

Research Associate

Research Interests

Research summary
The aim of my project is to characterize the role of placental infection in the aetiology of pregnancy complications. In this study we will utilize samples from a large, prospective cohort study consisting of approximately 4500 primiparous women. Using well-phenotyped cases and matched controls, we will explore the potential presence of infectious agents in the placenta, as well as investigating markers of inflammation in maternal blood serially-collected throughout pregnancy. Potentially, this project will further our understanding of the biological basis of foetal growth restriction and pre-eclampsia, while identifying biomarkers for clinical applications.

Key Publications

1) Lager S, Gaccioli F, Ramirez VI, Jones HN, Jansson T, Powell TL. “Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4.” J Lipid Res. 2013 Mar;54(3):725-33

2) Lager S, Jansson N, Olsson AL, Wennergren M, Jansson T, Powell TL. “Effect of IL-6 and TNF-α on fatty acid uptake in cultured human primary trophoblast cells.” Placenta. 2011 Feb;32(2):121-7

3) Magnusson-Olsson AL, Lager S, Jacobsson B, Jansson T, Powell TL. “Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency.” Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E24-30.