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Read more at: RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition

10 June 2021

Malwina Prater, Russell S. Hamilton, Hong Wa Yung, Andrew M. Sharkey, Paul Robson, N. Erlyani Abd Hamid, Eric Jauniaux, D. Stephen Charnock-Jones, Graham J. Burton, Tereza Cindrova-Davies Abstract The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset...

Read more at: New study led by Dr Amanda N. Sferruzzi-Perri provides hope a better understanding of the placenta will result in safer, healthier pregnancies

New study led by Dr Amanda N. Sferruzzi-Perri provides hope a better understanding of the placenta will result in safer, healthier pregnancies

10 June 2021

Women who will develop potentially life-threatening disorders during pregnancy can be identified early when hormone levels in the placenta are tested, a new study has shown. Pregnancy disorders affect around one in ten pregnant women. Nearly all of the organ systems of the mother’s body need to alter their function during...

Read more at: Professor W.R. (Twink) Allen

Professor W.R. (Twink) Allen

7 June 2021

It is with great sadness we note the passing of Twink (W.R.) Allen. Twink was a specialist in equine reproduction, and for many years Director of The Thoroughbred Breeders’ Association Equine Fertility Unit in Newmarket. His research covered many areas, from the endocrine and immunological properties of chorionic girdle...

Read more at: The International Society for Stem Cell Research (ISSCR) has released new guidance in response to emerging areas of stem cell and embryo research

The International Society for Stem Cell Research (ISSCR) has released new guidance in response to emerging areas of stem cell and embryo research

1 June 2021

a3de6a45-5086-bd65-e01d-1d5e1d9645d4.png The International Society for Stem Cell Research (ISSCR) has released new guidance in response to emerging areas of stem cell and embryo research , after a two-year consultation with experts in science, ethics and law including Professors Kathy Niakan and Azim Surani. Previous...

Read more at: Placental hypoxia: What have we learnt from small animal models?

Placental hypoxia: What have we learnt from small animal models?

1 June 2021

Emma Siragher, Amanda Sferruzzi-Perri Abstract Intrauterine hypoxia is a feature of pregnancy complications, both at high altitude and sea level. To understand the placental response to reduced oxygen availability, small animal models of maternal inhalation hypoxia (MIH) or reduced uterine perfusion pressure (RUPP) may be...

Read more at: Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

1 June 2021

genes_cover_with_credits_resized.png Image credit: Image acquired by Ionel Sandovici using a Philips XL30 FEG microscope at the Cambridge Advanced Imaging Centre, University of Cambridge In a recent study, Miguel Constância’s group, in collaboration with colleagues from the Loke Centre for Trophoblast Research and...

Read more at: Congratulations to Sue Ozanne and colleages for their review listed as one of the most cited articles published since 2018

Congratulations to Sue Ozanne and colleages for their review listed as one of the most cited articles published since 2018

20 May 2021

Congratulations to Sue Ozanne and colleages for their review "Sex and gender differences in developmental programming of metabolism" listed as one of the most cited articles published since 2018. Dearden, L, Bouret, S. G, Ozanne, S.E. (2018). Sex and gender differences in developmental programming of metabolism. Molecular...

Read more at: Cambridge scientists and CTR members awarded £1.3m to unravel how cardiovascular disease is programmed by obese pregnancy

Cambridge scientists and CTR members awarded £1.3m to unravel how cardiovascular disease is programmed by obese pregnancy

13 May 2021

Congratulations to Loke CTR members Professor Dino Giussani and Professor Sue Ozanne who have, with Professor Mike Murphy (MRC Mitochrondrial Biology Unit), been awarded a £1.3m grant from the Medical Research Council (MRC) to study the relationship between obesity in pregnancy and cardiovascular effects in the offspring...

Read more at: The RNA landscape of the human placenta in health and disease

The RNA landscape of the human placenta in health and disease

13 May 2021

Sungsam Gong, Francesca Gaccioli, Justyna Dopierala, Ulla Sovio, Emma Cook, Pieter-Jan Volders, Lennart Martens, Paul D. W. Kirk, Sylvia Richardson, Gordon C. S. Smith & D. Stephen Charnock-Jones Abstract The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term...

Read more at: Slowing of fetal growth and elevated maternal serum sFLT1:PlGF are associated with early term spontaneous labor

Slowing of fetal growth and elevated maternal serum sFLT1:PlGF are associated with early term spontaneous labor

27 April 2021

Ulla Sovio, Francesca Gaccioli, Emma Cook, Stephen Charnock-Jones, Gordon Smith Background The physiological control of human parturition at term is unknown. Objective To test the hypothesis that slowing of fetal growth or elevated maternal serum levels of markers of placental hypoxia in late gestation will be associated...

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