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Read more at: Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse

27 April 2021

Emily Angiolini, Ionel Sandovici, Philip M. Coan, Graham J. Burton, Colin P. Sibley, Abigail L. Fowden, Miguel Constância Abstract Genomic imprinting, an epigenetic phenomenon that causes the expression of a small set of genes in a parent-of-origin-specific manner, is thought to have co-evolved with placentation. Many...


Read more at: Mapping the expression of transient receptor potential channels across murine placental development

Mapping the expression of transient receptor potential channels across murine placental development

23 April 2021

Katrien De Clercq · Vicente Pérez‑García · Rieta Van Bree · Federica Pollastro · Karen Peeraer · Thomas Voets · Joris Vriens Abstract Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is governed by the processes of trophoblast...


Read more at: The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice

The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice

23 April 2021

Summary The conserved CD94/NKG2A inhibitory receptor is expressed by nearly all human and ∼50% of mouse uterine natural killer (uNK) cells. Binding human HLA-E and mouse Qa-1, NKG2A drives NK cell education, a process of unknown physiological importance influenced by HLA-B alleles. Here, we show that NKG2A genetic ablation...


Read more at: Anti-oxidant supplements during pregnancy may protect against the link between low oxygen in the womb and impaired memory function in adult offspring, a study using laboratory rats and led by Professor Dino Giussani shows.

Anti-oxidant supplements during pregnancy may protect against the link between low oxygen in the womb and impaired memory function in adult offspring, a study using laboratory rats and led by Professor Dino Giussani shows.

22 April 2021

A new study in laboratory rats has discovered a direct link between low oxygen in the womb and impaired memory function in the adult offspring. It also finds that anti-oxidant supplements during pregnancy may protect against this. Low oxygen in the womb - known as chronic fetal hypoxia - is one of the most common...


Read more at: Mapping cells of the reproductive tract across the lifespan will help fill critical gaps in our knowledge about health

Mapping cells of the reproductive tract across the lifespan will help fill critical gaps in our knowledge about health

20 April 2021

0_tsi06wu9v1xoqygd.jpg A typical fallopian tube epithelium stained to highlight cell membranes (red), nuclei (blue), and PAX8 genes (green). Photo provided by Ernst Lengyel, University of Chicago. 1 of 10 women in reproductive age suffer from endometriosis, but we don’t have a diagnostic tool and we don’t have a treatment...


Read more at: Investigation of infertility using endometrial organoids review just published in Repro Journal

Investigation of infertility using endometrial organoids review just published in Repro Journal

20 April 2021

Konstantina Nikolakopoulou, Margherita Y Turco Abstract Infertility is a common problem in modern societies with significant socio-psychological implications for women. Therapeutic interventions are often needed which, depending on the cause, can either be medical treatment, surgical procedures or assisted reproductive...


Read more at: Frequent loss-of-heterozygosity in CRISPR-Cas9–edited early human embryos

Frequent loss-of-heterozygosity in CRISPR-Cas9–edited early human embryos

12 April 2021

Gregorio Alanis-Lobato , Jasmin Zohren , Afshan McCarthy , Norah M. E. Fogarty , Nada Kubikova , Emily Hardman , Maria Greco , Dagan Wells , James M. A. Turner , and Kathy K. Niakan Abstract CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles...


Read more at: Fetal umbilical artery Doppler as a tool for universal third trimester screening: A systematic review and meta-analysis of diagnostic test accuracy

Fetal umbilical artery Doppler as a tool for universal third trimester screening: A systematic review and meta-analysis of diagnostic test accuracy

12 April 2021

Alexandros A. Moraitis , Thomas Bainton, Ulla Sovio, Peter Brocklehurst, Alexander EP. Heazell, Jim G. Thornton, Stephen C. Robson, Aris Papageorghiou, Gordon CS. Smith Abstract The objective of this study was to investigate the accuracy of universal third trimester umbilical artery (UA) Doppler to predict adverse...


Read more at: Developmental programming of the female reproductive system — a review

Developmental programming of the female reproductive system — a review

12 April 2021

Sijia Yao , Jorge Lopez-Tello , Amanda N Sferruzzi-Perri Abstract Exposures to adverse conditions in utero can lead to permanent changes in the structure and function of key physiological systems in the developing fetus, increasing the risk of disease and premature aging in later postnatal life. When considering the...


Read more at: Professor Bob Moor FRS

Professor Bob Moor FRS

11 March 2021

We are saddened to hear of the passing of Professor Bob Moor FRS, a great scientist and colleague. Bob identified many of the factors underpinning reproduction in ungulates during his time at the Babraham Institute, and also worked on generating transgenic animals and stem cells. His wisdom and collegiality will be sorely...