Research
The human body axis is established during the second week of gestation. At this stage, the embryonic disc is transformed to delineate the future body plan. Defects in the embryonic disc of mouse embryos have resulted in multiple body axes or congenital abnormalities. However, the mechanisms involved in human body axis formation remain elusive.
In my postdoctoral research, I investigate the origin of the human body axis using bioprinted embryo models. By combining high-resolution microscopy, transcriptomics, and gene editing tools, I dissect how alterations in the embryonic disc may influence the human body axis.
These findings will improve our understanding of human development and congenital anomalies - whose incidence is 1 out of 45 births in England. Moreover, this project will shed light on human embryo patterning and the formation of organ primordia, which will be an important step towards the generation of human organs in vitro.
Publications
Equal contribution highlighted with an asterisk (*).
Ceballos-González* et al. (2024). Chaos-assisted production of micro-architected spheres. Small (Accepted).
Ceballos-González* et al. (2023). Plug-and-play multimaterial chaotic printing/bioprinting to produce radial and axial micropatterns in hydrogel filaments. Adv. Mater. Technol., 8(17), 2202208. DOI: 10.1002/admt.202202208
Taravatfard, Ceballos-González* et al. (2023). Nitrogen-functionalized graphene quantum dot incorporated GelMA microgels as fluorescent 3D-tissue constructs. Nanoscale, 15(40), 16277-16286. DOI: 10.1039/D3NR02612D
Bolívar-Monsalve, Ceballos-González* et al. (2022). One-step bioprinting of multi-channel hydrogel filaments using chaotic advection: Fabrication of pre-vascularized muscle-like tissues. Adv Healthc Mater, 2200448. DOI: 10.1002/adhm.202200448
Ceballos-González* et al. (2021). High-throughput and continuous chaotic bioprinting of spatially controlled bacterial microcosms. ACS Biomater. Sci. Eng., 7(6): 2408–2419. DOI: 10.1021/acsbiomaterials.0c01646
Bolívar-Monsalve, Ceballos-González* et al. (2021). Continuous chaotic bioprinting of skeletal muscle-like constructs. Bioprinting, 21: e00125. DOI: 10.1016/j.bprint.2020.e00125
Chávez-Madero, …, Ceballos-González* et al. (2020). Using chaotic advection for facile high-throughput fabrication of ordered multilayer micro-and nanostructures: continuous chaotic printing. Biofabrication, 12(3): 035023. DOI: 10.1088/1758-5090/ab84cc
