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Centre for Trophoblast Research

 

In the UK, one in six women cannot control their blood sugar levels during pregnancy. This can lead to gestational diabetes (GDM) and predisposes mothers to type-2 diabetes (T2DM) years after delivery. Despite this, we lack information on what drives changes in maternal metabolism in pregnancy and how disruption to this process may lead to disease in later life. My current research uses a variety of animal models and molecular methods to understand how placental hormones drive changes in maternal metabolism that lead to GDM and T2DM in the mother. The final goal of this research is to increase our knowledge on the cause of GDM/T2DM and identify ways to prevent and treat metabolic diseases.

Biography

Jorge Lopez-Tello graduated as a veterinarian and after completing his PhD in Veterinary Science in Spain, he moved to Cambridge with the support of the Royal Society (Newton International Fellowship). Since 2020, Jorge holds a Sir Henry Wellcome Fellowship at the CTR.

Funding:

Wellcome Trust – Sir Henry Wellcome Postdoctoral Fellowship

Royal Society – Newton Fellowship

Society for Endocrinology - Early Career Award

Publications

Key publications: 

López-Tello J, Perez-Garcia V, KhiaraJ, KusinskiL, Cooper W, Andreani A, Grant I, Fernandez-Liger E, Hemberger M, Sandovici I, ConstanciaM, Sferruzzi-Perri AN (2019). Fetal and trophoblast PI3Kp110α have distinct roles in regulating resource supply to the growing fetus. eLIFE (DOI: 10.7554/eLife.45282)

López-Tello J, Arias-Álvarez M, González-Bulnes A, Sferruzzi-Perri AN (2019). Rabbit models for studying intrauterine growth restriction and fetal programming. Molecular Reproduction & Development (DOI: 10.1002/mrd.23271)

López-Tello J, Martínez-Jiménez MA, Herrera EA, KrauseBJ, Sferruzzi-Perri AN+ (2018). Progressive uterine artery occlusion leads to defects in placental formation that relate to fetal growth. Placenta (DOI: doi.org/10.1016/j.placenta.2018.10.003)

Sir Henry Wellcome Postdoctoral Fellow

Contact Details

Not available for consultancy

Affiliations

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