Research
Epidemiological data provides evidence associating placental dysfunction with increased risk of post-pregnancy maternal obesity, dyslipidaemia, insulin resistance, hypertension,
cardiovascular disease and mortality. However, the biological mechanism underlying this long-term impact remains unknown. I intend to use a novel mouse model of fetal growth
restriction (FGR) to identify alteration of substances secreted from the placenta into maternal circulation, explore their effect on gene expression in maternal end-organs and characterise the resulting development of maternal metabolic syndrome over time. I believe that a wider understanding of the regulatory process altering metabolic homeostasis inflicted by FGR, holds great potential for clinical interventions critical to maternal health.
Publications
1. Ben-Aharon, I., Meizner, I., Granot, T., Uri S., Hasky, N., Rizel, S., Yerushalmi, R., Sulkes, A. and Stemmer, S.M. Chemotherapy-induced ovarian failure as a prototype for
acute vascular toxicity. Oncologist 2012; 17(11):1386-93.
2. Chuderland, D*., Hasky, N.*, Ben-Ami, I., Kaplan-Kraicer, R.., Grossman, H., Shalgi, R. A physiological approach for treating endometriosis by recombinant pigment epithelialderived
factor. Human Reproduction 2013; 28(6):2867-76.
3. Chuderland, D., Ben-Ami, I., Fridler, S., Hasky, N., Ninio-Many L., Goldberg K., Bar- Joseph H., Grossman H., Shalgi R. Hormonal regulation of pigment epithelium-derived
factor (PEDF) expression in the endometrium. Mol Cell Endoc 2014; 390(1-2):85-92.
4. Uri, S., Shaish, A., Eliyahu, E., Grossman, H., Levi, M., Chuderland, D., Ninio-Many, L., Hasky, N., Shashar, D., Almog, T., Kandel-Kfir, M., Harats, D., Shalgi, R*., Kamari, Y*.Interleukin (IL)-1 deficiency prolongs ovarian life-span in mice. PNAS 2014; 26;111(34):12492-7.
5. Hasky, N., Uri-Belapolsky S., Goldberg K., Miller I., Grossman H., Stemmer, S.M., Ben- Aharon, I*., Shalgi, R*. Gonadotropin-Releasing Hormone Agonists (GnRH-a) for Fertility
Preservation – Unraveling the Enigma? Human reproduction 2015; 30(5):1089-101.
6. Grossman, H., Chuderland, D., Ninio-Many, L., Hasky, N., Kaplan-Kraicer, R. and Shalgi, R. A novel regulatory pathway in granulosa cells, the LH/human chorionic
gonadotropin-microRNA-125a-3p-Fyn pathway, is required for ovulation. FASEB J. 2015;
29(8):3206-16.
7. Ben-Aharon I., Granot T., Meizner I., Hasky N., Tobar A., Rizel S., Yerushalmi R., Ben-Haroush A., Fisch B., Stemmer S.M. Long-Term Follow-Up of Chemotherapy-Induced
Ovarian Failure in Young Breast Cancer Patients: The Role of Vascular Toxicity.
Oncologist 2015 Sep;20(9):985-91.
8. Levi M., Hasky N., Stemmer, S.M., Shalgi, R., Ben-Aharon, I. Anti-Müllerian hormone is a marker for chemotherapy-induced testicular toxicity. Endocrinology 2015
Oct;156(10):3818-27.
9. Goldberg K., Bar-Joseph H., Grossman H., Hasky N., Uri-Belapolsky S., Stemmer SM., Chuderland D., Shalgi R, Ben-Aharon I. Pigment Epithelium-Derived Factor Alleviates
Tamoxifen-Induced Endometrial Hyperplasia. Mol Cancer Ther. 2015 Dec;14(12):2840-9.
10. Ben-Aharon I., Levi M., Margel D., Yerushalmi R., Rizel S., Perry S., Sharon E., Hasky N., Abir R., Fisch B., Shalgi R., Stemmer, S.M. Premature ovarian aging in BRCA
carriers: a prototype of systemic precocious aging? Oncotarget. 2018 Mar; 9(22):15931-15941.
11. Asali A, Farladansky-Gershnabel S, Hasky N, Elbaz M, Fishman A, Ravid D, Wiser A, Biron-Shental T, Berkovitz A, Miller N. Physiological and psychological stress responses
to labor and delivery during COVID-19 pandemic: a cohort study. J Psychosom ObstetGynaecol. 2022 Dec; 43(4):441-446.
